PGM2_YEAST - dbPTM
PGM2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PGM2_YEAST
UniProt AC P37012
Protein Name Phosphoglucomutase 2 {ECO:0000303|PubMed:5784209}
Gene Name PGM2 {ECO:0000303|PubMed:5784209}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 569
Subcellular Localization Cytoplasm .
Protein Description Major phosphoglucomutase isozyme that catalyzes the reversible interconversion of glucose 1-phosphate and glucose 6-phosphate. [PubMed: 5784209 Constitutes about 80-90% of the phosphoglucomutase activity in the cell]
Protein Sequence MSFQIETVPTKPYEDQKPGTSGLRKKTKVFKDEPNYTENFIQSIMEAIPEGSKGATLVVGGDGRYYNDVILHKIAAIGAANGIKKLVIGQHGLLSTPAASHIMRTYEEKCTGGIILTASHNPGGPENDMGIKYNLSNGGPAPESVTNAIWEISKKLTSYKIIKDFPELDLGTIGKNKKYGPLLVDIIDITKDYVNFLKEIFDFDLIKKFIDNQRSTKNWKLLFDSMNGVTGPYGKAIFVDEFGLPADEVLQNWHPSPDFGGMHPDPNLTYASSLVKRVDREKIEFGAASDGDGDRNMIYGYGPSFVSPGDSVAIIAEYAAEIPYFAKQGIYGLARSFPTSGAIDRVAKAHGLNCYEVPTGWKFFCALFDAKKLSICGEESFGTGSNHVREKDGVWAIMAWLNILAIYNKHHPENEASIKTIQNEFWAKYGRTFFTRYDFEKVETEKANKIVDQLRAYVTKSGVVNSAFPADESLKVTDCGDFSYTDLDGSVSDHQGLYVKLSNGARFVLRLSGTGSSGATIRLYIEKYCDDKSQYQKTAEEYLKPIINSVIKFLNFKQVLGTEEPTVRT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSFQIETVP
------CCCEEEECC		26.3422369663
2Acetylation------MSFQIETVP
------CCCEEEECC		26.3422814378
13PhosphorylationETVPTKPYEDQKPGT
EECCCCCCCCCCCCC		33.4222369663
20PhosphorylationYEDQKPGTSGLRKKT
CCCCCCCCCCCCHHC		28.3122369663
21PhosphorylationEDQKPGTSGLRKKTK
CCCCCCCCCCCHHCE		41.5722369663
95PhosphorylationIGQHGLLSTPAASHI
ECCCCCCCCHHHHHH		37.0722369663
96PhosphorylationGQHGLLSTPAASHIM
CCCCCCCCHHHHHHH		19.5422369663
100PhosphorylationLLSTPAASHIMRTYE
CCCCHHHHHHHHHHH		18.6922369663
111PhosphorylationRTYEEKCTGGIILTA
HHHHHHCCCEEEEEC		49.8922890988
117PhosphorylationCTGGIILTASHNPGG
CCCEEEEECCCCCCC		18.7322369663
119PhosphorylationGGIILTASHNPGGPE
CEEEEECCCCCCCCC		20.6825521595
129OxidationPGGPENDMGIKYNLS
CCCCCCCCCCEEECC		10.1015665377
1552-HydroxyisobutyrylationAIWEISKKLTSYKII
HHHHHHHHHHCCCCC		50.65-
1602-HydroxyisobutyrylationSKKLTSYKIIKDFPE
HHHHHCCCCCCCCCC		37.41-
163AcetylationLTSYKIIKDFPELDL
HHCCCCCCCCCCCCC		57.7124489116
289PhosphorylationKIEFGAASDGDGDRN
HCEECCCCCCCCCCC		41.4128889911
4282-HydroxyisobutyrylationIQNEFWAKYGRTFFT
HHHHHHHHHCCCEEE		38.54-
428AcetylationIQNEFWAKYGRTFFT
HHHHHHHHHCCCEEE		38.5424489116
437PhosphorylationGRTFFTRYDFEKVET
CCCEEECCCHHHHCH		23.1727017623
441AcetylationFTRYDFEKVETEKAN
EECCCHHHHCHHHHH		45.4224489116
444PhosphorylationYDFEKVETEKANKIV
CCHHHHCHHHHHHHH		45.8627017623
446AcetylationFEKVETEKANKIVDQ
HHHHCHHHHHHHHHH		65.7624489116
449AcetylationVETEKANKIVDQLRA
HCHHHHHHHHHHHHH		49.3024489116
512PhosphorylationARFVLRLSGTGSSGA
CEEEEEECCCCCCCC		28.0730377154
514PhosphorylationFVLRLSGTGSSGATI
EEEEECCCCCCCCEE		30.4330377154
516PhosphorylationLRLSGTGSSGATIRL
EEECCCCCCCCEEEE		25.9922369663
517PhosphorylationRLSGTGSSGATIRLY
EECCCCCCCCEEEEE		33.5222369663
520PhosphorylationGTGSSGATIRLYIEK
CCCCCCCEEEEEEHH		15.3422369663
527AcetylationTIRLYIEKYCDDKSQ
EEEEEEHHHCCCHHH		41.4424489116
535PhosphorylationYCDDKSQYQKTAEEY
HCCCHHHHHHHHHHH		21.0425533186
537AcetylationDDKSQYQKTAEEYLK
CCHHHHHHHHHHHHH		44.7822865919
544SuccinylationKTAEEYLKPIINSVI
