| UniProt ID | COPB2_YEAST | |
|---|---|---|
| UniProt AC | P41811 | |
| Protein Name | Coatomer subunit beta' | |
| Gene Name | SEC27 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 889 | |
| Subcellular Localization |
Cytoplasm. Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane Peripheral membrane protein Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o |
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| Protein Description | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.. | |
| Protein Sequence | MKLDIKKTFSNRSDRVKGIDFHPTEPWVLTTLYSGRVELWNYETQVEVRSIQVTETPVRAGKFIARKNWIIVGSDDFRIRVFNYNTGEKVVDFEAHPDYIRSIAVHPTKPYVLSGSDDLTVKLWNWENNWALEQTFEGHEHFVMCVAFNPKDPSTFASGCLDRTVKVWSLGQSTPNFTLTTGQERGVNYVDYYPLPDKPYMITASDDLTIKIWDYQTKSCVATLEGHMSNVSFAVFHPTLPIIISGSEDGTLKIWNSSTYKVEKTLNVGLERSWCIATHPTGRKNYIASGFDNGFTVLSLGNDEPTLSLDPVGKLVWSGGKNAAASDIFTAVIRGNEEVEQDEPLSLQTKELGSVDVFPQSLAHSPNGRFVTVVGDGEYVIYTALAWRNKAFGKCQDFVWGPDSNSYALIDETGQIKYYKNFKEVTSWSVPMHSAIDRLFSGALLGVKSDGFVYFFDWDNGTLVRRIDVNAKDVIWSDNGELVMIVNTNSNGDEASGYTLLFNKDAYLEAANNGNIDDSEGVDEAFDVLYELSESITSGKWVGDVFIFTTATNRLNYFVGGKTYNLAHYTKEMYLLGYLARDNKVYLADREVHVYGYEISLEVLEFQTLTLRGEIEEAIENVLPNVEGKDSLTKIARFLEGQEYYEEALNISPDQDQKFELALKVGQLTLARDLLTDESAEMKWRALGDASLQRFNFKLAVEAFTNAHDLESLFLLHSSFNNKEGLVTLAKDAERAGKFNLAFNAYWIAGDIQGAKDLLIKSQRFSEAAFLGSTYGLGDDAVNDIVTKWKENLILNGKNTVSERVCGAEGLPGSSSSGDAQPLIDLDSTPAPEQADENKEAEVEDSEFKESNSEAVEAEKKEEEAPQQQQSEQQPEQGEAVPEPVEEES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 | Ubiquitination | SNRSDRVKGIDFHPT CCCHHCCCCCCCCCC | 51.55 | 23749301 | |
| 31 | Phosphorylation | TEPWVLTTLYSGRVE CCCCEEEEEECCCEE | 21.38 | 19779198 | |
| 33 | Phosphorylation | PWVLTTLYSGRVELW CCEEEEEECCCEEEE | 13.64 | 19779198 | |
| 67 | Ubiquitination | AGKFIARKNWIIVGS CCCEEEECCEEEECC | 47.84 | 17644757 | |
| 89 | Acetylation | FNYNTGEKVVDFEAH EECCCCCEEEECCCC | 49.23 | 24489116 | |
| 109 | Acetylation | SIAVHPTKPYVLSGS EEEECCCCCEEEECC | 38.51 | 24489116 | |
| 109 | Ubiquitination | SIAVHPTKPYVLSGS EEEECCCCCEEEECC | 38.51 | 24961812 | |
| 122 | Ubiquitination | GSDDLTVKLWNWENN CCCCEEEEEEEECCC | 42.42 | 17644757 | |
| 166 | Ubiquitination | GCLDRTVKVWSLGQS CCCCCEEEEEECCCC | 37.06 | 24961812 | |
| 264 | Acetylation | SSTYKVEKTLNVGLE CCCEEEEEEEECCCC | 62.39 | 24489116 | |
| 265 | Phosphorylation | STYKVEKTLNVGLER CCEEEEEEEECCCCE | 15.28 | 21551504 | |
| 278 | Phosphorylation | ERSWCIATHPTGRKN CEEEEEEECCCCCCC | 14.42 | 21551504 | |
| 284 | Ubiquitination | ATHPTGRKNYIASGF EECCCCCCCEEEECC | 56.28 | 17644757 | |
| 326 | Phosphorylation | GGKNAAASDIFTAVI CCCCCCCHHHHHHHH | 26.89 | 28889911 | |
| 346 | Phosphorylation | VEQDEPLSLQTKELG CCCCCCCCCCCCCCC | 29.19 | 25752575 | |
| 350 | Ubiquitination | EPLSLQTKELGSVDV CCCCCCCCCCCCCCC | 37.67 | 23749301 | |
| 350 | Acetylation | EPLSLQTKELGSVDV CCCCCCCCCCCCCCC | 37.67 | 24489116 | |
| 354 | Phosphorylation | LQTKELGSVDVFPQS CCCCCCCCCCCCCHH | 27.98 | 23749301 | |
| 361 | Phosphorylation | SVDVFPQSLAHSPNG CCCCCCHHHCCCCCC | 27.97 | 22369663 | |
