| UniProt ID | TCPD_YEAST | |
|---|---|---|
| UniProt AC | P39078 | |
| Protein Name | T-complex protein 1 subunit delta | |
| Gene Name | CCT4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 528 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.. | |
| Protein Sequence | MSAKVPSNATFKNKEKPQEVRKANIIAARSVADAIRTSLGPKGMDKMIKTSRGEIIISNDGHTILKQMAILHPVARMLVEVSAAQDSEAGDGTTSVVILTGALLGAAERLLNKGIHPTIIADSFQSAAKRSVDILLEMCHKVSLSDREQLVRAASTSLSSKIVSQYSSFLAPLAVDSVLKISDENSKNVDLNDIRLVKKVGGTIDDTEMIDGVVLTQTAIKSAGGPTRKEKAKIGLIQFQISPPKPDTENNIIVNDYRQMDKILKEERAYLLNICKKIKKAKCNVLLIQKSILRDAVNDLALHFLSKLNIMVVKDIEREEIEFLSKGLGCKPIADIELFTEDRLGSADLVEEIDSDGSKIVRVTGIRNNNARPTVSVVIRGANNMIIDETERSLHDALCVIRCLVKERGLIAGGGAPEIEISRRLSKEARSMEGVQAFIWQEFASALEVIPTTLAENAGLNSIKVVTELRSKHENGELNDGISVRRSGTTNTYEEHILQPVLVSTSAITLASECVKSILRIDDIAFSR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSAKVPSNA ------CCCCCCCCC | 36.48 | 28152593 | |
| 10 | Phosphorylation | AKVPSNATFKNKEKP CCCCCCCCCCCCCCC | 39.12 | 28889911 | |
| 22 | Ubiquitination | EKPQEVRKANIIAAR CCCHHHHHHHHHHHH | 51.46 | 17644757 | |
| 66 | Ubiquitination | NDGHTILKQMAILHP CCCHHHHHHHHHHHH | 33.89 | 24961812 | |
| 113 | Ubiquitination | AAERLLNKGIHPTII HHHHHHHCCCCCCHH | 60.25 | 17644757 | |
| 129 | Ubiquitination | DSFQSAAKRSVDILL HHHHHHHHHHHHHHH | 44.94 | 17644757 | |
| 129 | Acetylation | DSFQSAAKRSVDILL HHHHHHHHHHHHHHH | 44.94 | 22865919 | |
| 161 | Ubiquitination | ASTSLSSKIVSQYSS HHHHHHHHHHHHHHH | 43.69 | 17644757 | |
| 164 | Phosphorylation | SLSSKIVSQYSSFLA HHHHHHHHHHHHCHH | 27.20 | 21126336 | |
| 180 | Ubiquitination | LAVDSVLKISDENSK HHHHHHEEECCCCCC | 37.70 | 17644757 | |
| 187 | Ubiquitination | KISDENSKNVDLNDI EECCCCCCCCCHHHH | 72.99 | 23749301 | |
| 187 | Acetylation | KISDENSKNVDLNDI EECCCCCCCCCHHHH | 72.99 | 24489116 | |
| 233 | Ubiquitination | PTRKEKAKIGLIQFQ CCHHHHCEEEEEEEE | 48.66 | 17644757 | |
| 245 | Ubiquitination | QFQISPPKPDTENNI EEEECCCCCCCCCCE | 59.93 | 17644757 | |
| 307 | Ubiquitination | LALHFLSKLNIMVVK HHHHHHHHCCEEEEE | 47.93 | 17644757 | |
| 346 | Phosphorylation | FTEDRLGSADLVEEI ECCCCCCCCCCEEEE | 24.17 | 27214570 | |
| 359 | Acetylation | EIDSDGSKIVRVTGI EECCCCCEEEEEEEC | 51.23 | 24489116 | |
| 516 | Ubiquitination | TLASECVKSILRIDD HHHHHHHHHHHCHHH | 43.36 | 17644757 | |
| 517 | Phosphorylation | LASECVKSILRIDDI HHHHHHHHHHCHHHH | 13.37 | 19823750 | |
| 527 | Phosphorylation | RIDDIAFSR------ CHHHHCCCC------ | 28.23 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TCPD_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TCPD_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TCPD_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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