TSC10_YEAST - dbPTM
TSC10_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TSC10_YEAST
UniProt AC P38342
Protein Name 3-ketodihydrosphingosine reductase TSC10
Gene Name TSC10
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 320
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein .
Protein Description Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS)..
Protein Sequence MKFTLEDQVVLITGGSQGLGKEFAKKYYNEAENTKIIIVSRSEARLLDTCNEIRIEAHLRRETTDEGQVQHKLAAPLDLEQRLFYYPCDLSCYESVECLFNALRDLDLLPTQTLCCAGGAVPKLFRGLSGHELNLGMDINYKTTLNVAHQIALAEQTKEHHLIIFSSATALYPFVGYSQYAPAKAAIKSLVAILRQELTNFRISCVYPGNFESEGFTVEQLTKPEITKLIEGPSDAIPCKQACDIIAKSLARGDDDVFTDFVGWMIMGMDLGLTAKKSRFVPLQWIFGVLSNILVVPFYMVGCSWYIRKWFRENDGKKAN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MKFTLEDQVVL
----CCCCCCCEEEE		24.5827017623
16PhosphorylationVVLITGGSQGLGKEF
EEEECCCCCCCCHHH		23.5527017623
63PhosphorylationEAHLRRETTDEGQVQ
HHHHCCCCCCCCHHE		37.4228889911
64PhosphorylationAHLRRETTDEGQVQH
HHHCCCCCCCCHHEE		27.5728889911
72UbiquitinationDEGQVQHKLAAPLDL
CCCHHEEEEECCCCH		23.8023749301
129PhosphorylationPKLFRGLSGHELNLG
HHHHCCCCCCCEECC		40.7127017623
141PhosphorylationNLGMDINYKTTLNVA
ECCCCCCHHHHHCHH		15.2827017623
223UbiquitinationFTVEQLTKPEITKLI
EEEEECCCHHHHHHC		49.6023749301
240UbiquitinationPSDAIPCKQACDIIA
CCCCCCHHHHHHHHH		35.2623749301
248UbiquitinationQACDIIAKSLARGDD
HHHHHHHHHHHCCCC		35.2824961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TSC10_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TSC10_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TSC10_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RL10_YEASTRPL10physical
16429126
SNA3_YEASTSNA3physical
18467557
CSG2_YEASTCSG2genetic
20093466
ELO2_YEASTELO2genetic
20093466
PAR32_YEASTPAR32genetic
20093466
SAC3_YEASTSAC3genetic
20093466
RPOM_YEASTRPO41genetic
20093466
CGR1_YEASTCGR1genetic
20093466
PHB2_YEASTPHB2genetic
20093466
MDM35_YEASTMDM35genetic
20093466
MAOM_YEASTMAE1genetic
20093466
VRP1_YEASTVRP1genetic
20093466
ROM2_YEASTROM2genetic
20093466
NU188_YEASTNUP188genetic
20093466
RAD14_YEASTRAD14genetic
20093466
LSM7_YEASTLSM7genetic
20093466
CSK22_YEASTCKA2genetic
20093466
PDE2_YEASTPDE2genetic
20093466
BRR1_YEASTBRR1genetic
20093466
THRC_YEASTTHR4genetic
21623372
PDX3_YEASTPDX3genetic
21623372
DUR3_YEASTDUR3genetic
21623372
HTD2_YEASTHTD2genetic
21623372
DCAM_YEASTSPE2genetic
21623372
TPS2_YEASTTPS2genetic
21623372
COX7_YEASTCOX7genetic
21623372
AATC_YEASTAAT2genetic
21623372
THDH_YEASTILV1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
ATPO_YEASTATP5genetic
21623372
NMA1_YEASTNMA1genetic
21623372
ERG2_YEASTERG2genetic
21623372
ALN_YEASTDAL1genetic
21623372
IDHH_YEASTIDP3genetic
21623372
ATP5E_YEASTATP15genetic
21623372
FABG_YEASTOAR1genetic
21623372
SCS7_YEASTSCS7genetic
21623372
FADH_YEASTSFA1genetic
21623372
CYS3_YEASTCYS3genetic
21623372
CEM1_YEASTCEM1genetic
21623372
DCOR_YEASTSPE1genetic
21623372
GPP2_YEASTGPP2genetic
21623372
ACON_YEASTACO1genetic
21623372
KDSR_HUMANKDSRgenetic
15328338
KDSR_MOUSEKdsrgenetic
15328338
CSG2_YEASTCSG2genetic
23891562
BPH1_YEASTBPH1genetic
23891562
KPC1_YEASTPKC1genetic
27708008
LCB2_YEASTLCB2genetic
27708008
PSB3_YEASTPUP3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
SDA1_YEASTSDA1genetic
27708008
RU1C_YEASTYHC1genetic
27708008
LCB1_YEASTLCB1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
ETR1_YEASTETR1genetic
27708008
THRC_YEASTTHR4genetic
27708008
VAM6_YEASTVAM6genetic
27708008
VPS41_YEASTVPS41genetic
27708008
UME6_YEASTUME6genetic
27708008
VPS60_YEASTVPS60genetic
27708008
CEM1_YEASTCEM1genetic
27708008
SA155_YEASTSAP155genetic
27708008
COM1_YEASTSAE2genetic
27708008
CUL3_YEASTCUL3genetic
27708008
RME1_YEASTRME1genetic
27708008
G3P3_YEASTTDH3genetic
27708008
TNA1_YEASTTNA1genetic
27708008
HTD2_YEASTHTD2genetic
27708008
NMD2_YEASTNMD2genetic
27708008
LPLA_YEASTAIM22genetic
27708008
NCA3_YEASTNCA3genetic
27708008
DS1P1_YEASTLCB3genetic
27708008
FABG_YEASTOAR1genetic
27708008
CANB_YEASTCNB1genetic
27708008
DID2_YEASTDID2genetic
27708008
SRN2_YEASTSRN2genetic
27708008
LIPB_YEASTLIP2genetic
27708008
VPS38_YEASTVPS38genetic
27708008
YMW4_YEASTYMR074Cgenetic
27708008
NAM7_YEASTNAM7genetic
27708008
GBLP_YEASTASC1genetic
27708008
PKR1_YEASTPKR1genetic
27708008
PUB1_YEASTPUB1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
CSK22_YEASTCKA2genetic
27708008
VPS17_YEASTVPS17genetic
27708008
LIPA_YEASTLIP5genetic
27708008
FABD_YEASTMCT1genetic
27708008
BECN1_YEASTVPS30genetic
27708008
TIP41_YEASTTIP41genetic
27708008
CGS5_YEASTCLB5genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TSC10_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory