dbPTM

EF3A_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EF3A_YEAST
UniProt AC	P16521
Protein Name	Elongation factor 3A
Gene Name	YEF3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1044
Subcellular Localization	Cytoplasm .
Protein Description	Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis. Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied. Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1-mediated GCN2 activation on ribosomes by reducing GCN1-ribosome affinity, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved or repleted cells. [PubMed: 22888004]
Protein Sequence	MSDSQQSIKVLEELFQKLSVATADNRHEIASEVASFLNGNIIEHDVPEHFFGELAKGIKDKKTAANAMQAVAHIANQSNLSPSVEPYIVQLVPAICTNAGNKDKEIQSVASETLISIVNAVNPVAIKALLPHLTNAIVETNKWQEKIAILAAISAMVDAAKDQVALRMPELIPVLSETMWDTKKEVKAAATAAMTKATETVDNKDIERFIPSLIQCIADPTEVPETVHLLGATTFVAEVTPATLSIMVPLLSRGLNERETGIKRKSAVIIDNMCKLVEDPQVIAPFLGKLLPGLKSNFATIADPEAREVTLRALKTLRRVGNVGEDDAIPEVSHAGDVSTTLQVVNELLKDETVAPRFKIVVEYIAAIGADLIDERIIDQQAWFTHITPYMTIFLHEKKAKDILDEFRKRAVDNIPVGPNFDDEEDEGEDLCNCEFSLAYGAKILLNKTQLRLKRARRYGICGPNGCGKSTLMRAIANGQVDGFPTQEECRTVYVEHDIDGTHSDTSVLDFVFESGVGTKEAIKDKLIEFGFTDEMIAMPISALSGGWKMKLALARAVLRNADILLLDEPTNHLDTVNVAWLVNYLNTCGITSITISHDSVFLDNVCEYIINYEGLKLRKYKGNFTEFVKKCPAAKAYEELSNTDLEFKFPEPGYLEGVKTKQKAIVKVTNMEFQYPGTSKPQITDINFQCSLSSRIAVIGPNGAGKSTLINVLTGELLPTSGEVYTHENCRIAYIKQHAFAHIESHLDKTPSEYIQWRFQTGEDRETMDRANRQINENDAEAMNKIFKIEGTPRRIAGIHSRRKFKNTYEYECSFLLGENIGMKSERWVPMMSVDNAWIPRGELVESHSKMVAEVDMKEALASGQFRPLTRKEIEEHCSMLGLDPEIVSHSRIRGLSGGQKVKLVLAAGTWQRPHLIVLDEPTNYLDRDSLGALSKALKEFEGGVIIITHSAEFTKNLTEEVWAVKDGRMTPSGHNWVSGQGAGPRIEKKEDEEDKFDAMGNKIAGGKKKKKLSSAELRKKKKERMKKKKELGDAYVSSDEEF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDSQQSIK ------CCHHHHHHH	58.22	9298649
2	Phosphorylation	------MSDSQQSIK ------CCHHHHHHH	58.22	30377154
4	Phosphorylation	----MSDSQQSIKVL ----CCHHHHHHHHH	39.14	28152593
7	Phosphorylation	-MSDSQQSIKVLEEL -CCHHHHHHHHHHHH	19.42	28152593
9	Acetylation	SDSQQSIKVLEELFQ CHHHHHHHHHHHHHH	46.12	24489116
9	Succinylation	SDSQQSIKVLEELFQ CHHHHHHHHHHHHHH	46.12	23954790
9	Ubiquitination	SDSQQSIKVLEELFQ CHHHHHHHHHHHHHH	46.12	24961812
17	Acetylation	VLEELFQKLSVATAD HHHHHHHHHCHHCCC	35.08	24489116
17	Ubiquitination	VLEELFQKLSVATAD HHHHHHHHHCHHCCC	35.08	17644757
