NU192_YEAST - dbPTM
NU192_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NU192_YEAST
UniProt AC P47054
Protein Name Nucleoporin NUP192
Gene Name NUP192
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1683
Subcellular Localization Nucleus, nuclear pore complex. Cytoplasmic and nucleoplasmic side of the nuclear pore complex in the nuclear envelope (symmetric distribution).
Protein Description Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP192 is located to the NPC core at the nuclear membrane and is essential for de novo assembly of NPCs..
Protein Sequence MKWSAIPFQTLYRSIESGEFDFDLFKEVLPDLQNLNLNTDKLKNNASRSQLEKGEIELSDGSTFKVNQEFIFEAISLSDELNLDEIVACELILSGDTTANNGKVQYFLRRQYILQIVSFIVNCFHEDTELYQELIKNGALVSNILSAFKFIHTQLSEIKQQINKAQILENYNALFQQNIKFRRDFLLREYDILSQILYGLVDKGAIMKNKDFILSLLHHVSELDSNDFFIIYYTPAFFHLFASLRVLPDADVKLLHSQFMKDLKDDSIYTKPVKVALIFIFFAYFIGWCKEDPKRRADTMDFKTDVDEPMTSAVELGAIEQILIFAADTSIVEQDKSMELFYDIRSLLERHIPRLIPKQLLDDEKIFSQTTNSTYNPASATDNMSGRGLWNPSYPGMMSTTGTARLNSMPNNVNEYSYTTIVLSDQTQEFFLSSFDDVLQTIITDCAFLLTKIKDAEEDSLLSGEDLTLDDISLKADLERFFLSIYFFYASRPEYSCTFWSDKESNAYGFIEWCSRCNDNLMRSCFYLMVSSLSFGPENALNVYHYFGENSSISWKNIAQCLSDYTKKISNFNSSLHKRQQFSESTHNDIDSTAVALEEGLNEEAVIFLSSLLTLVGSVTYQVDEDVKSSLSKVFSDVLFEFTKINTPLVGAAFKVISNLVPKLESSRTKFWSFLDSLIFKDSSLNYSSESYRNAFTNVLTKYSDVLGFLQLFHNLISIHSRENNSEYMVFGKLAFPTRLGQGYRKVGIWPYFDYIFNDILAHVDQIVDIRNKRAVQLPILKIIYTGLCSFDYSVILNSIPAAANLDALVDCENFFNYVQECPAIPIFNYIFTEKIYKSIFNVVDVGVDQLSIELEGGKNQAELLQLAVKIINKVLDYQETYVEELFPIVKKHGKTDYFLPKNYSLHGLRSFYDAIFFNIPLVAHLGLYVGVDDQILATNSLRILAKLSERSNGSVASLSKRNKLLTIFDSVDESARIKDAFITQLESSITDAGVLALKLELLDFLTSNLSNYSRTMTISHLLLGFQVSNVISLGPNLATFISSGTSLLDSLISVLEASLNSITKDNIDYAPMRLATAALEIILKLCRNPLTSGLLYSYLIKENFFERIMILDPQVTRFTTWNGSPFDNSTEEKCKNFIESESVGAFLSFLAYRNYWTQYLGLFIHKISFSGTKSEVLTYVNYLISNTMYSVRLFSFLDPLNYGNICEPKETLSIFTNVPLNLEQVTLNKYCSGNIYDFHKMENLMRLIKRVRAESLHSNSFSLTVSKEQFLKDADVECIKAKSHFTNIISRNKALELNLSVLHSWVQLVQIIVTDGKLEPSTRSNFILEVFGTIIPKISDYIEFNITFSEELVSLAVFLFDIYNRDRKLITDKGTVDGRLYQLFKTCIQGINSPLSSVALRSDFYILANHYLSRVLSDQVGSEKVLQDLRLGSKKLVEIIWNDVVYGEGTSRVTGILLLDSLIQLANRSKENFILDSLMKTTRLLLIIRSLKNTDALLNSTTEHINIDDLLYELTAFKATVFFLIRVAETRGGASALIENNLFRIIAELSFLKVDPDLGLDLMFDEVYVQNSKFLKVNVTLDNPLLVDKDANGVSLFELIVPIFQLISAVLVSMGSSNKAVVQTVKGLLNTYKRLVIGIFKRDLLREKEDKKNSSDPNNQSLNEMVKLIVMLCTLTGYQNND
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationAIPFQTLYRSIESGE
CCCHHHHHHHHHCCC		13.0028132839
41AcetylationNLNLNTDKLKNNASR
HCCCCHHHHHCCCCH		60.3624489116
47PhosphorylationDKLKNNASRSQLEKG
HHHHCCCCHHHHHCC		34.2929136822
49PhosphorylationLKNNASRSQLEKGEI
HHCCCCHHHHHCCEE		36.3029136822
53AcetylationASRSQLEKGEIELSD
CCHHHHHCCEEECCC		71.1324489116
379PhosphorylationNSTYNPASATDNMSG
CCCCCCCCCCCCCCC		32.7223749301
381PhosphorylationTYNPASATDNMSGRG
CCCCCCCCCCCCCCC		25.9723749301
393PhosphorylationGRGLWNPSYPGMMST
CCCCCCCCCCCCCCC		40.5229688323
394PhosphorylationRGLWNPSYPGMMSTT
CCCCCCCCCCCCCCC		12.6929688323
399PhosphorylationPSYPGMMSTTGTARL
CCCCCCCCCCCCCHH		17.5829688323
400PhosphorylationSYPGMMSTTGTARLN
CCCCCCCCCCCCHHH		16.0229688323
401PhosphorylationYPGMMSTTGTARLNS
CCCCCCCCCCCHHHC		25.8129688323
