| UniProt ID | NEP1_YEAST | |
|---|---|---|
| UniProt AC | Q06287 | |
| Protein Name | Ribosomal RNA small subunit methyltransferase NEP1 {ECO:0000305|PubMed:20972225} | |
| Gene Name | EMG1 {ECO:0000303|PubMed:11694595} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 252 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1189 (Psi1189) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. N1-methylation is independent on acp-modification at the N3-position of U1191. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 (RPS19A/RPS19B) during the formation of pre-ribosomes.. | |
| Protein Sequence | MVEDSRVRDALKGGDQKALPASLVPQAPPVLTSKDKITKRMIVVLAMASLETHKISSNGPGGDKYVLLNCDDHQGLLKKMGRDISEARPDITHQCLLTLLDSPINKAGKLQVYIQTSRGILIEVNPTVRIPRTFKRFSGLMVQLLHKLSIRSVNSEEKLLKVIKNPITDHLPTKCRKVTLSFDAPVIRVQDYIEKLDDDESICVFVGAMARGKDNFADEYVDEKVGLSNYPLSASVACSKFCHGAEDAWNIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MVEDSRVRDALK ---CCCHHHHHHHHC | 21.12 | 19795423 | |
| 22 | Phosphorylation | DQKALPASLVPQAPP CCCCCCHHHCCCCCC | 28.14 | 24961812 | |
| 34 | Acetylation | APPVLTSKDKITKRM CCCCCCCCCHHCHHH | 58.78 | 24489116 | |
| 64 | Acetylation | SNGPGGDKYVLLNCD CCCCCCCEEEEEECC | 40.30 | 24489116 | |
| 133 | Phosphorylation | PTVRIPRTFKRFSGL CCCCCCCCHHHHHHH | 28.31 | 27017623 | |
| 147 | Methylation | LMVQLLHKLSIRSVN HHHHHHHHCCCCCCC | 43.85 | 20137074 | |
| 158 | Acetylation | RSVNSEEKLLKVIKN CCCCCHHHHHHHHHC | 55.88 | 24489116 | |
| 213 | Acetylation | VGAMARGKDNFADEY HHHHHCCCCCCHHHH | 43.90 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NEP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NEP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NEP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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