MAC1_YEAST - dbPTM
MAC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAC1_YEAST
UniProt AC P35192
Protein Name Metal-binding activator 1
Gene Name MAC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 417
Subcellular Localization Nucleus.
Protein Description Regulatory protein involved in Cu/Fe utilization and stress resistance. Involved in basal level transcription of FRE1 and H(2)O(2)-induced transcription of CTT1. Regulates the transcription of CTR1 and CTR3 via the copper ion responsive elements in their promoters. Required for degradation of CTR1..
Protein Sequence MIIFNGNKYACASCIRGHRSSTCRHSHRMLIKVRTRGRPSPMAIRDAILVDSTSQSTEYENGAQIEGDCCSAMNQQPILFVRASAVRKARMINGKLHILMEEGFTAHEPKDISTFTDDGNKYITETEFLRKHSPKAPATGTISPDSTKSSSSSEKKERSRLQQEPIRHFSNCCKKDKSQNPASNGKTNKAPSDDIFTPYGSLESTSAFNDILQENYNSSVPGAHDSSETLTPQSTTTIAAPHSSDVASKVEVLTHKGIFLSTQCSCEDESCPCVNCLIHRSEEELNSYIQQSGVPLTNIGEAQITDKMMDYLDDCKCTDKECICPPDNCTCDGCFSHSTNIIPFEKFFFYGILNARLTRKTQIKFKGKLVPSKYWWDFLKLQVPLMTDAQLELLDIHAWFQKLVSNYAPHLSDATTS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationVRTRGRPSPMAIRDA
EEECCCCCCCCHHCE		26.4123749301
53PhosphorylationDAILVDSTSQSTEYE
CEEEECCCCCCCCCC		26.7319779198
57PhosphorylationVDSTSQSTEYENGAQ
ECCCCCCCCCCCCCE		34.6419779198
59PhosphorylationSTSQSTEYENGAQIE
CCCCCCCCCCCCEEE		18.1219779198
126PhosphorylationGNKYITETEFLRKHS
CCEEEEHHHHHHHHC		24.3224961812
133PhosphorylationTEFLRKHSPKAPATG
HHHHHHHCCCCCCCC		31.0021440633
139PhosphorylationHSPKAPATGTISPDS
HCCCCCCCCCCCCCC		33.5222369663
141PhosphorylationPKAPATGTISPDSTK
CCCCCCCCCCCCCCC		17.5822369663
143PhosphorylationAPATGTISPDSTKSS
CCCCCCCCCCCCCCC		23.6122369663
146PhosphorylationTGTISPDSTKSSSSS
CCCCCCCCCCCCCCH		40.9122369663
147PhosphorylationGTISPDSTKSSSSSE
CCCCCCCCCCCCCHH		42.1822369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAC1_YEASTMAC1physical
10506178
MAC1_YEASTMAC1physical
9867833
FRE1_YEASTFRE1genetic
12954629
MAC1_YEASTMAC1physical
11297731
HIR3_YEASTHIR3genetic
17314980
RGP1_YEASTRGP1genetic
17314980
MED5_YEASTNUT1genetic
17314980
PFD6_YEASTYKE2genetic
17314980
RIC1_YEASTRIC1genetic
17314980
YO111_YEASTYOR111Wphysical
18719252
MAC1_YEASTMAC1physical
18719252
SSB1_YEASTSSB1physical
19536198
SET3_YEASTSET3genetic
20959818
YPT6_YEASTYPT6genetic
20959818
SKN7_YEASTSKN7genetic
21127252
PACC_YEASTRIM101genetic
21127252
CTK3_YEASTCTK3genetic
21127252
PTK2_YEASTPTK2genetic
21127252
KCC1_YEASTCMK1genetic
21127252
RTG3_YEASTRTG3genetic
21127252
KIN2_YEASTKIN2genetic
21127252
CTR2_YEASTCTR2genetic
22445756
AFT1_YEASTAFT1physical
22683637
AFT1_YEASTAFT1genetic
22683637
STE50_YEASTSTE50genetic
27708008
SEC17_YEASTSEC17genetic
27708008
RPB1_YEASTRPO21genetic
27708008
TCPD_YEASTCCT4genetic
27708008
COPA_YEASTCOP1genetic
27708008
GLE1_YEASTGLE1genetic
27708008
RRP1_YEASTRRP1genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
TCPA_YEASTTCP1genetic
27708008
TRS23_YEASTTRS23genetic
27708008
SRPR_YEASTSRP101genetic
27708008
GPI11_YEASTGPI11genetic
27708008
RSC3_YEASTRSC3genetic
27708008
TFB1_YEASTTFB1genetic
27708008
GPI19_YEASTGPI19genetic
27708008
COG3_YEASTCOG3genetic
27708008
ACT_YEASTACT1genetic
27708008
PTI1_YEASTPTI1genetic
27708008
RPF1_YEASTRPF1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
ATC7_YEASTNEO1genetic
27708008
PAN1_YEASTPAN1genetic
27708008
GRP78_YEASTKAR2genetic
27708008
PSF2_YEASTPSF2genetic
27708008
IF2A_YEASTSUI2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
YKT6_YEASTYKT6genetic
27708008
BET3_YEASTBET3genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
SEC13_YEASTSEC13genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TAD3_YEASTTAD3genetic
27708008
GPI12_YEASTGPI12genetic
27708008
LST8_YEASTLST8genetic
27708008
NOP2_YEASTNOP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
PROF_YEASTPFY1genetic
27708008
LAS17_YEASTLAS17genetic
27708008
SEC63_YEASTSEC63genetic
27708008
PRS10_YEASTRPT4genetic
27708008
SEC62_YEASTSEC62genetic
27708008
SWC5_YEASTSWC5genetic
27708008
SLX5_YEASTSLX5genetic
27708008
WDR59_YEASTMTC5genetic
27708008
RAD4_YEASTRAD4genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
STB5_YEASTSTB5genetic
27708008
HPM1_YEASTHPM1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
CTK1_YEASTCTK1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
MSO1_YEASTMSO1genetic
27708008
GYP1_YEASTGYP1genetic
27708008
HST1_YEASTHST1genetic
27811238
BANP_HUMANBANPphysical
27107014
UBC9_HUMANUBE2Iphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAC1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, AND MASSSPECTROMETRY.

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