RSE1_YEAST - dbPTM
RSE1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RSE1_YEAST
UniProt AC Q04693
Protein Name Pre-mRNA-splicing factor RSE1
Gene Name RSE1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1361
Subcellular Localization Nucleus.
Protein Description Involved in G2/M transition (By similarity). Required for pre-mRNA splicing and endoplasmic reticulum (ER) to Golgi secretion pathway. U2 snRNPs associated protein required for the pre-spliceosome assembly. The involvement in ER to Golgi secretion is probably indirect and due to the splicing of the pre-mRNA coding for SAR1, a small GTP-binding protein required for COPII vesicle formation from the ER..
Protein Sequence MWGGGKMAVVSLSPHTAKMRKLFGQASTTMAYDGLKREAERRTRSDHNITMVAKDDELYLYHLTLKKQTNFVHSCIGHFVDLEAGSKREQSQLCVATETHLELYDTADGELKLIAKFQNLFATITSMKSLDLPHSGSRAKASNWPTFLALTSDSGNLSIVQIIMHAGALRLKTLVNQPLTRTTLRRVSPISYMEIDPNGRCIILSSVEQNKLCFLVDYAQKLRISSPLEIIRPHMVTLDMAVVDVNFNNPCFVTLEIDNAATQLSVHLIFYVLELGLNHIVKKADYLVNPSANFVLSLPDLSRYNITTSLSDNNYDADYDTLFNPFVVIGFENHILVKDMNGFFSLKVEIPKRSITNSRHKNVTIISGIVQKLKNDFFVLLQSNHGDLFKLTVSPDTNDRNRPLVQLSYFDTIQNSHQLHIFKNGYLFALSEMNNNFLFQFEKLGVEKNDFSNVLTSKDPNKSLVFEPSIKLQNLSILSQQLNLNPSIKSQIVSDSPLSIATKHFTNNKIITLTNAVNYSNLISTSLPPNATKLWLIPDPATTGDNNTLLFITFPKKTMILQIDNESMEELTPDEATRSAFKLSQDTTIHTCLMGSHSIIQVCTAELRHIVPTGKSRYSNKLTWVPPAGIRIVCATSSKTQLIISLSNYELVYFKIDVSSDSLIELTTHPELDTMPSKVAIVQDTQHADLLAIADNEGMIKIMSLKDQKEDFLTVISLQLVSEKISDMIMVRDSSIGQLNLHVGLENGVYMKFHIGDVDGSFTDIKRRFLGLKPVSLSYLREISVSLNNEEEEEEEEDDDDEKEEEEINSSGAKWMSCVVCHSSSTWVSYTWKNVWTIRQLKDQNMLSCSKFVNADVAINGVCSISSSGRLNIGRVSNFPTLDNWFHVHESSVNKQENGGGDESNEEEEDEMEEEMEMLQISTFRPRTILSFPNNPKSILFIDNHSGKKQCRISLQIDGECLKFGSSDHLYKILDDIDCVSAAIIDFTRQADHLIICAGDKRLLTYKILVNKDKLSFDIELLHQTEIISPIHAMLKFKNFLLTAMGSTIVLYGLGKKQLLRRSVTQTPVSITKIVSMHQWNYERLAVGDIHESVTLFIWDPAGNVFIPYVDDSVKRHVTVLKFLDEATVIGADRYGNAWTLRSPPECEKIMSNHDPSELSNGAIKYPLDVITLQQKLPNTYDCKFKFQLLNHFFVNDIITDFHILDSLSNSDRPGCIYMGLQGTVGCFIPLLSKGNVFMMGNIENIMAEADDTFYLDYESRKKNNNMRKEDDEEESGSVVLQGRHGIEDEIICEGSCSILGRDHQEYRSYYAPVRKVIDGDLCENFLRLSLNEQEFLAKNLKSVQVEDIIQTINEVRTNYM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationGGKMAVVSLSPHTAK
CCCEEEEEECHHHHH		19.2730377154
16PhosphorylationVVSLSPHTAKMRKLF
EEEECHHHHHHHHHH		31.2128889911
191PhosphorylationLRRVSPISYMEIDPN
CCCCCCCCEEEECCC		23.0827017623
205PhosphorylationNGRCIILSSVEQNKL
CCCEEEEEECCCCCE		23.1727017623
206PhosphorylationGRCIILSSVEQNKLC
CCEEEEEECCCCCEE		26.6527017623
494PhosphorylationSIKSQIVSDSPLSIA
HHHHHHCCCCCCEEE		33.7224961812
496PhosphorylationKSQIVSDSPLSIATK
HHHHCCCCCCEEEEE		21.8925752575
499PhosphorylationIVSDSPLSIATKHFT
HCCCCCCEEEEECCC		17.3524961812
502PhosphorylationDSPLSIATKHFTNNK
CCCCEEEEECCCCCE		24.3124961812
567PhosphorylationILQIDNESMEELTPD
EEEECCCCHHHCCCC		37.4419779198
572PhosphorylationNESMEELTPDEATRS
CCCHHHCCCCHHHHH		31.7919779198
579PhosphorylationTPDEATRSAFKLSQD
CCCHHHHHHHHHCCC		33.4319779198
750PhosphorylationVGLENGVYMKFHIGD
EEEECCEEEEEEECC		8.9328889911
1165AcetylationELSNGAIKYPLDVIT
HHCCCCCCCCCEEEE		40.0424489116
1255PhosphorylationAEADDTFYLDYESRK
HHCCCCEECCHHHHH		10.7627017623
1258PhosphorylationDDTFYLDYESRKKNN
CCCEECCHHHHHCCC		17.1427017623
1260PhosphorylationTFYLDYESRKKNNNM
CEECCHHHHHCCCCC		43.0727017623
1276PhosphorylationKEDDEEESGSVVLQG
CCCCCCCCCCEEEEC		39.3822369663
1278PhosphorylationDDEEESGSVVLQGRH
CCCCCCCCEEEECCC		20.5222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RSE1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RSE1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RSE1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SF3B1_YEASTHSH155physical
