TPS1_YEAST - dbPTM
TPS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TPS1_YEAST
UniProt AC Q00764
Protein Name Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit
Gene Name TPS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 495
Subcellular Localization Cytoplasm .
Protein Description Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process. Can function independently of the complex..
Protein Sequence MTTDNAKAQLTSSSGGNIIVVSNRLPVTITKNSSTGQYEYAMSSGGLVTALEGLKKTYTFKWFGWPGLEIPDDEKDQVRKDLLEKFNAVPIFLSDEIADLHYNGFSNSILWPLFHYHPGEINFDENAWLAYNEANQTFTNEIAKTMNHNDLIWVHDYHLMLVPEMLRVKIHEKQLQNVKVGWFLHTPFPSSEIYRILPVRQEILKGVLSCDLVGFHTYDYARHFLSSVQRVLNVNTLPNGVEYQGRFVNVGAFPIGIDVDKFTDGLKKESVQKRIQQLKETFKGCKIIVGVDRLDYIKGVPQKLHAMEVFLNEHPEWRGKVVLVQVAVPSRGDVEEYQYLRSVVNELVGRINGQFGTVEFVPIHFMHKSIPFEELISLYAVSDVCLVSSTRDGMNLVSYEYIACQEEKKGSLILSEFTGAAQSLNGAIIVNPWNTDDLSDAINEALTLPDVKKEVNWEKLYKYISKYTSAFWGENFVHELYSTSSSSTSSSATKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Ubiquitination-MTTDNAKAQLTSSS
-CCCHHHHHEEECCC		42.8117644757
11PhosphorylationDNAKAQLTSSSGGNI
HHHHHEEECCCCCEE		17.9322369663
12PhosphorylationNAKAQLTSSSGGNII
HHHHEEECCCCCEEE		30.9722369663
13PhosphorylationAKAQLTSSSGGNIIV
HHHEEECCCCCEEEE		27.9722369663
14PhosphorylationKAQLTSSSGGNIIVV
HHEEECCCCCEEEEE		50.9522369663
31UbiquitinationRLPVTITKNSSTGQY
CCEEEEEECCCCCEE		51.4817644757
33PhosphorylationPVTITKNSSTGQYEY
EEEEEECCCCCEEEE		30.7227017623
49PhosphorylationMSSGGLVTALEGLKK
EECCCCCCCCCHHHC		30.4827017623
1692-HydroxyisobutyrylationVPEMLRVKIHEKQLQ
CHHHHHHHCCHHHHC		31.73-
179UbiquitinationEKQLQNVKVGWFLHT
HHHHCCCEEEEEEEC		42.4517644757
205UbiquitinationPVRQEILKGVLSCDL
HHHHHHHHHHHCCCE		53.2717644757
261AcetylationPIGIDVDKFTDGLKK
CCEECHHHCCCCCCH		50.4324489116
261UbiquitinationPIGIDVDKFTDGLKK
CCEECHHHCCCCCCH		50.4324961812
263PhosphorylationGIDVDKFTDGLKKES
EECHHHCCCCCCHHH		34.5927017623
267AcetylationDKFTDGLKKESVQKR
HHCCCCCCHHHHHHH		61.0824489116
267UbiquitinationDKFTDGLKKESVQKR
HHCCCCCCHHHHHHH		61.0817644757
2672-HydroxyisobutyrylationDKFTDGLKKESVQKR
HHCCCCCCHHHHHHH		61.08-
268UbiquitinationKFTDGLKKESVQKRI
HCCCCCCHHHHHHHH		61.3317644757
2732-HydroxyisobutyrylationLKKESVQKRIQQLKE
CCHHHHHHHHHHHHH		49.68-
279AcetylationQKRIQQLKETFKGCK
HHHHHHHHHHHCCCE		50.8222865919
286UbiquitinationKETFKGCKIIVGVDR
HHHHCCCEEEEECCC		44.1017644757
298AcetylationVDRLDYIKGVPQKLH
CCCHHHHCCCCCHHH		47.8524489116
298UbiquitinationVDRLDYIKGVPQKLH
CCCHHHHCCCCCHHH		47.8524961812
459AcetylationKKEVNWEKLYKYISK
HHHCCHHHHHHHHHH		49.0524489116
459UbiquitinationKKEVNWEKLYKYISK
HHHCCHHHHHHHHHH		49.0524961812
462UbiquitinationVNWEKLYKYISKYTS
CCHHHHHHHHHHHHH		46.6923749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TPS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TPS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TPS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CTR3_YEASTCTR3physical
11805826
ALLA_YEASTDAL3physical
11805826
GLNA_YEASTGLN1physical
11805826
IML1_YEASTIML1physical
11805826
MCM2_YEASTMCM2physical
11805826
MKS1_YEASTMKS1physical
11805826
REG1_YEASTREG1physical
11805826
IF4A_YEASTTIF2physical
11805826
TPS2_YEASTTPS2physical
11805826
TPS3_YEASTTPS3physical
11805826
TSC10_YEASTTSC10physical
11805826
TSL1_YEASTTSL1physical
11805826
YIR7_YEASTYIL177Cphysical
11805826
GTO3_YEASTGTO3physical
11805826
TPS2_YEASTTPS2physical
9194697
TPS3_YEASTTPS3physical
9194697
TSL1_YEASTTSL1physical
9194697
TPS1_YEASTTPS1physical
9194697
GTS1_YEASTGTS1genetic
12782635
TPS2_YEASTTPS2genetic
8809751
QCR9_YEASTQCR9genetic
8544831
AAKG_YEASTSNF4genetic
8544831
MIG1_YEASTMIG1genetic
1597433
HXKB_YEASTHXK2genetic
10217505
HXKB_YEASTHXK2genetic
8467527
GLG1_YEASTGLG1genetic