403PhosphorylationGMMSTTGTARLNSMP
CCCCCCCCCHHHCCC		13.4029688323
484PhosphorylationDLERFFLSIYFFYAS
HHHHHHHHHHHHHHC		15.3027017623
489PhosphorylationFLSIYFFYASRPEYS
HHHHHHHHHCCCCCE		8.1827017623
574PhosphorylationKKISNFNSSLHKRQQ
HHHHCCCHHHHHHHH		30.0921440633
575PhosphorylationKISNFNSSLHKRQQF
HHHCCCHHHHHHHHH		35.2821551504
663AcetylationVISNLVPKLESSRTK
HHHHHHHHHHCCCHH		58.3624489116
902AcetylationKTDYFLPKNYSLHGL
CCCEECCCCCCCCCH		71.3324489116
955PhosphorylationLSERSNGSVASLSKR
HHHHCCCCCCCHHHH		20.8230377154
958PhosphorylationRSNGSVASLSKRNKL
HCCCCCCCHHHHCCE		30.9023749301
967PhosphorylationSKRNKLLTIFDSVDE
HHHCCEEEEECCCCH		29.9927017623
971PhosphorylationKLLTIFDSVDESARI
CEEEEECCCCHHHHH		22.2519779198
1011PhosphorylationDFLTSNLSNYSRTMT
HHHHHCCCCCCCHHC		37.6628889911
1013PhosphorylationLTSNLSNYSRTMTIS
HHHCCCCCCCHHCHH		8.9928889911
1014PhosphorylationTSNLSNYSRTMTISH
HHCCCCCCCHHCHHH		26.0628889911
1241AcetylationGNIYDFHKMENLMRL
CCCCCHHHHHHHHHH		48.1524489116
1256PhosphorylationIKRVRAESLHSNSFS
HHHHHHHHHCCCCEE		30.3330377154
1259PhosphorylationVRAESLHSNSFSLTV
HHHHHHCCCCEEEEE		39.1930377154
1261PhosphorylationAESLHSNSFSLTVSK
HHHHCCCCEEEEEEH		21.1630377154
1386UbiquitinationGRLYQLFKTCIQGIN
HHHHHHHHHHHHHCC		51.5917644757
1425UbiquitinationSDQVGSEKVLQDLRL
HCCCCCHHHHHHHHC		50.3623749301
1425AcetylationSDQVGSEKVLQDLRL
HCCCCCHHHHHHHHC		50.3624489116
1627AcetylationKAVVQTVKGLLNTYK
HHHHHHHHHHHHHHH		47.4225381059
1634AcetylationKGLLNTYKRLVIGIF
HHHHHHHHHHHHHHH		36.9025381059
1655PhosphorylationEKEDKKNSSDPNNQS
HHHHHCCCCCCCHHH		45.0219823750
1656PhosphorylationKEDKKNSSDPNNQSL
HHHHCCCCCCCHHHH		67.4919823750
1662PhosphorylationSSDPNNQSLNEMVKL
CCCCCHHHHHHHHHH		34.9719823750
1668UbiquitinationQSLNEMVKLIVMLCT
HHHHHHHHHHHHHHH		31.0519722269
1677PhosphorylationIVMLCTLTGYQNND-
HHHHHHHHCCCCCC-		18.7127017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NU192_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NU192_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NU192_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP72_YEASTSSA2physical
16429126
TBA1_YEASTTUB1physical
16429126
NUP53_YEASTNUP53physical
11283351
NUP2_YEASTNUP2physical
18467557
PO152_YEASTPOM152physical
18046405
NU116_YEASTNUP116physical
18046405
NIC96_YEASTNIC96physical
18046405
NUP84_YEASTNUP84physical
18046405
NUP82_YEASTNUP82physical
18046405
NSP1_YEASTNSP1physical
18046405
NUP57_YEASTNUP57physical
18046405
EF3A_YEASTYEF3physical
18046405
PFKA1_YEASTPFK1physical
18046405
PFKA2_YEASTPFK2physical
18046405
EF1A_YEASTTEF2physical
18046405
HSP71_YEASTSSA1physical
18046405
SSB2_YEASTSSB2physical
18046405
KPYK1_YEASTCDC19physical
18046405
PDC1_YEASTPDC1physical
18046405
ENO2_YEASTENO2physical
18046405
ADH1_YEASTADH1physical
18046405
G3P3_YEASTTDH3physical
18046405
RS3A2_YEASTRPS1Bphysical
18046405
PMG1_YEASTGPM1physical
18046405
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NU192_YEAST

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Related Literatures of Post-Translational Modification

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