| UniProt ID | COG3_YEAST | |
|---|---|---|
| UniProt AC | P40094 | |
| Protein Name | Conserved oligomeric Golgi complex subunit 3 | |
| Gene Name | COG3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 801 | |
| Subcellular Localization |
Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side . |
|
| Protein Description | Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events. COG3 is also involved in actin cytoskeleton organization.. | |
| Protein Sequence | MARSRKNSLVRDIASHPTIPESQTIVGLLDDSYLFDKLKKLSLAVENSDSLQRTDVSEGCSEVNGSEATTSADVKKTNKYLYYTTYLDQLNIKIDEYKVVLDQTRQVNDQLDSSIKKFRKISQDTGAFIEETKTIYEKQSKLSNLTESIPKALHYFEVLDPIMRRLNHATSPAIVKKSSFTTMLATIDESLRFLDENSDLKDAAAYRIKFKQCLIRACELISHFLTNLLKQTNQEILDKTKNKNSLTGLPSTTRDAFLYSKFYTIADTFKIQVSEIVKRSNEKAYNKYHDELNSILYECFNHYFQTRLRLLTPVIWSHIDEIVVKDKDQGLVKFIQDGKVYFQQLCADEYKLFVEFFPEKECRFKINQWFLQLCEPLYDSIRVRVLKETDICTLCDSVTLFAPYYEFEEGSEEYVKQFTDIQYDKLFEPIVQKVQARLILRVQIYVQQNILSYRPTRDVFMISNRRRKSKTSLQGGNEDATTSDDNPDPLLESYLSSFKNRSILPISPNDADDKSIDSEESTDKISQLQTYYPPLLKTLALLSKIYEMINSVVFDDLAHHVVHDCIVSLRNAYDMVIKSSAGKSDFNNLDISLAYLKNLLMLRDSIQNFNIQYTVNETYLDFSGVEGFFKSLKENGRNVLKKTKSSSILTLARELVPKVVNNMVDARTELISELRNVIKDFTESTSLELIDDTLDINSDEDLLSKNVKLRENIKARLPRIYEQILNYIDDQEIVTNLLDAVQELITQSYSKYYETITELAENGKFAKDQVADVMYLDVFTDFFAKEVADLLRNGDIDTITK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MARSRKNSLVR ----CCCCCCCHHHH | 37.76 | 24961812 | |
| 8 | Phosphorylation | MARSRKNSLVRDIAS CCCCCCCHHHHHHHC | 31.14 | 24961812 | |
| 15 | Phosphorylation | SLVRDIASHPTIPES HHHHHHHCCCCCCHH | 30.27 | 21440633 | |
| 18 | Phosphorylation | RDIASHPTIPESQTI HHHHCCCCCCHHHCH | 43.68 | 24961812 | |
| 22 | Phosphorylation | SHPTIPESQTIVGLL CCCCCCHHHCHHCCC | 27.54 | 24961812 | |
| 42 | Phosphorylation | FDKLKKLSLAVENSD HHHHHHHCHHHCCCC | 24.14 | 21551504 | |
| 48 | Phosphorylation | LSLAVENSDSLQRTD HCHHHCCCCHHCCCC | 18.31 | 21551504 | |
| 57 | Phosphorylation | SLQRTDVSEGCSEVN HHCCCCCCCCCCCCC | 30.95 | 21551504 | |
| 66 | Phosphorylation | GCSEVNGSEATTSAD CCCCCCCCCCCCCCC | 20.89 | 21551504 | |
| 148 | Phosphorylation | KLSNLTESIPKALHY HHHCCHHHHHHHHHH | 38.67 | 27214570 | |
| 181 | Phosphorylation | IVKKSSFTTMLATID HCCCCCCHHHHHHHH | 17.16 | 30377154 | |
| 182 | Phosphorylation | VKKSSFTTMLATIDE CCCCCCHHHHHHHHH | 14.26 | 30377154 | |
| 186 | Phosphorylation | SFTTMLATIDESLRF CCHHHHHHHHHHHHH | 25.62 | 28889911 | |
| 190 | Phosphorylation | MLATIDESLRFLDEN HHHHHHHHHHHHCCC | 22.54 | 28889911 | |
| 198 | Phosphorylation | LRFLDENSDLKDAAA HHHHCCCCCHHHHHH | 42.12 | 28889911 | |
| 201 | Acetylation | LDENSDLKDAAAYRI HCCCCCHHHHHHHHH | 50.76 | 24489116 | |
| 240 | Phosphorylation | NQEILDKTKNKNSLT CHHHHHHHCCCCCCC | 39.24 | 27017623 | |
| 264 | Phosphorylation | FLYSKFYTIADTFKI HHHCCCCHHHHHCCE | 16.90 | 21126336 | |
| 360 | Ubiquitination | FVEFFPEKECRFKIN HHHHCCCCHHCHHCH | 63.45 | 19722269 | |
| 469 | Phosphorylation | ISNRRRKSKTSLQGG EECCCCCCCCCCCCC | 39.08 | 28889911 | |
| 471 | Phosphorylation | NRRRKSKTSLQGGNE CCCCCCCCCCCCCCC | 41.58 | 21440633 | |
| 502 | Phosphorylation | LSSFKNRSILPISPN HHHCCCCCCCCCCCC | 37.56 | 19779198 | |
| 507 | Phosphorylation | NRSILPISPNDADDK CCCCCCCCCCCCCCC | 18.73 | 17330950 | |
| 515 | Phosphorylation | PNDADDKSIDSEEST CCCCCCCCCCCHHHH | 38.33 | 22369663 | |
| 518 | Phosphorylation | ADDKSIDSEESTDKI CCCCCCCCHHHHHHH | 41.41 | 22369663 | |
| 521 | Phosphorylation | KSIDSEESTDKISQL CCCCCHHHHHHHHHH | 37.54 | 22369663 | |
| 522 | Phosphorylation | SIDSEESTDKISQLQ CCCCHHHHHHHHHHH | 44.59 | 22369663 | |
| 526 | Phosphorylation | EESTDKISQLQTYYP HHHHHHHHHHHHHCH | 30.49 | 27738172 | |
| 643 | Phosphorylation | GRNVLKKTKSSSILT CCCHHHHCCCHHHHH | 34.27 | 22369663 | |
| 645 | Phosphorylation | NVLKKTKSSSILTLA CHHHHCCCHHHHHHH | 34.25 | 22369663 | |
| 646 | Phosphorylation | VLKKTKSSSILTLAR HHHHCCCHHHHHHHH | 23.97 | 22369663 | |
| 647 | Phosphorylation | LKKTKSSSILTLARE HHHCCCHHHHHHHHH | 28.80 | 22369663 | |
| 650 | Phosphorylation | TKSSSILTLARELVP CCCHHHHHHHHHHHH | 19.39 | 22890988 | |
| 798 | Phosphorylation | LRNGDIDTITK---- HHCCCCCCCCC---- | 30.77 | 21440633 | |
| 800 | Phosphorylation | NGDIDTITK------ CCCCCCCCC------ | 32.56 | 24961812 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COG3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COG3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COG3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469; THR-471; SER-645AND SER-646, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507 AND SER-647, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645, AND MASSSPECTROMETRY. | |
