dbPTM

ASK10_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ASK10_YEAST
UniProt AC	P48361
Protein Name	Activator of SKN7 protein 10
Gene Name	ASK10
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1146
Subcellular Localization	Cytoplasm . Displays diffuse cytoplasmic localization, but very rapidly aggregates into punctate spots that appear near the cell surface in response to hypo-osmotic shock.
Protein Description	Positive regulator of FPS1 glycerol channel required for the glycerol efflux. As a component of the RNA polymerase II holoenzyme, is required for SSN8 destruction in response to oxidative stress but not heat shock. Required for cell survival in response to heat shock independent of SSN8..
Protein Sequence	MSDYFSSRPSQTLTPMGNKPSGGGGGDDASSIHSKSSQYLMDILPDSMTLNESVSSIVANNQAKEFILPETDERSPYFINVPIPKAQPTSTTETKKPLAGDEAIDGQFVKEYPTDILVDRFYKWKKILKGLVIYLREVAYAQEQFARINYQLKGSVKFPFLTDIDETTNTITDPFTTAPRGPKKAQPAQKKVGLTDSEQFQMQMQQEQQENAVQAPTDESKMSLAPHEYKPVQTTESDNTSAASGFVKFGSGSIQDIQVILKKYHLSLANQQFKISKEITSTVIPKLEELRKDLRYKITEIKDLHGDFKTNIGAHIQLTSQLLKKYIAAVKFMNAHGIGNDRASPTNKKPHKLDPKHDPYLLKLQLDLQLKRQVAEETYLQEAFINLQSSGLQLEKIIYTKIQHALLRYSALIDSEARLMIKNMCQELQHGIISKPPAFEWDNFVTQHPSCLLNWKSNDPIPPPRKVSDVIYPHMKSPLAKCIKAGYFLKKSELLPTYHQGYFVLTSNYIHEFQSSDFYNLSSSTPNSTKSSAYSSSVSIADTYANANNAKANNHHRQASDVHNSSTTTGGTAGANGIRGIRKKSYLAPIMSIPLNDCTLKDASSTKFVLVGKPTLNENADVRKSSSSTYLSGSSQASLPKYGHETAKIFSKAPFHKFLKGSKPKNKNTKSSELDQFYAAAQKESNNYVTWTFKIVSPEPSEEELKHFKRWVQDLKNLTSFNDTKDRIKFIEDRVMKSHRFKAGHMSRNSVNIGSHTPCLTDSTFTLQDGTTTSVNLKGRAEKPQYIHIQNNSLADFDGNGFRSKVNTPAIDDYGNLITVERRPAQSPHQYSDYMATSGNTTPSYSSGSRPQSMYNGYNPAVSITSNGMMLQQSTANNNTNPTTNLRHQRNISQTSSLPGFSYTSLSLPVNSPGSSNSESSSGGYFAIPLHGNNNNNNYTQRNSEGSSPCYNDDQIRQQQQPLQMQPLSRTSSSSVNVTAMRSTSAGNSITANAPVVPKVMVNNQNVKTVAADQSATAPSSPTMNSSVTTINRESPYQTLKKTNSTGNVPCLTAEKTHAHPAFYKRGNNSAQNLTTSSSTASRVHPIRKHKKNVSFSSLNSLMFSKKGANHGGNLMTNQFMSGGIQEDDGDSTNNDTIKLNQSIYS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDYFSSRP ------CCCCCCCCC	52.93	19823750
4	Phosphorylation	----MSDYFSSRPSQ ----CCCCCCCCCCC	18.04	19823750
6	Phosphorylation	--MSDYFSSRPSQTL --CCCCCCCCCCCCC	21.14	19823750
7	Phosphorylation	-MSDYFSSRPSQTLT -CCCCCCCCCCCCCC	38.01	19823750
10	Phosphorylation	DYFSSRPSQTLTPMG CCCCCCCCCCCCCCC	34.39	19823750
12	Phosphorylation	FSSRPSQTLTPMGNK CCCCCCCCCCCCCCC	36.62	19823750
14	Phosphorylation	SRPSQTLTPMGNKPS CCCCCCCCCCCCCCC	18.02	19823750
21	Phosphorylation	TPMGNKPSGGGGGDD CCCCCCCCCCCCCCC	52.24	28889911
30	Phosphorylation	GGGGDDASSIHSKSS CCCCCCHHHHCCCCH	36.50	28152593
31	Phosphorylation	GGGDDASSIHSKSSQ CCCCCHHHHCCCCHH	26.49	28152593
34	Phosphorylation	DDASSIHSKSSQYLM CCHHHHCCCCHHHHH	32.34	28152593
53	Phosphorylation	DSMTLNESVSSIVAN CCCCCCHHHHHHHHC	26.65	28889911
55	Phosphorylation	MTLNESVSSIVANNQ CCCCHHHHHHHHCCC	24.51	21440633
