TCPE_YEAST - dbPTM
TCPE_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TCPE_YEAST
UniProt AC P40413
Protein Name T-complex protein 1 subunit epsilon
Gene Name CCT5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 562
Subcellular Localization Cytoplasm.
Protein Description Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation..
Protein Sequence MAARPQQPPMEMPDLSNAIVAQDEMGRPFIIVKDQGNKKRQHGLEAKKSHILAARSVASIIKTSLGPRGLDKILISPDGEITITNDGATILSQMELDNEIAKLLVQLSKSQDDEIGDGTTGVVVLASALLDQALELIQKGIHPIKIANGFDEAAKLAISKLEETCDDISASNDELFRDFLLRAAKTSLGSKIVSKDHDRFAEMAVEAVINVMDKDRKDVDFDLIKMQGRVGGSISDSKLINGVILDKDFSHPQMPKCVLPKEGSDGVKLAILTCPFEPPKPKTKHKLDISSVEEYQKLQTYEQDKFKEMIDDVKKAGADVVICQWGFDDEANHLLLQNDLPAVRWVGGQELEHIAISTNGRIVPRFQDLSKDKLGTCSRIYEQEFGTTKDRMLIIEQSKETKTVTCFVRGSNKMIVDEAERALHDSLCVVRNLVKDSRVVYGGGAAEVTMSLAVSEEADKQRGIDQYAFRGFAQALDTIPMTLAENSGLDPIGTLSTLKSKQLKEKISNIGVDCLGYGSNDMKELFVVDPFIGKKQQILLATQLCRMILKIDNVIISGKDEY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
62AcetylationRSVASIIKTSLGPRG
HHHHHHHHHCCCCCC		30.3224489116
145UbiquitinationQKGIHPIKIANGFDE
HCCCCCEEECCCCHH		39.9723749301
160UbiquitinationAAKLAISKLEETCDD
HHHHHHHHHHHHCCC		54.5323749301
186PhosphorylationFLLRAAKTSLGSKIV
HHHHHHHHHHCCCHH		25.1828889911
190PhosphorylationAAKTSLGSKIVSKDH
HHHHHHCCCHHCCCH		25.2228889911
194PhosphorylationSLGSKIVSKDHDRFA
HHCCCHHCCCHHHHH		35.5228889911
225AcetylationDVDFDLIKMQGRVGG
CCCHHEEECCCCCCC		32.2524489116
233PhosphorylationMQGRVGGSISDSKLI
CCCCCCCCCCCCCEE		17.0021440633
235PhosphorylationGRVGGSISDSKLING
CCCCCCCCCCCEECE		37.2121551504
237PhosphorylationVGGSISDSKLINGVI
CCCCCCCCCEECEEE		23.6727717283
238AcetylationGGSISDSKLINGVIL
CCCCCCCCEECEEEE		59.3824489116
247AcetylationINGVILDKDFSHPQM
ECEEEECCCCCCCCC		58.1724489116
261AcetylationMPKCVLPKEGSDGVK
CCCEECCCCCCCCEE		71.2325381059
280AcetylationTCPFEPPKPKTKHKL
ECCCCCCCCCCCCCC		70.6224489116
286AcetylationPKPKTKHKLDISSVE
CCCCCCCCCCCCCHH		49.7824489116
357PhosphorylationELEHIAISTNGRIVP
EEEEEEEECCCCEEC		13.5427017623
389AcetylationEQEFGTTKDRMLIIE
HCCCCCCCCEEEEEE		43.0824489116
389SuccinylationEQEFGTTKDRMLIIE
HCCCCCCCCEEEEEE		43.0823954790
399AcetylationMLIIEQSKETKTVTC
EEEEECCCCCCEEEE		69.9224489116
413UbiquitinationCFVRGSNKMIVDEAE
EEEECCCCEECCHHH		31.5323749301
494PhosphorylationSGLDPIGTLSTLKSK
CCCCCCCCHHHHCHH		20.4627017623
496PhosphorylationLDPIGTLSTLKSKQL
CCCCCCHHHHCHHHH		31.3727017623
497PhosphorylationDPIGTLSTLKSKQLK
CCCCCHHHHCHHHHH		41.1227017623
534AcetylationVVDPFIGKKQQILLA
EEECCCCHHHHHHHH		42.4624489116
559UbiquitinationDNVIISGKDEY----
CCEEECCCCCC----		40.3623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TCPE_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TCPE_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TCPE_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSP71_YEASTSSA1physical
19536198
APC11_YEASTAPC11genetic
27708008
IWS1_YEASTSPN1genetic
27708008
PDP2_YEASTPTC6genetic
27708008
UBA4_YEASTUBA4genetic
27708008
IST3_YEASTIST3genetic
27708008
POC1_YEASTPBA1genetic
27708008
TOP1_YEASTTOP1genetic
27708008
CDC15_YEASTCDC15genetic
27708008
STU1_YEASTSTU1genetic
27708008
TAF5_YEASTTAF5genetic
27708008
SCC1_YEASTMCD1genetic
27708008
ARP2_YEASTARP2genetic
27708008
PRP9_YEASTPRP9genetic
27708008
TIM22_YEASTTIM22genetic
27708008
PDC2_YEASTPDC2genetic
27708008
TCPA_YEASTTCP1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
