| UniProt ID | SRGP2_HUMAN | |
|---|---|---|
| UniProt AC | O75044 | |
| Protein Name | SLIT-ROBO Rho GTPase-activating protein 2 | |
| Gene Name | SRGAP2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1071 | |
| Subcellular Localization | Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, postsynaptic cell membrane. Cell projection, lamellipodium. Cytoplasmic vesicle, phagosome. Nucleus. Cytopla | |
| Protein Description | RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.. | |
| Protein Sequence | MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKRPESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGSLNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MTSPAKFKK ------CCCCCCCCC | 26074081 | ||
| 3 | Phosphorylation | -----MTSPAKFKKD -----CCCCCCCCCC | 26074081 | ||
| 22 | Ubiquitination | AEYDTQVKEIRAQLT HHHHHHHHHHHHHHH | - | ||
| 33 | Ubiquitination | AQLTEQMKCLDQQCE HHHHHHHHHHHHHHH | - | ||
| 88 | Ubiquitination | TKDQQFKKDQNVLSP CCCHHHCHHCCCCCH | - | ||
| 110 | Phosphorylation | LNQVKRESRDHTTLS HHHHHHHCCCCCCHH | 29083192 | ||
| 114 | Phosphorylation | KRESRDHTTLSDIYL HHHCCCCCCHHHHHH | 29083192 | ||
| 115 | Phosphorylation | RESRDHTTLSDIYLN HHCCCCCCHHHHHHC | 29083192 | ||
| 117 | Phosphorylation | SRDHTTLSDIYLNNI CCCCCCHHHHHHCCC | 29083192 | ||
| 120 | Phosphorylation | HTTLSDIYLNNIIPR CCCHHHHHHCCCCHH | 29083192 | ||
| 143 | Ubiquitination | GRLFKKSKEVGQQLQ CCHHHHHHHHHHHHH | - | ||
| 161 | Phosphorylation | MKVLNELYSVMKTYH HHHHHHHHHHHHHHH | 25147952 | ||
| 174 | Phosphorylation | YHMYNADSISAQSKL HHCCCHHHCCHHHHH | 28857561 | ||
| 176 | Phosphorylation | MYNADSISAQSKLKE CCCHHHCCHHHHHHH | - | ||
| 179 | Phosphorylation | ADSISAQSKLKEAEK HHHCCHHHHHHHHHH | - | ||
| 180 | Ubiquitination | DSISAQSKLKEAEKQ HHCCHHHHHHHHHHH | - | ||
| 203 | Phosphorylation | VKQEDRQTPRSPDST HCHHHCCCCCCCCCC | 23403867 | ||
| 206 | Phosphorylation | EDRQTPRSPDSTANV HHCCCCCCCCCCCCC | 29255136 | ||
| 209 | Phosphorylation | QTPRSPDSTANVRIE CCCCCCCCCCCCCEE | 25849741 | ||
| 210 | Phosphorylation | TPRSPDSTANVRIEE CCCCCCCCCCCCEEE | 23403867 | ||
| 223 | Phosphorylation | EEKHVRRSSVKKIEK EEHHHHHHHHHHHHH | - | ||
| 224 | Phosphorylation | EKHVRRSSVKKIEKM EHHHHHHHHHHHHHH | - | ||
| 226 | Acetylation | HVRRSSVKKIEKMKE HHHHHHHHHHHHHHH | - | ||
| 230 | Acetylation | SSVKKIEKMKEKRQA HHHHHHHHHHHHHHH | - | ||
| 232 | Acetylation | VKKIEKMKEKRQAKY HHHHHHHHHHHHHHH | - | ||
| 234 | Acetylation | KIEKMKEKRQAKYTE HHHHHHHHHHHHHCH | - | ||
| 239 | Phosphorylation | KEKRQAKYTENKLKA HHHHHHHHCHHHHHH | 27259358 | ||
| 240 | Phosphorylation | EKRQAKYTENKLKAI HHHHHHHCHHHHHHH | 27259358 | ||