56	Phosphorylation	TLNESVSSIVANNQA CCCHHHHHHHHCCCC	20.94	21440633
223	Phosphorylation	PTDESKMSLAPHEYK CCCHHHHCCCCCCCC	25.72	21551504
251	Phosphorylation	SGFVKFGSGSIQDIQ CCCEEECCCCHHHHH	32.28	30377154
253	Phosphorylation	FVKFGSGSIQDIQVI CEEECCCCHHHHHHH	20.83	30377154
282	Phosphorylation	ISKEITSTVIPKLEE CCHHHHHHHHHHHHH	17.50	21440633
286	Acetylation	ITSTVIPKLEELRKD HHHHHHHHHHHHHHH	58.36	24489116
302	Acetylation	RYKITEIKDLHGDFK HHHHHHHHHHCCCCC	48.26	24489116
344	Phosphorylation	GIGNDRASPTNKKPH CCCCCCCCCCCCCCC	32.90	19823750
346	Phosphorylation	GNDRASPTNKKPHKL CCCCCCCCCCCCCCC	58.12	19823750
356	Acetylation	KPHKLDPKHDPYLLK CCCCCCCCCCHHHHH	61.38	24489116
468	Phosphorylation	IPPPRKVSDVIYPHM CCCCCCHHHCCHHHC	29.24	25521595
472	Phosphorylation	RKVSDVIYPHMKSPL CCHHHCCHHHCCCHH	6.22	21440633
477	Phosphorylation	VIYPHMKSPLAKCIK CCHHHCCCHHHHHHH	19.99	28889911
531	Phosphorylation	STPNSTKSSAYSSSV CCCCCCCCCCCCCCE	21.93	21551504
532	Phosphorylation	TPNSTKSSAYSSSVS CCCCCCCCCCCCCEE	32.55	30377154
534	Phosphorylation	NSTKSSAYSSSVSIA CCCCCCCCCCCEEHH	15.84	27017623
535	Phosphorylation	STKSSAYSSSVSIAD CCCCCCCCCCEEHHH	18.82	23749301
536	Phosphorylation	TKSSAYSSSVSIADT CCCCCCCCCEEHHHH	23.29	20377248
537	Phosphorylation	KSSAYSSSVSIADTY CCCCCCCCEEHHHHH	17.59	28889911
539	Phosphorylation	SAYSSSVSIADTYAN CCCCCCEEHHHHHHC	17.63	20377248
543	Phosphorylation	SSVSIADTYANANNA CCEEHHHHHHCCCCH	18.60	28889911
560	Phosphorylation	NNHHRQASDVHNSST CCCCCCCHHCCCCCC	31.65	22369663
565	Phosphorylation	QASDVHNSSTTTGGT CCHHCCCCCCCCCCC	17.74	22369663
566	Phosphorylation	ASDVHNSSTTTGGTA CHHCCCCCCCCCCCC	34.78	22369663
567	Phosphorylation	SDVHNSSTTTGGTAG HHCCCCCCCCCCCCC	28.35	22369663
568	Phosphorylation	DVHNSSTTTGGTAGA HCCCCCCCCCCCCCC	25.95	22369663
569	Phosphorylation	VHNSSTTTGGTAGAN CCCCCCCCCCCCCCC	33.43	22369663
572	Phosphorylation	SSTTTGGTAGANGIR CCCCCCCCCCCCCCC	24.22	22369663
585	Phosphorylation	IRGIRKKSYLAPIMS CCCCCCCCCCCCCEE	28.54	21551504
607	Acetylation	LKDASSTKFVLVGKP CCCCCCCCEEEECCC	35.11	24489116
625	Phosphorylation	ENADVRKSSSSTYLS CCCCCCCCCCCCCCC	25.53	22369663
626	Phosphorylation	NADVRKSSSSTYLSG CCCCCCCCCCCCCCC	31.20	22369663
627	Phosphorylation	ADVRKSSSSTYLSGS CCCCCCCCCCCCCCC	33.52	22369663
628	Phosphorylation	DVRKSSSSTYLSGSS CCCCCCCCCCCCCCC	24.02	22369663
629	Phosphorylation	VRKSSSSTYLSGSSQ CCCCCCCCCCCCCCC	30.35	22369663
630	Phosphorylation	RKSSSSTYLSGSSQA CCCCCCCCCCCCCCC	10.79	22369663
632	Phosphorylation	SSSSTYLSGSSQASL CCCCCCCCCCCCCCC	26.64	20377248
634	Phosphorylation	SSTYLSGSSQASLPK CCCCCCCCCCCCCCC	18.85	22369663
635	Phosphorylation	STYLSGSSQASLPKY CCCCCCCCCCCCCCC	33.04	20377248
638	Phosphorylation	LSGSSQASLPKYGHE CCCCCCCCCCCCCCC	37.25	22369663
706	Acetylation	EPSEEELKHFKRWVQ CCCHHHHHHHHHHHH	50.72	24489116
