MYO1G_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYO1G_HUMAN
• UniProt AC: B0I1T2
• Protein Name: Unconventional myosin-Ig
• Gene Name: MYO1G
• Organism: Homo sapiens (Human).
• Sequence Length: 1018
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Cell projection, phagocytic cup . Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup. In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membra
• Protein Description: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis.; Minor histocompatibility antigen HA-2: Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201..
• Protein Sequence: MEDEEGPEYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIARYQGRELYERPPHLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDKQLHELHLERNPAVYNFTHQGAGLNMTVHSALDSDEQSHQAVTEAMRVIGFSPEEVESVHRILAAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLARTVASGGRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNNATIVDLVERPHRGILAVLDEACSSAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKTMEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAYLGLLENVRVRRAGFASRQPYSRFLLRYKMTCEYTWPNHLLGSDKAAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIMRWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPPAVLQPFQDTCHALFCRWRARQLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDYLSSATDNPTASSLFAQRLKTLQDKDGFGAVLFSSHVRKVNRFHKIRNRALLLTDQHLYKLDPDRQYRVMRAVPLEAVTGLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPLDNRVGELVGVLAAHCQGEGRTLEVRVSDCIPLSHRGVRRLISVEPRPEQPEPDFRCARGSFTLLWPSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEDEEGPE -------CCCCCCCC	55.20	25944712
11	Acetylation	EEGPEYGKPDFVLLD CCCCCCCCCCEEEEE	40.28	11912627
66	Phosphorylation	GPEAIARYQGRELYE CHHHHHHHCCHHHHH	13.29	20058876
72	Phosphorylation	RYQGRELYERPPHLY HHCCHHHHHCCCHHH	12.73	28064214
73	Ubiquitination	YQGRELYERPPHLYA HCCHHHHHCCCHHHH	71.92	21890473
78	Ubiquitination	LYERPPHLYAVANAA HHHCCCHHHHHHHHH	3.46	22817900
87	Acetylation	AVANAAYKAMKHRSR HHHHHHHHHHHHCCC	36.96	25953088
87	Ubiquitination	AVANAAYKAMKHRSR HHHHHHHHHHHHCCC	36.96	22505724
90	Acetylation	NAAYKAMKHRSRDTC HHHHHHHHHCCCCEE	40.50	11695841
93	Phosphorylation	YKAMKHRSRDTCIVI HHHHHHCCCCEEEEE	33.94	27251275
103	Ubiquitination	TCIVISGESGAGKTE EEEEEECCCCCCHHH	38.93	22505724
108	Ubiquitination	SGESGAGKTEASKHI ECCCCCCHHHHHHHH	42.53	29967540
113	Ubiquitination	AGKTEASKHIMQYIA CCHHHHHHHHHHHHH	44.17	29967540
118	Phosphorylation	ASKHIMQYIAAVTNP HHHHHHHHHHHHCCH	3.83	27642862
119	Ubiquitination	SKHIMQYIAAVTNPS HHHHHHHHHHHCCHH	0.82	22505724
135	Acetylation	RAEVERVKDVLLKST HHHHHHHHHHHHHCH	48.63	25953088
135	Ubiquitination	RAEVERVKDVLLKST HHHHHHHHHHHHHCH	48.63	29967540
140	Acetylation	RVKDVLLKSTCVLEA HHHHHHHHCHHHHHH	39.29	25953088
140	Methylation	RVKDVLLKSTCVLEA HHHHHHHHCHHHHHH	39.29	-
