VHS2_YEAST - dbPTM
VHS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VHS2_YEAST
UniProt AC P40463
Protein Name Protein VHS2
Gene Name VHS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 436
Subcellular Localization Cytoplasm .
Protein Description Can suppress the synthetic lethality of the hal3 sit4 double mutation when overexpressed, suggesting that it is involved in the G1-S transition..
Protein Sequence MDTSNHNQDHDSHVAAQRENDNNYMPPSPSMSESSMIFERNVEDPSYLYKTVSNNAANSLSRQSSRTSLFNHNNSSNRNFHNLSQRSSAVNLHLQPSRTNESIASYQTYNPDFVVQTPLDHRRTLENFVPPALDAGCSIVTDDTTGLDDVDMVYSRRPSTIGLDRALGRTRSLSSQSFDNETSPAHPRSPNDHGSRLLRFYSYADMLSDDNNNNVSNATSTSSTANPLRRPPMQGHYSFSSSLLNSPSHLPSPPSASASPPQHMNFTNPFIISRRYSNTTINNANGGTSAGSTTGAALSRSPSNQQYLLKQQRSPSGSARSRRNSNRPGSAANIMIGKPKSKFHMESSGSEGFSSEEEDNTMIERDKLNLKQKLQSQLAQPPSIANMVNDNHNNTNKHKNTINNNIKNSPAFTNSNPSSKSNSNSTITSMNPDTTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MDTSNHNQDH
-----CCCCCCCCCC		30.0828889911
4Phosphorylation----MDTSNHNQDHD
----CCCCCCCCCCH		31.6528132839
12PhosphorylationNHNQDHDSHVAAQRE
CCCCCCHHHHHHHHC		19.2128889911
24PhosphorylationQRENDNNYMPPSPSM
HHCCCCCCCCCCCCC		19.7724909858
28PhosphorylationDNNYMPPSPSMSESS
CCCCCCCCCCCCHHH		24.6027738172
30PhosphorylationNYMPPSPSMSESSMI
CCCCCCCCCCHHHCE		39.0027017623
32PhosphorylationMPPSPSMSESSMIFE
CCCCCCCCHHHCEEE		38.3719684113
34PhosphorylationPSPSMSESSMIFERN
CCCCCCHHHCEEEEC		20.2128889911
35PhosphorylationSPSMSESSMIFERNV
CCCCCHHHCEEEECC		16.3128132839
49PhosphorylationVEDPSYLYKTVSNNA
CCCHHHHHHHHCCHH		9.0719779198
50UbiquitinationEDPSYLYKTVSNNAA
CCHHHHHHHHCCHHH		39.5915699485
51PhosphorylationDPSYLYKTVSNNAAN
CHHHHHHHHCCHHHH		18.6622890988
53PhosphorylationSYLYKTVSNNAANSL
HHHHHHHCCHHHHHH		29.6022369663
59PhosphorylationVSNNAANSLSRQSSR
HCCHHHHHHHCCCCC		24.0122369663
61PhosphorylationNNAANSLSRQSSRTS
CHHHHHHHCCCCCHH		28.2622369663
64PhosphorylationANSLSRQSSRTSLFN
HHHHHCCCCCHHHCC		22.2222369663
65PhosphorylationNSLSRQSSRTSLFNH
HHHHCCCCCHHHCCC		31.1022369663
67PhosphorylationLSRQSSRTSLFNHNN
HHCCCCCHHHCCCCC		31.5622369663
68PhosphorylationSRQSSRTSLFNHNNS
HCCCCCHHHCCCCCC		29.8322369663
75PhosphorylationSLFNHNNSSNRNFHN
HHCCCCCCCCCCCCC		34.0222369663
76PhosphorylationLFNHNNSSNRNFHNL
HCCCCCCCCCCCCCH		41.7622369663
84PhosphorylationNRNFHNLSQRSSAVN
CCCCCCHHHHHCCEE		28.9422369663
87PhosphorylationFHNLSQRSSAVNLHL
CCCHHHHHCCEEEEE		18.2722369663
88PhosphorylationHNLSQRSSAVNLHLQ
CCHHHHHCCEEEEEC		38.1222369663
97PhosphorylationVNLHLQPSRTNESIA
EEEEECCCCCCCCHH		38.4822369663
99PhosphorylationLHLQPSRTNESIASY
EEECCCCCCCCHHHC		47.9128889911
102PhosphorylationQPSRTNESIASYQTY
CCCCCCCCHHHCCCC		26.0623749301
105PhosphorylationRTNESIASYQTYNPD
CCCCCHHHCCCCCCC		18.9923749301
106PhosphorylationTNESIASYQTYNPDF
CCCCHHHCCCCCCCC		8.8919779198
108PhosphorylationESIASYQTYNPDFVV
CCHHHCCCCCCCCEE		19.6219779198
109PhosphorylationSIASYQTYNPDFVVQ
CHHHCCCCCCCCEEE		14.7919779198
117PhosphorylationNPDFVVQTPLDHRRT
CCCCEEECCCCCCCH		17.7627017623
124PhosphorylationTPLDHRRTLENFVPP
