GIC2_YEAST - dbPTM
GIC2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GIC2_YEAST
UniProt AC Q06648
Protein Name GTPase-interacting component 2
Gene Name GIC2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 383
Subcellular Localization Bud neck. Bud tip. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Protein Description Required for cell size and shape control, bud site selection, bud emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, and mating projection formation in response to mating pheromone..
Protein Sequence MTSASITNTGNETMNLPQMRSIWLDEDEEAEKLYGLQAQQFMGSDDEENLGITFINSDKPVLSNKKNIELPPLSPNSHPSCHHRRSNSNSAKSKESSSSSSSANKTNHKKVFLKLNLLKKKLLGAQPDIRGKGISTPFDFQHISHADTRNGFQDEQLQEPSSLSTEIKDDYTSSSSKRDSKSLNKAFVTERIPANRESKLISRSHENKTSRLSVARSISVTSSNYSKNTQGNNHSINGRVVSTSTMATSIFEYSPNASPKQFKNKSHALGHRYTNSTDSSESSLDFLKNYNFPTLLEDKPILDFLPRSQRSSAYRSLLETPNSNKDSAKAFFPSRQSPLPKRRNSIATPSPQSKFSYSDSPVNHRKSFDDVLYSFNQLEPLQT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTSASITNT
------CCCCCEECC		32.7627017623
3Phosphorylation-----MTSASITNTG
-----CCCCCEECCC		20.7930377154
5Phosphorylation---MTSASITNTGNE
---CCCCCEECCCCC		29.7030377154
44PhosphorylationQAQQFMGSDDEENLG
HHHHHCCCCCCCCCE		30.0520377248
74PhosphorylationNIELPPLSPNSHPSC
CCCCCCCCCCCCCCC		28.0121082442
99PhosphorylationKSKESSSSSSSANKT
CCCCCCCCCCCCCCC		35.8717563356
132UbiquitinationAQPDIRGKGISTPFD
CCCCCCCCCCCCCCC		43.1317644757
168UbiquitinationSSLSTEIKDDYTSSS
CCCCCCCCCCCCCCC		38.0117644757
171PhosphorylationSTEIKDDYTSSSSKR
CCCCCCCCCCCCCCC		20.7528889911
176PhosphorylationDDYTSSSSKRDSKSL
CCCCCCCCCCCCCHH		33.3928889911
177UbiquitinationDYTSSSSKRDSKSLN
CCCCCCCCCCCCHHH		63.2717644757
180PhosphorylationSSSSKRDSKSLNKAF
CCCCCCCCCHHHHHH		28.3327017623
198PhosphorylationRIPANRESKLISRSH
CCCCCHHHHCCCCCC		29.5328889911
202PhosphorylationNRESKLISRSHENKT
CHHHHCCCCCCCCCC		37.8630377154
217PhosphorylationSRLSVARSISVTSSN
CCCEEEEEEEEECCC		14.9622369663
219PhosphorylationLSVARSISVTSSNYS
CEEEEEEEEECCCCC		22.1622369663
221PhosphorylationVARSISVTSSNYSKN
EEEEEEEECCCCCCC		21.4622369663
222PhosphorylationARSISVTSSNYSKNT
EEEEEEECCCCCCCC		17.9022369663
223PhosphorylationRSISVTSSNYSKNTQ
EEEEEECCCCCCCCC		30.3522369663
225PhosphorylationISVTSSNYSKNTQGN
EEEECCCCCCCCCCC		23.9922369663
226PhosphorylationSVTSSNYSKNTQGNN
EEECCCCCCCCCCCC		24.5522369663
235PhosphorylationNTQGNNHSINGRVVS
CCCCCCCCCCCEEEE		21.6328889911
254PhosphorylationATSIFEYSPNASPKQ
CCHHHHCCCCCCHHH		12.4117330950
258PhosphorylationFEYSPNASPKQFKNK
HHCCCCCCHHHHCCH		38.9917330950
273PhosphorylationSHALGHRYTNSTDSS
HHHCCCCCCCCCCCC		12.4722890988
