| UniProt ID | PRP46_YEAST | |
|---|---|---|
| UniProt AC | Q12417 | |
| Protein Name | Pre-mRNA-splicing factor PRP46 | |
| Gene Name | PRP46 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 451 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Involved in pre-mRNA splicing. May also be required for cell cycle progression at G2/M (By similarity).. | |
| Protein Sequence | MDGNDHKVENLGDVDKFYSRIRWNNQFSYMATLPPHLQSEMEGQKSLLMRYDTYRKESSSFSGEGKKVTLQHVPTDFSEASQAVISKKDHDTHASAFVNKIFQPEVAEELIVNRYEKLLSQRPEWHAPWKLSRVINGHLGWVRCVAIDPVDNEWFITGSNDTTMKVWDLATGKLKTTLAGHVMTVRDVAVSDRHPYLFSVSEDKTVKCWDLEKNQIIRDYYGHLSGVRTVSIHPTLDLIATAGRDSVIKLWDMRTRIPVITLVGHKGPINQVQCTPVDPQVVSSSTDATVRLWDVVAGKTMKVLTHHKRSVRATALHPKEFSVASACTDDIRSWGLAEGSLLTNFESEKTGIINTLSINQDDVLFAGGDNGVLSFYDYKSGHKYQSLATREMVGSLEGERSVLCSTFDKTGLRLITGEADKSIKIWKQDETATKESEPGLAWNPNLSAKRF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Acetylation | -MDGNDHKVENLGDV -CCCCCCCCCCCHHH | 54.85 | 22865919 | |
| 16 | Acetylation | ENLGDVDKFYSRIRW CCCHHHHHHHHHHCC | 46.15 | 22865919 | |
| 58 | Phosphorylation | YDTYRKESSSFSGEG HHCCCCCCCCCCCCC | 34.03 | 28889911 | |
| 59 | Phosphorylation | DTYRKESSSFSGEGK HCCCCCCCCCCCCCC | 36.17 | 28889911 | |
| 60 | Phosphorylation | TYRKESSSFSGEGKK CCCCCCCCCCCCCCE | 32.48 | 28889911 | |
| 384 | Phosphorylation | DYKSGHKYQSLATRE ECCCCCEEEEHHHHH | 9.54 | 27017623 | |
| 386 | Phosphorylation | KSGHKYQSLATREMV CCCCEEEEHHHHHHH | 19.51 | 27017623 | |
| 395 | Phosphorylation | ATREMVGSLEGERSV HHHHHHHCCCCCCEE | 16.31 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRP46_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRP46_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRP46_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND SER-60, AND MASSSPECTROMETRY. | |