19	Phosphorylation	EELFQKLSVATADNR HHHHHHHCHHCCCCH	19.42	28889911
31	Phosphorylation	DNRHEIASEVASFLN CCHHHHHHHHHHHHC	37.96	22369663
35	Phosphorylation	EIASEVASFLNGNII HHHHHHHHHHCCCCC	35.13	22369663
56	Ubiquitination	HFFGELAKGIKDKKT HHHHHHHHCCCCHHH	74.02	17644757
102	Ubiquitination	ICTNAGNKDKEIQSV HHCCCCCCCHHHHHH	70.07	17644757
104	Ubiquitination	TNAGNKDKEIQSVAS CCCCCCCHHHHHHHH	59.32	17644757
127	Ubiquitination	AVNPVAIKALLPHLT CCCHHHHHHHHHHHH	24.20	17644757
134	Phosphorylation	KALLPHLTNAIVETN HHHHHHHHHHHHHCC	21.41	22369663
140	Phosphorylation	LTNAIVETNKWQEKI HHHHHHHCCCHHHHH	31.07	22369663
142	Acetylation	NAIVETNKWQEKIAI HHHHHCCCHHHHHHH	58.64	24489116
142	Ubiquitination	NAIVETNKWQEKIAI HHHHHCCCHHHHHHH	58.64	23749301
146	Ubiquitination	ETNKWQEKIAILAAI HCCCHHHHHHHHHHH	23.49	22817900
161	Ubiquitination	SAMVDAAKDQVALRM HHHHHHHHHHHHHHC	50.87	23749301
176	Phosphorylation	PELIPVLSETMWDTK HHHHHHHCHHCCCCH	31.12	22369663
178	Phosphorylation	LIPVLSETMWDTKKE HHHHHCHHCCCCHHH	21.86	22369663
182	Phosphorylation	LSETMWDTKKEVKAA HCHHCCCCHHHHHHH	28.62	21440633
183	Acetylation	SETMWDTKKEVKAAA CHHCCCCHHHHHHHH	44.45	24489116
183	Succinylation	SETMWDTKKEVKAAA CHHCCCCHHHHHHHH	44.45	23954790
183	Ubiquitination	SETMWDTKKEVKAAA CHHCCCCHHHHHHHH	44.45	22106047
184	Acetylation	ETMWDTKKEVKAAAT HHCCCCHHHHHHHHH	70.59	24489116
184	Ubiquitination	ETMWDTKKEVKAAAT HHCCCCHHHHHHHHH	70.59	17644757
187	"N6,N6,N6-trimethyllysine"	WDTKKEVKAAATAAM CCCHHHHHHHHHHHH	33.14	-
187	Methylation	WDTKKEVKAAATAAM CCCHHHHHHHHHHHH	33.14	22522802
187	Ubiquitination	WDTKKEVKAAATAAM CCCHHHHHHHHHHHH	33.14	23749301
191	Phosphorylation	KEVKAAATAAMTKAT HHHHHHHHHHHHHHH	15.38	22369663
195	Phosphorylation	AAATAAMTKATETVD HHHHHHHHHHHHCCC	16.89	22369663
196	"N6,N6,N6-trimethyllysine"	AATAAMTKATETVDN HHHHHHHHHHHCCCH	39.98	-
196	2-Hydroxyisobutyrylation	AATAAMTKATETVDN HHHHHHHHHHHCCCH	39.98	-
196	Acetylation	AATAAMTKATETVDN HHHHHHHHHHHCCCH	39.98	24489116
196	Methylation	AATAAMTKATETVDN HHHHHHHHHHHCCCH	39.98	22522802
196	Succinylation	AATAAMTKATETVDN HHHHHHHHHHHCCCH	39.98	23954790
196	Ubiquitination	AATAAMTKATETVDN HHHHHHHHHHHCCCH	39.98	23749301
198	Phosphorylation	TAAMTKATETVDNKD HHHHHHHHHCCCHHH	33.47	23749301
200	Phosphorylation	AMTKATETVDNKDIE HHHHHHHCCCHHHHH	28.89	23749301
204	2-Hydroxyisobutyrylation	ATETVDNKDIERFIP HHHCCCHHHHHHHHH	56.47	-
