| UniProt ID | PRP16_YEAST | |
|---|---|---|
| UniProt AC | P15938 | |
| Protein Name | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 | |
| Gene Name | PRP16 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1071 | |
| Subcellular Localization | Nucleus. Binds to the spliceosome. | |
| Protein Description | Influences the fidelity of branchpoint recognition in yeast splicing. This is RNA-dependent ATPase which is essential for viability. It may mediate one of the many ATP-requiring steps of spliceosome assembly and that accuracy of branchpoint recognition may be coupled to ATP binding and/or hydrolysis.. | |
| Protein Sequence | MGHSGREERIKDIFKELTSKELTPGLLLTLQKLAQKPNTNLEQFIASCKALTKLSSNNPIIFNELLELLKNKSEEDSTGPKKIAPSINKRKKFKIQLDLDDNEDELDSPVQKKPAPTRTLFKRIDKLKAKQLRQYSPTVKDPSPNSEQQTQNGHAETKDYEPTRSEVVEEDREWYDNDDDYGNLVPEPLSELPEEAKLLPVIRNIDNDDALRNTVQLYPIPLKQRMEWIPPFLSKFALENKVPTSIIIGSISETSSQVSALSMVNPFRNPDSEFSANAKRGSKLVALRRINMEHIQQSRDNTTVLNTAMGEVLGLENNNKAKDKSNQKICDDTALFTPSKDDIKHTKEQLPVFRCRSQLLSLIRENQVVVIIGETGSGKTTQLAQYLYEEGYANDRGKSIVVTQPRRVAAISVAKRVAMEMQVPLGKEVGYSIRFEDVTDSECTKLKFVTDGILLRETLLDDTLDKYSCVIIDEAHERSLNTDILLGFFKILLARRRDLKLIITSATMNAKKFSAFFGNAPQFTIPGRTFPVQTIYTSNPVQDYVEAAVSQAVKIHLANDCSSGDILIFMTGQEDIETTFDTLQEKFLQVYSKKFGTANFEEINDIEILPIYSALPADLQFKIFQDLHGTKRKIIIATNIAETSLTIKGIRYVIDCGYSKLKVYNPKIGLDSLVITPISKANADQRSGRAGRTAPGTAYRLYTEDTFKEDMYLQTIPEIQRTNLSNTLLLLKSLDVTDELSKFPFIDKPPLQTFLSSLYELWFIGAIDTSGQLTPLGLQMAKFPLQPSLSKILLIAVRNGCSDEMLTIVSMLSVPQVFYRPKERQKEADIARNKFFIAKSDHLTLLNVFEQWRANNFSSHWCNKHFVQYKSLVRARDIRDQLLTILKSQKIPVISSGKDWDIIKKCICSGFAHQAAKITGLRNYVHLKTGVSVQLHPTSALHGLGDLPPYVVYHELLMTSKEYICCVTSVDPFWLMEYGGLLYDIKRIKNDQEATTTGLFGEHYEHTLDKVEDDIDINIRRCKDMRDSVIQELKMTDNSNKEDKKQKTKKQNILNGKENSMKPFKRRKPFF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 108 | Phosphorylation | DNEDELDSPVQKKPA CCCCCCCCCCCCCCC | 39.33 | 28889911 | |
| 117 | Phosphorylation | VQKKPAPTRTLFKRI CCCCCCCHHHHHHHH | 38.09 | 21551504 | |
| 135 | Phosphorylation | KAKQLRQYSPTVKDP HHHHHHHHCCCCCCC | 15.35 | 29136822 | |
| 136 | Phosphorylation | AKQLRQYSPTVKDPS HHHHHHHCCCCCCCC | 13.03 | 29136822 | |
| 138 | Phosphorylation | QLRQYSPTVKDPSPN HHHHHCCCCCCCCCC | 33.96 | 29136822 | |
| 143 | Phosphorylation | SPTVKDPSPNSEQQT CCCCCCCCCCCHHHC | 47.01 | 29136822 | |
| 146 | Phosphorylation | VKDPSPNSEQQTQNG CCCCCCCCHHHCCCC | 39.92 | 24961812 | |
| 150 | Phosphorylation | SPNSEQQTQNGHAET CCCCHHHCCCCCCCC | 24.56 | 29136822 | |
| 399 | Phosphorylation | YANDRGKSIVVTQPR CCCCCCCEEEEECCC | 24.36 | 27017623 | |
| 884 | Phosphorylation | DIRDQLLTILKSQKI HHHHHHHHHHHHCCC | 32.62 | 27017623 | |
| 888 | Phosphorylation | QLLTILKSQKIPVIS HHHHHHHHCCCCEEC | 33.01 | 27017623 | |
| 895 | Phosphorylation | SQKIPVISSGKDWDI HCCCCEECCCCCHHH | 33.02 | 28889911 | |
| 896 | Phosphorylation | QKIPVISSGKDWDII CCCCEECCCCCHHHH | 38.44 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRP16_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRP16_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRP16_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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