274PhosphorylationHALGHRYTNSTDSSE
HHCCCCCCCCCCCCH		23.7322890988
276PhosphorylationLGHRYTNSTDSSESS
CCCCCCCCCCCCHHH		26.2822890988
277PhosphorylationGHRYTNSTDSSESSL
CCCCCCCCCCCHHHH		41.8022890988
279PhosphorylationRYTNSTDSSESSLDF
CCCCCCCCCHHHHHH		35.7722890988
280PhosphorylationYTNSTDSSESSLDFL
CCCCCCCCHHHHHHH		44.2922890988
282PhosphorylationNSTDSSESSLDFLKN
CCCCCCHHHHHHHHH		37.8422890988
283PhosphorylationSTDSSESSLDFLKNY
CCCCCHHHHHHHHHC		28.1022890988
288UbiquitinationESSLDFLKNYNFPTL
HHHHHHHHHCCCCCH		58.3317644757
299UbiquitinationFPTLLEDKPILDFLP
CCCHHCCCCHHHHCC		25.2817644757
316PhosphorylationQRSSAYRSLLETPNS
HCHHHHHHHHHCCCC		25.3228132839
320PhosphorylationAYRSLLETPNSNKDS
HHHHHHHCCCCCHHH		27.9522369663
323PhosphorylationSLLETPNSNKDSAKA
HHHHCCCCCHHHHHH		46.6022369663
334PhosphorylationSAKAFFPSRQSPLPK
HHHHHCCCCCCCCCC		37.4828152593
337PhosphorylationAFFPSRQSPLPKRRN
HHCCCCCCCCCCCCC		27.5621082442
345PhosphorylationPLPKRRNSIATPSPQ
CCCCCCCCCCCCCCC		16.2819823750
348PhosphorylationKRRNSIATPSPQSKF
CCCCCCCCCCCCCCC		23.7219795423
350PhosphorylationRNSIATPSPQSKFSY
CCCCCCCCCCCCCCC		31.0819795423
353PhosphorylationIATPSPQSKFSYSDS
CCCCCCCCCCCCCCC		38.7721440633
356PhosphorylationPSPQSKFSYSDSPVN
CCCCCCCCCCCCCCC		27.7128132839
357PhosphorylationSPQSKFSYSDSPVNH
CCCCCCCCCCCCCCC		21.4528132839
358PhosphorylationPQSKFSYSDSPVNHR
CCCCCCCCCCCCCCC		30.3419823750
360PhosphorylationSKFSYSDSPVNHRKS
CCCCCCCCCCCCCCC		25.4720377248
366UbiquitinationDSPVNHRKSFDDVLY
CCCCCCCCCHHHHHH		48.1817644757
367PhosphorylationSPVNHRKSFDDVLYS
CCCCCCCCHHHHHHH		33.5922369663
373PhosphorylationKSFDDVLYSFNQLEP
CCHHHHHHHHHHCCC		15.8622890988
374PhosphorylationSFDDVLYSFNQLEPL
CHHHHHHHHHHCCCC		17.3522890988
383PhosphorylationNQLEPLQT-------
HHCCCCCC-------		48.5422890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseGRR1P24814
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GIC2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GIC2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC24_YEASTCDC24physical
9822386
CDC42_YEASTCDC42physical
9367979
CAPZA_YEASTCAP1physical
11489916
GIC1_YEASTGIC1physical
11489916
CDC12_YEASTCDC12physical
11489916
CLA4_YEASTCLA4physical
11489916
STE50_YEASTSTE50physical
11489916
CSM1_YEASTCSM1physical
11489916
RRP14_YEASTRRP14physical
11489916
ZDS1_YEASTZDS1physical
11489916
ZDS2_YEASTZDS2physical
11489916
CDC42_YEASTCDC42genetic
9367980
CDC5_YEASTCDC5genetic
14734533
BNI1_YEASTBNI1genetic
10938101
BUD6_YEASTBUD6genetic
10938101
SPA2_YEASTSPA2genetic
10938101
CDC11_YEASTCDC11physical
16371506
CDC12_YEASTCDC12physical