11805826
SF3B1_YEASTHSH155physical
15565172
CUS1_YEASTCUS1physical
15565172
HSH49_YEASTHSH49physical
15565172
RDS3_YEASTRDS3physical
15565172
SAR1_YEASTSAR1genetic
9819400
SF3B1_YEASTHSH155physical
16429126
HSH49_YEASTHSH49physical
16429126
ATC7_YEASTNEO1genetic
27708008
LSM2_YEASTLSM2genetic
27708008
AAR2_YEASTAAR2genetic
27708008
SEC18_YEASTSEC18genetic
27708008
SP381_YEASTSPP381genetic
27708008
PRP5_YEASTPRP5genetic
27708008
PRP9_YEASTPRP9genetic
27708008
PRP11_YEASTPRP11genetic
27708008
FAD1_YEASTFAD1genetic
27708008
LUC7_YEASTLUC7genetic
27708008
SNU23_YEASTSNU23genetic
27708008
CWC2_YEASTCWC2genetic
27708008
RPC10_YEASTRPC11genetic
27708008
PRP28_YEASTPRP28genetic
27708008
SYF1_YEASTSYF1genetic
27708008
GPI19_YEASTGPI19genetic
27708008
RSP5_YEASTRSP5genetic
27708008
COG3_YEASTCOG3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
SAD1_YEASTSAD1genetic
27708008
HSF_YEASTHSF1genetic
27708008
COPB2_YEASTSEC27genetic
27708008
DAM1_YEASTDAM1genetic
27708008
YIP1_YEASTYIP1genetic
27708008
CWC22_YEASTCWC22genetic
27708008
BET1_YEASTBET1genetic
27708008
MET30_YEASTMET30genetic
27708008
PRP21_YEASTPRP21genetic
27708008
HSP77_YEASTSSC1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
CWC16_YEASTYJU2genetic
27708008
SN114_YEASTSNU114genetic
27708008
YKT6_YEASTYKT6genetic
27708008
PRP19_YEASTPRP19genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
CFT2_YEASTCFT2genetic
27708008
BBP_YEASTMSL5genetic
27708008
CLF1_YEASTCLF1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RU1C_YEASTYHC1genetic
27708008
VTI1_YEASTVTI1genetic
27708008
CEF1_YEASTCEF1genetic
27708008
CUS1_YEASTCUS1genetic
27708008
GPI15_YEASTGPI15genetic
27708008
NOP2_YEASTNOP2genetic
27708008
PRP2_YEASTPRP2genetic
27708008
SEC12_YEASTSEC12genetic
27708008
TYSY_YEASTCDC21genetic
27708008
GPI2_YEASTGPI2genetic
27708008
SEC16_YEASTSEC16genetic
27708008
NAB3_YEASTNAB3genetic
27708008
RDS3_YEASTRDS3genetic
27708008
BUR1_YEASTSGV1genetic
27708008
SEC23_YEASTSEC23genetic
27708008
SWC3_YEASTSWC3genetic
27708008
SHE1_YEASTSHE1genetic
27708008
RU1A_YEASTMUD1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RS14A_YEASTRPS14Agenetic
27708008
BRE1_YEASTBRE1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
RV167_YEASTRVS167genetic
27708008
IOC3_YEASTIOC3genetic
27708008
MON1_YEASTMON1genetic
27708008
CWC26_YEASTBUD13genetic
27708008
ATG1_YEASTATG1genetic
27708008
RTF1_YEASTRTF1genetic
27708008
NAM8_YEASTNAM8genetic
27708008
MUD2_YEASTMUD2genetic
27708008
YK21_YEASTYKR041Wgenetic
27708008
MLP1_YEASTMLP1genetic
27708008
PML1_YEASTPML1genetic
27708008
ARP6_YEASTARP6genetic
27708008
ACE2_YEASTACE2genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
HSC82_YEASTHSC82genetic
27708008
SCS7_YEASTSCS7genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
PHO23_YEASTPHO23genetic
27708008
ADE_YEASTAAH1genetic
27708008
STI1_YEASTSTI1genetic
27708008
VAM3_YEASTVAM3genetic
27708008
SNU66_YEASTSNU66genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
RU2A_YEASTLEA1genetic
27708008
BRR1_YEASTBRR1genetic
27708008
URN1_YEASTURN1genetic
27708008
ATG13_YEASTATG13genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RSE1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496, AND MASSSPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-750, AND MASSSPECTROMETRY.

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