AIM3_YEAST - dbPTM
AIM3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AIM3_YEAST
UniProt AC P38266
Protein Name Altered inheritance of mitochondria protein 3
Gene Name AIM3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 947
Subcellular Localization Membrane raft
Peripheral membrane protein . Localize within detergent-insoluble glycolipid-enriched membranes.
Protein Description
Protein Sequence MGFWENNKDSITSGLKSAGKYGYQGTKYVAKTGYKASKKHYNNSKARRERKSGKKNSSDEEYDSEDEMEYERKPTDIRSLKDPKSFPPPPLKPGQKTYTGQQQQQMPNGQASYAFQGAYQGQPGAGSTEQSQYAQPQYNQYPQQQLQQGVMPQQQQLQQGVVPQQPPIYGEQVPPYGSNSNATSYQSLPQQNQPQNAIPSQVSLNSASQQSTGFVSQNLQYGTQSSNPAPSPSFQNGLQCHQQPQYVSHGSTNLGQSQFPSGQQQQPTTQFGQQVLPSPAQPQQQQQGQPLPPPRGQVILPAPGEPLSNGFGQQQQQQQQQQQPLNQNNALLPQMNVEGVSGMAAVQPVYGQAMSSTTNMQDSNPSYGASPMQGQPPVGGQPPVPVRMQPQPPQPMQQGNIYPIEPSLDSTGSTPHFEVTPFDPDAPAPKPKIDIPTVDVSSLPPPPTHRDRGAVVHQEPAPSGKIQPNTTSSAASLPAKHSRTTTADNERNSGNKENDESTSKSSILGHYDVDVNIMPPPKPFRHGLDSVPSEHTTKNAPERAVPILPPRNNVEPPPPPSRGNFERTESVLSTNAANVQEDPISNFLPPPKPFRHTETKQNQNSKASPVEMKGEVLPGHPSEEDRNVEPSLVPQSKPQSQSQFRRAHMETQPIQNFQPPPKPFRRSQSSNSSDSSYTIDGPEANHGRGRGRIAKHHDGDEYNPKSENSTENGRLGDAPNSFIRKRAPTPPAPSRSEKLHEGTITSEVDSSKDANKYEKSIPPVTSSIQAQQSTKKAPPPVVKPKPRNFSLKANEYPKELTREATGQDEVLNSITNELSHIKLRKTNVNLEKLGGSKKVKDSSPVPSDLDEKYVSASGSITPPRPPPSRSSPKKVPPVVPKKNDNLKKKPPVVPKKKPLLKSLEPRPIEMERAYSGDISAADDNLNPFERYKRNVVPQEDDRLHKLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20AcetylationSGLKSAGKYGYQGTK
HHHHHHCCCCCCCCC		34.9125381059
27AcetylationKYGYQGTKYVAKTGY
CCCCCCCCEECCCCH		44.5522865919
57PhosphorylationRKSGKKNSSDEEYDS
HHHCCCCCCHHHCCC		48.3122369663
58PhosphorylationKSGKKNSSDEEYDSE
HHCCCCCCHHHCCCH		59.4422369663
62PhosphorylationKNSSDEEYDSEDEME
CCCCHHHCCCHHHHH		23.7922369663
64PhosphorylationSSDEEYDSEDEMEYE
CCHHHCCCHHHHHHC		46.1522369663
70PhosphorylationDSEDEMEYERKPTDI
CCHHHHHHCCCCCCH		21.5221440633
75PhosphorylationMEYERKPTDIRSLKD
HHHCCCCCCHHHCCC		47.2824961812
79PhosphorylationRKPTDIRSLKDPKSF
CCCCCHHHCCCCCCC		39.8524961812
463PhosphorylationVHQEPAPSGKIQPNT
EECCCCCCCCCCCCC		55.6223749301
465UbiquitinationQEPAPSGKIQPNTTS
CCCCCCCCCCCCCCC		42.3723749301
470PhosphorylationSGKIQPNTTSSAASL
CCCCCCCCCCCCCCC		34.4428132839
471PhosphorylationGKIQPNTTSSAASLP
CCCCCCCCCCCCCCC		27.5920377248
472PhosphorylationKIQPNTTSSAASLPA
CCCCCCCCCCCCCCC		18.8828152593
473PhosphorylationIQPNTTSSAASLPAK
CCCCCCCCCCCCCCC		26.2622369663
476PhosphorylationNTTSSAASLPAKHSR
CCCCCCCCCCCCCCC		34.3022369663
482PhosphorylationASLPAKHSRTTTADN
CCCCCCCCCCCCCCC		30.5323749301
493PhosphorylationTADNERNSGNKENDE
