| UniProt ID | SERC_YEAST | |
|---|---|---|
| UniProt AC | P33330 | |
| Protein Name | Phosphoserine aminotransferase | |
| Gene Name | SER1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 395 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.. | |
| Protein Sequence | MSLEREEPQHFGAGPAQMPTPVLQQAAKDLINFNDIGLGIGEISHRSKDATKVIEDSKKHLIELLNIPDTHEVFYLQGGGTTGFSSVATNLAAAYVGKHGKIAPAGYLVTGSWSQKSFEEAKRLHVPAEVIFNAKDYNNGKFGKIPDESLWEDKIKGKAFSYVYLCENETVHGVEWPELPKCLVNDPNIEIVADLSSDILSRKIDVSQYGVIMAGAQKNIGLAGLTLYIIKKSILKNISGASDETLHELGVPITPIAFDYPTVVKNNSAYNTIPIFTLHVMDLVFQHILKKGGVEAQQAENEEKAKILYEALDANSDFYNVPVDPKCRSKMNVVFTLKKDGLDDQFLKEAAARHLTGLKGHRSVGGFRASIYNALSVKAVQNLVDFIKEFAEKNA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLEREEPQ ------CCCCCCCCC | 38.65 | 22369663 | |
| 20 | Phosphorylation | AGPAQMPTPVLQQAA CCCCCCCCHHHHHHH | 22.23 | 22369663 | |
| 58 | 2-Hydroxyisobutyrylation | TKVIEDSKKHLIELL HHHHHHHHHHHHHHH | 57.44 | - | |
| 58 | Succinylation | TKVIEDSKKHLIELL HHHHHHHHHHHHHHH | 57.44 | 23954790 | |
| 101 | Acetylation | AYVGKHGKIAPAGYL HHHCCCCCCCCCEEE | 35.10 | 24489116 | |
| 110 | Phosphorylation | APAGYLVTGSWSQKS CCCEEEECCCCCCCC | 23.93 | 21440633 | |
| 112 | Phosphorylation | AGYLVTGSWSQKSFE CEEEECCCCCCCCHH | 17.75 | 22369663 | |
| 114 | Phosphorylation | YLVTGSWSQKSFEEA EEECCCCCCCCHHHH | 29.45 | 22369663 | |
| 116 | Acetylation | VTGSWSQKSFEEAKR ECCCCCCCCHHHHHH | 52.15 | 24489116 | |
| 122 | Ubiquitination | QKSFEEAKRLHVPAE CCCHHHHHHCCCCCE | 59.79 | 23749301 | |
| 122 | Succinylation | QKSFEEAKRLHVPAE CCCHHHHHHCCCCCE | 59.79 | 23954790 | |
| 135 | Acetylation | AEVIFNAKDYNNGKF CEEEECCCCCCCCCC | 62.95 | 24489116 | |
| 141 | Acetylation | AKDYNNGKFGKIPDE CCCCCCCCCCCCCCH | 53.73 | 25381059 | |
| 144 | Acetylation | YNNGKFGKIPDESLW CCCCCCCCCCCHHHH | 54.95 | 24489116 | |
| 154 | Acetylation | DESLWEDKIKGKAFS CHHHHCHHHCCEEEE | 34.50 | 24489116 | |
| 197 | Phosphorylation | EIVADLSSDILSRKI EEEEECCHHHHHCCC | 35.65 | 28889911 | |
| 218 | Other | VIMAGAQKNIGLAGL HHHHHCCCCCCCCHH | 50.42 | - | |
| 218 | N6-(pyridoxal phosphate)lysine | VIMAGAQKNIGLAGL HHHHHCCCCCCCCHH | 50.42 | - | |
| 226 | Phosphorylation | NIGLAGLTLYIIKKS CCCCCHHHHHHHHHH | 19.32 | 21126336 | |
| 228 | Phosphorylation | GLAGLTLYIIKKSIL CCCHHHHHHHHHHHH | 8.72 | 21126336 | |
| 348 | Acetylation | GLDDQFLKEAAARHL CCCHHHHHHHHHHHC | 46.74 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SERC_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SERC_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SERC_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20 AND SER-112, AND MASSSPECTROMETRY. | |