NU145_YEASTNUP145genetic
27708008
CDC20_YEASTCDC20genetic
27708008
SYV_YEASTVAS1genetic
27708008
DAM1_YEASTDAM1genetic
27708008
MOB1_YEASTMOB1genetic
27708008
ARP4_YEASTARP4genetic
27708008
UGPA1_YEASTUGP1genetic
27708008
TOR2_YEASTTOR2genetic
27708008
TEM1_YEASTTEM1genetic
27708008
PGA3_YEASTPGA3genetic
27708008
SEC59_YEASTSEC59genetic
27708008
TAP42_YEASTTAP42genetic
27708008
ARP9_YEASTARP9genetic
27708008
UTP15_YEASTUTP15genetic
27708008
ROT1_YEASTROT1genetic
27708008
PRP24_YEASTPRP24genetic
27708008
LST8_YEASTLST8genetic
27708008
ARPC2_YEASTARC35genetic
27708008
OST2_YEASTOST2genetic
27708008
LAS17_YEASTLAS17genetic
27708008
YTM1_YEASTYTM1genetic
27708008
KRE5_YEASTKRE5genetic
27708008
IF6_YEASTTIF6genetic
27708008
MDM10_YEASTMDM10genetic
27708008
SLA1_YEASTSLA1genetic
27708008
SHE1_YEASTSHE1genetic
27708008
ECM33_YEASTECM33genetic
27708008
SIF2_YEASTSIF2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
MTC4_YEASTMTC4genetic
27708008
STE50_YEASTSTE50genetic
27708008
RV161_YEASTRVS161genetic
27708008
SNT1_YEASTSNT1genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
QRI7_YEASTQRI7genetic
27708008
CYK3_YEASTCYK3genetic
27708008
OST4_YEASTOST4genetic
27708008
DHAS_YEASTHOM2genetic
27708008
PLP1_YEASTPLP1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
SWR1_YEASTSWR1genetic
27708008
RV167_YEASTRVS167genetic
27708008
VPS72_YEASTVPS72genetic
27708008
AK_YEASTHOM3genetic
27708008
SWI4_YEASTSWI4genetic
27708008
WWM1_YEASTWWM1genetic
27708008
FAB1_YEASTFAB1genetic
27708008
YG036_YEASTYGL036Wgenetic
27708008
MRM2_YEASTMRM2genetic
27708008
HOS2_YEASTHOS2genetic
27708008
CLG1_YEASTCLG1genetic
27708008
PFD3_YEASTPAC10genetic
27708008
BUB1_YEASTBUB1genetic
27708008
PMT6_YEASTPMT6genetic
27708008
SLI1_YEASTSLI1genetic
27708008
SMI1_YEASTSMI1genetic
27708008
PHB2_YEASTPHB2genetic
27708008
SLT2_YEASTSLT2genetic
27708008
NAM8_YEASTNAM8genetic
27708008
CTM1_YEASTCTM1genetic
27708008
SET5_YEASTSET5genetic
27708008
PRK1_YEASTPRK1genetic
27708008
BCK1_YEASTBCK1genetic
27708008
PBS2_YEASTPBS2genetic
27708008
PAN3_YEASTPAN3genetic
27708008
PGM1_YEASTPGM1genetic
27708008
CBT1_YEASTCBT1genetic
27708008
SA190_YEASTSAP190genetic
27708008
UTH1_YEASTUTH1genetic
27708008
PAM17_YEASTPAM17genetic
27708008
ALAM_YEASTALT1genetic
27708008
CCW12_YEASTCCW12genetic
27708008
HOG1_YEASTHOG1genetic
27708008
ACE2_YEASTACE2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
UPS1_YEASTUPS1genetic
27708008
PFD6_YEASTYKE2genetic
27708008
VRP1_YEASTVRP1genetic
27708008
ROM2_YEASTROM2genetic
27708008
RCF1_YEASTRCF1genetic
27708008
TBA3_YEASTTUB3genetic
27708008
YMW4_YEASTYMR074Cgenetic
27708008
MYO5_YEASTMYO5genetic
27708008
SIW14_YEASTSIW14genetic
27708008
EOS1_YEASTEOS1genetic
27708008
PFD4_YEASTGIM3genetic
27708008
RTC1_YEASTRTC1genetic
27708008
BUB3_YEASTBUB3genetic
27708008
SERC_YEASTSER1genetic
27708008
GSP2_YEASTGSP2genetic
27708008
CIN1_YEASTCIN1genetic
27708008
MSC6_YEASTMSC6genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
MGR2_YEASTMGR2genetic
27708008
FMP30_YEASTFMP30genetic
27708008
POC4_YEASTPOC4genetic
27708008
TBCC_YEASTCIN2genetic
27708008
TKT1_YEASTTKL1genetic
27708008
AXL1_YEASTAXL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TCPE_YEAST

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Related Literatures of Post-Translational Modification

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