| UniProt ID | KPC1_YEAST | |
|---|---|---|
| UniProt AC | P24583 | |
| Protein Name | Protein kinase C-like 1 | |
| Gene Name | PKC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1151 | |
| Subcellular Localization | ||
| Protein Description | Required for cell growth and for the G2->M transition of the cell division cycle. Mediates a protein kinase cascade; it activates BCK1 which itself activates MKK1/MKK2.. | |
| Protein Sequence | MSFSQLEQNIKKKIAVEENIIRGASALKKKTSNVMVIQKCNTNIREARQNLEYLEDSLKKLRLKTAQQSQGENGSEDNERCNSKEYGFLSTKSPNEHIFSRLDLVKYDCPSLAQRIQYMLQQLEFKLQVEKQYQEANTKLTKLYQIDGDQRSSSAAEGGAMESKYRIQMLNKALKKYQAINVDFDQFKHQPNDIMDNQQPKFRRKQLTGVLTIGITAARDVDHIQSPMFARKPESYVTIKIDDTIKARTKPSRNDRWSEDFQIPVEKGNEIEITVYDKVNDSLIPVAIMWLLLSDIAEEIRKKKAGQTNEQQGWVNASNINGGSSLASEEGSTLTSTYSNSAIQSTSAKNVQGENTSTSQISTNSWFVLEPSGQILLTLGFHKSSQIERKQLMGGLHRHGAIINRKEEIFEQHGHHFVQKSFYNIMCCAYCGDFLRYTGFQCQDCKFLCHKKCYTNVVTKCIAKTSTDTDPDEAKLNHRIPHRFLPTSNRGTKWCCHCGYILPWGRHKVRKCSECGIMCHAQCAHLVPDFCGMSMEMANKILKTIQDTKRNQEKKKRTVPSAQLGSSIGTANGSDLSPSKLAERANAPLPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRISLQTHGREKLNKFIDENEAYLNFTEGAQQTAEFSSPEKTLDPTSNRRSLGLTDLSIEHSQTWESKDDLMRDELELWKAQREEMELEIKQDSGEIQEDLEVDHIDLETKQKLDWENKNDFREADLTIDSTHTNPFRDMNSETFQIEQDHASKEVLQETVSLAPTSTHASRTTDQQSPQKSQTSTSAKHKKRAAKRRKVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLATKTKHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQNQRLSVRRAKFYAAEVLLALKYFHDNGVIYRDLKLENILLTPEGHIKIADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFGVLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLGAGPRDADEVMEEPFFRNINFDDILNLRVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTPLPSVLTTSQQEEFRGFSFMPDDLDL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSFSQLEQN ------CCHHHHHHH | 44.93 | 28152593 | |
| 4 | Phosphorylation | ----MSFSQLEQNIK ----CCHHHHHHHHH | 43.05 | 30377154 | |
| 31 | Phosphorylation | ASALKKKTSNVMVIQ HHHHCHHCCCEEEEE | 34.12 | 27717283 | |
| 32 | Phosphorylation | SALKKKTSNVMVIQK HHHCHHCCCEEEEEE | 35.99 | 23749301 | |
| 39 | Ubiquitination | SNVMVIQKCNTNIRE CCEEEEEECCCCHHH | 20.51 | 23749301 | |
| 64 | Ubiquitination | SLKKLRLKTAQQSQG HHHHHHHHHHHHHCC | 35.07 | 23749301 | |
| 65 | Phosphorylation | LKKLRLKTAQQSQGE HHHHHHHHHHHHCCC | 34.00 | 21551504 | |
| 75 | Phosphorylation | QSQGENGSEDNERCN HHCCCCCCCCCHHCC | 54.05 | 23749301 | |
| 83 | Phosphorylation | EDNERCNSKEYGFLS CCCHHCCCCCCCCCC | 30.41 | 21551504 | |
| 86 | Phosphorylation | ERCNSKEYGFLSTKS HHCCCCCCCCCCCCC | 19.53 | 21551504 | |
| 93 | Phosphorylation | YGFLSTKSPNEHIFS CCCCCCCCCCCCHHH | 32.80 | 21440633 | |
| 106 | Ubiquitination | FSRLDLVKYDCPSLA HHHHCCHHCCCHHHH | 42.54 | 23749301 | |
| 107 | Phosphorylation | SRLDLVKYDCPSLAQ HHHCCHHCCCHHHHH | 18.46 | 28889911 | |