CCCCCCCCCCCCCCC		50.3828889911
608PhosphorylationQNQNSKASPVEMKGE
CCCCCCCCCCEECCE		32.9628889911
667PhosphorylationPPKPFRRSQSSNSSD
CCCCCCCCCCCCCCC		30.1122369663
669PhosphorylationKPFRRSQSSNSSDSS
CCCCCCCCCCCCCCC		32.5022369663
670PhosphorylationPFRRSQSSNSSDSSY
CCCCCCCCCCCCCCC		32.8523749301
672PhosphorylationRRSQSSNSSDSSYTI
CCCCCCCCCCCCCEE		37.1522369663
673PhosphorylationRSQSSNSSDSSYTID
CCCCCCCCCCCCEEC		45.8422369663
675PhosphorylationQSSNSSDSSYTIDGP
CCCCCCCCCCEECCC		27.4822369663
676PhosphorylationSSNSSDSSYTIDGPE
CCCCCCCCCEECCCC		31.1422369663
677PhosphorylationSNSSDSSYTIDGPEA
CCCCCCCCEECCCCC		16.2122369663
678PhosphorylationNSSDSSYTIDGPEAN
CCCCCCCEECCCCCC		17.9722369663
695AcetylationRGRGRIAKHHDGDEY
CCCCCCCCCCCCCCC		38.8225381059
709PhosphorylationYNPKSENSTENGRLG
CCCCCCCCCCCCCCC		32.8021440633
710PhosphorylationNPKSENSTENGRLGD
CCCCCCCCCCCCCCC		45.0829136822
721PhosphorylationRLGDAPNSFIRKRAP
CCCCCCCCHHHHCCC		22.4622369663
729PhosphorylationFIRKRAPTPPAPSRS
HHHHCCCCCCCCCHH		40.7022369663
734PhosphorylationAPTPPAPSRSEKLHE
CCCCCCCCHHHCCCC		51.0122369663
736PhosphorylationTPPAPSRSEKLHEGT
CCCCCCHHHCCCCCC		43.3419823750
750PhosphorylationTITSEVDSSKDANKY
CEEECCCCCCCHHHH		44.4522369663
751PhosphorylationITSEVDSSKDANKYE
EEECCCCCCCHHHHH		30.0522369663
756AcetylationDSSKDANKYEKSIPP
CCCCCHHHHHHCCCC		57.4124489116
790PhosphorylationKPKPRNFSLKANEYP
CCCCCCCCCCCCCCC		32.2923749301
792AcetylationKPRNFSLKANEYPKE
CCCCCCCCCCCCCHH		48.2225381059
796PhosphorylationFSLKANEYPKELTRE
CCCCCCCCCHHHHHH		21.2919779198
801PhosphorylationNEYPKELTREATGQD
CCCCHHHHHHHHCCH		27.7922369663
805PhosphorylationKELTREATGQDEVLN
HHHHHHHHCCHHHHH		30.5322369663
813PhosphorylationGQDEVLNSITNELSH
CCHHHHHHHHHHHHC		26.9922369663
815PhosphorylationDEVLNSITNELSHIK
HHHHHHHHHHHHCCE		23.5922369663
819PhosphorylationNSITNELSHIKLRKT
HHHHHHHHCCEECCC		19.5822369663
826PhosphorylationSHIKLRKTNVNLEKL
HCCEECCCCCCHHHH		37.6625521595
842PhosphorylationGSKKVKDSSPVPSDL
CCCCCCCCCCCCCCC		30.7222369663
843PhosphorylationSKKVKDSSPVPSDLD
CCCCCCCCCCCCCCC		39.8022369663
847PhosphorylationKDSSPVPSDLDEKYV
CCCCCCCCCCCCCCC		51.5522369663
853PhosphorylationPSDLDEKYVSASGSI
CCCCCCCCCCCCCCC		9.5122369663
855PhosphorylationDLDEKYVSASGSITP
CCCCCCCCCCCCCCC		17.3922369663
857PhosphorylationDEKYVSASGSITPPR
CCCCCCCCCCCCCCC		26.1022369663
859PhosphorylationKYVSASGSITPPRPP
CCCCCCCCCCCCCCC		22.3122369663
861PhosphorylationVSASGSITPPRPPPS
CCCCCCCCCCCCCCC		29.0122369663
868PhosphorylationTPPRPPPSRSSPKKV
CCCCCCCCCCCCCCC		51.0422369663