CCCCCCCHHHHCCCH		38.0830377154
144PhosphorylationCSIVTDDTTGLDDVD
CEEECCCCCCCCCCC		26.1021440633
145PhosphorylationSIVTDDTTGLDDVDM
EEECCCCCCCCCCCE		42.6221440633
154PhosphorylationLDDVDMVYSRRPSTI
CCCCCEEECCCCHHH		6.9921440633
155PhosphorylationDDVDMVYSRRPSTIG
CCCCEEECCCCHHHC		15.4821440633
159PhosphorylationMVYSRRPSTIGLDRA
EEECCCCHHHCHHHH		30.7422369663
160PhosphorylationVYSRRPSTIGLDRAL
EECCCCHHHCHHHHC		23.0322369663
170PhosphorylationLDRALGRTRSLSSQS
HHHHCCCCCCCCCCC		23.8622369663
172PhosphorylationRALGRTRSLSSQSFD
HHCCCCCCCCCCCCC		31.8022369663
174PhosphorylationLGRTRSLSSQSFDNE
CCCCCCCCCCCCCCC		27.8122369663
175PhosphorylationGRTRSLSSQSFDNET
CCCCCCCCCCCCCCC		34.8322369663
177PhosphorylationTRSLSSQSFDNETSP
CCCCCCCCCCCCCCC		36.1922369663
182PhosphorylationSQSFDNETSPAHPRS
CCCCCCCCCCCCCCC		46.3822369663
183PhosphorylationQSFDNETSPAHPRSP
CCCCCCCCCCCCCCC		17.5722890988
189PhosphorylationTSPAHPRSPNDHGSR
CCCCCCCCCCCHHHH		32.2928889911
195PhosphorylationRSPNDHGSRLLRFYS
CCCCCHHHHHHHHHH		19.1428889911
201PhosphorylationGSRLLRFYSYADMLS
HHHHHHHHHHHHHCC		8.3722369663
202PhosphorylationSRLLRFYSYADMLSD
HHHHHHHHHHHHCCC		15.9022369663
203PhosphorylationRLLRFYSYADMLSDD
HHHHHHHHHHHCCCC		8.6722369663
208PhosphorylationYSYADMLSDDNNNNV
HHHHHHCCCCCCCCC		35.9622369663
248PhosphorylationSSLLNSPSHLPSPPS
HHHCCCCCCCCCCCC		37.1628889911
276PhosphorylationPFIISRRYSNTTINN
CEEEEECCCCCEEEC		12.7422369663
277PhosphorylationFIISRRYSNTTINNA
EEEEECCCCCEEECC		26.3722369663
279PhosphorylationISRRYSNTTINNANG
EEECCCCCEEECCCC		24.1022369663
280PhosphorylationSRRYSNTTINNANGG
EECCCCCEEECCCCC		26.4222369663
288PhosphorylationINNANGGTSAGSTTG
EECCCCCCCCCCCCC		19.4622369663
289PhosphorylationNNANGGTSAGSTTGA
ECCCCCCCCCCCCCC		33.6322369663
292PhosphorylationNGGTSAGSTTGAALS
CCCCCCCCCCCCCCC		23.6322369663
293PhosphorylationGGTSAGSTTGAALSR
CCCCCCCCCCCCCCC		28.4722369663
294PhosphorylationGTSAGSTTGAALSRS
CCCCCCCCCCCCCCC		26.9022369663
299PhosphorylationSTTGAALSRSPSNQQ
CCCCCCCCCCCCHHH		26.4522369663
301PhosphorylationTGAALSRSPSNQQYL
CCCCCCCCCCHHHHH		29.3322369663
303PhosphorylationAALSRSPSNQQYLLK
CCCCCCCCHHHHHHH		48.8222369663
307PhosphorylationRSPSNQQYLLKQQRS
CCCCHHHHHHHHCCC		12.3022890988
310UbiquitinationSNQQYLLKQQRSPSG
CHHHHHHHHCCCCCC		41.6123749301
325PhosphorylationSARSRRNSNRPGSAA
CCCCCCCCCCCCCCC		32.1922369663
330PhosphorylationRNSNRPGSAANIMIG
CCCCCCCCCCHHEEC		27.2222369663
338UbiquitinationAANIMIGKPKSKFHM
CCHHEECCCCCCEEE		38.0415699485
340UbiquitinationNIMIGKPKSKFHMES
HHEECCCCCCEEECC		70.5315699485
341PhosphorylationIMIGKPKSKFHMESS
HEECCCCCCEEECCC		49.4324961812
347PhosphorylationKSKFHMESSGSEGFS
CCCEEECCCCCCCCC		32.2122369663
348PhosphorylationSKFHMESSGSEGFSS
CCEEECCCCCCCCCC		32.7922369663
350PhosphorylationFHMESSGSEGFSSEE
EEECCCCCCCCCCHH		36.1722369663
354PhosphorylationSSGSEGFSSEEEDNT
CCCCCCCCCHHHHCC		47.9322369663
355PhosphorylationSGSEGFSSEEEDNTM
CCCCCCCCHHHHCCH		46.9322369663
361PhosphorylationSSEEEDNTMIERDKL
CCHHHHCCHHHHHHC		31.6722369663
383PhosphorylationSQLAQPPSIANMVND
