GNAS1_HUMAN - dbPTM
GNAS1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GNAS1_HUMAN
UniProt AC Q5JWF2
Protein Name Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Gene Name GNAS
Organism Homo sapiens (Human).
Sequence Length 1037
Subcellular Localization Cell membrane
Peripheral membrane protein . Apical cell membrane .
Protein Description Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as GNAS isoforms (By similarity)..
Protein Sequence MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
154PhosphorylationARPGLGGYSPPPEEA
CCCCCCCCCCCHHHH		19.0625002506
155PhosphorylationRPGLGGYSPPPEEAM
CCCCCCCCCCHHHHC		33.9225002506
327PhosphorylationDTPVNMDSPPIALDG
CCCCCCCCCCEECCC		23.08-
375PhosphorylationAEGGKVPSPGYGSPA
HCCCCCCCCCCCCCC		33.6628842319
378PhosphorylationGKVPSPGYGSPAAGA
CCCCCCCCCCCCCCC		20.1525884760
380PhosphorylationVPSPGYGSPAAGAAS
CCCCCCCCCCCCCCC		11.6824719451
515PhosphorylationAQVRRAASAAPASGA
HHHHHHHHCCCCCCC		24.7924825855
520PhosphorylationAASAAPASGARRKIH
HHHCCCCCCCCCCEE		31.74-
532PhosphorylationKIHLRPPSPEIQAAD
CEECCCCCHHHCCCC		37.5425849741
542PhosphorylationIQAADPPTPRPTRAS
HCCCCCCCCCCCCCC		37.0030242111
546PhosphorylationDPPTPRPTRASAWRG
CCCCCCCCCCCCCCC		39.9028842319
565PhosphorylationSRGRRVYYDEGVASS
CCCCEEEEECCCCCC		12.5028985074
571PhosphorylationYYDEGVASSDDDSSG
EEECCCCCCCCCCCC		31.7128985074
577PhosphorylationASSDDDSSGDESDDG
CCCCCCCCCCCCCCC		58.2028985074
623PhosphorylationFGGCFGRSESPQPKA
HCCCCCCCCCCCCCC		42.6924719451
625PhosphorylationGCFGRSESPQPKASR
CCCCCCCCCCCCCCC		30.0422617229
680PhosphorylationLQDEKMGYMCTHRLL
HHHHHHHHHHHHHHH		5.8722461510
694PhosphorylationLLLGAGESGKSTIVK
HHCCCCCCCCHHHHE		51.0720873877
696UbiquitinationLGAGESGKSTIVKQM
CCCCCCCCHHHHEEE		54.4221890473
696 (in isoform 1)Ubiquitination-54.4221890473
696 (in isoform 2)Ubiquitination-54.4221890473
697PhosphorylationGAGESGKSTIVKQMR
CCCCCCCHHHHEEEE		27.2229514088
698PhosphorylationAGESGKSTIVKQMRI
CCCCCCHHHHEEEEE		33.0229514088
7012-HydroxyisobutyrylationSGKSTIVKQMRILHV
CCCHHHHEEEEEEEE		34.23-
701UbiquitinationSGKSTIVKQMRILHV
CCCHHHHEEEEEEEE		34.2321890473
701 (in isoform 2)Ubiquitination-34.2321890473
701 (in isoform 1)Ubiquitination-34.2321890473
717 (in isoform 2)Ubiquitination-70.8121890473
720 (in isoform 2)Ubiquitination-29.0521890473
725 (in isoform 2)Ubiquitination-35.6421890473
731UbiquitinationRSNSDGEKATKVQDI
HCCCCCCHHHHHHHH		67.87-
731 (in isoform 1)Ubiquitination-67.8721890473
734UbiquitinationSDGEKATKVQDIKNN
CCCCHHHHHHHHHHH		42.6421890473
7342-HydroxyisobutyrylationSDGEKATKVQDIKNN
CCCCHHHHHHHHHHH		42.64-
734 (in isoform 1)Ubiquitination-42.6421890473
739AcetylationATKVQDIKNNLKEAI
HHHHHHHHHHHHHHH		48.3427452117
739UbiquitinationATKVQDIKNNLKEAI
HHHHHHHHHHHHHHH		48.3421890473
739 (in isoform 1)Ubiquitination-48.3421890473
773PhosphorylationENQFRVDYILSVMNV
CCCCCCCEEEEECCC		10.8227642862
810 (in isoform 2)Ubiquitination-59.2121890473
815 (in isoform 2)Ubiquitination-2.1121890473
820PhosphorylationQLIDCAQYFLDKIDV
CHHHHHHHHHHHCHH		6.38-
824UbiquitinationCAQYFLDKIDVIKQA
HHHHHHHHCHHHHHC		42.84-
824 (in isoform 1)Ubiquitination-42.8421890473
829UbiquitinationLDKIDVIKQADYVPS
HHHCHHHHHCCCCCC		39.0021890473
8292-HydroxyisobutyrylationLDKIDVIKQADYVPS
HHHCHHHHHCCCCCC		39.00-
829 (in isoform 1)Ubiquitination-39.0021890473
833PhosphorylationDVIKQADYVPSDQDL
HHHHHCCCCCCCHHH		19.7828796482
836PhosphorylationKQADYVPSDQDLLRC
HHCCCCCCCHHHHHH		37.5530622161
840 (in isoform 2)Ubiquitination-2.4321890473
844ADP-ribosylationDQDLLRCRVLTSGIF
CHHHHHHEEECCCCC		21.75-
844ADP-ribosylationDQDLLRCRVLTSGIF
CHHHHHHEEECCCCC		21.75-
845 (in isoform 2)Ubiquitination-8.6121890473
847PhosphorylationLLRCRVLTSGIFETK
HHHHEEECCCCCEEE		23.2729759185
848PhosphorylationLRCRVLTSGIFETKF
HHHEEECCCCCEEEE		26.2329759185
853PhosphorylationLTSGIFETKFQVDKV
ECCCCCEEEEEECEE		26.8129759185
8542-HydroxyisobutyrylationTSGIFETKFQVDKVN
CCCCCEEEEEECEEE		26.97-
854UbiquitinationTSGIFETKFQVDKVN
CCCCCEEEEEECEEE		26.9721890473
854 (in isoform 1)Ubiquitination-26.9721890473
8592-HydroxyisobutyrylationETKFQVDKVNFHMFD
EEEEEECEEEEEEEE		39.97-
859UbiquitinationETKFQVDKVNFHMFD
EEEEEECEEEEEEEE		39.9721890473
859 (in isoform 1)Ubiquitination-39.9721890473
903 (in isoform 2)Ubiquitination-42.5621890473
917 (in isoform 1)Ubiquitination-44.1721890473
917UbiquitinationQEALNLFKSIWNNRW
HHHHHHHHHHHCCHH		44.1721890473
917AcetylationQEALNLFKSIWNNRW
HHHHHHHHHHHCCHH		44.1726051181
922 (in isoform 2)Ubiquitination-22.8521890473
929 (in isoform 2)Ubiquitination-11.5121890473
934 (in isoform 2)Ubiquitination-7.5921890473
936 (in isoform 1)Ubiquitination-47.5421890473
936UbiquitinationSVILFLNKQDLLAEK
HHHHHCCHHHHHHHH		47.5421906983
936 (in isoform 2)Ubiquitination-47.5421890473
943UbiquitinationKQDLLAEKVLAGKSK
HHHHHHHHHHCCCHH		36.6221890473
943 (in isoform 1)Ubiquitination-36.6221890473
943AcetylationKQDLLAEKVLAGKSK
HHHHHHHHHHCCCHH		36.6227452117
948UbiquitinationAEKVLAGKSKIEDYF
HHHHHCCCHHHHHHC		42.8621890473
948 (in isoform 1)Ubiquitination-42.8621890473
949PhosphorylationEKVLAGKSKIEDYFP
HHHHCCCHHHHHHCH		37.6425002506
950 (in isoform 1)Ubiquitination-54.3121890473
9502-HydroxyisobutyrylationKVLAGKSKIEDYFPE
HHHCCCHHHHHHCHH		54.31-
950UbiquitinationKVLAGKSKIEDYFPE
HHHCCCHHHHHHCHH		54.3121890473
954PhosphorylationGKSKIEDYFPEFARY
CCHHHHHHCHHHHCC		14.2928152594
961PhosphorylationYFPEFARYTTPEDAT
HCHHHHCCCCCCCCC		16.1320860994
962PhosphorylationFPEFARYTTPEDATP
CHHHHCCCCCCCCCC		30.2628796482
963PhosphorylationPEFARYTTPEDATPE
HHHHCCCCCCCCCCC		18.7528796482
967 (in isoform 2)Ubiquitination-24.3221890473
968PhosphorylationYTTPEDATPEPGEDP
CCCCCCCCCCCCCCC		40.2728796482
978PhosphorylationPGEDPRVTRAKYFIR
CCCCCCCCEEEEEEC		26.6224719451
981 (in isoform 1)Ubiquitination-37.0921890473
981UbiquitinationDPRVTRAKYFIRDEF
CCCCCEEEEEECCCH		37.0921890473
982PhosphorylationPRVTRAKYFIRDEFL