16371506
MLF3_YEASTMLF3genetic
16816427
VHS2_YEASTVHS2genetic
16816427
SSD1_YEASTSSD1genetic
9367979
CDC42_YEASTCDC42genetic
9367979
CLA4_YEASTCLA4genetic
9367979
CDC24_YEASTCDC24genetic
9367979
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
ECM33_YEASTECM33genetic
20093466
BEM1_YEASTBEM1genetic
20093466
ASK10_YEASTASK10genetic
20093466
YIT6_YEASTYIR016Wgenetic
20093466
COX12_YEASTCOX12genetic
20093466
SWI6_YEASTSWI6genetic
20093466
ATP10_YEASTATP10genetic
20093466
ECM7_YEASTECM7genetic
20093466
BEM4_YEASTBEM4genetic
20093466
RSR1_YEASTRSR1genetic
12622721
BUD2_YEASTBUD2genetic
12622721
BUD5_YEASTBUD5genetic
12622721
RSR1_YEASTRSR1genetic
16816427
AXL2_YEASTAXL2genetic
16816427
BNI1_YEASTBNI1genetic
16816427
STE20_YEASTSTE20genetic
16816427
CG12_YEASTCLN2genetic
16816427
CYC8_YEASTCYC8genetic
16816427
TUP1_YEASTTUP1genetic
16816427
SKG6_YEASTSKG6genetic
16816427
TOS2_YEASTTOS2genetic
16816427
MSB2_YEASTMSB2genetic
16816427
MSB1_YEASTMSB1genetic
16816427
RSR1_YEASTRSR1genetic
20587777
GYP3_YEASTMSB3genetic
10679030
MSB4_YEASTMSB4genetic
10679030
UBA4_YEASTUBA4physical
9736614
YCY0_YEASTYCR090Cgenetic
27708008
ASK10_YEASTASK10genetic
27708008
SWI6_YEASTSWI6genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
CHK1_YEASTCHK1genetic
27708008
AGP1_YEASTAGP1genetic
27708008
RV161_YEASTRVS161genetic
27708008
NHP10_YEASTNHP10genetic
27708008
MTU1_YEASTSLM3genetic
27708008
PEX19_YEASTPEX19genetic
27708008
BRE1_YEASTBRE1genetic
27708008
FCY2_YEASTFCY2genetic
27708008
AIM11_YEASTAIM11genetic
27708008
UBP3_YEASTUBP3genetic
27708008
PT122_YEASTPET122genetic
27708008
YFF1_YEASTYFL051Cgenetic
27708008
YGY5_YEASTYGL235Wgenetic
27708008
MTO1_YEASTMTO1genetic
27708008
FLX1_YEASTFLX1genetic
27708008
YJ24_YEASTKCH1genetic
27708008
HAP4_YEASTHAP4genetic
27708008
COA4_YEASTCOA4genetic
27708008
ATP10_YEASTATP10genetic
27708008
MDM12_YEASTMDM12genetic
27708008
YO087_YEASTDUF1genetic
27708008
RTC1_YEASTRTC1genetic
27708008
YO08A_YEASTYOR008C-Agenetic
27708008
CYC2_YEASTCYC2genetic
27708008
WHI2_YEASTWHI2genetic
27708008
CY1_YEASTCYT1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
MNE1_YEASTMNE1genetic
27708008
HAP5_YEASTHAP5genetic
27708008
BEM4_YEASTBEM4genetic
27708008
NIP80_YEASTNIP100genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GIC2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND SER-337, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-345, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254; SER-258 ANDSER-367, AND MASS SPECTROMETRY.

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