| UniProt ID | SLU7_YEAST | |
|---|---|---|
| UniProt AC | Q02775 | |
| Protein Name | Pre-mRNA-splicing factor SLU7 | |
| Gene Name | SLU7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 382 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Essential protein involved in the second catalytic step of pre-mRNA splicing. Involved in the selection of 3'-type splice sites; this selection could be done via a 3'-splice site-binding factor, PRP16.. | |
| Protein Sequence | MNNNSRNNENRSTINRNKRQLQQAKEKNENIHIPRYIRNQPWYYKDTPKEQEGKKPGNDDTSTAEGGEKSDYLVHHRQKAKGGALDIDNNSEPKIGMGIKDEFKLIRPQKMSVRDSHSLSFCRNCGEAGHKEKDCMEKPRKMQKLVPDLNSQKNNGTVLVRATDDDWDSRKDRWYGYSGKEYNELISKWERDKRNKIKGKDKSQTDETLWDTDEEIELMKLELYKDSVGSLKKDDADNSQLYRTSTRLREDKAAYLNDINSTESNYDPKSRLYKTETLGAVDEKSKMFRRHLTGEGLKLNELNQFARSHAKEMGIRDEIEDKEKVQHVLVANPTKYEYLKKKREQEETKQPKIVSIGDLEARKVDGTKQSEEQRNHLKDLYG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 25 | Acetylation | KRQLQQAKEKNENIH HHHHHHHHHHCCCCC | 65.95 | 25381059 | |
| 45 | Acetylation | RNQPWYYKDTPKEQE HCCCCCCCCCCHHHC | 39.15 | 25381059 | |
| 91 | Phosphorylation | ALDIDNNSEPKIGMG CCCCCCCCCCCCCCC | 62.62 | 30377154 | |
| 120 | Phosphorylation | VRDSHSLSFCRNCGE CCCCCCHHHCCCCCC | 25.89 | 28889911 | |
| 144 | Acetylation | EKPRKMQKLVPDLNS HCCHHHHHHCCCHHH | 48.21 | 25381059 | |
| 151 | Phosphorylation | KLVPDLNSQKNNGTV HHCCCHHHCCCCCEE | 50.24 | 21440633 | |
| 180 | Acetylation | RWYGYSGKEYNELIS CCCCCCHHHHHHHHH | 51.60 | 24489116 | |
| 203 | Phosphorylation | KIKGKDKSQTDETLW CCCCCCHHHCCCCCC | 48.74 | 22369663 | |
| 205 | Phosphorylation | KGKDKSQTDETLWDT CCCCHHHCCCCCCCC | 42.78 | 22369663 | |
| 208 | Phosphorylation | DKSQTDETLWDTDEE CHHHCCCCCCCCHHH | 35.64 | 22369663 | |
| 212 | Phosphorylation | TDETLWDTDEEIELM CCCCCCCCHHHHHHH | 33.46 | 22369663 | |
| 224 | Phosphorylation | ELMKLELYKDSVGSL HHHCHHHHHCCCCCC | 11.90 | 21440633 | |
| 274 | Acetylation | DPKSRLYKTETLGAV CCCCCCCCEECCCCC | 44.47 | 25381059 | |
| 284 | Acetylation | TLGAVDEKSKMFRRH CCCCCCHHHHHHHHH | 51.41 | 25381059 | |
| 293 | Phosphorylation | KMFRRHLTGEGLKLN HHHHHHHHCCCCCHH | 27.36 | 17563356 | |
| 298 | Acetylation | HLTGEGLKLNELNQF HHHCCCCCHHHHHHH | 61.19 | 24489116 | |
| 335 | Acetylation | VLVANPTKYEYLKKK EEECCHHHHHHHHHH | 37.02 | 24489116 | |
| 336 | Phosphorylation | LVANPTKYEYLKKKR EECCHHHHHHHHHHH | 16.57 | 25533186 | |
| 349 | Acetylation | KREQEETKQPKIVSI HHHHHCCCCCCEEEE | 68.81 | 25381059 | |
| 355 | Phosphorylation | TKQPKIVSIGDLEAR CCCCCEEEEHHHHEE | 25.07 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SLU7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLU7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLU7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND THR-212, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-212, AND MASSSPECTROMETRY. | |
