| UniProt ID | NDC80_YEAST | |
|---|---|---|
| UniProt AC | P40460 | |
| Protein Name | Kinetochore protein NDC80 {ECO:0000303|PubMed:11179222} | |
| Gene Name | NDC80 {ECO:0000303|PubMed:9585415} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 691 | |
| Subcellular Localization | Nucleus. Chromosome, centromere, kinetochore. Associated with kinetochores. | |
| Protein Description | Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.. | |
| Protein Sequence | MQSSTSTDQHVLHHMDPHRFTSQIPTATSSQLRRRNSTNQGLTDMINKSIARNTISGTGIPTGGINKNKRTRSTVAGGTNGTALALNDKSNSRNSVSRLSINQLGSLQQHLSNRDPRPLRDKNFQSAIQEEIYDYLKKNKFDIETNHPISIKFLKQPTQKGFIIIFKWLYLRLDPGYGFTKSIENEIYQILKNLRYPFLESINKSQISAVGGSNWHKFLGMLHWMVRTNIKLDMCLNKVDRSLINQNTQEITILSQPLKTLDEQDQRQERYELMVEKLLIDYFTESYKSFLKLEDNYEPSMQELKLGFEKFVHIINTDIANLQTQNDNLYEKYQEVMKISQKIKTTREKWKALKSDSNKYENYVNAMKQKSQEWPGKLEKMKSECELKEEEIKALQSNISELHKILRKKGISTEQFELQNQEREKLTRELDKINIQSDKLTSSIKSRKLEAEGIFKSLLDTLRQYDSSIQNLTRSRSQLGHNVNDSSLKINISENLLDRDFHEGISYEQLFPKGSGINESIKKSILKLNDEIQERIKTIEKDNITLEKDIKNLKHDINEKTQINEKLELELSEANSKFELSKQENERLLVAQRIEIEKMEKKINDSNLLMKTKISDAEELVTSTELKLEELKVDLNRKRYKLHQQVIHVIDITSKFKINIQSSLENSENELGNVIEELRNLEFETEHNVTN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MQSSTSTDQH -----CCCCCCCCHH | 33.99 | 28132839 | |
| 4 | Phosphorylation | ----MQSSTSTDQHV ----CCCCCCCCHHH | 14.97 | 19300438 | |
| 5 | Phosphorylation | ---MQSSTSTDQHVL ---CCCCCCCCHHHH | 40.67 | 19300438 | |
| 6 | Phosphorylation | --MQSSTSTDQHVLH --CCCCCCCCHHHHH | 31.75 | 19300438 | |
| 7 | Phosphorylation | -MQSSTSTDQHVLHH -CCCCCCCCHHHHHH | 39.50 | 28132839 | |
| 21 | Phosphorylation | HMDPHRFTSQIPTAT HCCCCCCCCCCCCCC | 21.48 | 19300438 | |
| 22 | Phosphorylation | MDPHRFTSQIPTATS CCCCCCCCCCCCCCH | 24.33 | 19300438 | |
| 37 | Phosphorylation | SQLRRRNSTNQGLTD HHHHHHCCCCCCHHH | 27.24 | 21082442 | |
| 38 | Phosphorylation | QLRRRNSTNQGLTDM HHHHHCCCCCCHHHH | 34.80 | 19300438 | |
| 43 | Phosphorylation | NSTNQGLTDMINKSI CCCCCCHHHHHHHHH | 30.28 | 19300438 | |
| 49 | Phosphorylation | LTDMINKSIARNTIS HHHHHHHHHHHCCCC | 19.59 | 21440633 | |
| 54 | Phosphorylation | NKSIARNTISGTGIP HHHHHHCCCCCCCCC | 15.80 | 21440633 | |
| 56 | Phosphorylation | SIARNTISGTGIPTG HHHHCCCCCCCCCCC | 28.41 | 21440633 | |
| 62 | Phosphorylation | ISGTGIPTGGINKNK CCCCCCCCCCCCCCC | 46.23 | 27017623 | |
| 71 | Phosphorylation | GINKNKRTRSTVAGG CCCCCCCCCCCCCCC | 30.49 | 21440633 | |
| 73 | Phosphorylation | NKNKRTRSTVAGGTN CCCCCCCCCCCCCCC | 26.98 | 28889911 | |
| 79 | Phosphorylation | RSTVAGGTNGTALAL CCCCCCCCCCCEEEE | 29.56 | 23749301 | |
| 95 | Phosphorylation | DKSNSRNSVSRLSIN CCCCCCCCCCCCCHH | 21.99 | 28889911 | |
| 100 | Phosphorylation | RNSVSRLSINQLGSL CCCCCCCCHHHHHHH | 20.55 | 19300438 | |
| 137 | Ubiquitination | EEIYDYLKKNKFDIE HHHHHHHHHCCCCCC | 48.33 | 15699485 | |
| 138 | Ubiquitination | EIYDYLKKNKFDIET HHHHHHHHCCCCCCC | 63.88 | 15699485 | |
| 205 | Phosphorylation | FLESINKSQISAVGG HHHCCCHHHCCCCCC | 28.40 | 19300438 | |
| 231 | Sumoylation | WMVRTNIKLDMCLNK HHHHCCCCHHHHCCC | 40.27 | - | |
| 248 | Phosphorylation | RSLINQNTQEITILS HHHHCCCCCEEEEEC | 20.15 | 19300438 | |
| 252 | Phosphorylation | NQNTQEITILSQPLK CCCCCEEEEECCCCC | 18.34 | 19300438 | |
| 345 | Phosphorylation | KISQKIKTTREKWKA HHHHHHHHHHHHHHH | 34.26 | 21126336 | |
| 360 | Phosphorylation | LKSDSNKYENYVNAM HHCCCHHHHHHHHHH | 17.41 | 28889911 | |
| 371 | Phosphorylation | VNAMKQKSQEWPGKL HHHHHHHCCCCCCHH | 30.73 | 28889911 | |
| 443 | Phosphorylation | QSDKLTSSIKSRKLE CHHHCHHHHHHCHHH | 28.88 | 27017623 | |
| 468 | Phosphorylation | TLRQYDSSIQNLTRS HHHHHHHHHHHHHHH | 25.87 | 27017623 | |
| 477 | Phosphorylation | QNLTRSRSQLGHNVN HHHHHHHHHHCCCCC | 30.88 | 30377154 | |
| 486 | Phosphorylation | LGHNVNDSSLKINIS HCCCCCCCCCEEECC | 32.16 | 23749301 | |
| 487 | Phosphorylation | GHNVNDSSLKINISE CCCCCCCCCEEECCC | 36.22 | 23749301 | |
| 541 | Acetylation | ERIKTIEKDNITLEK HHHHHHHHCCCCCHH | 52.83 | 24489116 | |
| 606 | Phosphorylation | MEKKINDSNLLMKTK HHHHHCCCCCCEEEC | 25.53 | 21440633 | |
| 612 | Phosphorylation | DSNLLMKTKISDAEE CCCCCEEECCCCHHH | 21.46 | 28889911 | |
| 690 | Phosphorylation | FETEHNVTN------ CCCCCCCCC------ | 40.29 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 100 | S | Phosphorylation | Kinase | IPL1 | P38991 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NDC80_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NDC80_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-248, AND MASSSPECTROMETRY. | |
