| UniProt ID | PRP45_YEAST | |
|---|---|---|
| UniProt AC | P28004 | |
| Protein Name | Pre-mRNA-processing protein 45 | |
| Gene Name | PRP45 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 379 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Involved in pre-mRNA splicing. Associated with the spliceosome throughout the splicing reactions, until after the second catalytic step.. | |
| Protein Sequence | MFSNRLPPPKHSQGRVSTALSSDRVEPAILTDQIAKNVKLDDFIPKRQSNFELSVPLPTKAEIQECTARTKSYIQRLVNAKLANSNNRASSRYVTETHQAPANLLLNNSHHIEVVSKQMDPLLPRFVGKKARKVVAPTENDEVVPVLHMDGSNDRGEADPNEWKIPAAVSNWKNPNGYTVALERRVGKALDNENNTINDGFMKLSEALENADKKARQEIRSKMELKRLAMEQEMLAKESKLKELSQRARYHNGTPQTGAIVKPKKQTSTVARLKELAYSQGRDVSEKIILGAAKRSEQPDLQYDSRFFTRGANASAKRHEDQVYDNPLFVQQDIESIYKTNYEKLDEAVNVKSEGASGSHGPIQFTKAESDDKSDNYGA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Phosphorylation | RVSTALSSDRVEPAI CHHHCCCCCCCCCCC | 30.22 | 30377154 | |
| 81 | Acetylation | IQRLVNAKLANSNNR HHHHHHHHHHCCCCC | 42.82 | 25381059 | |
| 188 | Acetylation | ALERRVGKALDNENN EEEEHHHHHHCCCCC | 42.81 | 25381059 | |
| 245 | Phosphorylation | ESKLKELSQRARYHN HHHHHHHHHHHHHCC | 20.79 | 30377154 | |
| 268 | Phosphorylation | VKPKKQTSTVARLKE ECCCCCCCHHHHHHH | 20.56 | 30377154 | |
| 287 | Acetylation | QGRDVSEKIILGAAK CCCCHHHHHHHHHHH | 27.78 | 24489116 | |
| 353 | Phosphorylation | DEAVNVKSEGASGSH HHHHCCCCCCCCCCC | 36.66 | 21440633 | |
| 370 | Phosphorylation | IQFTKAESDDKSDNY EEEEECCCCCCCCCC | 56.84 | 23749301 | |
| 374 | Phosphorylation | KAESDDKSDNYGA-- ECCCCCCCCCCCC-- | 37.78 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRP45_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRP45_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRP45_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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