| 111 | Phosphorylation | LVKYDCPSLAQRIQY CHHCCCHHHHHHHHH | 42.54 | 28889911 | |
| 142 | Ubiquitination | EANTKLTKLYQIDGD HHCHHHEEEEEECCC | 56.48 | 23749301 | |
| 152 | Phosphorylation | QIDGDQRSSSAAEGG EECCCCCCCCHHCCC | 24.02 | 23749301 | |
| 164 | Ubiquitination | EGGAMESKYRIQMLN CCCHHHHHHHHHHHH | 25.83 | 23749301 | |
| 175 | Ubiquitination | QMLNKALKKYQAINV HHHHHHHHHHHHCCC | 55.05 | 17644757 | |
| 176 | Ubiquitination | MLNKALKKYQAINVD HHHHHHHHHHHCCCC | 43.37 | 17644757 | |
| 188 | Ubiquitination | NVDFDQFKHQPNDIM CCCHHHHCCCCCCCC | 35.38 | 17644757 | |
| 226 | Phosphorylation | RDVDHIQSPMFARKP CCCCCCCCCCCCCCC | 20.10 | 23749301 | |
| 244 | Phosphorylation | VTIKIDDTIKARTKP EEEEECCCEECCCCC | 22.19 | 26447709 | |
| 464 | Ubiquitination | VVTKCIAKTSTDTDP HHHHHHHCCCCCCCH | 24.09 | 23749301 | |
| 558 | Phosphorylation | NQEKKKRTVPSAQLG HHHHHHCCCCHHHHH | 45.72 | 19823750 | |
| 561 | Phosphorylation | KKKRTVPSAQLGSSI HHHCCCCHHHHHCCC | 25.06 | 24961812 | |
| 566 | Phosphorylation | VPSAQLGSSIGTANG CCHHHHHCCCCCCCC | 27.63 | 24961812 | |
| 567 | Phosphorylation | PSAQLGSSIGTANGS CHHHHHCCCCCCCCC | 24.20 | 24961812 | |
| 570 | Phosphorylation | QLGSSIGTANGSDLS HHHCCCCCCCCCCCC | 18.45 | 28889911 | |
| 574 | Phosphorylation | SIGTANGSDLSPSKL CCCCCCCCCCCHHHH | 34.87 | 25521595 | |
| 577 | Phosphorylation | TANGSDLSPSKLAER CCCCCCCCHHHHHHH | 31.92 | 25521595 | |
| 579 | Phosphorylation | NGSDLSPSKLAERAN CCCCCCHHHHHHHCC | 36.60 | 19823750 | |
| 599 | Phosphorylation | QPRKHDKTPSPQKVG CCCCCCCCCCCHHCC | 34.75 | 19684113 | |
| 601 | Phosphorylation | RKHDKTPSPQKVGRD CCCCCCCCCHHCCCC | 45.23 | 19684113 | |
| 609 | Phosphorylation | PQKVGRDSPTKQHDP CHHCCCCCCCCCCCC | 32.86 | 24909858 | |
| 611 | Phosphorylation | KVGRDSPTKQHDPII HCCCCCCCCCCCCCC | 47.49 | 19823750 | |
| 623 | Phosphorylation | PIIDKRISLQTHGRE CCCCHHHHCCCCCHH | 20.61 | 23749301 | |
| 656 | Phosphorylation | AQQTAEFSSPEKTLD HHHHCCCCCCCCCCC | 36.17 | 28889911 | |
| 657 | Phosphorylation | QQTAEFSSPEKTLDP HHHCCCCCCCCCCCC | 42.26 | 28889911 | |
| 666 | Phosphorylation | EKTLDPTSNRRSLGL CCCCCCCCCCCCCCC | 33.45 | 21440633 | |
| 670 | Phosphorylation | DPTSNRRSLGLTDLS CCCCCCCCCCCCCCC | 24.45 | 24909858 | |
| 674 | Phosphorylation | NRRSLGLTDLSIEHS CCCCCCCCCCCCCCC | 32.85 | 22369663 | |
| 677 | Phosphorylation | SLGLTDLSIEHSQTW CCCCCCCCCCCCCCC | 28.83 | 22369663 | |
| 681 | Phosphorylation | TDLSIEHSQTWESKD CCCCCCCCCCCCCCC | 19.26 | 22369663 | |
| 683 | Phosphorylation | LSIEHSQTWESKDDL CCCCCCCCCCCCCHH | 33.93 | 22369663 | |
| 686 | Phosphorylation | EHSQTWESKDDLMRD CCCCCCCCCCHHHHH | 32.71 | 22369663 | |
| 747 | Phosphorylation | DFREADLTIDSTHTN CHHHCCCEEECCCCC | 24.24 | 27214570 | |
