HAP4_YEAST - dbPTM
HAP4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HAP4_YEAST
UniProt AC P14064
Protein Name Transcriptional activator HAP4
Gene Name HAP4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 554
Subcellular Localization Nucleus.
Protein Description Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP4 encodes a regulatory subunit of the DNA-bound complex and seems to provide the principal transcriptional activation domains. Does not bind DNA directly, but augments the binding of HAP2 and HAP3..
Protein Sequence MTAKTFLLQASASRPRSNHFKNEHNNIPLAPVPIAPNTNHHNNSSLEFENDGSKKKKKSSLVVRTSKHWVLPPRPRPGRRSSSHNTLPANNTNNILNVGPNSRNSSNNNNNNNIISNRKQASKEKRKIPRHIQTIDEKLINDSNYLAFLKFDDLENEKFHSSASSISSPSYSSPSFSSYRNRKKSEFMDDESCTDVETIAAHNSLLTKNHHIDSSSNVHAPPTKKSKLNDFDLLSLSSTSSSATPVPQLTKDLNMNLNFHKIPHKASFPDSPADFSPADSVSLIRNHSLPTNLQVKDKIEDLNEIKFFNDFEKLEFFNKYAKVNTNNDVNENNDLWNSYLQSMDDTTGKNSGNYQQVDNDDNMSLLNLPILEETVSSGQDDKVEPDEEDIWNYLPSSSSQQEDSSRALKKNTNSEKANIQAKNDETYLFLQDQDESADSHHHDELGSEITLADNKFSYLPPTLEELMEEQDCNNGRSFKNFMFSNDTGIDGSAGTDDDYTKVLKSKKISTSKSNANLYDLNDNNNDATATNELDQSSFIDDLDEDVDFLKVQVF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
83PhosphorylationRPGRRSSSHNTLPAN
CCCCCCCCCCCCCCC		23.2319779198
119UbiquitinationNNIISNRKQASKEKR
CCCCCCHHHHHHHHH		55.2417644757
192PhosphorylationSEFMDDESCTDVETI
HHCCCCCCCCCHHHH		29.3427017623
194PhosphorylationFMDDESCTDVETIAA
CCCCCCCCCHHHHHH		52.9727017623
207PhosphorylationAAHNSLLTKNHHIDS
HHCCCHHHCCCCCCC		34.7827017623
235PhosphorylationLNDFDLLSLSSTSSS
CCCCCEEECCCCCCC		33.2422890988
237PhosphorylationDFDLLSLSSTSSSAT
CCCEEECCCCCCCCC		28.3522890988
238PhosphorylationFDLLSLSSTSSSATP
CCEEECCCCCCCCCC		37.2922890988
239PhosphorylationDLLSLSSTSSSATPV
CEEECCCCCCCCCCC		29.2922890988
240PhosphorylationLLSLSSTSSSATPVP
EEECCCCCCCCCCCC		25.0122890988
241PhosphorylationLSLSSTSSSATPVPQ
EECCCCCCCCCCCCH		24.8722890988
242PhosphorylationSLSSTSSSATPVPQL
ECCCCCCCCCCCCHH		35.6122890988
244PhosphorylationSSTSSSATPVPQLTK
CCCCCCCCCCCHHHC		27.1122890988
250PhosphorylationATPVPQLTKDLNMNL
CCCCCHHHCCCCCCC		19.7722890988
265UbiquitinationNFHKIPHKASFPDSP
CCCCCCCCCCCCCCC		40.1317644757
271PhosphorylationHKASFPDSPADFSPA
CCCCCCCCCCCCCCC		23.4021440633
288PhosphorylationVSLIRNHSLPTNLQV
HHHHHCCCCCCCCEE		39.3223749301
322UbiquitinationEFFNKYAKVNTNNDV
HHHHHHCCCCCCCCC		32.6917644757
349UbiquitinationSMDDTTGKNSGNYQQ
HHCCCCCCCCCCCEE		45.9417644757
393PhosphorylationDEEDIWNYLPSSSSQ
CHHHHHHHCCCCCCC		12.6628889911
399PhosphorylationNYLPSSSSQQEDSSR
HHCCCCCCCHHHHHH		37.5228889911
405PhosphorylationSSQQEDSSRALKKNT
CCCHHHHHHHHHHHC		33.6228889911
479UbiquitinationCNNGRSFKNFMFSND
CCCCCCCHHHCCCCC		50.9917644757
487PhosphorylationNFMFSNDTGIDGSAG
HHCCCCCCCCCCCCC		40.0427017623
492PhosphorylationNDTGIDGSAGTDDDY
CCCCCCCCCCCCCCH		21.5627017623
495PhosphorylationGIDGSAGTDDDYTKV
CCCCCCCCCCCHHHH		35.6527017623
499PhosphorylationSAGTDDDYTKVLKSK
CCCCCCCHHHHHHHC		18.5627017623
500PhosphorylationAGTDDDYTKVLKSKK
CCCCCCHHHHHHHCC		22.9827017623
501UbiquitinationGTDDDYTKVLKSKKI