| 365 | Phosphorylation | FPQSLAHSPNGRFVT CCHHHCCCCCCCEEE | 17.91 | 22369663 | |
| 423 | Acetylation | IKYYKNFKEVTSWSV EEEEECCCCCCCCCC | 61.75 | 24489116 | |
| 448 | Ubiquitination | SGALLGVKSDGFVYF HCCCEEEECCCEEEE | 40.82 | 17644757 | |
| 540 | Ubiquitination | SESITSGKWVGDVFI HHHHHCCCCCCEEEE | 38.17 | 17644757 | |
| 557 | Phosphorylation | TATNRLNYFVGGKTY ECCCCEEEEECCEEE | 12.30 | 28132839 | |
| 562 | Ubiquitination | LNYFVGGKTYNLAHY EEEEECCEEEEHHHH | 41.74 | 17644757 | |
| 562 | Acetylation | LNYFVGGKTYNLAHY EEEEECCEEEEHHHH | 41.74 | 24489116 | |
| 564 | Phosphorylation | YFVGGKTYNLAHYTK EEECCEEEEHHHHHC | 16.21 | 28132839 | |
| 569 | Phosphorylation | KTYNLAHYTKEMYLL EEEEHHHHHCHHHHH | 17.56 | 28132839 | |
| 571 | Ubiquitination | YNLAHYTKEMYLLGY EEHHHHHCHHHHHHH | 33.06 | 17644757 | |
| 578 | Phosphorylation | KEMYLLGYLARDNKV CHHHHHHHHHCCCEE | 9.36 | 28132839 | |
| 584 | Ubiquitination | GYLARDNKVYLADRE HHHHCCCEEEEECCE | 36.22 | 23749301 | |
| 634 | Ubiquitination | EGKDSLTKIARFLEG CCHHHHHHHHHHHCC | 39.39 | 23749301 | |
| 664 | Ubiquitination | QKFELALKVGQLTLA HHHHHHHHHCHHHHH | 38.42 | 17644757 | |
| 669 | Phosphorylation | ALKVGQLTLARDLLT HHHHCHHHHHHHHCC | 15.52 | 21440633 | |
| 683 | Acetylation | TDESAEMKWRALGDA CCCCHHHHHHHHCHH | 25.65 | 24489116 | |
| 683 | Ubiquitination | TDESAEMKWRALGDA CCCCHHHHHHHHCHH | 25.65 | 17644757 | |
| 731 | Acetylation | EGLVTLAKDAERAGK CCEEEEEHHHHHHCC | 61.66 | 24489116 | |
| 731 | Ubiquitination | EGLVTLAKDAERAGK CCEEEEEHHHHHHCC | 61.66 | 24961812 | |
| 738 | Ubiquitination | KDAERAGKFNLAFNA HHHHHHCCCCEEEEE | 30.05 | 17644757 | |
| 756 | Ubiquitination | AGDIQGAKDLLIKSQ ECCCCCHHHHHHHCH | 56.59 | 17644757 | |
| 761 | Acetylation | GAKDLLIKSQRFSEA CHHHHHHHCHHHHHH | 40.27 | 24489116 | |
| 773 | Phosphorylation | SEAAFLGSTYGLGDD HHHHHHCCCCCCCHH | 22.17 | 30377154 | |
| 798 | Ubiquitination | ENLILNGKNTVSERV HHEEECCCCCCCEEE | 48.66 | 24961812 | |
| 800 | Phosphorylation | LILNGKNTVSERVCG EEECCCCCCCEEECC | 28.97 | 19823750 | |
| 802 | Phosphorylation | LNGKNTVSERVCGAE ECCCCCCCEEECCCC | 20.04 | 19823750 | |
| 814 | Phosphorylation | GAEGLPGSSSSGDAQ CCCCCCCCCCCCCCC | 25.71 | 19823750 | |
| 815 | Phosphorylation | AEGLPGSSSSGDAQP CCCCCCCCCCCCCCC | 34.14 | 21551504 | |
| 816 | Phosphorylation | EGLPGSSSSGDAQPL CCCCCCCCCCCCCCC | 39.78 | 20377248 | |
| 817 | Phosphorylation | GLPGSSSSGDAQPLI CCCCCCCCCCCCCCC | 42.51 | 19823750 | |
| 828 | Phosphorylation | QPLIDLDSTPAPEQA CCCCCCCCCCCHHHC | 43.52 | 22369663 | |
| 829 | Phosphorylation | PLIDLDSTPAPEQAD CCCCCCCCCCHHHCC | 24.12 | 22369663 | |
| 846 | Phosphorylation | KEAEVEDSEFKESNS CCCCCCCHHHHHHHH | 31.28 | 28889911 | |
| 851 | Phosphorylation | EDSEFKESNSEAVEA CCHHHHHHHHHHHHH | 46.36 | 21126336 | |
| 853 | Phosphorylation | SEFKESNSEAVEAEK HHHHHHHHHHHHHHH | 35.89 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COPB2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COPB2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COPB2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-669 AND THR-829, ANDMASS SPECTROMETRY. | |
