| UniProt ID | EAF1_YEAST | |
|---|---|---|
| UniProt AC | Q06337 | |
| Protein Name | Chromatin modification-related protein EAF1 | |
| Gene Name | EAF1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 982 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.. | |
| Protein Sequence | MSSRPSSAVPNSASLSEDQSSDRSKFPKADDLIDERDRKLTELYCVSRLNQLLELTDENKLRKEIDAFLKKNDIRRGIRFDEASLPKLLHTAATPITKKKLKDVNLINVPNQRLSDSKMSRELPENSENVSVKSESHFVPSHDNSIRENMMDSLRPAEKTGGMWNKRPLESTMGGEEERHEKRQKMQSQSLESSNNSEMASLPISPRPPVPNALAHYTYYENIEYPPADPTEVQPAVKFKDPLIKNIMAKEIDTSDHYNENNVDALETVFLLMNDYIPSKIPQALPLAELKYMSQTLPLINLIPRAHKALTTNIINNALNEARITVVGSRIEELRRLGLWSLRQPKRFIDPWKQHNTHQNILLEEAKWMQADFKEGHKYKVAICTAMAQAIKDYWTYGEICCVKRKTLLPGKENKLSDDGRISEKSGRPSDTSRNDSDISIAGKDDIGIIANVDDITEKESAAANDNDENGKNEAGAKSDFDFADGLLSQEGAHDQIISSIDTKLLLKKPSSSSEVVLIQHEVAASSALIETEESKKELAPPFKLSIFVDELNTFEKTLIQDLPLYNGINEERPKKDDSLPFIPISKSVVSLDDNGFYKLLERQLIDEEPSISQLSKRRGMFYGNRRNHYLRPPAVPSLRYLQNRTPTIWLSEDDQELVKNINTYGYNWELISAHMTHRLTYSYLSNIERRTPWQCFERFVQLNERFNFSDLKGPRAHSAQQWLIEAHKFQQRQNRRISPLGVNTESIQRGHRRLRWASMFEAIRKCMKKRENTPRPNPTQPRKPLDCKNMKVPTPAEMSLLKAQRDEALRRDIQLRRTVKNRLQQRQQQSQQAHSSRAQSPIPSNGKSSSNLARNGQASAPRPNQKQYTEQDIIESYSRKLLEQKPDIGPEMALKAAKNYYRTLREQQQQLKQHQIQQQRQQLQEESSHVQQLQQLQPGSQAPPPKSSPSQSSLSNISNINSAPRIKSPTPQEILQRFQKQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 14 | Phosphorylation | SAVPNSASLSEDQSS CCCCCCCCCCCCCCC | 32.05 | 30377154 | |
| 20 | Phosphorylation | ASLSEDQSSDRSKFP CCCCCCCCCCHHHCC | 46.67 | 30377154 | |
| 94 | Phosphorylation | KLLHTAATPITKKKL HHHHHCCCCCCHHHC | 16.86 | 28152593 | |
| 97 | Phosphorylation | HTAATPITKKKLKDV HHCCCCCCHHHCCCC | 37.71 | 21440633 | |
| 115 | Phosphorylation | NVPNQRLSDSKMSRE CCCCCCCCCCHHCCC | 41.86 | 21440633 | |
| 117 | Phosphorylation | PNQRLSDSKMSRELP CCCCCCCCHHCCCCC | 27.21 | 21440633 | |
| 134 | Phosphorylation | SENVSVKSESHFVPS CCCCCCCCCCCCCCC | 42.02 | 28889911 | |
| 136 | Phosphorylation | NVSVKSESHFVPSHD CCCCCCCCCCCCCCC | 29.35 | 25371407 | |
| 141 | Phosphorylation | SESHFVPSHDNSIRE CCCCCCCCCCHHHHH | 37.86 | 19779198 | |
| 145 | Phosphorylation | FVPSHDNSIRENMMD CCCCCCHHHHHHHHH | 29.13 | 25371407 | |
| 171 | Phosphorylation | WNKRPLESTMGGEEE CCCCCCHHCCCCHHH | 31.23 | 21551504 | |
| 280 | Acetylation | MNDYIPSKIPQALPL HHCCCCCCCCCCCCH | 53.72 | 23572591 | |
| 423 | Phosphorylation | LSDDGRISEKSGRPS CCCCCCCCCCCCCCC | 37.30 | 27017623 | |
| 432 | Phosphorylation | KSGRPSDTSRNDSDI CCCCCCCCCCCCCCC | 33.64 | 21551504 | |