| 306 | Ubiquitination | ELNLEQSKHEGLDAI HCCHHHHHHHHHHHH | 21906983 | ||
| 326 | Ubiquitination | NLDATSDKQRLMEMY HCCCCCHHHHHHHHH | 21906983 | ||
| 381 | Ubiquitination | QSRLSTLKIENEEVK HHHHHHCCCCCHHHH | - | ||
| 424 | Phosphorylation | NSMESVKSTVSETFM CCHHHHHHHHHHHHH | 30266825 | ||
| 425 | Phosphorylation | SMESVKSTVSETFMS CHHHHHHHHHHHHHC | 30266825 | ||
| 427 | Phosphorylation | ESVKSTVSETFMSKP HHHHHHHHHHHHCCH | 30266825 | ||
| 429 | Phosphorylation | VKSTVSETFMSKPSI HHHHHHHHHHCCHHH | 30266825 | ||
| 432 | Phosphorylation | TVSETFMSKPSIAKR HHHHHHHCCHHHHHH | 23403867 | ||
| 433 | Ubiquitination | VSETFMSKPSIAKRR HHHHHHCCHHHHHHH | 21906983 | ||
| 435 | Phosphorylation | ETFMSKPSIAKRRAN HHHHCCHHHHHHHCC | 23403867 | ||
| 470 | Ubiquitination | LITKLQAKHDLLQKT HHHHHHHHHHHHHHH | - | ||
| 484 | Phosphorylation | TLGESQRTDCSLARR HHCCCHHHHHHHHHC | 23882029 | ||
| 487 | Phosphorylation | ESQRTDCSLARRSST CCHHHHHHHHHCCCC | 30576142 | ||
| 492 | Phosphorylation | DCSLARRSSTVRKQD HHHHHHCCCCCCCCC | 26699800 | ||
| 493 | Phosphorylation | CSLARRSSTVRKQDS HHHHHCCCCCCCCCH | 26699800 | ||
| 494 | Phosphorylation | SLARRSSTVRKQDSS HHHHCCCCCCCCCHH | 26699800 | ||
| 500 | Phosphorylation | STVRKQDSSQAIPLV CCCCCCCHHCHHHHH | 28450419 | ||
| 501 | Phosphorylation | TVRKQDSSQAIPLVV CCCCCCHHCHHHHHH | 28450419 | ||
| 510 | Phosphorylation | AIPLVVESCIRFISR HHHHHHHHHHHHHHH | 23312004 | ||
| 531 | Phosphorylation | GIFRVSGSQVEVNDI CEEEEECCEEEHHHH | 24505115 | ||
| 691 | Phosphorylation | ELEGPVYSRGGSMED HCCCCEECCCCCHHH | 27499020 | ||
| 695 | Phosphorylation | PVYSRGGSMEDYCDS CEECCCCCHHHHCCC | 24144214 | ||
| 699 | Phosphorylation | RGGSMEDYCDSPHGE CCCCHHHHCCCCCCC | 23927012 | ||
| 702 | Phosphorylation | SMEDYCDSPHGETTS CHHHHCCCCCCCCCC | 23663014 | ||
| 707 | Phosphorylation | CDSPHGETTSVEDST CCCCCCCCCCCCCCC | 23663014 | ||
| 708 | Phosphorylation | DSPHGETTSVEDSTQ CCCCCCCCCCCCCCC | 23663014 | ||
| 709 | Phosphorylation | SPHGETTSVEDSTQD CCCCCCCCCCCCCCC | 23663014 | ||
| 713 | Phosphorylation | ETTSVEDSTQDVTAE CCCCCCCCCCCEECC | 23663014 | ||
| 714 | Phosphorylation | TTSVEDSTQDVTAEH CCCCCCCCCCEECCC | 23663014 | ||
| 718 | Phosphorylation | EDSTQDVTAEHHTSD CCCCCCEECCCCCCC | 23663014 | ||
| 723 | Phosphorylation | DVTAEHHTSDDECEP CEECCCCCCCCCCCC | 23663014 | ||
| 724 | Phosphorylation | VTAEHHTSDDECEPI EECCCCCCCCCCCCH | 23927012 | ||
| 748 | Phosphorylation | GRTARELSFKKGASL CCCHHHHCCCCCCEE | 24719451 | ||
| 754 | Phosphorylation | LSFKKGASLLLYQRA HCCCCCCEEEEEECC | 28857561 | ||
| 781 | Phosphorylation | DGLIPHQYIVVQDTE CCCCCCEEEEEEECC | 28270605 | ||
| 787 | Phosphorylation | QYIVVQDTEDGVVER EEEEEEECCCCEEEC | 28270605 | ||
| 795 | Phosphorylation | EDGVVERSSPKSEIE CCCEEECCCCCCCEE | 23927012 | ||
| 796 | Phosphorylation | DGVVERSSPKSEIEV CCEEECCCCCCCEEE | 23927012 | ||
| 799 | Phosphorylation | VERSSPKSEIEVISE EECCCCCCCEEEECC | 23927012 | ||
| 805 | Phosphorylation | KSEIEVISEPPEEKV CCCEEEECCCCCCCC | 25159151 | ||
| 811 | Acetylation | ISEPPEEKVTARAGA ECCCCCCCCEEECCC | 11922375 | ||
| 819 | Phosphorylation | VTARAGASCPSGGHV CEEECCCCCCCCCCH | 26552605 | ||
| 822 | Phosphorylation | RAGASCPSGGHVADI ECCCCCCCCCCHHEE | 25159151 | ||
| 830 | Phosphorylation | GGHVADIYLANINKQ CCCHHEEEEEECCCC | 25394399 | ||
| 843 | Phosphorylation | KQRKRPESGSIRKTF CCCCCCCCCCCCHHH | 29514088 | ||
| 845 | Phosphorylation | RKRPESGSIRKTFRS CCCCCCCCCCHHHCC | 30576142 | ||
| 852 | Phosphorylation | SIRKTFRSDSHGLSS CCCHHHCCCCCCCCC | 28450419 | ||
| 854 | Phosphorylation | RKTFRSDSHGLSSSL CHHHCCCCCCCCCCC | 26657352 | ||
| 858 | Phosphorylation | RSDSHGLSSSLTDSS CCCCCCCCCCCCCCC | 28450419 | ||
| 859 | Phosphorylation | SDSHGLSSSLTDSSS CCCCCCCCCCCCCCC | 28450419 | ||
| 860 | Phosphorylation | DSHGLSSSLTDSSSP CCCCCCCCCCCCCCC | 28450419 | ||
| 862 | Phosphorylation | HGLSSSLTDSSSPGV CCCCCCCCCCCCCCC | 28450419 | ||
| 864 | Phosphorylation | LSSSLTDSSSPGVGA CCCCCCCCCCCCCCC | 30576142 | ||
| 865 | Phosphorylation | SSSLTDSSSPGVGAS CCCCCCCCCCCCCCC | 25850435 | ||
| 866 | Phosphorylation | SSLTDSSSPGVGASC CCCCCCCCCCCCCCC | 30576142 | ||
| 872 | Phosphorylation | SSPGVGASCRPSSQP CCCCCCCCCCCCCCC | 28348404 | ||
| 876 | Phosphorylation | VGASCRPSSQPIMSQ CCCCCCCCCCCCCCC | 27732954 | ||
| 877 | Phosphorylation | GASCRPSSQPIMSQS CCCCCCCCCCCCCCC | 30576142 | ||
| 882 | Phosphorylation | PSSQPIMSQSLPKEG CCCCCCCCCCCCCCC | 29255136 | ||
| 884 | Phosphorylation | SQPIMSQSLPKEGPD CCCCCCCCCCCCCCC | 29255136 | ||
| 894 | Phosphorylation | KEGPDKCSISGHGSL CCCCCCCCCCCCCCC | 23312004 | ||
| 896 | Phosphorylation | GPDKCSISGHGSLNS CCCCCCCCCCCCCCH | 23403867 | ||
| 900 | Phosphorylation | CSISGHGSLNSISRH CCCCCCCCCCHHHCC | 23927012 | ||
| 903 | Phosphorylation | SGHGSLNSISRHSSL CCCCCCCHHHCCHHH | 25159151 | ||
| 905 | Phosphorylation | HGSLNSISRHSSLKN CCCCCHHHCCHHHHH | 23927012 | ||
| 908 | Phosphorylation | LNSISRHSSLKNRLD CCHHHCCHHHHHCCC | 20068231 | ||
| 909 | Phosphorylation | NSISRHSSLKNRLDS CHHHCCHHHHHCCCC | 27422710 | ||
| 916 | Phosphorylation | SLKNRLDSPQIRKTA HHHHCCCCHHHHHHH | 30266825 | ||
| 922 | Phosphorylation | DSPQIRKTATAGRSK CCHHHHHHHCCCCCC | 21712546 | ||
| 924 | Phosphorylation | PQIRKTATAGRSKSF HHHHHHHCCCCCCCC | 20068231 | ||
