SF3B1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SF3B1_YEAST
• UniProt AC: P49955
• Protein Name: U2 snRNP component HSH155
• Gene Name: HSH155
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 971
• Subcellular Localization: Nucleus.
• Protein Description: Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly..
• Protein Sequence: MSHPIQFVNANNSDKSHQLGGQYSIPQDLRENLQKEAARIGENEKDVLQEKMETRTVQNREDSYHKRRFDMKFEPDSDTQTVTSSENTQDAVVPRKRKSRWDVKGYEPPDESSTAVKENSDSALVNVEGIHDLMFFKPSDHKYFADVISKKPIDELNKDEKKERTLSMLLLKIKNGNTASRRTSMRILTDKAVTFGPEMIFNRLLPILLDRSLEDQERHLMIKTIDRVLYQLGDLTKPYVHKILVVAAPLLIDEDPMVRSTGQEIITNLSTVAGLKTILTVMRPDIENEDEYVRNVTSRAAAVVAKALGVNQLLPFINAACHSRKSWKARHTGIKIVQQIGILLGIGVLNHLTGLMSCIKDCLMDDHVPVRIVTAHTLSTLAENSYPYGIEVFNVVLEPLWKGIRSHRGKVLSSFLKAVGSMIPLMDPEYAGYYTTEAMRIIRREFDSPDDEMKKTILLVLQKCSAVESITPKFLREEIAPEFFQKFWVRRVALDRPLNKVVTYTTVTLAKKLGCSYTIDKLLTPLRDEAEPFRTMAVHAVTRTVNLLGTADLDERLETRLIDALLIAFQEQTNSDSIIFKGFGAVTVSLDIRMKPFLAPIVSTILNHLKHKTPLVRQHAADLCAILIPVIKNCHEFEMLNKLNIILYESLGEVYPEVLGSIINAMYCITSVMDLDKLQPPINQILPTLTPILRNKHRKVEVNTIKFVGLIGKLAPTYAPPKEWMRICFELLELLKSTNKEIRRSANATFGFIAEAIGPHDVLVALLNNLKVQERQLRVCTAVAIGIVAKVCGPYNVLPVIMNEYTTPETNVQNGVLKAMSFMFEYIGNMSKDYIYFITPLLEDALTDRDLVHRQTASNVITHLALNCSGTGHEDAFIHLMNLLIPNIFETSPHAIMRILEGLEALSQALGPGLFMNYIWAGLFHPAKNVRKAFWRVYNNMYVMYQDAMVPFYPVTPDNNEEYIEELDLVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Phosphorylation	DMKFEPDSDTQTVTS CCCCCCCCCCCEEEC	53.96	28889911
79	Phosphorylation	KFEPDSDTQTVTSSE CCCCCCCCCEEECCC	30.05	29734811
81	Phosphorylation	EPDSDTQTVTSSENT CCCCCCCEEECCCCC	28.04	30377154
83	Phosphorylation	DSDTQTVTSSENTQD CCCCCEEECCCCCCC	29.89	23749301
88	Phosphorylation	TVTSSENTQDAVVPR EEECCCCCCCCCCCC	24.63	28889911
224	Phosphorylation	ERHLMIKTIDRVLYQ HHHHHHHHHHHHHHH	19.72	19779198
503	Phosphorylation	RPLNKVVTYTTVTLA CCCCCEEEEHHHHHH	20.38	28889911
504	Phosphorylation	PLNKVVTYTTVTLAK CCCCEEEEHHHHHHH	6.71	28889911
506	Phosphorylation	NKVVTYTTVTLAKKL CCEEEEHHHHHHHHH	10.90	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SF3B1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SF3B1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SF3B1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RSE1_YEAST	RSE1	physical	11805826
RSE1_YEAST	RSE1	physical	16554755
RU2A_YEAST	LEA1	physical	16554755
RSE1_YEAST	RSE1	physical	16429126
SSB1_YEAST	SSB1	physical	19536198
PRP5_YEAST	PRP5	physical	28087715
PUF60_HUMAN	PUF60	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-88, AND MASSSPECTROMETRY.
PubMed: 18407956