870PhosphorylationPRPPPSRSSPKKVPP
CCCCCCCCCCCCCCC		56.1622369663
871PhosphorylationRPPPSRSSPKKVPPV
CCCCCCCCCCCCCCC		39.3622369663
902PhosphorylationKKKPLLKSLEPRPIE
CCCCCHHHCCCCCCC		37.6224961812
914PhosphorylationPIEMERAYSGDISAA
CCCCHHHHCCCCCCC		21.2922369663
915PhosphorylationIEMERAYSGDISAAD
CCCHHHHCCCCCCCC		29.0722369663
919PhosphorylationRAYSGDISAADDNLN
HHHCCCCCCCCCCCC		23.3422369663
931PhosphorylationNLNPFERYKRNVVPQ
CCCHHHHHHHCCCCC		13.7022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AIM3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AIM3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AIM3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RV167_YEASTRVS167physical
11489916
RV161_YEASTRVS161physical
16554755
RV167_YEASTRVS167physical
16554755
PIL1_YEASTPIL1physical
16554755
LSP1_YEASTLSP1physical
16554755
RV167_YEASTRVS167physical
11283351
LSB1_YEASTLSB1physical
11283351
AIM3_YEASTAIM3physical
19345193
RNH2A_YEASTRNH201genetic
21035341
CAPZA_YEASTCAP1genetic
21035341
CAPZB_YEASTCAP2genetic
21035341
PMP3_YEASTPMP3genetic
21035341
SMF1_YEASTSMF1genetic
21035341
MSC1_YEASTMSC1genetic
21035341
SUL1_YEASTSUL1genetic
21035341
XRN1_YEASTXRN1genetic
21035341
RV161_YEASTRVS161genetic
21035341
SLA1_YEASTSLA1genetic
21035341
VRP1_YEASTVRP1genetic
21035341
PACC_YEASTRIM101genetic
21035341
SPEE_YEASTSPE3genetic
21035341
LAM1_YEASTYSP1genetic
21035341
YMC0_YEASTYML020Wgenetic
21035341
COQ11_YEASTYLR290Cgenetic
21035341
HPRT_YEASTHPT1genetic
21035341
AP3S_YEASTAPS3genetic
21035341
SIN3_YEASTSIN3genetic
21035341
NSG1_YEASTNSG1genetic
21035341
CYC2_YEASTCYC2genetic
21035341
BUD31_YEASTBUD31genetic
21035341
MED20_YEASTSRB2genetic
21035341
HXT2_YEASTHXT2genetic
21035341
SGF73_YEASTSGF73genetic
21035341
YP027_YEASTYPR027Cgenetic
21035341
FSF1_YEASTFSF1genetic
21035341
TWF1_YEASTTWF1genetic
21035341
YO268_YEASTYOR268Cgenetic
21035341
PDR10_YEASTPDR10genetic
21035341
YFL5_YEASTYFR045Wgenetic
21035341
TDA11_YEASTTDA11genetic
21035341
SERC_YEASTSER1genetic
21035341
MEP3_YEASTMEP3genetic
21035341
MPH1_YEASTMPH1genetic
21035341
SWI4_YEASTSWI4genetic
21035341
CSR2_YEASTCSR2genetic
21035341
AQY1_YEASTAQY1genetic
21035341
YHT8_YEASTYHR138Cgenetic
21035341
SHE4_YEASTSHE4genetic
21035341
MAL32_YEASTMAL32genetic
21035341
YAK1_YEASTYAK1genetic
21035341
RRT5_YEASTRRT5genetic
21035341
AXL2_YEASTAXL2genetic
21035341
RS14B_YEASTRPS14Bgenetic
21035341
YJC7_YEASTYJL027Cgenetic
21035341
FLO11_YEASTFLO11genetic
21035341
GET3_YEASTGET3genetic
21035341
RS3A1_YEASTRPS1Agenetic
21035341
ENO1_YEASTENO1genetic