204	Acetylation	ATETVDNKDIERFIP HHHCCCHHHHHHHHH	56.47	24489116
204	Succinylation	ATETVDNKDIERFIP HHHCCCHHHHHHHHH	56.47	23954790
204	Ubiquitination	ATETVDNKDIERFIP HHHCCCHHHHHHHHH	56.47	23749301
263	2-Hydroxyisobutyrylation	NERETGIKRKSAVII CCCCCCCCHHHEEEE	55.93	-
263	Ubiquitination	NERETGIKRKSAVII CCCCCCCCHHHEEEE	55.93	22817900
265	Ubiquitination	RETGIKRKSAVIIDN CCCCCCHHHEEEECC	37.45	23749301
266	Phosphorylation	ETGIKRKSAVIIDNM CCCCCHHHEEEECCH	31.62	21440633
275	Acetylation	VIIDNMCKLVEDPQV EEECCHHHHCCCHHH	44.81	24489116
275	Ubiquitination	VIIDNMCKLVEDPQV EEECCHHHHCCCHHH	44.81	17644757
289	Acetylation	VIAPFLGKLLPGLKS HHHHHHHHHCCCHHH	49.34	24489116
289	Succinylation	VIAPFLGKLLPGLKS HHHHHHHHHCCCHHH	49.34	23954790
289	Ubiquitination	VIAPFLGKLLPGLKS HHHHHHHHHCCCHHH	49.34	23749301
295	Acetylation	GKLLPGLKSNFATIA HHHCCCHHHCCCCCC	49.63	24489116
295	Succinylation	GKLLPGLKSNFATIA HHHCCCHHHCCCCCC	49.63	23954790
295	Ubiquitination	GKLLPGLKSNFATIA HHHCCCHHHCCCCCC	49.63	23749301
296	Phosphorylation	KLLPGLKSNFATIAD HHCCCHHHCCCCCCC	42.07	21440633
315	2-Hydroxyisobutyrylation	EVTLRALKTLRRVGN HHHHHHHHHHHHHCC	44.52	-
350	Acetylation	QVVNELLKDETVAPR HHHHHHHCCCCCCHH	67.17	24489116
350	Ubiquitination	QVVNELLKDETVAPR HHHHHHHCCCCCCHH	67.17	23749301
359	Ubiquitination	ETVAPRFKIVVEYIA CCCCHHHHHHHHHHH	35.55	17644757
364	Phosphorylation	RFKIVVEYIAAIGAD HHHHHHHHHHHHCCC	5.57	29688323
385	Phosphorylation	IDQQAWFTHITPYMT CCCHHHHHCCCCCHH	11.15	29688323
388	Phosphorylation	QAWFTHITPYMTIFL HHHHHCCCCCHHHHC	10.77	29688323
390	Phosphorylation	WFTHITPYMTIFLHE HHHCCCCCHHHHCCH	9.76	29688323
392	Phosphorylation	THITPYMTIFLHEKK HCCCCCHHHHCCHHH	11.61	29688323
398	Acetylation	MTIFLHEKKAKDILD HHHHCCHHHHHHHHH	47.48	24489116
398	Ubiquitination	MTIFLHEKKAKDILD HHHHCCHHHHHHHHH	47.48	17644757
399	Acetylation	TIFLHEKKAKDILDE HHHCCHHHHHHHHHH	58.65	24489116
399	Ubiquitination	TIFLHEKKAKDILDE HHHCCHHHHHHHHHH	58.65	17644757
401	2-Hydroxyisobutyrylation	FLHEKKAKDILDEFR HCCHHHHHHHHHHHH	54.93	-
401	Acetylation	FLHEKKAKDILDEFR HCCHHHHHHHHHHHH	54.93	24489116
401	Ubiquitination	FLHEKKAKDILDEFR HCCHHHHHHHHHHHH	54.93	23749301
409	Ubiquitination	DILDEFRKRAVDNIP HHHHHHHHHHHHCCC	50.45	17644757
443	Ubiquitination	FSLAYGAKILLNKTQ HHHHHHHHHHHCHHH	29.53	22817900