HHHHHHHHHHHHHHH		33.0123954790
544AcetylationKTAEEYLKPIINSVI
HHHHHHHHHHHHHHH		33.0124489116
557AcetylationVIKFLNFKQVLGTEE
HHHHCCHHHHHCCCC		38.1224489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PGM2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PGM2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PGM2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TPS1_YEASTTPS1genetic
15164360
PFKA2_YEASTPFK2genetic
12351653
PUR92_YEASTADE17physical
18467557
ARPC2_YEASTARC35physical
18467557
SNC2_YEASTSNC2physical
18467557
PGM2_YEASTPGM2physical
18467557
PGM1_YEASTPGM1genetic
18408719
PIN4_YEASTPIN4genetic
20093466
CCZ1_YEASTCCZ1genetic
20093466
PBP4_YEASTPBP4genetic
20093466
PAA1_YEASTPAA1genetic
20093466
BCS1_YEASTBCS1genetic
20093466
PT122_YEASTPET122genetic
20093466
RPOM_YEASTRPO41genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
MED5_YEASTNUT1genetic
20093466
FYV4_YEASTFYV4genetic
20093466
ICE2_YEASTICE2genetic
20093466
CBT1_YEASTCBT1genetic
20093466
PGM1_YEASTPGM1genetic
20093466
FABG_YEASTOAR1genetic
20093466
MEH1_YEASTMEH1genetic
20093466
SRN2_YEASTSRN2genetic
20093466
COX8_YEASTCOX8genetic
20093466
BCH1_YEASTBCH1genetic
20093466
INO4_YEASTINO4genetic
20093466
FYV12_YEASTFYV12genetic
20093466
SNU66_YEASTSNU66genetic
20093466
PPAL_YEASTLTP1genetic
20093466
MDM36_YEASTMDM36genetic
20093466
MSS18_YEASTMSS18genetic
20093466
SUCB_YEASTLSC2genetic
21623372
PGM1_YEASTPGM1genetic
21623372
GDE1_YEASTGDE1genetic
21623372
ELO3_YEASTELO3genetic
21623372
CHMU_YEASTARO7genetic
21623372
CYS3_YEASTCYS3genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
THRC_YEASTTHR4genetic
21623372
ELO1_YEASTELO1genetic
21623372
FAT1_YEASTFAT1genetic
21623372
BAP3_YEASTBAP3genetic
21623372
ASNS2_YEASTASN2genetic
21623372
ACEA_YEASTICL1genetic
21623372
MDHM_YEASTMDH1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
GSHR_YEASTGLR1genetic
21623372
PYC2_YEASTPYC2genetic
21623372
FCY1_YEASTFCY1genetic
21623372
SPEE_YEASTSPE3genetic
21623372
INV2_YEASTSUC2genetic
21623372
PGM1_YEASTPGM1genetic
23891562
BLM10_YEASTBLM10genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
ELO2_YEASTELO2genetic
27708008
IMG2_YEASTIMG2genetic
27708008
BCS1_YEASTBCS1genetic
27708008
LCMT1_YEASTPPM1genetic
27708008
RAD51_YEASTRAD51genetic
27708008
PT122_YEASTPET122genetic
27708008
MED5_YEASTNUT1genetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
HUA1_YEASTHUA1genetic
27708008
URM1_YEASTURM1genetic
27708008
ICE2_YEASTICE2genetic
27708008
ASF1_YEASTASF1genetic
27708008
YJ66_YEASTYJR096Wgenetic
27708008
FABG_YEASTOAR1genetic
27708008
EF1G2_YEASTTEF4genetic
27708008
PGM1_YEASTPGM1genetic
27708008
CBT1_YEASTCBT1genetic
27708008
MEH1_YEASTMEH1genetic
27708008
YL407_YEASTYLR407Wgenetic
27708008
FYV12_YEASTFYV12genetic
27708008
SNU66_YEASTSNU66genetic
27708008
COX10_YEASTCOX10genetic
27708008
MED1_YEASTMED1genetic
27708008
PPAL_YEASTLTP1genetic
27708008
MSS18_YEASTMSS18genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PGM2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-117 AND SER-119, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, AND MASSSPECTROMETRY.

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