HHHCCCCHHHHHHCC		40.8023749301
397UbiquitinationDNHNNTNKHKNTINN
CCCCCCCCCCCHHCC		54.6515699485
399UbiquitinationHNNTNKHKNTINNNI
CCCCCCCCCHHCCCC		58.3515699485
407UbiquitinationNTINNNIKNSPAFTN
CHHCCCCCCCCCCCC		54.2015699485
409PhosphorylationINNNIKNSPAFTNSN
HCCCCCCCCCCCCCC		16.7728152593
413PhosphorylationIKNSPAFTNSNPSSK
CCCCCCCCCCCCCCC		39.5822369663
415PhosphorylationNSPAFTNSNPSSKSN
CCCCCCCCCCCCCCC		47.2422369663
418PhosphorylationAFTNSNPSSKSNSNS
CCCCCCCCCCCCCCC		55.4322369663
419PhosphorylationFTNSNPSSKSNSNST
CCCCCCCCCCCCCCC		41.1622369663
420UbiquitinationTNSNPSSKSNSNSTI
CCCCCCCCCCCCCCC		58.9815699485
421PhosphorylationNSNPSSKSNSNSTIT
CCCCCCCCCCCCCCE		47.6522369663
423PhosphorylationNPSSKSNSNSTITSM
CCCCCCCCCCCCEEC		38.9722369663
425PhosphorylationSSKSNSNSTITSMNP
CCCCCCCCCCEECCC		22.4722369663
426PhosphorylationSKSNSNSTITSMNPD
CCCCCCCCCEECCCC		32.3122369663
428PhosphorylationSNSNSTITSMNPDTT
CCCCCCCEECCCCCC		23.2419795423
429PhosphorylationNSNSTITSMNPDTTK
CCCCCCEECCCCCCC		16.8322369663
434PhosphorylationITSMNPDTTK-----
CEECCCCCCC-----		37.4322369663
435PhosphorylationTSMNPDTTK------
EECCCCCCC------		41.9822369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VHS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VHS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VHS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WHI2_YEASTWHI2physical
16554755
MLF3_YEASTMLF3genetic
16816427
CAB3_YEASTCAB3physical
18467557
PPZ1_YEASTPPZ1physical
18467557
GIC2_YEASTGIC2genetic
16816427
PCL2_YEASTPCL2genetic
16816427
CG11_YEASTCLN1genetic
16816427
CG12_YEASTCLN2genetic
16816427
PCL1_YEASTPCL1genetic
16816427
GIC1_YEASTGIC1genetic
16816427
CDC3_YEASTCDC3genetic
24646733
CDC12_YEASTCDC12genetic
24646733
SHS1_YEASTSHS1genetic
24646733
2A5D_YEASTRTS1genetic
24646733
CND2_YEASTBRN1genetic
27708008
CDS1_YEASTCDS1genetic
27708008
FAD1_YEASTFAD1genetic
27708008
DPOD_YEASTPOL3genetic
27708008
CDC13_YEASTCDC13genetic
27708008
COG3_YEASTCOG3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
RPN12_YEASTRPN12genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
IF2A_YEASTSUI2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
PRS7_YEASTRPT1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
POB3_YEASTPOB3genetic
27708008
CLP1_YEASTCLP1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
NSL1_YEASTNSL1genetic
27708008
ARO1_YEASTARO1genetic
27708008
YL287_YEASTYLR287Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VHS2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-53; SER-59;SER-87; SER-88; SER-159; THR-160; THR-170; SER-172; SER-174; SER-177;SER-301; SER-303; THR-413; SER-418 AND SER-421, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84; SER-87; SER-88;SER-159; SER-172; SER-175; SER-177; SER-277 AND THR-279, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303 AND SER-325, ANDMASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61, AND MASSSPECTROMETRY.

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