448	2-Hydroxyisobutyrylation	GAKILLNKTQLRLKR HHHHHHCHHHHHHHH	37.30	-
448	Acetylation	GAKILLNKTQLRLKR HHHHHHCHHHHHHHH	37.30	24489116
448	Succinylation	GAKILLNKTQLRLKR HHHHHHCHHHHHHHH	37.30	23954790
448	Ubiquitination	GAKILLNKTQLRLKR HHHHHHCHHHHHHHH	37.30	23749301
449	Phosphorylation	AKILLNKTQLRLKRA HHHHHCHHHHHHHHH	31.59	21440633
469	Acetylation	CGPNGCGKSTLMRAI CCCCCCCHHHHHHHH	44.32	24489116
469	Ubiquitination	CGPNGCGKSTLMRAI CCCCCCCHHHHHHHH	44.32	23749301
470	Phosphorylation	GPNGCGKSTLMRAIA CCCCCCHHHHHHHHH	16.44	23749301
520	Ubiquitination	FESGVGTKEAIKDKL HCCCCCCHHHHHHHH	38.94	17644757
524	2-Hydroxyisobutyrylation	VGTKEAIKDKLIEFG CCCHHHHHHHHHHCC	56.72	-
526	Ubiquitination	TKEAIKDKLIEFGFT CHHHHHHHHHHCCCC	46.49	15699485
549	Ubiquitination	SALSGGWKMKLALAR HHHCCCHHHHHHHHH	29.45	15699485
551	2-Hydroxyisobutyrylation	LSGGWKMKLALARAV HCCCHHHHHHHHHHH	27.21	-
551	Ubiquitination	LSGGWKMKLALARAV HCCCHHHHHHHHHHH	27.21	23749301
620	Ubiquitination	YEGLKLRKYKGNFTE CCCCCCEEECCCHHH	62.85	17644757
622	2-Hydroxyisobutyrylation	GLKLRKYKGNFTEFV CCCCEEECCCHHHHH	50.87	-
622	Acetylation	GLKLRKYKGNFTEFV CCCCEEECCCHHHHH	50.87	24489116
622	Succinylation	GLKLRKYKGNFTEFV CCCCEEECCCHHHHH	50.87	23954790
622	Ubiquitination	GLKLRKYKGNFTEFV CCCCEEECCCHHHHH	50.87	23749301
626	Phosphorylation	RKYKGNFTEFVKKCP EEECCCHHHHHHHCH	32.30	21440633
630	2-Hydroxyisobutyrylation	GNFTEFVKKCPAAKA CCHHHHHHHCHHHHH	54.71	-
630	Acetylation	GNFTEFVKKCPAAKA CCHHHHHHHCHHHHH	54.71	24489116
630	Succinylation	GNFTEFVKKCPAAKA CCHHHHHHHCHHHHH	54.71	23954790
630	Ubiquitination	GNFTEFVKKCPAAKA CCHHHHHHHCHHHHH	54.71	23749301
631	Ubiquitination	NFTEFVKKCPAAKAY CHHHHHHHCHHHHHH	39.90	22817900
636	Ubiquitination	VKKCPAAKAYEELSN HHHCHHHHHHHHHCC	54.32	23749301
638	Phosphorylation	KCPAAKAYEELSNTD HCHHHHHHHHHCCCC	14.83	25521595
642	Phosphorylation	AKAYEELSNTDLEFK HHHHHHHCCCCCEEC	40.75	22369663
644	Phosphorylation	AYEELSNTDLEFKFP HHHHHCCCCCEECCC	38.29	25521595
649	Acetylation	SNTDLEFKFPEPGYL CCCCCEECCCCCCCC	51.11	24489116
649	Succinylation	SNTDLEFKFPEPGYL CCCCCEECCCCCCCC	51.11	23954790
649	Ubiquitination	SNTDLEFKFPEPGYL CCCCCEECCCCCCCC	51.11	24961812
660	Acetylation	PGYLEGVKTKQKAIV CCCCCCCCCCCEEEE	61.94	24489116
660	Succinylation	PGYLEGVKTKQKAIV CCCCCCCCCCCEEEE	61.94	23954790
660	Ubiquitination	PGYLEGVKTKQKAIV CCCCCCCCCCCEEEE	61.94	23749301