CCCCEEEEEECCCHH		11.8528152594
990MethylationFIRDEFLRISTASGD
EECCCHHEEEECCCC		26.57-
992PhosphorylationRDEFLRISTASGDGR
CCCHHEEEECCCCCC		16.1028176443
993PhosphorylationDEFLRISTASGDGRH
CCHHEEEECCCCCCC		23.5929255136
995PhosphorylationFLRISTASGDGRHYC
HHEEEECCCCCCCCE		37.1912727968
1001PhosphorylationASGDGRHYCYPHFTC
CCCCCCCCEECCCEE		7.7228152594
1003PhosphorylationGDGRHYCYPHFTCAV
CCCCCCEECCCEEEE		7.8028464451
1007PhosphorylationHYCYPHFTCAVDTEN
CCEECCCEEEECHHH		9.1221406692
1012PhosphorylationHFTCAVDTENIRRVF
CCEEEECHHHHHHHH		25.0821406692
1034PhosphorylationQRMHLRQYELL----
HHHHHHHHHCC----		11.3429496907
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GNAS1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GNAS1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GNAS1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FSCN1_HUMANFSCN1physical
17353931
PUR6_HUMANPAICSphysical
17353931
RUVB1_HUMANRUVBL1physical
17353931
GLYM_HUMANSHMT2physical
17353931
ADCY6_HUMANADCY6genetic
9228084
GNAS3_HUMANGNASphysical
7797570
GNAS2_HUMANGNASphysical
7797570
ALEX_HUMANGNASphysical
7797570
GNAS1_HUMANGNASphysical
7797570
NUCB1_HUMANNUCB1physical
21988832
NUCB2_HUMANNUCB2physical
21988832
1A02_HUMANHLA-Aphysical
9914489
1A03_HUMANHLA-Aphysical
9914489
1A01_HUMANHLA-Aphysical
9914489
1A26_HUMANHLA-Aphysical
9914489
AXIN1_HUMANAXIN1physical
16293724
PANX1_HUMANPANX1physical
16293724
GNAL_HUMANGNALphysical
26186194
GBG4_HUMANGNG4physical
26186194
TROP_HUMANTROphysical
26186194
MAGD2_HUMANMAGED2physical
26186194
GBB1_HUMANGNB1physical
26186194
GBB2_HUMANGNB2physical
26186194
GBB4_HUMANGNB4physical
26186194
C1QBP_HUMANC1QBPphysical
26186194
MAP2_HUMANMETAP2physical
26186194
CPT2_HUMANCPT2physical
26186194
YBEY_HUMANYBEYphysical
26186194
GBG10_HUMANGNG10physical
26186194
OCAD1_HUMANOCIAD1physical
26186194
GNA12_HUMANGNA12physical
26186194
ARMX3_HUMANARMCX3physical
26186194
GBG5_HUMANGNG5physical
26186194
IF4H_HUMANEIF4Hphysical
26344197
EMAL2_HUMANEML2physical
26344197
GIPC1_HUMANGIPC1physical
26344197
PUR4_HUMANPFASphysical
26344197
RIC8B_HUMANRIC8Bphysical
12652642
ADCY2_HUMANADCY2physical
25241761
GPA1_YEASTGPA1genetic
8943324
GBB_YEASTSTE4genetic
8943324
GNAL_HUMANGNALphysical
28514442
TROP_HUMANTROphysical
28514442
OCAD1_HUMANOCIAD1physical
28514442
MAGD2_HUMANMAGED2physical
28514442
GBB4_HUMANGNB4physical
28514442
CPT2_HUMANCPT2physical
28514442
GBG5_HUMANGNG5physical
28514442
MAP2_HUMANMETAP2physical
28514442
GNA12_HUMANGNA12physical
28514442
C1QBP_HUMANC1QBPphysical
28514442
GBB1_HUMANGNB1physical
28514442
Drug and Disease Associations
Kegg Disease
OMIM Disease
139320GNAS hyperfunction (GNASHYP)
219080ACTH-independent macronodular adrenal hyperplasia 1 (AIMAH1)
603233Pseudohypoparathyroidism 1B (PHP1B)
612462Pseudohypoparathyroidism 1C (PHP1C)
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GNAS1_HUMAN

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