| 437 | Phosphorylation | SDTSRNDSDISIAGK CCCCCCCCCCEECCC | 40.15 | 28889911 | |
| 440 | Phosphorylation | SRNDSDISIAGKDDI CCCCCCCEECCCCCE | 16.04 | 21551504 | |
| 472 | Acetylation | NDNDENGKNEAGAKS CCCCCCCCCCCCCCC | 64.30 | 24489116 | |
| 489 | Phosphorylation | DFADGLLSQEGAHDQ CHHHHHHCCCCHHHH | 31.09 | 21440633 | |
| 588 | Phosphorylation | PFIPISKSVVSLDDN CCEECCCCEEECCCC | 22.44 | 21440633 | |
| 591 | Phosphorylation | PISKSVVSLDDNGFY ECCCCEEECCCCCHH | 24.75 | 28889911 | |
| 599 | Ubiquitination | LDDNGFYKLLERQLI CCCCCHHHHHHHHHC | 44.31 | 24961812 | |
| 613 | Phosphorylation | IDEEPSISQLSKRRG CCCCCCHHHHHHHCC | 29.43 | 28889911 | |
| 713 | Ubiquitination | RFNFSDLKGPRAHSA HCCHHHCCCCCCCCH | 72.38 | 24961812 | |
| 739 | Phosphorylation | QRQNRRISPLGVNTE HHHCCCCCCCCCCHH | 16.56 | 23749301 | |
| 841 | Phosphorylation | AHSSRAQSPIPSNGK HHHHHCCCCCCCCCC | 24.66 | 21551504 | |
| 845 | Phosphorylation | RAQSPIPSNGKSSSN HCCCCCCCCCCCHHH | 59.96 | 21440633 | |
| 848 | Acetylation | SPIPSNGKSSSNLAR CCCCCCCCCHHHCHH | 51.95 | 24489116 | |
| 849 | Phosphorylation | PIPSNGKSSSNLARN CCCCCCCCHHHCHHC | 40.16 | 21440633 | |
| 851 | Phosphorylation | PSNGKSSSNLARNGQ CCCCCCHHHCHHCCC | 42.84 | 21440633 | |
| 948 | Phosphorylation | SQAPPPKSSPSQSSL CCCCCCCCCCCHHHH | 53.94 | 21440633 | |
| 949 | Phosphorylation | QAPPPKSSPSQSSLS CCCCCCCCCCHHHHH | 34.40 | 22369663 | |
| 951 | Phosphorylation | PPPKSSPSQSSLSNI CCCCCCCCHHHHHCC | 44.64 | 22369663 | |
| 953 | Phosphorylation | PKSSPSQSSLSNISN CCCCCCHHHHHCCCC | 37.27 | 22369663 | |
| 954 | Phosphorylation | KSSPSQSSLSNISNI CCCCCHHHHHCCCCC | 28.34 | 22369663 | |
| 956 | Phosphorylation | SPSQSSLSNISNINS CCCHHHHHCCCCCCC | 33.78 | 22369663 | |
| 959 | Phosphorylation | QSSLSNISNINSAPR HHHHHCCCCCCCCCC | 35.59 | 22369663 | |
| 963 | Phosphorylation | SNISNINSAPRIKSP HCCCCCCCCCCCCCC | 35.53 | 22369663 | |
| 969 | Phosphorylation | NSAPRIKSPTPQEIL CCCCCCCCCCHHHHH | 31.47 | 22369663 | |
| 971 | Phosphorylation | APRIKSPTPQEILQR CCCCCCCCHHHHHHH | 44.70 | 22369663 | |
| 981 | Ubiquitination | EILQRFQKQ------ HHHHHHHHC------ | 100.00 | 24961812 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EAF1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EAF1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EAF1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-94; SER-591; SER-613;SER-841; SER-951 AND THR-971, AND MASS SPECTROMETRY. | |