664	Ubiquitination	EGVKTKQKAIVKVTN CCCCCCCEEEEEEEC	41.45	22817900
668	Ubiquitination	TKQKAIVKVTNMEFQ CCCEEEEEEECCEEE	36.91	23749301
679	Phosphorylation	MEFQYPGTSKPQITD CEEECCCCCCCCEEE	29.13	28889911
680	Phosphorylation	EFQYPGTSKPQITDI EEECCCCCCCCEEEE	48.53	21440633
681	Acetylation	FQYPGTSKPQITDIN EECCCCCCCCEEEEE	40.56	24489116
681	Ubiquitination	FQYPGTSKPQITDIN EECCCCCCCCEEEEE	40.56	23749301
707	Ubiquitination	IGPNGAGKSTLINVL ECCCCCCHHHHHHHH	39.47	23749301
708	Phosphorylation	GPNGAGKSTLINVLT CCCCCCHHHHHHHHC	27.77	28889911
709	Phosphorylation	PNGAGKSTLINVLTG CCCCCHHHHHHHHCC	34.83	29136822
715	Phosphorylation	STLINVLTGELLPTS HHHHHHHCCCCCCCC	25.07	30377154
721	Phosphorylation	LTGELLPTSGEVYTH HCCCCCCCCCCEECC	49.70	28889911
726	Phosphorylation	LPTSGEVYTHENCRI CCCCCCEECCCCCEE	9.70	28889911
727	Phosphorylation	PTSGEVYTHENCRIA CCCCCEECCCCCEEE	28.08	28889911
735	Phosphorylation	HENCRIAYIKQHAFA CCCCEEEEEHHHHHH	13.28	19779198
737	2-Hydroxyisobutyrylation	NCRIAYIKQHAFAHI CCEEEEEHHHHHHHH	24.29	-
737	Acetylation	NCRIAYIKQHAFAHI CCEEEEEHHHHHHHH	24.29	22865919
737	Ubiquitination	NCRIAYIKQHAFAHI CCEEEEEHHHHHHHH	24.29	24961812
750	Acetylation	HIESHLDKTPSEYIQ HHHHHHCCCHHHHHH	69.56	24489116
750	Ubiquitination	HIESHLDKTPSEYIQ HHHHHHCCCHHHHHH	69.56	17644757
751	Phosphorylation	IESHLDKTPSEYIQW HHHHHCCCHHHHHHH	31.54	28889911
753	Phosphorylation	SHLDKTPSEYIQWRF HHHCCCHHHHHHHHH	48.54	28889911
755	Phosphorylation	LDKTPSEYIQWRFQT HCCCHHHHHHHHHCC	11.62	19779198
762	Phosphorylation	YIQWRFQTGEDRETM HHHHHHCCCCCHHHH	39.57	17287358
768	Phosphorylation	QTGEDRETMDRANRQ CCCCCHHHHHHHHHH	25.84	17287358
786	Acetylation	NDAEAMNKIFKIEGT HHHHHHHHHHEEECC	36.11	24489116
786	Succinylation	NDAEAMNKIFKIEGT HHHHHHHHHHEEECC	36.11	23954790
786	Ubiquitination	NDAEAMNKIFKIEGT HHHHHHHHHHEEECC	36.11	23749301
789	"N6,N6,N6-trimethyllysine"	EAMNKIFKIEGTPRR HHHHHHHEEECCCCE	43.23	-
789	2-Hydroxyisobutyrylation	EAMNKIFKIEGTPRR HHHHHHHEEECCCCE	43.23	-
789	Acetylation	EAMNKIFKIEGTPRR HHHHHHHEEECCCCE	43.23	24489116
789	Methylation	EAMNKIFKIEGTPRR HHHHHHHEEECCCCE	43.23	22522802
789	Succinylation	EAMNKIFKIEGTPRR HHHHHHHEEECCCCE	43.23	23954790
789	Ubiquitination	EAMNKIFKIEGTPRR HHHHHHHEEECCCCE	43.23	23749301
793	Phosphorylation	KIFKIEGTPRRIAGI HHHEEECCCCEECCC	10.79	23749301