CCCCCHHHHHHHCCC		39.0617644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HAP4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HAP4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HAP4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNF5_YEASTSNF5physical
11865042
SWI1_YEASTSWI1physical
11865042
SNF2_YEASTSNF2physical
11865042
SNF2_YEASTSNF2physical
10549297
ARP7_YEASTARP7physical
10549297
TAF14_YEASTTAF14physical
10549297
TRA1_YEASTTRA1physical
11423663
HAP2_YEASTHAP2physical
9372932
HAP3_YEASTHAP3physical
9372932
HAP5_YEASTHAP5physical
9372932
HAP5_YEASTHAP5physical
16278450
HAP3_YEASTHAP3physical
16278450
HAP2_YEASTHAP2physical
16278450
SCH9_YEASTSCH9genetic
18469137
MDHM_YEASTMDH1genetic
18381895
AATM_YEASTAAT1genetic
18381895
HAC1_YEASTHAC1genetic
20959818
YPT6_YEASTYPT6genetic
20959818
STB1_YEASTSTB1genetic
20959818
PHO23_YEASTPHO23genetic
20959818
STH1_YEASTSTH1physical
26086550
ORC6_YEASTORC6genetic
27708008
ATG1_YEASTATG1genetic
27708008
IPYR_YEASTIPP1genetic
27708008
POP7_YEASTPOP7genetic
27708008
TAF5_YEASTTAF5genetic
27708008
ARP2_YEASTARP2genetic
27708008
DPOD_YEASTPOL3genetic
27708008
SLU7_YEASTSLU7genetic
27708008
CDC1_YEASTCDC1genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
TCPA_YEASTTCP1genetic
27708008
PCF11_YEASTPCF11genetic
27708008
SNU56_YEASTSNU56genetic
27708008
TRS23_YEASTTRS23genetic
27708008
SRPR_YEASTSRP101genetic
27708008
GPI11_YEASTGPI11genetic
27708008
RSP5_YEASTRSP5genetic
27708008
COG3_YEASTCOG3genetic
27708008
CCA1_YEASTCCA1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
YPT1_YEASTYPT1genetic
27708008
ACT_YEASTACT1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
TAF6_YEASTTAF6genetic
27708008
MCE1_YEASTCEG1genetic
27708008
SYMC_YEASTMES1genetic
27708008
MED6_YEASTMED6genetic
27708008
NNF1_YEASTNNF1genetic
27708008
COFI_YEASTCOF1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
CFT2_YEASTCFT2genetic
27708008
BET5_YEASTBET5genetic
27708008
SEC65_YEASTSEC65genetic
27708008
CEF1_YEASTCEF1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
RPC6_YEASTRPC34genetic
27708008
PRS10_YEASTRPT4genetic
27708008
SEC62_YEASTSEC62genetic
27708008
RDS3_YEASTRDS3genetic
27708008
PSB5_YEASTPRE2genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
RV161_YEASTRVS161genetic
27708008
TGL2_YEASTTGL2genetic
27708008
OCA6_YEASTOCA6genetic
27708008
SUR2_YEASTSUR2genetic
27708008
SCS2_YEASTSCS2genetic
27708008
RAD54_YEASTRAD54genetic
27708008
HXKB_YEASTHXK2genetic
27708008
PEX31_YEASTPEX31genetic
27708008
ASK10_YEASTASK10genetic
27708008
SLT2_YEASTSLT2genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
MMR1_YEASTMMR1genetic
27708008
PABC_YEASTABZ2genetic
27708008
ATP23_YEASTATP23genetic
27708008
IRA2_YEASTIRA2genetic
27708008
RL36A_YEASTRPL36Agenetic
29158977
DOM34_YEASTDOM34genetic
29158977
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HAP4_YEAST

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Related Literatures of Post-Translational Modification

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