AGE2_YEAST - dbPTM
AGE2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AGE2_YEAST
UniProt AC P40529
Protein Name ADP-ribosylation factor GTPase-activating protein effector protein 2
Gene Name AGE2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 298
Subcellular Localization Cytoplasm . Golgi apparatus . Associates with the Golgi complex.
Protein Description GTPase-activating protein for the ADP ribosylation factor family..
Protein Sequence MSTSVPVKKALSALLRDPGNSHCADCKAQLHPRWASWSLGVFICIKCAGIHRSLGTHISKVKSVDLDTWKEEHLVKLIQFKNNLRANSYYEATLADELKQRKITDTSSLQNFIKNKYEYKKWIGDLSSIEGLNDSTEPVLHKPSANHSLPASNARLDQSSNSLQKTQTQPPSHLLSTSRSNTSLLNLQVSSLSKTTSNTSVTSSATSIGAANTKTGNRVGEFGQRNDLKKSILSLYSKPSAQTQSQNSFFTSTTPQPCNTPSPFVNTGITATNNNSMNSNSSSNISLDDNELFKNVWS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSTSVPVKK
------CCCCHHHHH		29.4122814378
4Phosphorylation----MSTSVPVKKAL
----CCCCHHHHHHH		19.6725533186
59PhosphorylationRSLGTHISKVKSVDL
HHHCHHHHCCEECCC		24.6427017623
63PhosphorylationTHISKVKSVDLDTWK
HHHHCCEECCCCCCC		24.6924961812
70AcetylationSVDLDTWKEEHLVKL
ECCCCCCCHHHHHHH		56.1524489116
117PhosphorylationQNFIKNKYEYKKWIG
HHHHHCHHHHHHHHC		33.6127017623
159PhosphorylationSNARLDQSSNSLQKT
CCCCCCCCCCCHHHH		31.0222369663
160PhosphorylationNARLDQSSNSLQKTQ
CCCCCCCCCCHHHHC		25.4622369663
162PhosphorylationRLDQSSNSLQKTQTQ
CCCCCCCCHHHHCCC		33.8422369663
166PhosphorylationSSNSLQKTQTQPPSH
CCCCHHHHCCCCCHH		24.7222369663
168PhosphorylationNSLQKTQTQPPSHLL
CCHHHHCCCCCHHHH		48.5522369663
172PhosphorylationKTQTQPPSHLLSTSR
HHCCCCCHHHHCCCC		33.1920377248
176PhosphorylationQPPSHLLSTSRSNTS
CCCHHHHCCCCCCCC		30.6022369663
177PhosphorylationPPSHLLSTSRSNTSL
CCHHHHCCCCCCCCC		28.2920377248
178PhosphorylationPSHLLSTSRSNTSLL
CHHHHCCCCCCCCCE		30.2722369663
180PhosphorylationHLLSTSRSNTSLLNL
HHHCCCCCCCCCEEE		44.2022369663
182PhosphorylationLSTSRSNTSLLNLQV
HCCCCCCCCCEEEEE		23.2322369663
183PhosphorylationSTSRSNTSLLNLQVS
CCCCCCCCCEEEEEE		34.8022369663
190PhosphorylationSLLNLQVSSLSKTTS
CCEEEEEEECCCCCC		16.7622890988
191PhosphorylationLLNLQVSSLSKTTSN
CEEEEEEECCCCCCC		37.4922890988
193PhosphorylationNLQVSSLSKTTSNTS
EEEEEECCCCCCCCE		29.8822890988
195PhosphorylationQVSSLSKTTSNTSVT
EEEECCCCCCCCEEC		31.8922890988
196PhosphorylationVSSLSKTTSNTSVTS
EEECCCCCCCCEECC		24.5822890988
197PhosphorylationSSLSKTTSNTSVTSS
EECCCCCCCCEECCC		43.2622369663
199PhosphorylationLSKTTSNTSVTSSAT
CCCCCCCCEECCCCC		25.0922890988
200PhosphorylationSKTTSNTSVTSSATS
CCCCCCCEECCCCCE		27.8722890988
202PhosphorylationTTSNTSVTSSATSIG
CCCCCEECCCCCEEC		19.4122890988
203PhosphorylationTSNTSVTSSATSIGA
CCCCEECCCCCEECC		18.8022890988
204PhosphorylationSNTSVTSSATSIGAA
CCCEECCCCCEECCC		26.6322890988
206PhosphorylationTSVTSSATSIGAANT
CEECCCCCEECCCCC		23.8722890988
207PhosphorylationSVTSSATSIGAANTK
EECCCCCEECCCCCC		20.8122369663
213PhosphorylationTSIGAANTKTGNRVG
CEECCCCCCCCCCCH		25.8422890988
214UbiquitinationSIGAANTKTGNRVGE
EECCCCCCCCCCCHH		55.0023749301
231PhosphorylationQRNDLKKSILSLYSK
CCCHHHHHHHHHHCC		27.4622369663
234PhosphorylationDLKKSILSLYSKPSA
HHHHHHHHHHCCCCC		24.4821440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AGE2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AGE2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AGE2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCS1_YEASTGCS1genetic
12627398
GCS1_YEASTGCS1genetic
16269340
SWA2_YEASTSWA2genetic
16269340
AP3M_YEASTAPM3genetic
16269340
AP3S_YEASTAPS3genetic
16269340
AP3D_YEASTAPL5genetic
16269340
GDA1_YEASTGDA1genetic
16269340
BFR1_YEASTBFR1genetic
16269340
ATC3_YEASTDRS2genetic
16269340
VPS21_YEASTVPS21genetic
16269340
PKR1_YEASTPKR1genetic
16269340
OSH1_YEASTSWH1genetic
16269340
MON2_YEASTMON2genetic
16269340
RGP1_YEASTRGP1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
GLO3_YEASTGLO3genetic
12627398
SWC3_YEASTSWC3genetic
20093466
OSH1_YEASTSWH1genetic
20093466
AVT5_YEASTAVT5genetic
20093466
HAP3_YEASTHAP3genetic
20093466
RU1A_YEASTMUD1genetic
20093466
TPS1_YEASTTPS1genetic
20093466
NGR1_YEASTNGR1genetic
20093466
THRC_YEASTTHR4genetic
20093466
YCV1_YEASTYCR061Wgenetic
20093466
GCS1_YEASTGCS1genetic
20093466
RLA1_YEASTRPP1Agenetic
20093466
PP2C1_YEASTPTC1genetic
20093466
NHP10_YEASTNHP10genetic
20093466
SWI5_YEASTSWI5genetic
20093466
VPS72_YEASTVPS72genetic
20093466
AK_YEASTHOM3genetic
20093466
CEM1_YEASTCEM1genetic
20093466
UBP3_YEASTUBP3genetic
20093466
VMA21_YEASTVMA21genetic
20093466
SERB_YEASTSER2genetic
20093466
GGA2_YEASTGGA2genetic
20093466
DHOM_YEASTHOM6genetic
20093466
OAC1_YEASTOAC1genetic
20093466
ERG3_YEASTERG3genetic
20093466
AVL9_YEASTAVL9genetic
20093466
TPM1_YEASTTPM1genetic
20093466
BRE5_YEASTBRE5genetic
20093466
MSB4_YEASTMSB4genetic
20093466
INP53_YEASTINP53genetic
20093466
AIM44_YEASTAIM44genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
GCS1_YEASTGCS1genetic
21135091
AGE1_YEASTAGE1genetic
21135091
CSR1_YEASTCSR1genetic
21135091
AP1B1_YEASTAPL2genetic
23891562
TPM1_YEASTTPM1genetic
23891562
GTO2_YEASTECM4genetic
23891562
SED5_YEASTSED5genetic
27708008
UME6_YEASTUME6genetic
27708008
PRP6_YEASTPRP6genetic
27708008
CKS1_YEASTCKS1genetic
27708008
MCM7_YEASTMCM7genetic
27708008
SEC7_YEASTSEC7genetic
27708008
GDI1_YEASTGDI1genetic
27708008
ACT_YEASTACT1genetic
27708008
PRP18_YEASTPRP18genetic
27708008
SPC97_YEASTSPC97genetic
27708008
GRP78_YEASTKAR2genetic
27708008
ARP4_YEASTARP4genetic
27708008
EXO70_YEASTEXO70genetic
27708008
CDC11_YEASTCDC11genetic
27708008
TAD3_YEASTTAD3genetic
27708008
RSC9_YEASTRSC9genetic
27708008
CAP_YEASTSRV2genetic
27708008
DED1_YEASTDED1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
ATC3_YEASTDRS2genetic
27708008
OSH1_YEASTSWH1genetic
27708008
AVT5_YEASTAVT5genetic
27708008
RU1A_YEASTMUD1genetic
27708008
THRC_YEASTTHR4genetic
27708008
NHP10_YEASTNHP10genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
GCS1_YEASTGCS1genetic
27708008
SWI5_YEASTSWI5genetic
27708008
YD249_YEASTYDR249Cgenetic
27708008
SWA2_YEASTSWA2genetic
27708008
UBP3_YEASTUBP3genetic
27708008
IES1_YEASTIES1genetic
27708008
VMA21_YEASTVMA21genetic
27708008
GGA2_YEASTGGA2genetic
27708008
ERG3_YEASTERG3genetic
27708008
AVL9_YEASTAVL9genetic
27708008
MSC1_YEASTMSC1genetic
27708008
BRE5_YEASTBRE5genetic
27708008
SIN3_YEASTSIN3genetic
27708008
INP53_YEASTINP53genetic
27708008
MCA1_YEASTMCA1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AGE2_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; SER-180; SER-183;THR-195 AND SER-197, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-182, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory