| UniProt ID | GBB_YEAST | |
|---|---|---|
| UniProt AC | P18851 | |
| Protein Name | Guanine nucleotide-binding protein subunit beta | |
| Gene Name | STE4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 423 | |
| Subcellular Localization | ||
| Protein Description | Implicated in the a- and alpha-factor response pathway. The beta and gamma chains of the putative yeast mating response pathway G protein play a positive role in initiation of the mating response. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.. | |
| Protein Sequence | MAAHQMDSITYSNNVTQQYIQPQSLQDISAVEDEIQNKIEAARQESKQLHAQINKAKHKIQDASLFQMANKVTSLTKNKINLKPNIVLKGHNNKISDFRWSRDSKRILSASQDGFMLIWDSASGLKQNAIPLDSQWVLSCAISPSSTLVASAGLNNNCTIYRVSKENRVAQNVASIFKGHTCYISDIEFTDNAHILTASGDMTCALWDIPKAKRVREYSDHLGDVLALAIPEEPNSENSSNTFASCGSDGYTYIWDSRSPSAVQSFYVNDSDINALRFFKDGMSIVAGSDNGAINMYDLRSDCSIATFSLFRGYEERTPTPTYMAANMEYNTAQSPQTLKSTSSSYLDNQGVVSLDFSASGRLMYSCYTDIGCVVWDVLKGEIVGKLEGHGGRVTGVRSSPDGLAVCTGSWDSTMKIWSPGYQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MAAHQMDSITYSNNV CCCCCCCEEEECCCC | 16.10 | 30377154 | |
| 59 | Ubiquitination | QINKAKHKIQDASLF HHHHHHHHHHHHHHH | 41.16 | 23749301 | |
| 71 | Ubiquitination | SLFQMANKVTSLTKN HHHHHHHHHHHHCCC | 37.03 | 23749301 | |
| 77 | Ubiquitination | NKVTSLTKNKINLKP HHHHHHCCCCCCCCC | 62.63 | 23749301 | |
| 79 | Ubiquitination | VTSLTKNKINLKPNI HHHHCCCCCCCCCCE | 34.23 | 22817900 | |
| 307 | Phosphorylation | RSDCSIATFSLFRGY CCCCEEEEHHHCCCC | 16.46 | 27017623 | |
| 309 | Phosphorylation | DCSIATFSLFRGYEE CCEEEEHHHCCCCCC | 23.42 | 27017623 | |
| 314 | Phosphorylation | TFSLFRGYEERTPTP EHHHCCCCCCCCCCC | 15.45 | 22369663 | |
| 318 | Phosphorylation | FRGYEERTPTPTYMA CCCCCCCCCCCCEEE | 34.49 | 22369663 | |
| 320 | Phosphorylation | GYEERTPTPTYMAAN CCCCCCCCCCEEEEE | 27.87 | 22369663 | |
| 322 | Phosphorylation | EERTPTPTYMAANME CCCCCCCCEEEEECC | 28.54 | 22369663 | |
| 323 | Phosphorylation | ERTPTPTYMAANMEY CCCCCCCEEEEECCC | 5.98 | 22369663 | |
| 330 | Phosphorylation | YMAANMEYNTAQSPQ EEEEECCCCCCCCCC | 13.67 | 22369663 | |
| 332 | Phosphorylation | AANMEYNTAQSPQTL EEECCCCCCCCCCCC | 25.77 | 22369663 | |
| 335 | Phosphorylation | MEYNTAQSPQTLKST CCCCCCCCCCCCCCC | 19.26 | 22369663 | |
| 338 | Phosphorylation | NTAQSPQTLKSTSSS CCCCCCCCCCCCCCH | 39.27 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GBB_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GBB_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GBB_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-318, AND MASSSPECTROMETRY. | |