21035341
UME6_YEASTUME6genetic
21035341
KEL3_YEASTKEL3genetic
21035341
PCL8_YEASTPCL8genetic
21035341
QCR2_YEASTQCR2genetic
21035341
PRY2_YEASTPRY2genetic
21035341
YME1_YEASTYME1genetic
21035341
YL287_YEASTYLR287Cgenetic
21035341
NBP2_YEASTNBP2genetic
21035341
YP147_YEASTYPR147Cgenetic
21035341
BSC6_YEASTBSC6genetic
21035341
PUS3_YEASTDEG1genetic
21035341
NEJ1_YEASTNEJ1genetic
21035341
YEY6_YEASTYER156Cgenetic
21035341
YD218_YEASTYDL218Wgenetic
21035341
TBP7_YEASTYTA7genetic
21035341
BUL1_YEASTBUL1genetic
21035341
SKI7_YEASTSKI7genetic
21035341
VTC2_YEASTVTC2genetic
21035341
ZDS1_YEASTZDS1genetic
21035341
YO159_YEASTYOL159Cgenetic
21035341
DAS1_YEASTDAS1genetic
21035341
ARK1_YEASTARK1genetic
21035341
MBP1_YEASTMBP1genetic
21035341
SGM1_YEASTSGM1genetic
21035341
DGR2_YEASTDGR2genetic
21035341
ATPA_YEASTATP1physical
23333351
RXT3_YEASTRXT3genetic
27708008
KEL1_YEASTKEL1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
MPCP_YEASTMIR1genetic
27708008
ARP2_YEASTARP2genetic
27708008
PDC2_YEASTPDC2genetic
27708008
ACT_YEASTACT1genetic
27708008
RRP4_YEASTRRP4genetic
27708008
ARPC5_YEASTARC15genetic
27708008
NSE1_YEASTNSE1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
PROF_YEASTPFY1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
RV161_YEASTRVS161genetic
27708008
BRE1_YEASTBRE1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
PMP3_YEASTPMP3genetic
27708008
SPS2_YEASTSPS2genetic
27708008
RAD4_YEASTRAD4genetic
27708008
XRN1_YEASTXRN1genetic
27708008
NEM1_YEASTNEM1genetic
27708008
CAPZB_YEASTCAP2genetic
27708008
ICE2_YEASTICE2genetic
27708008
AP3S_YEASTAPS3genetic
27708008
CAPZA_YEASTCAP1genetic
27708008
MRT4_YEASTMRT4genetic
27708008
VRP1_YEASTVRP1genetic
27708008
DATI_YEASTDAT1genetic
27708008
MSC1_YEASTMSC1genetic
27708008
RNH2A_YEASTRNH201genetic
27708008
SIN3_YEASTSIN3genetic
27708008
SMF1_YEASTSMF1genetic
27708008
ELP4_YEASTELP4genetic
27708008
KA120_YEASTKAP120genetic
27708008
POC4_YEASTPOC4genetic
27708008
PP2B1_YEASTCNA1physical
24930733
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AIM3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57; SER-58; SER-64;SER-476; THR-729; SER-842; SER-843; SER-847; THR-861; TYR-914; SER-915AND SER-919, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-669; THR-805; SER-842AND SER-843, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-805 AND SER-915, ANDMASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-729 AND THR-826, ANDMASS SPECTROMETRY.

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