720	Phosphorylation	QDLKNLTSFNDTKDR HHHHCCCCCCCHHHH	25.81	28889911
763	Phosphorylation	HTPCLTDSTFTLQDG CCCCEECCEEEECCC	21.86	19779198
764	Phosphorylation	TPCLTDSTFTLQDGT CCCEECCEEEECCCC	24.37	19779198
793	Phosphorylation	YIHIQNNSLADFDGN EEEEECCCCCCCCCC	32.27	17330950
804	Phosphorylation	FDGNGFRSKVNTPAI CCCCCCHHCCCCCCC	38.40	21551504
808	Phosphorylation	GFRSKVNTPAIDDYG CCHHCCCCCCCCCCC	19.65	22369663
814	Phosphorylation	NTPAIDDYGNLITVE CCCCCCCCCCEEEEE	12.26	22369663
819	Phosphorylation	DDYGNLITVERRPAQ CCCCCEEEEECCCCC	21.34	29688323
944	Phosphorylation	NNYTQRNSEGSSPCY CCCCCCCCCCCCCCC	45.59	22369663
947	Phosphorylation	TQRNSEGSSPCYNDD CCCCCCCCCCCCCHH	27.36	22369663
948	Phosphorylation	QRNSEGSSPCYNDDQ CCCCCCCCCCCCHHH	29.82	22369663
951	Phosphorylation	SEGSSPCYNDDQIRQ CCCCCCCCCHHHHHH	25.63	30377154
969	Phosphorylation	PLQMQPLSRTSSSSV CCCCCCCCCCCCCCC	39.95	22369663
971	Phosphorylation	QMQPLSRTSSSSVNV CCCCCCCCCCCCCEE	29.59	22369663
972	Phosphorylation	MQPLSRTSSSSVNVT CCCCCCCCCCCCEEE	27.41	22369663
973	Phosphorylation	QPLSRTSSSSVNVTA CCCCCCCCCCCEEEE	26.48	22369663
974	Phosphorylation	PLSRTSSSSVNVTAM CCCCCCCCCCEEEEE	37.76	22369663
975	Phosphorylation	LSRTSSSSVNVTAMR CCCCCCCCCEEEEEE	21.47	22369663
979	Phosphorylation	SSSSVNVTAMRSTSA CCCCCEEEEEEECCC	14.99	22369663
983	Phosphorylation	VNVTAMRSTSAGNSI CEEEEEEECCCCCCE	17.40	22369663
984	Phosphorylation	NVTAMRSTSAGNSIT EEEEEEECCCCCCEE	16.54	22890988
985	Phosphorylation	VTAMRSTSAGNSITA EEEEEECCCCCCEEC	35.11	22369663
989	Phosphorylation	RSTSAGNSITANAPV EECCCCCCEECCCCC	22.02	22369663
991	Phosphorylation	TSAGNSITANAPVVP CCCCCCEECCCCCCC	17.43	22890988
1009	Phosphorylation	VNNQNVKTVAADQSA ECCCCCEEEEECCCC	15.87	22369663
1015	Phosphorylation	KTVAADQSATAPSSP EEEEECCCCCCCCCC	28.30	22369663
1017	Phosphorylation	VAADQSATAPSSPTM EEECCCCCCCCCCCC	44.33	22369663
1020	Phosphorylation	DQSATAPSSPTMNSS CCCCCCCCCCCCCCC	46.62	22369663
1021	Phosphorylation	QSATAPSSPTMNSSV CCCCCCCCCCCCCCC	24.27	22369663
1023	Phosphorylation	ATAPSSPTMNSSVTT CCCCCCCCCCCCCEE	30.82	20377248
1026	Phosphorylation	PSSPTMNSSVTTINR CCCCCCCCCCEECCC	18.50	22369663
1027	Phosphorylation	SSPTMNSSVTTINRE CCCCCCCCCEECCCC	20.62	22369663
1029	Phosphorylation	PTMNSSVTTINRESP CCCCCCCEECCCCCC	24.73	22369663
1030	Phosphorylation	TMNSSVTTINRESPY CCCCCCEECCCCCCC	17.69	22369663
1035	Phosphorylation	VTTINRESPYQTLKK CEECCCCCCCCCHHH	26.18	21440633
1043	Phosphorylation	PYQTLKKTNSTGNVP CCCCHHHCCCCCCCC	32.58	22890988
1045	Phosphorylation	QTLKKTNSTGNVPCL CCHHHCCCCCCCCCE	42.81	22369663
1046	Phosphorylation	TLKKTNSTGNVPCLT CHHHCCCCCCCCCEE	34.54	22890988
1053	Phosphorylation	TGNVPCLTAEKTHAH CCCCCCEECCCCCCC	39.21	22369663
1070	Phosphorylation	FYKRGNNSAQNLTTS HHHCCCCCCCCCCCC	34.92	22369663
