| UniProt ID | PUS3_YEAST | |
|---|---|---|
| UniProt AC | P31115 | |
| Protein Name | tRNA pseudouridine(38/39) synthase | |
| Gene Name | DEG1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 442 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Formation of pseudouridines at positions 38 and 39 in the anticodon stem and loop of transfer RNAs.. | |
| Protein Sequence | MSNFIRRLVGKMKAISTGTNAIVSKKDSIYANWSKEQLIRRITELENANKPHSEKFQHIEDNKKRKISQEEVTRSKAKKAPKKFDFSKHNTRFIALRFAYLGWNYNGLAVQKEYTPLPTVEGTILEAMNKCKLVPSMVLQDYKFSRCGRTDKGVSAMNQVISLEVRSNLTDEEQRDPTNDSREIPYVHVLNQLLPDDIRISAVCLRPPPNFDARFSCVHRHYKYIFNGKNLNIEKMSKAASYFVGERDFRNFCKLDGSKQITNFKRTIISSKILPLSETFYCFDLVGSAFLWHQVRCMMAILFLVGQSLEVPEIVLRLTDIEKTPQRPVYEMANDIPLLLYDCKFPEMDWQEPTVDDYKAIKFTTATEALTLHYELKAAVCNIFKDVLPTANTNNFSKTIINLGDGRGKVVGTYVKLEDRSVMEPVEVVNAKYSKKKNNKNK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 55 | Acetylation | ANKPHSEKFQHIEDN CCCCCCHHCCCHHHH | 54.03 | 22865919 | |
| 68 | Phosphorylation | DNKKRKISQEEVTRS HHHCCCCCHHHHHHH | 34.28 | 27738172 | |
| 73 | Phosphorylation | KISQEEVTRSKAKKA CCCHHHHHHHHHHHC | 32.29 | 30377154 | |
| 83 | Acetylation | KAKKAPKKFDFSKHN HHHHCCCCCCCCCCC | 49.45 | 22865919 | |
| 167 | Phosphorylation | VISLEVRSNLTDEEQ HEEEEHHHCCCCHHH | 41.17 | 27017623 | |
| 170 | Phosphorylation | LEVRSNLTDEEQRDP EEHHHCCCCHHHCCC | 45.69 | 27017623 | |
| 178 | Phosphorylation | DEEQRDPTNDSREIP CHHHCCCCCCCCCCC | 56.82 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PUS3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PUS3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PUS3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, AND MASSSPECTROMETRY. | |