802	Phosphorylation	RRIAGIHSRRKFKNT CEECCCCCCCCCCCC	31.68	21440633
807	Ubiquitination	IHSRRKFKNTYEYEC CCCCCCCCCCEEEEE	51.95	23749301
825	Acetylation	LGENIGMKSERWVPM HCCCCCCCCCCEEEE	43.91	24489116
825	Ubiquitination	LGENIGMKSERWVPM HCCCCCCCCCCEEEE	43.91	23749301
826	Phosphorylation	GENIGMKSERWVPMM CCCCCCCCCCEEEEE	24.41	21440633
834	Phosphorylation	ERWVPMMSVDNAWIP CCEEEEEEECCCEEE	21.77	24961812
848	Phosphorylation	PRGELVESHSKMVAE ECCHHHHHHCCEEEE	26.11	21440633
850	Phosphorylation	GELVESHSKMVAEVD CHHHHHHCCEEEEEC	31.55	28889911
851	Ubiquitination	ELVESHSKMVAEVDM HHHHHHCCEEEEECH	31.78	24961812
859	Acetylation	MVAEVDMKEALASGQ EEEEECHHHHHHCCC	35.06	24489116
859	Ubiquitination	MVAEVDMKEALASGQ EEEEECHHHHHHCCC	35.06	23749301
864	Phosphorylation	DMKEALASGQFRPLT CHHHHHHCCCCCCCC	33.70	28889911
873	Acetylation	QFRPLTRKEIEEHCS CCCCCCHHHHHHHHH	58.78	24489116
873	Ubiquitination	QFRPLTRKEIEEHCS CCCCCCHHHHHHHHH	58.78	23749301
902	Ubiquitination	RGLSGGQKVKLVLAA CCCCCCCEEEEEEEC	44.61	23749301
904	Ubiquitination	LSGGQKVKLVLAAGT CCCCCEEEEEEECCC	39.66	17644757
931	Phosphorylation	TNYLDRDSLGALSKA CCCCCHHHHHHHHHH	29.60	21440633
936	Phosphorylation	RDSLGALSKALKEFE HHHHHHHHHHHHHCC	18.49	21440633
937	Acetylation	DSLGALSKALKEFEG HHHHHHHHHHHHCCC	59.60	24489116
937	Ubiquitination	DSLGALSKALKEFEG HHHHHHHHHHHHCCC	59.60	23749301
940	Ubiquitination	GALSKALKEFEGGVI HHHHHHHHHCCCCEE	66.28	22817900
957	Ubiquitination	THSAEFTKNLTEEVW ECCHHHHCCCCCEEE	56.11	17644757
967	2-Hydroxyisobutyrylation	TEEVWAVKDGRMTPS CCEEEEEECCCCCCC	46.87	-
967	Acetylation	TEEVWAVKDGRMTPS CCEEEEEECCCCCCC	46.87	24489116
967	Succinylation	TEEVWAVKDGRMTPS CCEEEEEECCCCCCC	46.87	23954790
967	Ubiquitination	TEEVWAVKDGRMTPS CCEEEEEECCCCCCC	46.87	23749301
972	Phosphorylation	AVKDGRMTPSGHNWV EEECCCCCCCCCCCC	16.97	22369663
974	Phosphorylation	KDGRMTPSGHNWVSG ECCCCCCCCCCCCCC	43.44	22369663
980	Phosphorylation	PSGHNWVSGQGAGPR CCCCCCCCCCCCCCC	19.60	29136822
990	Ubiquitination	GAGPRIEKKEDEEDK CCCCCCCCCCCCCCC	60.12	17644757
991	Acetylation	AGPRIEKKEDEEDKF CCCCCCCCCCCCCCC	58.57	25381059
991	Ubiquitination	AGPRIEKKEDEEDKF CCCCCCCCCCCCCCC	58.57	17644757
997	Acetylation	KKEDEEDKFDAMGNK CCCCCCCCCHHHCCC	48.72	24489116
997	Ubiquitination	KKEDEEDKFDAMGNK CCCCCCCCCHHHCCC	48.72	17644757
1004	Acetylation	KFDAMGNKIAGGKKK CCHHHCCCCCCCHHC	28.36	22865919