1075	Phosphorylation	NNSAQNLTTSSSTAS CCCCCCCCCCCCCCC	31.98	22890988
1076	Phosphorylation	NSAQNLTTSSSTASR CCCCCCCCCCCCCCC	29.76	22890988
1077	Phosphorylation	SAQNLTTSSSTASRV CCCCCCCCCCCCCCC	19.63	22890988
1078	Phosphorylation	AQNLTTSSSTASRVH CCCCCCCCCCCCCCC	29.62	22890988
1079	Phosphorylation	QNLTTSSSTASRVHP CCCCCCCCCCCCCCC	27.97	22890988
1080	Phosphorylation	NLTTSSSTASRVHPI CCCCCCCCCCCCCCC	30.51	22890988
1082	Phosphorylation	TTSSSTASRVHPIRK CCCCCCCCCCCCCHH	34.62	22890988
1095	Phosphorylation	RKHKKNVSFSSLNSL HHCCCCCCHHHHHHH	28.89	22369663
1097	Phosphorylation	HKKNVSFSSLNSLMF CCCCCCHHHHHHHHH	26.81	22369663
1098	Phosphorylation	KKNVSFSSLNSLMFS CCCCCHHHHHHHHHH	29.56	22369663
1101	Phosphorylation	VSFSSLNSLMFSKKG CCHHHHHHHHHHCCC	26.89	22369663
1105	Phosphorylation	SLNSLMFSKKGANHG HHHHHHHHCCCCCCC	21.35	23749301
1117	Phosphorylation	NHGGNLMTNQFMSGG CCCCCCCCCCCCCCC	29.09	27017623
1122	Phosphorylation	LMTNQFMSGGIQEDD CCCCCCCCCCCCCCC	34.85	27017623
1132	Phosphorylation	IQEDDGDSTNNDTIK CCCCCCCCCCCCCEE	38.27	24961812
1133	Phosphorylation	QEDDGDSTNNDTIKL CCCCCCCCCCCCEEE	42.66	21440633
1137	Phosphorylation	GDSTNNDTIKLNQSI CCCCCCCCEEECHHH	23.33	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ASK10_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ASK10_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ASK10_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSN8_YEAST	SSN8	physical	14555478
BMH2_YEAST	BMH2	physical	16554755
NUP84_YEAST	NUP84	genetic	17314980
RPB1_YEAST	RPO21	genetic	17314980
UME6_YEAST	UME6	genetic	17314980
RGP1_YEAST	RGP1	genetic	17314980
EAF1_YEAST	EAF1	genetic	17314980
PTA1_YEAST	PTA1	genetic	17314980
XRN1_YEAST	XRN1	genetic	17314980
SSN2_YEAST	SSN2	genetic	17314980
BMH1_YEAST	BMH1	physical	20489023
ERB1_YEAST	ERB1	physical	20489023
NOG1_YEAST	NOG1	physical	20489023
NSA1_YEAST	NSA1	physical	20489023
RGC1_YEAST	RGC1	physical	20489023
XRN1_YEAST	XRN1	genetic	20526336
TOR2_YEAST	TOR2	genetic	20526336
YG2A_YEAST	YGR067C	genetic	21127252
FPS1_YEAST	FPS1	genetic	22030956
KDX1_YEAST	KDX1	physical	24554767
FPS1_YEAST	FPS1	genetic	26274562
ASK10_YEAST	ASK10	physical	26024902
FPS1_YEAST	FPS1	genetic	27607883

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ASK10_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; SER-344; SER-625;SER-627; SER-628; THR-629; TYR-630; SER-793; THR-808; SER-947;SER-948; SER-969; SER-972; SER-973; SER-983; SER-985; SER-989;SER-1021; SER-1045 AND SER-1070, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344 AND SER-1070, ANDMASS SPECTROMETRY.	17287358 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-793 AND THR-1017, ANDMASS SPECTROMETRY.	17330950 [Abstract]
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-627 AND SER-985, ANDMASS SPECTROMETRY.	15665377 [Abstract]