RNH2A_YEAST - dbPTM
RNH2A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RNH2A_YEAST
UniProt AC P53942
Protein Name Ribonuclease H2 subunit A
Gene Name RNH201
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 307
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes..
Protein Sequence MVPPTVEASLESPYTKSYFSPVPSALLEQNDSPIIMGIDEAGRGPVLGPMVYAVAYSTQKYQDETIIPNYEFDDSKKLTDPIRRMLFSKIYQDNEELTQIGYATTCITPLDISRGMSKFPPTRNYNLNEQAHDVTMALIDGVIKQNVKLSHVYVDTVGPPASYQKKLEQRFPGVKFTVAKKADSLYCMVSVASVVAKVTRDILVESLKRDPDEILGSGYPSDPKTVAWLKRNQTSLMGWPANMVRFSWQTCQTLLDDASKNSIPIKWEEQYMDSRKNAAQKTKQLQLQMVAKPVRRKRLRTLDNWYR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
52PhosphorylationPVLGPMVYAVAYSTQ
CCHHHHHHHHHHCCC
6.7927017623
58PhosphorylationVYAVAYSTQKYQDET
HHHHHHCCCCCCCCC
19.1927017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RNH2A_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RNH2A_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RNH2A_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RNH2B_YEASTRNH202physical
16554755
XRS2_YEASTXRS2genetic
17314980
TAF12_YEASTTAF12genetic
17314980
ESC2_YEASTESC2genetic
17314980
MMS22_YEASTMMS22genetic
17314980
RAD55_YEASTRAD55genetic
17314980
TAF7_YEASTTAF7genetic
17314980
DDR48_YEASTDDR48genetic
17314980
CUL8_YEASTRTT101genetic
19061648
NMD5_YEASTNMD5genetic
19061648
RAD52_YEASTRAD52genetic
19061648
CAK1_YEASTCAK1genetic
19061648
SLX5_YEASTSLX5genetic
19061648
HMT1_YEASTHMT1genetic
19061648
EI2BA_YEASTGCN3genetic
19061648
THP1_YEASTTHP1genetic
19061648
SLX8_YEASTSLX8genetic
19061648
AIM3_YEASTAIM3genetic
21035341
DPOE_YEASTPOL2genetic
21414850
MSH6_YEASTMSH6genetic
21414850
MSH3_YEASTMSH3genetic
21414850
TOP1_YEASTTOP1genetic
21700875
RNH2C_YEASTRNH203physical
22004424
RNH2B_YEASTRNH202physical
22004424
MSH2_YEASTMSH2genetic
22139012
RNH1_YEASTRNH1genetic
22244334
HPR1_YEASTHPR1genetic
22244334
MMS2_YEASTMMS2genetic
22244334
REV1_YEASTREV1genetic
22244334
REV7_YEASTREV7genetic
22244334
DPOZ_YEASTREV3genetic
22244334
POLH_YEASTRAD30genetic
22244334
RAD51_YEASTRAD51genetic
22244334
RAD52_YEASTRAD52genetic
22244334
APN1_YEASTAPN1genetic
22244334
APN2_YEASTAPN2genetic
22244334
TOP1_YEASTTOP1genetic
23375499
RNH1_YEASTRNH1genetic
26400613
SEC62_YEASTSEC62genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RFA1_YEASTRFA1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
NSE4_YEASTNSE4genetic
27708008
MAK21_YEASTMAK21genetic
27708008
NSE3_YEASTNSE3genetic
27708008
SMT3_YEASTSMT3genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRS8_YEASTRPT6genetic
27708008
CDC20_YEASTCDC20genetic
27708008
COPB2_YEASTSEC27genetic
27708008
CDC12_YEASTCDC12genetic
27708008
DNA2_YEASTDNA2genetic
27708008
KTHY_YEASTCDC8genetic
27708008
CDC11_YEASTCDC11genetic
27708008
NSE1_YEASTNSE1genetic
27708008
CDC3_YEASTCDC3genetic
27708008
SMC6_YEASTSMC6genetic
27708008
NSE5_YEASTNSE5genetic
27708008
RNA1_YEASTRNA1genetic
27708008
TBF1_YEASTTBF1genetic
27708008
CHK1_YEASTCHK1genetic
27708008
RNQ1_YEASTRNQ1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
PEX19_YEASTPEX19genetic
27708008
CYK3_YEASTCYK3genetic
27708008
HOSC_YEASTLYS20genetic
27708008
XRS2_YEASTXRS2genetic
27708008
AIM11_YEASTAIM11genetic
27708008
TDA3_YEASTTDA3genetic
27708008
ASF1_YEASTASF1genetic
27708008
DPOD3_YEASTPOL32genetic
27708008
FEN1_YEASTRAD27genetic
27708008
RT109_YEASTRTT109genetic
27708008
TOP3_YEASTTOP3genetic
27708008
MMS22_YEASTMMS22genetic
27708008
VID22_YEASTVID22genetic
27708008
RAD52_YEASTRAD52genetic
27708008
SGS1_YEASTSGS1genetic
27708008
MRE11_YEASTMRE11genetic
27708008
RMI1_YEASTRMI1genetic
27708008
TOP1_YEASTTOP1genetic
27257064
RIF2_YEASTRIF2physical
28666126
RIF1_YEASTRIF1physical
28666126
DPOE_YEASTPOL2genetic
28325498
TOP1_YEASTTOP1genetic
28325498
TOP1_YEASTTOP1genetic
28268090
RNH1_YEASTRNH1genetic
28268090
DPOE_YEASTPOL2genetic
28268090
FCY1_YEASTFCY1genetic
28923949
EXO1_YEASTEXO1genetic
28923949
RAD1_YEASTRAD1genetic
28923949
RAD2_YEASTRAD2genetic
28923949
MLH1_YEASTMLH1genetic
28923949
MLH3_YEASTMLH3genetic
28923949
DPOE_YEASTPOL2genetic
25751426
DPOD_YEASTPOL3genetic
25751426
DPOA_YEASTPOL1genetic
25751426
TOP1_YEASTTOP1genetic
25751426
RNH1_YEASTRNH1genetic
25751426
TOP1_YEASTTOP1genetic
27932446
DPOE_YEASTPOL2genetic
27932446
RAD51_YEASTRAD51genetic
27932446
TOP1_YEASTTOP1genetic
26400612
DPOD_YEASTPOL3genetic
26400612
DPOA_YEASTPOL1genetic
26400612
RNH1_YEASTRNH1genetic
29281624
SMC6_YEASTSMC6genetic
29281624
SMC5_YEASTSMC5genetic
29281624
MPH1_YEASTMPH1genetic
29281624

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RNH2A_YEAST

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Related Literatures of Post-Translational Modification

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