CMC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CMC1_HUMAN
• UniProt AC: O75746
• Protein Name: Calcium-binding mitochondrial carrier protein Aralar1
• Gene Name: SLC25A12
• Organism: Homo sapiens (Human).
• Sequence Length: 678
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. [PubMed: 11566871]
• Protein Sequence: MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWFYIDFGGLKPAGSEPTPKSRIADLPPANPDHIGGYRLATATFAGIENKFGLYLPKFKSPSVAVVQPKAAVAATQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVKVQTTK ------CCEEEEECC	15.16	22814378
4	Ubiquitination	----MAVKVQTTKRG ----CCEEEEECCCC	21.06	22505724
55	Ubiquitination	NDPNSNPKIVQLLAG CCCCCCHHHHHHHHH	60.81	21906983
101	Phosphorylation	AFQLFDKSGNGEVTF EEEEECCCCCCCEEE	39.06	20833797
112	Acetylation	EVTFENVKEIFGQTI CEEEECHHHHHCCEE	57.59	30592431
143	Ubiquitination	HFGHNRKKHLNYTEF HHCCCCCCCCCHHHH	50.52	-
183	Phosphorylation	MISGLDFSDIMVTIR CCCCCCHHHHHHHHH	26.37	-
188	Phosphorylation	DFSDIMVTIRSHMLT CHHHHHHHHHHHCCC	8.03	-
236	Phosphorylation	MELVRKIYSTLAGTR HHHHHHHHHHHCCCC	9.91	21406692
237	Phosphorylation	ELVRKIYSTLAGTRK HHHHHHHHHHCCCCC	22.03	26437602
238	Phosphorylation	LVRKIYSTLAGTRKD HHHHHHHHHCCCCCC	12.03	21406692
242	Phosphorylation	IYSTLAGTRKDVEVT HHHHHCCCCCCEEEC	29.01	26437602
249	Phosphorylation	TRKDVEVTKEEFAQS CCCCEEECHHHHHHH	21.16	-
250	Ubiquitination	RKDVEVTKEEFAQSA CCCEEECHHHHHHHH	61.49	2190698
256	O-linked_Glycosylation	TKEEFAQSAIRYGQV CHHHHHHHHHHCCCC	23.41	30379171
278	Phosphorylation	LYQLADLYNASGRLT HHHHHHHHCCCCCEE	14.83	22673903
281	Phosphorylation	LADLYNASGRLTLAD HHHHHCCCCCEEHHH	22.32	22673903
299	Ubiquitination	IAPLAEGALPYNLAE HHHHCCCCCCCCHHH	9.25	-
315	Ubiquitination	QRQQSPGLGRPIWLQ HHHCCCCCCCCHHHH	6.29	21890473
360	Phosphorylation	RMQNQRGSGSVVGEL HHHCCCCCCCHHHHH	30.04	28857561
369	Phosphorylation	SVVGELMYKNSFDCF CHHHHHEECCCHHHH	21.46	-
370	Methylation	VVGELMYKNSFDCFK HHHHHEECCCHHHHH	31.95	-
375	Ubiquitination	MYKNSFDCFKKVLRY EECCCHHHHHHHHHH	5.19	21890473
377	Methylation	KNSFDCFKKVLRYEG CCCHHHHHHHHHHHC	48.59	2380341
377	Acetylation	KNSFDCFKKVLRYEG CCCHHHHHHHHHHHC	48.59	25825284
377	Ubiquitination	KNSFDCFKKVLRYEG CCCHHHHHHHHHHHC	48.59	32142685
378	Ubiquitination	NSFDCFKKVLRYEGF CCHHHHHHHHHHHCC	26.67	-
391	Ubiquitination	GFFGLYRGLIPQLIG CCHHHHHCHHHHHHC	17.88	21890473
394	Ubiquitination	GLYRGLIPQLIGVAP HHHHCHHHHHHCCCC	28.15	21890473
406	Ubiquitination	VAPEKAIKLTVNDFV CCCHHHEECCHHHHH	42.86	21890473
451	Methylation	TNPLEIVKIRLQVAG CCCCEEEEEEEEECC	27.98	83136529
461	Phosphorylation	LQVAGEITTGPRVSA EEECCCCCCCCCCCH	22.77	22210691
482	Ubiquitination	LGIFGLYKGAKACFL HCCCCHHCCCEEEEC	58.39	21890473
485	Ubiquitination	FGLYKGAKACFLRDI CCHHCCCEEEECCCC	55.12	21890473
537	Phosphorylation	VPAASLVTPADVIKT CCHHHCCCHHHHHHH	20.32	20068231
578	Acetylation	EGPSAFWKGTAARVF HCCCHHHCCHHHHHH	39.67	30592425
606	Phosphorylation	ELLQRWFYIDFGGLK HHHHHHEECCCCCCC	7.82	-
643	Phosphorylation	IGGYRLATATFAGIE CCCCEEEEEEEECHH	30.72	-
656	Phosphorylation	IENKFGLYLPKFKSP HHHHCCEECCCCCCC	22.72	-
661	Methylation	GLYLPKFKSPSVAVV CEECCCCCCCCEEEE	68.53	115981107
662	Phosphorylation	LYLPKFKSPSVAVVQ EECCCCCCCCEEEEC	26.07	20833797
664	Phosphorylation	LPKFKSPSVAVVQPK CCCCCCCCEEEECCC	29.78	26437602
677	Phosphorylation	PKAAVAATQ------ CCHHHHCCC------	25.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CMC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CMC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CMC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAS3_HUMAN	GNAS	physical	22939629
GNAS2_HUMAN	GNAS	physical	22939629
ALEX_HUMAN	GNAS	physical	22939629
GNAS1_HUMAN	GNAS	physical	22939629
MIC60_HUMAN	IMMT	physical	26344197

Drug and Disease Associations

• Kegg Disease
• H01305: Global cerebral hypomyelination
• OMIM Disease
• 612949: Global cerebral hypomyelination (GCHM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00128: L-Aspartic Acid