| UniProt ID | CDC73_YEAST | |
|---|---|---|
| UniProt AC | Q06697 | |
| Protein Name | Cell division control protein 73 | |
| Gene Name | CDC73 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 393 | |
| Subcellular Localization | Nucleus, nucleoplasm . | |
| Protein Description | The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of NRD1 and NAB3 with RNA polymerase II. Also has a role in transcription-coupled histone modification. Required for activation of RAD6 ubiquitin conjugate and the BRE1 ubiquitin ligase which ubiquitinate 'Lys-126' histone H2B. Activates the SET1 histone methyltransferase complex for methylation of 'Lys-4' of histone H3 and for methylation of 'Lys-73' of histone H3 by DOT1 and 'Lys-36' of histone H3 by SET2.. | |
| Protein Sequence | MANSLDRLREHLKNGDKLVLKNNEGQSTDDITKATMVETLSSDGSTQDSFPLNEETEIEIDGSLVQLRIIVHCWMNKDSSAADYLADCQNKQLTNVSFLQRTDLINWLSGNTESSQYLKAPGQKGETSDKVDIENKTLAGELSTVKSTTSASLENDSEVSDPVVVETMKHERILVDHNSALRGAKPINFGYLIKDAELKLVQSIKGSLRGSKLPPGHKGAHGRISKTNGSSGGPRKDPIILIPSAASSILTVANIKQFLLESKYVNPRNLPSVPNGLVNIEKNFERISRPIRFIIVDNTRMFTKPEYWDRVVAIFTTGHTWQFNNYQWNSPQELFQRCKGYYFHFAGDSVPQHVQQWNVEKVELDKNKRFKDVEVVRYFWHSLEKELISRGYR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 109 | Phosphorylation | TDLINWLSGNTESSQ HHHHHHHCCCCCCCC | 22.93 | 30377154 | |
| 112 | Phosphorylation | INWLSGNTESSQYLK HHHHCCCCCCCCCCC | 40.55 | 30377154 | |
| 114 | Phosphorylation | WLSGNTESSQYLKAP HHCCCCCCCCCCCCC | 22.24 | 28889911 | |
| 115 | Phosphorylation | LSGNTESSQYLKAPG HCCCCCCCCCCCCCC | 19.33 | 20190278 | |
| 127 | Phosphorylation | APGQKGETSDKVDIE CCCCCCCCCCCEECC | 51.39 | 27717283 | |
| 128 | Phosphorylation | PGQKGETSDKVDIEN CCCCCCCCCCEECCC | 31.00 | 23749301 | |
| 143 | Phosphorylation | KTLAGELSTVKSTTS CEECEEHHCCEECCC | 27.18 | 28889911 | |
| 144 | Phosphorylation | TLAGELSTVKSTTSA EECEEHHCCEECCCC | 44.57 | 30377154 | |
| 147 | Phosphorylation | GELSTVKSTTSASLE EEHHCCEECCCCCCC | 32.36 | 30377154 | |
| 149 | Phosphorylation | LSTVKSTTSASLEND HHCCEECCCCCCCCC | 29.41 | 28889911 | |
| 150 | Phosphorylation | STVKSTTSASLENDS HCCEECCCCCCCCCC | 18.89 | 28889911 | |
| 152 | Phosphorylation | VKSTTSASLENDSEV CEECCCCCCCCCCCC | 35.66 | 30377154 | |
| 157 | Phosphorylation | SASLENDSEVSDPVV CCCCCCCCCCCCCEE | 52.02 | 21551504 | |
| 169 | Acetylation | PVVVETMKHERILVD CEEEEECCCCEEEEC | 50.13 | 24489116 | |
| 191 | Phosphorylation | AKPINFGYLIKDAEL CCCCCCEEEECHHHH | 10.91 | 28889911 | |
| 194 | Acetylation | INFGYLIKDAELKLV CCCEEEECHHHHHHH | 48.57 | 24489116 | |
| 199 | Acetylation | LIKDAELKLVQSIKG EECHHHHHHHHHHHH | 37.81 | 24489116 | |
| 203 | Phosphorylation | AELKLVQSIKGSLRG HHHHHHHHHHHHCCC | 20.84 | 19795423 | |
| 226 | Acetylation | GAHGRISKTNGSSGG CCCCCCCCCCCCCCC | 43.57 | 25381059 | |
| 282 | Acetylation | NGLVNIEKNFERISR CCCCCHHHHHHHHCC | 64.24 | 24489116 | |
| 304 | Acetylation | DNTRMFTKPEYWDRV CCCCCCCCHHHHHHE | 25.29 | 24489116 | |
| 385 | Acetylation | YFWHSLEKELISRGY HHHHHHHHHHHHCCC | 64.21 | 24489116 | |
| 385 | Ubiquitination | YFWHSLEKELISRGY HHHHHHHHHHHHCCC | 64.21 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDC73_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC73_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC73_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-143; THR-149;SER-150 AND TYR-191, AND MASS SPECTROMETRY. | |