140	Ubiquitination	RVKDVLLKSTCVLEA HHHHHHHHCHHHHHH	39.29	29967540
164	Ubiquitination	HNSSRFGKYMDINFD CCCCCCCCEEEEEEE	34.39	-
173	Ubiquitination	MDINFDFKGDPIGGH EEEEEEECCCCCCHH	65.33	29967540
188	Ubiquitination	IHSYLLEKSRVLKQH HHHHHHHHHHHHHHH	43.46	22817900
188 (in isoform 1)	Ubiquitination	-	43.46	21890473
188 (in isoform 2)	Ubiquitination	-	43.46	21890473
188 (in isoform 3)	Ubiquitination	-	43.46	21890473
188 (in isoform 4)	Ubiquitination	-	43.46	21890473
193	Acetylation	LEKSRVLKQHVGERN HHHHHHHHHHHCCCH	35.19	25953088
193	Ubiquitination	LEKSRVLKQHVGERN HHHHHHHHHHHCCCH	35.19	22817900
205	Phosphorylation	ERNFHAFYQLLRGSE CCHHHHHHHHHHCCC	10.07	28796482
214	Acetylation	LLRGSEDKQLHELHL HHHCCCCHHHHHHHH	51.19	25953088
214	Ubiquitination	LLRGSEDKQLHELHL HHHCCCCHHHHHHHH	51.19	29967540
226	Ubiquitination	LHLERNPAVYNFTHQ HHHCCCCCEECCCCC	21.70	22505724
242	Ubiquitination	AGLNMTVHSALDSDE CCCCCEEECCCCCCH	9.74	22505724
269	Ubiquitination	IGFSPEEVESVHRIL HCCCHHHHHHHHHHH	6.74	22505724
274	Dimethylation	EEVESVHRILAAILH HHHHHHHHHHHHHHH	24.38	-
274	Methylation	EEVESVHRILAAILH HHHHHHHHHHHHHHH	24.38	18939031
306	Ubiquitination	GLAVAEEALVDHVAE CCHHHHHHHHHHHHH	12.37	21890473
325	Phosphorylation	PRDLVLRSLLARTVA HHHHHHHHHHHHHHH	24.47	27067055
333	Phosphorylation	LLARTVASGGRELIE HHHHHHHHCHHHHHH	37.13	27067055
333	Ubiquitination	LLARTVASGGRELIE HHHHHHHHCHHHHHH	37.13	21890473
341	Acetylation	GGRELIEKGHTAAEA CHHHHHHCCCCHHHH	49.34	25953088
341	Ubiquitination	GGRELIEKGHTAAEA CHHHHHHCCCCHHHH	49.34	22505724
349	Phosphorylation	GHTAAEASYARDACA CCCHHHHHHHHHHHH	15.72	-
350	Phosphorylation	HTAAEASYARDACAK CCHHHHHHHHHHHHH	16.83	-
356	Ubiquitination	SYARDACAKAVYQRL HHHHHHHHHHHHHHH	12.45	22505724
357	Ubiquitination	YARDACAKAVYQRLF HHHHHHHHHHHHHHH	37.96	22505724
373	Phosphorylation	WVVNRINSVMEPRGR HHHHHHHHHCCCCCC	22.07	-
375	Sulfoxidation	VNRINSVMEPRGRDP HHHHHHHCCCCCCCC	6.19	21406390
392	Ubiquitination	DGKDTVIGVLDIYGF CCCCCEEEEEEECCC	15.03	22505724
414	Phosphorylation	FEQFCINYCNEKLQQ HHHHHHHHHHHHHHH	4.09	18452278
429	Ubiquitination	LFIQLILKQEQEEYE HHHHHHHHHHHHHHH	44.81	21890473
435	Phosphorylation	LKQEQEEYEREGITW HHHHHHHHHHCCCCC	21.38	27642862
447	Phosphorylation	ITWQSVEYFNNATIV CCCEEHHHHCCCEEE	14.95	-
456	Ubiquitination	NNATIVDLVERPHRG CCCEEEECCCCCCCC	2.74	21890473
473	Phosphorylation	AVLDEACSSAGTITD HHHHHHHHCCCCCHH	30.21	28122231
474	Phosphorylation	VLDEACSSAGTITDR HHHHHHHCCCCCHHH	30.51	30108239
477	Phosphorylation	EACSSAGTITDRIFL HHHHCCCCCHHHHHH	22.03	30108239
479	Phosphorylation	CSSAGTITDRIFLQT HHCCCCCHHHHHHHH	21.04	30108239
479	Ubiquitination	CSSAGTITDRIFLQT HHCCCCCHHHHHHHH	21.04	22505724
497	Phosphorylation	HHRHHLHYTSRQLCP CCCHHCCCCCCCCCC	16.87	-
498	Phosphorylation	HRHHLHYTSRQLCPT CCHHCCCCCCCCCCC	13.49	30108239
499	Phosphorylation	RHHLHYTSRQLCPTD CHHCCCCCCCCCCCC	15.74	30108239