1004	Ubiquitination	KFDAMGNKIAGGKKK CCHHHCCCCCCCHHC	28.36	17644757
1011	Ubiquitination	KIAGGKKKKKLSSAE CCCCCHHCCCCCHHH	59.64	17644757
1012	Ubiquitination	IAGGKKKKKLSSAEL CCCCHHCCCCCHHHH	68.75	17644757
1013	Acetylation	AGGKKKKKLSSAELR CCCHHCCCCCHHHHH	63.58	25381059
1013	Ubiquitination	AGGKKKKKLSSAELR CCCHHCCCCCHHHHH	63.58	17644757
1015	Phosphorylation	GKKKKKLSSAELRKK CHHCCCCCHHHHHHH	36.06	22369663
1016	Phosphorylation	KKKKKLSSAELRKKK HHCCCCCHHHHHHHH	35.88	22369663
1021	Ubiquitination	LSSAELRKKKKERMK CCHHHHHHHHHHHHH	79.96	17644757
1030	Ubiquitination	KKERMKKKKELGDAY HHHHHHHHHHHHHCC	46.06	23749301
1037	Phosphorylation	KKELGDAYVSSDEEF HHHHHHCCCCCCCCC	12.95	25521595
1039	Phosphorylation	ELGDAYVSSDEEF-- HHHHCCCCCCCCC--	21.28	22369663
1040	Phosphorylation	LGDAYVSSDEEF--- HHHCCCCCCCCC---	38.71	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EF3A_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EF3A_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EF3A_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YEC3_YEAST	YEL023C	physical	16554755
HFM1_YEAST	HFM1	physical	16554755
NU159_YEAST	NUP159	physical	16554755
POB3_YEAST	POB3	physical	16554755
SEC65_YEAST	SEC65	physical	16554755
NEW1_YEAST	NEW1	physical	16554755
EF1B_YEAST	EFB1	physical	17179749
EF1G2_YEAST	TEF4	genetic	17179749
EF1G2_YEAST	TEF4	genetic	22194687
RS22A_YEAST	RPS22A	physical	22888004
RS22B_YEAST	RPS22B	physical	22888004
DED1_YEAST	DED1	genetic	27708008
STU1_YEAST	STU1	genetic	27708008
KPC1_YEAST	PKC1	genetic	27708008
CDC12_YEAST	CDC12	genetic	27708008
DCP2_YEAST	DCP2	genetic	27708008
PMP1_YEAST	PMP1	physical	26404137

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EF3A_YEAST

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Proteome studies of Saccharomyces cerevisiae: identification andcharacterization of abundant proteins."; Garrels J.I., McLaughlin C.S., Warner J.R., Futcher B., Latter G.I.,Kobayashi R., Schwender B., Volpe T., Anderson D.S.,Mesquita-Fuentes R., Payne W.E.; Electrophoresis 18:1347-1360(1997). Cited for: ACETYLATION AT SER-2.	9298649 [Abstract]
Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-642; THR-644; THR-972;TYR-1037; SER-1039 AND SER-1040, AND MASS SPECTROMETRY.	18407956 [Abstract]
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