| 750 | Phosphorylation | EADLTIDSTHTNPFR HCCCEEECCCCCCCC | 20.45 | 23749301 | |
| 751 | Phosphorylation | ADLTIDSTHTNPFRD CCCEEECCCCCCCCC | 29.04 | 25752575 | |
| 753 | Phosphorylation | LTIDSTHTNPFRDMN CEEECCCCCCCCCCC | 44.68 | 21440633 | |
| 761 | Phosphorylation | NPFRDMNSETFQIEQ CCCCCCCCCCEEEEH | 31.23 | 22369663 | |
| 763 | Phosphorylation | FRDMNSETFQIEQDH CCCCCCCCEEEEHHH | 22.21 | 22369663 | |
| 772 | Phosphorylation | QIEQDHASKEVLQET EEEHHHHCHHHHHHH | 26.40 | 22369663 | |
| 779 | Phosphorylation | SKEVLQETVSLAPTS CHHHHHHHHCCCCCC | 11.48 | 30377154 | |
| 781 | Phosphorylation | EVLQETVSLAPTSTH HHHHHHHCCCCCCCC | 26.66 | 21551504 | |
| 785 | Phosphorylation | ETVSLAPTSTHASRT HHHCCCCCCCCCCCC | 40.42 | 21551504 | |
| 786 | Phosphorylation | TVSLAPTSTHASRTT HHCCCCCCCCCCCCC | 19.69 | 21551504 | |
| 787 | Phosphorylation | VSLAPTSTHASRTTD HCCCCCCCCCCCCCC | 24.76 | 21551504 | |
| 790 | Phosphorylation | APTSTHASRTTDQQS CCCCCCCCCCCCCCC | 23.66 | 30377154 | |
| 792 | Phosphorylation | TSTHASRTTDQQSPQ CCCCCCCCCCCCCCC | 32.03 | 21551504 | |
| 793 | Phosphorylation | STHASRTTDQQSPQK CCCCCCCCCCCCCCC | 30.60 | 21551504 | |
| 797 | Phosphorylation | SRTTDQQSPQKSQTS CCCCCCCCCCCCCCC | 24.54 | 25752575 | |
| 801 | Phosphorylation | DQQSPQKSQTSTSAK CCCCCCCCCCCHHHH | 33.18 | 23749301 | |
| 803 | Phosphorylation | QSPQKSQTSTSAKHK CCCCCCCCCHHHHHH | 40.85 | 28889911 | |
| 804 | Phosphorylation | SPQKSQTSTSAKHKK CCCCCCCCHHHHHHH | 16.84 | 19684113 | |
| 820 | Phosphorylation | AAKRRKVSLDNFVLL HHHHCCCCHHCEEEE | 32.80 | 21440633 | |
| 981 | Phosphorylation | EMWYGNRTSTFCGTP CEECCCCCCCCCCCC | 35.80 | 22890988 | |
| 982 | Phosphorylation | MWYGNRTSTFCGTPE EECCCCCCCCCCCCC | 19.09 | 22890988 | |
| 983 | Phosphorylation | WYGNRTSTFCGTPEF ECCCCCCCCCCCCCH | 23.49 | 25521595 | |
| 987 | Phosphorylation | RTSTFCGTPEFMAPE CCCCCCCCCCHHCHH | 22.33 | 22890988 | |
| 1123 | Phosphorylation | EFTSAPPTLTPLPSV HHCCCCCCCCCCCCC | 42.05 | 30377154 | |
| 1125 | Phosphorylation | TSAPPTLTPLPSVLT CCCCCCCCCCCCCCC | 25.84 | 23749301 | |
| 1132 | Phosphorylation | TPLPSVLTTSQQEEF CCCCCCCCCCCCHHH | 23.42 | 30377154 | |
| 1134 | Phosphorylation | LPSVLTTSQQEEFRG CCCCCCCCCCHHHCC | 25.32 | 27214570 | |
| 1143 | Phosphorylation | QEEFRGFSFMPDDLD CHHHCCCCCCCCCCC | 24.37 | 10074427 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 983 | T | Phosphorylation | Kinase | PKH2 | Q12236 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KPC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KPC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226; SER-577; THR-751;SER-761; THR-981; THR-983 AND THR-1125, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-577 AND SER-761, ANDMASS SPECTROMETRY. | |