16004992
GLG2_YEASTGLG2genetic
16004992
HXKG_YEASTGLK1physical
16554755
CD123_YEASTCDC123physical
16554755
TPS3_YEASTTPS3physical
16554755
SSB2_YEASTSSB2physical
16554755
GLNA_YEASTGLN1physical
16429126
IML1_YEASTIML1physical
16429126
MCM2_YEASTMCM2physical
16429126
MKS1_YEASTMKS1physical
16429126
REG1_YEASTREG1physical
16429126
TPS2_YEASTTPS2physical
16429126
TPS3_YEASTTPS3physical
16429126
TSC10_YEASTTSC10physical
16429126
TSL1_YEASTTSL1physical
16429126
GPD1_YEASTGPD1genetic
7729414
FPS1_YEASTFPS1genetic
7729414
MIG1_YEASTMIG1genetic
7729414
TPS1_YEASTTPS1physical
18719252
TPS3_YEASTTPS3physical
18719252
HXKB_YEASTHXK2genetic
19269370
ADK_YEASTADO1genetic
19269370
TPS3_YEASTTPS3genetic
16941010
TSL1_YEASTTSL1genetic
16941010
HS104_YEASTHSP104genetic
8913738
MAL11_YEASTMAL11genetic
25918382
HS104_YEASTHSP104genetic
25934390
HSP73_YEASTSSA3genetic
25934390
HSP82_YEASTHSP82genetic
25934390
HSC82_YEASTHSC82genetic
25934390
MAL11_YEASTMAL11genetic
25918381
IMB1_YEASTKAP95genetic
27708008
ASK10_YEASTASK10genetic
27708008
MPH1_YEASTMPH1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
GBLP_YEASTASC1genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
STU1_YEASTSTU1genetic
27708008
GPI8_YEASTGPI8genetic
27708008
TSC11_YEASTTSC11genetic
27708008
RSP5_YEASTRSP5genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
BRR6_YEASTBRR6genetic
27708008
YHI0_YEASTYHR020Wgenetic
27708008
LCB1_YEASTLCB1genetic
27708008
LST8_YEASTLST8genetic
27708008
GPI2_YEASTGPI2genetic
27708008
BUR1_YEASTSGV1genetic
27708008
ATC3_YEASTDRS2genetic
27708008
RV161_YEASTRVS161genetic
27708008
THRC_YEASTTHR4genetic
27708008
BUD31_YEASTBUD31genetic
27708008
PAT1_YEASTPAT1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
THI3_YEASTTHI3genetic
27708008
WDR59_YEASTMTC5genetic
27708008
HNT2_YEASTHNT2genetic
27708008
RV167_YEASTRVS167genetic
27708008
SNF1_YEASTSNF1genetic
27708008
IES5_YEASTIES5genetic
27708008
FTR1_YEASTFTR1genetic
27708008
IES1_YEASTIES1genetic
27708008
HXKA_YEASTHXK1genetic
27708008
PIB2_YEASTPIB2genetic
27708008
PALF_YEASTRIM8genetic
27708008
MED5_YEASTNUT1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
MAL12_YEASTMAL12genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
YHE4_YEASTYHL044Wgenetic
27708008
SDP1_YEASTSDP1genetic
27708008
IMPX_YEASTIMP2genetic
27708008
DAL81_YEASTDAL81genetic
27708008
VPS53_YEASTVPS53genetic
27708008
LSM1_YEASTLSM1genetic
27708008
RPA34_YEASTRPA34genetic
27708008
RCY1_YEASTRCY1genetic
27708008
MEH1_YEASTMEH1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
DNM1_YEASTDNM1genetic
27708008
FPS1_YEASTFPS1genetic
27708008
YPT6_YEASTYPT6genetic
27708008
VRP1_YEASTVRP1genetic
27708008
AMPD_YEASTAMD1genetic
27708008
GAL80_YEASTGAL80genetic
27708008
GTR1_YEASTGTR1genetic
27708008
PALI_YEASTRIM9genetic
27708008
RIM13_YEASTRIM13genetic
27708008
HDA1_YEASTHDA1genetic
27708008
APJ1_YEASTAPJ1genetic
27708008
SSK2_YEASTSSK2genetic
27708008
PALA_YEASTRIM20genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
DAP1_YEASTDAP1genetic
27708008
MED1_YEASTMED1genetic
27708008
HDA3_YEASTHDA3genetic
27708008
HXKB_YEASTHXK2genetic
27811238
GYS2_YEASTGSY2genetic
27923067
NUC1_YEASTNUC1genetic
27507670
AIF1_YEASTAIF1genetic
27507670
MCA1_YEASTMCA1genetic
27507670
SNF1_YEASTSNF1genetic
27189362
MIG1_YEASTMIG1genetic
27189362
HXKB_YEASTHXK2genetic
27189362
RAS2_YEASTRAS2genetic
29030545
PDE2_YEASTPDE2genetic
29030545
IRA1_YEASTIRA1genetic
29030545
IRA2_YEASTIRA2genetic
29030545
CDC25_YEASTCDC25genetic
29030545
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TPS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.

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