| UniProt ID | BECN1_YEAST | |
|---|---|---|
| UniProt AC | Q02948 | |
| Protein Name | Vacuolar protein sorting-associated protein 30 | |
| Gene Name | VPS30 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 557 | |
| Subcellular Localization |
Endosome membrane Peripheral membrane protein. Vacuole membrane Peripheral membrane protein. Preautophagosomal structure membrane Peripheral membrane protein. With the VPS34 PI3-kinase complex I, localizes to the vacuole-isolation membrane contac |
|
| Protein Description | Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Plays also a role in regulation of filamentous growth.. | |
| Protein Sequence | MKCQTCHLPLQLDPSLEGLSLTQRNLLLSNNSIITATNENVISNKGIEAADNCGPQIPKERLRRLGEIQNIKDLNLKDDKLITDSFVFLNHDDDDNANITSNSREDQRYGNANGNDNKKANSDTSDGTSTFRDHDEEEQEATDEDENQQIQLNSKTLSTQVNAMTNVFNILSSQTNIDFPICQDCCNILINRLKSEYDDAIKERDTYAQFLSKLESQNKEISESNKEKQYSHNLSEKENLKKEEERLLDQLLRLEMTDDDLDGELVRLQEKKVQLENEKLQKLSDQNLMDLNNIQFNKNLQSLKLQYELSLNQLDKLRKINIFNATFKISHSGPFATINGLRLGSIPESVVPWKEINAALGQLILLLATINKNLKINLVDYELQPMGSFSKIKKRMVNSVEYNNSTTNAPGDWLILPVYYDENFNLGRIFRKETKFDKSLETTLEIISEITRQLSTIASSYSSQTLTTSQDESSMNNANDVENSTSILELPYIMNKDKINGLSVKLHGSSPNLEWTTAMKFLLTNVKWLLAFSSNLLSKSITLSPTVNYNDKTISGN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | Phosphorylation | TQRNLLLSNNSIITA HHHCEEECCCCEEEE | 30377154 | ||
| 83 | Phosphorylation | LKDDKLITDSFVFLN CCCCEEEECEEEEEC | 21551504 | ||
| 85 | Phosphorylation | DDKLITDSFVFLNHD CCEEEECEEEEECCC | 21551504 | ||
| 122 | Phosphorylation | NDNKKANSDTSDGTS CCCCCCCCCCCCCCC | 28889911 | ||
| 124 | Phosphorylation | NKKANSDTSDGTSTF CCCCCCCCCCCCCCC | 21440633 | ||
| 125 | Phosphorylation | KKANSDTSDGTSTFR CCCCCCCCCCCCCCC | 21440633 | ||
| 129 | Phosphorylation | SDTSDGTSTFRDHDE CCCCCCCCCCCCCCH | 28889911 | ||
| 130 | Phosphorylation | DTSDGTSTFRDHDEE CCCCCCCCCCCCCHH | 21551504 | ||
| 142 | Phosphorylation | DEEEQEATDEDENQQ CHHHHHCCCCCHHHH | 22369663 | ||
| 257 | Phosphorylation | QLLRLEMTDDDLDGE HHHHHHCCCCCCCCH | 28889911 | ||
| 284 | Phosphorylation | NEKLQKLSDQNLMDL HHHHHHHHHCCCHHH | 28889911 | ||
| 540 | Phosphorylation | SSNLLSKSITLSPTV CCCHHCCCEEECCCC | 21126336 | ||
| 542 | Phosphorylation | NLLSKSITLSPTVNY CHHCCCEEECCCCCC | 23749301 | ||
| 544 | Phosphorylation | LSKSITLSPTVNYND HCCCEEECCCCCCCC | 25752575 | ||
| 549 | Phosphorylation | TLSPTVNYNDKTISG EECCCCCCCCCCCCC | 30377154 | ||
| 552 | Ubiquitination | PTVNYNDKTISGN-- CCCCCCCCCCCCC-- | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BECN1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BECN1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BECN1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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