CSR1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSR1_YEAST
• UniProt AC: Q06705
• Protein Name: Phosphatidylinositol transfer protein CSR1
• Gene Name: CSR1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 408
• Subcellular Localization: Cytoplasm. Endosome.
• Protein Description: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Activates SPO14/PLD1 (phospholipase D1) by stimulating phosphoinositide synthesis via the STT4 PtdIns 4-kinase. Modulates ArfGAP function through effects on SPO14 activity. Inhibits phosphatidylcholine degradation by PLB1 (phospholipase B1). May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress..
• Protein Sequence: MSFDRQLTEDQEVVLKQIWTHLFHLWQVPVDGTHIFPNNSLHSSSTPAKKKKSSWFSKLQSSDHTQDSSEAAEAAHLYEKGKIHKALANLDPQTTKKQFWHDIKNETPDATILKFIRARKWNADKTIAMLGHDLYWRKDTINKIINGGERAVYENNETGVIKNLELQKATIQGYDNDMRPVILVRPRLHHSSDQTEQELEKFSLLVIEQSKLFFKENYPASTTILFDLNGFSMSNMDYAPVKFLITCFEAHYPESLGHLLIHKAPWIFNPIWNIIKNWLDPVVASKIVFTKNIDELHKFIQPQYIPRYLGGENDNDLDHYTPPDGSLDVHLKDTETRAMIEKEREELVEQFLTVTAQWIEHQPLNDPAYIQLQEKRVQLSTALCENYSKLDPYIRSRSVYDYNGSLKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSFDRQLTE ------CCCCCCCCC	35.54	15665377
2	Phosphorylation	------MSFDRQLTE ------CCCCCCCCC	35.54	22369663
8	Phosphorylation	MSFDRQLTEDQEVVL CCCCCCCCCCHHHHH	29.22	22369663
54	Phosphorylation	PAKKKKSSWFSKLQS CCCCCCCHHHHHHCC	40.81	21440633
58	Acetylation	KKSSWFSKLQSSDHT CCCHHHHHHCCCCCC	40.86	24489116
61	Phosphorylation	SWFSKLQSSDHTQDS HHHHHHCCCCCCCCH	48.44	21440633
62	Phosphorylation	WFSKLQSSDHTQDSS HHHHHCCCCCCCCHH	22.05	21440633
80	Acetylation	EAAHLYEKGKIHKAL HHHHHHHHCCHHHHH	52.53	24489116
114	Ubiquitination	TPDATILKFIRARKW CCCHHHHHHHHHHCC	34.59	24961812
291	Acetylation	ASKIVFTKNIDELHK HHEEEEECCHHHHHH	40.20	24489116
298	Acetylation	KNIDELHKFIQPQYI CCHHHHHHHHCHHHC	57.71	24489116
342	Ubiquitination	ETRAMIEKEREELVE HHHHHHHHHHHHHHH	51.66	23749301
396	Phosphorylation	KLDPYIRSRSVYDYN HCCHHHHCCCCCCCC	21.24	27017623
405	Phosphorylation	SVYDYNGSLKV---- CCCCCCCCCCC----	22.75	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSR1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSR1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSR1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ROK1_YEAST	ROK1	genetic	10705369
HSP78_YEAST	HSP78	physical	19536198
KAPS_YEAST	MET14	genetic	20093466
NAP1_YEAST	NAP1	genetic	20093466
DS1P2_YEAST	YSR3	genetic	20093466
FAR3_YEAST	FAR3	genetic	20093466
AGE1_YEAST	AGE1	genetic	21135091
SNF5_YEAST	SNF5	genetic	27708008
H3_YEAST	HHT1	genetic	27708008
NPL4_YEAST	NPL4	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.