505	Phosphorylation	TSRQLCPTDKTMEFG CCCCCCCCCCCCCCC	49.48	30108239
507	Acetylation	RQLCPTDKTMEFGRD CCCCCCCCCCCCCCC	52.85	23749302
507	Ubiquitination	RQLCPTDKTMEFGRD CCCCCCCCCCCCCCC	52.85	22505724
508	Phosphorylation	QLCPTDKTMEFGRDF CCCCCCCCCCCCCCE	25.41	30108239
518	Methylation	FGRDFRIKHYAGDVT CCCCEEEEEECCCEE	26.72	23644510
518	Ubiquitination	FGRDFRIKHYAGDVT CCCCEEEEEECCCEE	26.72	29967540
525	Phosphorylation	KHYAGDVTYSVEGFI EEECCCEEEEEEEEE	18.15	27080861
526	Phosphorylation	HYAGDVTYSVEGFID EECCCEEEEEEEEEC	15.57	27080861
527	Phosphorylation	YAGDVTYSVEGFIDK ECCCEEEEEEEEECC	12.34	27080861
534	Ubiquitination	SVEGFIDKNRDFLFQ EEEEEECCCCCHHHH	49.41	29967540
544	Acetylation	DFLFQDFKRLLYNST CHHHHHHHHHHHCCC	50.88	26822725
544	Ubiquitination	DFLFQDFKRLLYNST CHHHHHHHHHHHCCC	50.88	22817900
544 (in isoform 1)	Ubiquitination	-	50.88	21890473
544 (in isoform 4)	Ubiquitination	-	50.88	21890473
548	Phosphorylation	QDFKRLLYNSTDPTL HHHHHHHHCCCCCCH	16.20	25147952
571	Ubiquitination	QDITEVTKRPLTAGT CCCHHHHCCCCCHHH	58.14	22817900
571 (in isoform 1)	Ubiquitination	-	58.14	21890473
571 (in isoform 4)	Ubiquitination	-	58.14	21890473
575	Phosphorylation	EVTKRPLTAGTLFKN HHHCCCCCHHHHHHH	26.23	24719451
575	Ubiquitination	EVTKRPLTAGTLFKN HHHCCCCCHHHHHHH	26.23	22817900
577	Ubiquitination	TKRPLTAGTLFKNSM HCCCCCHHHHHHHHH	20.09	21890473
578	Phosphorylation	KRPLTAGTLFKNSMV CCCCCHHHHHHHHHH	26.93	26546556
581	Ubiquitination	LTAGTLFKNSMVALV CCHHHHHHHHHHHHH	51.75	29967540
583	Phosphorylation	AGTLFKNSMVALVEN HHHHHHHHHHHHHHH	18.41	30576142
593	Phosphorylation	ALVENLASKEPFYVR HHHHHHHHCCCEEEE	40.49	24719451
594	Ubiquitination	LVENLASKEPFYVRC HHHHHHHCCCEEEEE	64.89	22505724
598	Phosphorylation	LASKEPFYVRCIKPN HHHCCCEEEEEECCC	9.56	25147952
603	Ubiquitination	PFYVRCIKPNEDKVA CEEEEEECCCCCCCC	45.47	29967540
608	Acetylation	CIKPNEDKVAGKLDE EECCCCCCCCCCCCC	28.01	23749302
608	Ubiquitination	CIKPNEDKVAGKLDE EECCCCCCCCCCCCC	28.01	29967540
612	Ubiquitination	NEDKVAGKLDENHCR CCCCCCCCCCCCHHH	42.92	29967540
620	Ubiquitination	LDENHCRHQVAYLGL CCCCHHHHHHHHHHH	31.68	22817900
624	Phosphorylation	HCRHQVAYLGLLENV HHHHHHHHHHHHHHH	11.49	28152594
625	Ubiquitination	CRHQVAYLGLLENVR HHHHHHHHHHHHHHH	2.55	21890473
652	Ubiquitination	SRFLLRYKMTCEYTW HHHHHHHEEEEEECC	22.69	-
654	Phosphorylation	FLLRYKMTCEYTWPN HHHHHEEEEEECCCC	9.68	-
657	Phosphorylation	RYKMTCEYTWPNHLL HHEEEEEECCCCCCC	19.09	27642862
660	Ubiquitination	MTCEYTWPNHLLGSD EEEEECCCCCCCCCC	15.57	21890473
666	Phosphorylation	WPNHLLGSDKAAVSA CCCCCCCCCHHHHHH	35.59	-
668	Ubiquitination	NHLLGSDKAAVSALL CCCCCCCHHHHHHHH	39.69	29967540
689	Phosphorylation	GDVAFGHSKLFIRSP CCEEECCCEEEECCC	31.28	27080861
690	Ubiquitination	DVAFGHSKLFIRSPR CEEECCCEEEECCCC	41.56	-
695	Phosphorylation	HSKLFIRSPRTLVTL CCEEEECCCCCEEEH	17.58	27067055