| 927 | Methylation | RKTATAGRSKSFNNH HHHHCCCCCCCCCCC | 20810653 | ||
| 928 | Phosphorylation | KTATAGRSKSFNNHR HHHCCCCCCCCCCCC | 29116813 | ||
| 930 | Phosphorylation | ATAGRSKSFNNHRPM HCCCCCCCCCCCCCC | 25159151 | ||
| 949 | Phosphorylation | IAQDIEATMNSALNE HHHHHHHHHHHHHHH | 21406692 | ||
| 952 | Phosphorylation | DIEATMNSALNELRE HHHHHHHHHHHHHHH | 21406692 | ||
| 964 | Phosphorylation | LRELERQSSVKHTPD HHHHHHHHCCCCCCC | 23401153 | ||
| 965 | Phosphorylation | RELERQSSVKHTPDV HHHHHHHCCCCCCCE | 28450419 | ||
| 969 | Phosphorylation | RQSSVKHTPDVVLDT HHHCCCCCCCEEECC | 22199227 | ||
| 976 | Phosphorylation | TPDVVLDTLEPLKTS CCCEEECCCCCCCCC | 22199227 | ||
| 982 | Phosphorylation | DTLEPLKTSPVVAPT CCCCCCCCCCCCCCC | 23927012 | ||
| 983 | Phosphorylation | TLEPLKTSPVVAPTS CCCCCCCCCCCCCCC | 23927012 | ||
| 989 | Phosphorylation | TSPVVAPTSEPSSPL CCCCCCCCCCCCCCH | 23927012 | ||
| 990 | Phosphorylation | SPVVAPTSEPSSPLH CCCCCCCCCCCCCHH | 28355574 | ||
| 993 | Phosphorylation | VAPTSEPSSPLHTQL CCCCCCCCCCHHHHH | 28355574 | ||
| 994 | Phosphorylation | APTSEPSSPLHTQLL CCCCCCCCCHHHHHH | 25159151 | ||
| 998 | Phosphorylation | EPSSPLHTQLLKDPE CCCCCHHHHHHCCCC | 23927012 | ||
| 1011 | Phosphorylation | PEPAFQRSASTAGDI CCHHHHCCCCCHHHH | 22617229 | ||
| 1013 | Phosphorylation | PAFQRSASTAGDIAC HHHHCCCCCHHHHHH | 29255136 | ||
| 1014 | Phosphorylation | AFQRSASTAGDIACA HHHCCCCCHHHHHHE | 29255136 | ||
| 1027 | Phosphorylation | CAFRPVKSVKMAAPV HEEEECCEEEECCCC | 23401153 | ||
| 1035 | Acetylation | VKMAAPVKPPATRPK EEECCCCCCCCCCCC | 25953088 | ||
| 1049 | Phosphorylation | KPTVFPKTNATSPGV CCCCCCCCCCCCCCC | 22115753 | ||
| 1052 | Phosphorylation | VFPKTNATSPGVNSS CCCCCCCCCCCCCCC | 25159151 | ||
| 1053 | Phosphorylation | FPKTNATSPGVNSST CCCCCCCCCCCCCCC | 25159151 | ||
| 1058 | Phosphorylation | ATSPGVNSSTSPQST CCCCCCCCCCCCCCC | 25159151 | ||
| 1059 | Phosphorylation | TSPGVNSSTSPQSTD CCCCCCCCCCCCCCC | 25159151 | ||
| 1060 | Phosphorylation | SPGVNSSTSPQSTDK CCCCCCCCCCCCCCC | 25159151 | ||
| 1061 | Phosphorylation | PGVNSSTSPQSTDKS CCCCCCCCCCCCCCC | 25159151 | ||
| 1064 | Phosphorylation | NSSTSPQSTDKSCTV CCCCCCCCCCCCCCC | 22115753 | ||
| 1065 | Phosphorylation | SSTSPQSTDKSCTV- CCCCCCCCCCCCCC- | 22115753 | ||
| 1070 | Phosphorylation | QSTDKSCTV------ CCCCCCCCC------ | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SRGP2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference |
|---|---|---|---|---|
| 927 | R | Methylation |
| 20810653 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SRGP2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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