| UniProt ID | SMI1_YEAST | |
|---|---|---|
| UniProt AC | P32566 | |
| Protein Name | Cell wall assembly regulator SMI1 | |
| Gene Name | SMI1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 505 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Protein involved in the regulation of cell wall assembly and 1,3-beta-glucan synthesis, possibly through the transcriptional regulation of cell wall glucan and chitin synthesis.. | |
| Protein Sequence | MDLFKRKVKEWVYSLSTDDHYAEYNPDETPTFNMGKRLNSNNGQVNPSQMHLNSVDEEMSMGFQNGVPSNEDINIDEFTSTESNDGVSETLLAWRHIDFWTSEHNPDLNATLSDPCTQNDITHAEEDLEVSFPNPVKASFKIHDGQEDLESMTGTSGLFYGFQLMTLDQVVAMTQAWRNVAKNLNKRSQQGLSHVTSTGSSSSMERLNGNKFKLPNIPDQKSIPPNAVQPVYAHPAWIPLITDNAGNHIGVDLAPGPNGKYAQIITFGRDFDTKFVIAENWGEFLLSFANDLEAGNWYLVDDNDDYFSGDGELVFRDKKSNGPIQDYFEVLKRRTWIKYQENLRSQQQKSQPDTSLQEQKYVPASQKKVAAEQPSTLNAESIKGEDSGSADVQSVQDHESVKIVKTEPSEAETTTVNTESLGQAEHEIKADNVDIKQESERKEDEKQPKVEEKEHVENEHVTESAKKDDDVNKQTEEMNKKEENEIRSDDAKVEEAREEFENIAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Ubiquitination | TPTFNMGKRLNSNNG CCCCCCCCCCCCCCC | 42.83 | 23749301 | |
| 188 | Phosphorylation | AKNLNKRSQQGLSHV HHHHHHHHHHCCCCC | 28.59 | 22890988 | |
| 193 | Phosphorylation | KRSQQGLSHVTSTGS HHHHHCCCCCCCCCC | 23.80 | 22890988 | |
| 196 | Phosphorylation | QQGLSHVTSTGSSSS HHCCCCCCCCCCCCH | 18.36 | 22890988 | |
| 197 | Phosphorylation | QGLSHVTSTGSSSSM HCCCCCCCCCCCCHH | 29.67 | 22369663 | |
| 198 | Phosphorylation | GLSHVTSTGSSSSME CCCCCCCCCCCCHHH | 31.55 | 22369663 | |
| 200 | Phosphorylation | SHVTSTGSSSSMERL CCCCCCCCCCHHHHH | 27.43 | 22369663 | |
| 201 | Phosphorylation | HVTSTGSSSSMERLN CCCCCCCCCHHHHHC | 27.98 | 22369663 | |
| 202 | Phosphorylation | VTSTGSSSSMERLNG CCCCCCCCHHHHHCC | 35.09 | 22369663 | |
| 203 | Phosphorylation | TSTGSSSSMERLNGN CCCCCCCHHHHHCCC | 26.98 | 22369663 | |
| 213 | Acetylation | RLNGNKFKLPNIPDQ HHCCCCCCCCCCCCC | 65.72 | 24489116 | |
| 320 | Phosphorylation | LVFRDKKSNGPIQDY EEEEECCCCCCHHHH | 53.40 | 21551504 | |
| 338 | Acetylation | LKRRTWIKYQENLRS HHHHHHHHHHHHHHH | 32.23 | 24489116 | |
| 349 | Ubiquitination | NLRSQQQKSQPDTSL HHHHHHHHCCCCCCH | 46.88 | 23749301 | |
| 350 | Phosphorylation | LRSQQQKSQPDTSLQ HHHHHHHCCCCCCHH | 42.48 | 21440633 | |
| 355 | Phosphorylation | QKSQPDTSLQEQKYV HHCCCCCCHHHHHCC | 35.12 | 23749301 | |
| 360 | Ubiquitination | DTSLQEQKYVPASQK CCCHHHHHCCCHHHH | 47.68 | 23749301 | |
| 360 | Acetylation | DTSLQEQKYVPASQK CCCHHHHHCCCHHHH | 47.68 | 24489116 | |
| 375 | Phosphorylation | KVAAEQPSTLNAESI HHHCCCCCCCCHHHH | 45.26 | 20377248 | |
| 376 | Phosphorylation | VAAEQPSTLNAESIK HHCCCCCCCCHHHHC | 30.62 | 22890988 | |
| 381 | Phosphorylation | PSTLNAESIKGEDSG CCCCCHHHHCCCCCC | 27.47 | 22369663 | |
| 383 | Ubiquitination | TLNAESIKGEDSGSA CCCHHHHCCCCCCCC | 66.58 | 23749301 | |
| 387 | Phosphorylation | ESIKGEDSGSADVQS HHHCCCCCCCCCCCC | 30.28 | 22369663 | |
| 389 | Phosphorylation | IKGEDSGSADVQSVQ HCCCCCCCCCCCCCC | 25.83 | 22369663 | |
| 394 | Phosphorylation | SGSADVQSVQDHESV CCCCCCCCCCCCCCE | 22.92 | 22369663 | |
| 400 | Phosphorylation | QSVQDHESVKIVKTE CCCCCCCCEEEEECC | 25.87 | 22369663 | |
| 405 | Ubiquitination | HESVKIVKTEPSEAE CCCEEEEECCCCCCE | 51.12 | 23749301 | |
| 406 | Phosphorylation | ESVKIVKTEPSEAET CCEEEEECCCCCCEE | 42.08 | 22369663 | |
| 409 | Phosphorylation | KIVKTEPSEAETTTV EEEECCCCCCEEEEE | 43.11 | 22369663 | |
| 413 | Phosphorylation | TEPSEAETTTVNTES CCCCCCEEEEECHHH | 34.51 | 22369663 | |
| 414 | Phosphorylation | EPSEAETTTVNTESL CCCCCEEEEECHHHH | 21.91 | 22369663 | |
| 415 | Phosphorylation | PSEAETTTVNTESLG CCCCEEEEECHHHHH | 21.12 | 22369663 | |
| 418 | Phosphorylation | AETTTVNTESLGQAE CEEEEECHHHHHCHH | 23.71 | 22369663 | |
| 420 | Phosphorylation | TTTVNTESLGQAEHE EEEECHHHHHCHHHH | 35.44 | 22369663 | |
| 436 | Ubiquitination | KADNVDIKQESERKE CCCCCCCCHHHHCCC | 43.48 | 23749301 | |
| 453 | Ubiquitination | KQPKVEEKEHVENEH CCCCHHHHHHHHCHH | 39.35 | 22106047 | |
| 488 | Phosphorylation | KEENEIRSDDAKVEE HHHHCCCCCHHHHHH | 45.57 | 28889911 | |
| 492 | Ubiquitination | EIRSDDAKVEEAREE CCCCCHHHHHHHHHH | 58.11 | 24961812 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SMI1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SMI1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SMI1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-198; SER-200; SER-202;SER-203; SER-381; SER-389; SER-394; SER-400 AND SER-420, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203; SER-389; SER-394;SER-400; SER-409 AND SER-420, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200; SER-201 ANDSER-203, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202; SER-203; SER-381;SER-394 AND SER-400, AND MASS SPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200 AND SER-203, ANDMASS SPECTROMETRY. | |