698	Ubiquitination	LFIRSPRTLVTLEQS EEECCCCCEEEHHHH	29.03	22817900
700	Ubiquitination	IRSPRTLVTLEQSRA ECCCCCEEEHHHHHH	5.92	21890473
724	Phosphorylation	LQKAWRGTLARWRCR HHHHCCHHHHHHHHH	14.52	27067055
737	Phosphorylation	CRRLRAIYTIMRWFR HHHHHHHHHHHHHHH	6.82	28796482
738	Phosphorylation	RRLRAIYTIMRWFRR HHHHHHHHHHHHHHH	11.37	28796482
743	Ubiquitination	IYTIMRWFRRHKVRA HHHHHHHHHHHHHHH	3.29	22817900
748	Ubiquitination	RWFRRHKVRAHLAEL HHHHHHHHHHHHHHH	5.51	21890473
783	Ubiquitination	LPPAVLQPFQDTCHA CCHHHCHHHHHHHHH	25.38	21890473
802	Ubiquitination	WRARQLVKNIPPSDM HHHHHHHHCCCHHHC	58.72	-
813	Ubiquitination	PSDMPQIKAKVAAMG HHHCHHHHHHHHHHH	36.59	22817900
815	Ubiquitination	DMPQIKAKVAAMGAL HCHHHHHHHHHHHHH	27.66	22817900
815 (in isoform 1)	Ubiquitination	-	27.66	21890473
819	Sulfoxidation	IKAKVAAMGALQGLR HHHHHHHHHHHHHHH	2.02	21406390
839	Phosphorylation	RRAWARDYLSSATDN HHHHHHHHHHHCCCC	11.70	-
841	Phosphorylation	AWARDYLSSATDNPT HHHHHHHHHCCCCCC	16.23	27080861
842	Phosphorylation	WARDYLSSATDNPTA HHHHHHHHCCCCCCH	32.37	27080861
844	Phosphorylation	RDYLSSATDNPTASS HHHHHHCCCCCCHHH	37.95	27080861
848	Phosphorylation	SSATDNPTASSLFAQ HHCCCCCCHHHHHHH	45.48	27080861
850	Phosphorylation	ATDNPTASSLFAQRL CCCCCCHHHHHHHHH	30.01	27080861
851	Phosphorylation	TDNPTASSLFAQRLK CCCCCHHHHHHHHHH	25.66	27080861
858	Ubiquitination	SLFAQRLKTLQDKDG HHHHHHHHHCCCCCC	49.75	22817900
859	Phosphorylation	LFAQRLKTLQDKDGF HHHHHHHHCCCCCCC	33.95	-
863	Ubiquitination	RLKTLQDKDGFGAVL HHHHCCCCCCCCHHH	46.95	22817900
863 (in isoform 1)	Ubiquitination	-	46.95	21890473
872	Phosphorylation	GFGAVLFSSHVRKVN CCCHHHCHHHHHHHH	18.51	28122231
873	Phosphorylation	FGAVLFSSHVRKVNR CCHHHCHHHHHHHHH	20.76	28122231
892	Phosphorylation	RNRALLLTDQHLYKL HHHHEHHCCHHHHCC	33.32	27067055
897	Phosphorylation	LLTDQHLYKLDPDRQ HHCCHHHHCCCCCCC	13.84	28796482
898	Ubiquitination	LTDQHLYKLDPDRQY HCCHHHHCCCCCCCC	53.42	22817900
898 (in isoform 1)	Ubiquitination	-	53.42	21890473
905	Phosphorylation	KLDPDRQYRVMRAVP CCCCCCCCEEEECCC	13.18	-
971	Phosphorylation	HCQGEGRTLEVRVSD HCCCCCCEEEEEHHH	37.82	24247654
983	Phosphorylation	VSDCIPLSHRGVRRL HHHEEECCCCCEEEE	13.04	-
992	Phosphorylation	RGVRRLISVEPRPEQ CCEEEEEECCCCCCC	25.64	23401153
1010	Phosphorylation	DFRCARGSFTLLWPS CCCCCCCEEEEECCC	14.98	22115753
1012	Phosphorylation	RCARGSFTLLWPSR- CCCCCEEEEECCCC-	23.73	22115753
1017	Phosphorylation	SFTLLWPSR------ EEEEECCCC------	38.75	24247654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYO1G_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYO1G_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYO1G_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RALA_HUMAN	RALA	physical	22939629
TFR1_HUMAN	TFRC	physical	19968988

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.