| UniProt ID | SGS1_YEAST | |
|---|---|---|
| UniProt AC | P35187 | |
| Protein Name | ATP-dependent helicase SGS1 {ECO:0000303|PubMed:7969174} | |
| Gene Name | SGS1 {ECO:0000303|PubMed:7969174} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1447 | |
| Subcellular Localization | Nucleus, nucleolus . Localizes to S-phase-specific nuclear foci (PubMed:10640278). | |
| Protein Description | ATP-dependent DNA helicase able to unwind duplex DNA or DNA- RNA heteroduplex. [PubMed: 9545297 Displacement of the DNA strand occurs in the 3' to 5' direction with respect to the single-stranded DNA flanking the duplex] | |
| Protein Sequence | MVTKPSHNLRREHKWLKETATLQEDKDFVFQAIQKHIANKRPKTNSPPTTPSKDECGPGTTNFITSIPASGPTNTATKQHEVMQTLSNDTEWLSYTATSNQYADVPMVDIPASTSVVSNPRTPNGSKTHNFNTFRPHMASSLVENDSSRNLGSRNNNKSVIDNSSIGKQLENDIKLEVIRLQGSLIMALKEQSKLLLQKCSIIESTSLSEDAKRLQLSRDIRPQLSNMSIRIDSLEKEIIKAKKDGMSKDQSKGRSQVSSQDDNIISSILPSPLEYNTSSRNSNLTSTTATTVTKALAITGAKQNITNNTGKNSNNDSNNDDLIQVLDDEDDIDCDPPVILKEGAPHSPAFPHLHMTSEEQDELTRRRNMRSREPVNYRIPDRDDPFDYVMGKSLRDDYPDVEREEDELTMEAEDDAHSSYMTTRDEEKEENELLNQSDFDFVVNDDLDPTQDTDYHDNMDVSANIQESSQEGDTRSTITLSQNKNVQVILSSPTAQSVPSNGQNQIGVEHIDLLEDDLEKDAILDDSMSFSFGRQHMPMSHSDLELIDSEKENEDFEEDNNNNGIEYLSDSDLERFDEERENRTQVADIQELDNDLKIITERKLTGDNEHPPPSWSPKIKREKSSVSQKDEEDDFDDDFSLSDIVSKSNLSSKTNGPTYPWSDEVLYRLHEVFKLPGFRPNQLEAVNATLQGKDVFVLMPTGGGKSLCYQLPAVVKSGKTHGTTIVISPLISLMQDQVEHLLNKNIKASMFSSRGTAEQRRQTFNLFINGLLDLVYISPEMISASEQCKRAISRLYADGKLARIVVDEAHCVSNWGHDFRPDYKELKFFKREYPDIPMIALTATASEQVRMDIIHNLELKEPVFLKQSFNRTNLYYEVNKKTKNTIFEICDAVKSRFKNQTGIIYCHSKKSCEQTSAQMQRNGIKCAYYHAGMEPDERLSVQKAWQADEIQVICATVAFGMGIDKPDVRFVYHFTVPRTLEGYYQETGRAGRDGNYSYCITYFSFRDIRTMQTMIQKDKNLDRENKEKHLNKLQQVMAYCDNVTDCRRKLVLSYFNEDFDSKLCHKNCDNCRNSANVINEERDVTEPAKKIVKLVESIQNERVTIIYCQDVFKGSRSSKIVQANHDTLEEHGIGKSMQKSEIERIFFHLITIRVLQEYSIMNNSGFASSYVKVGPNAKKLLTGKMEIKMQFTISAPNSRPSTSSSFQANEDNIPVIAQKSTTIGGNVAANPPRFISAKEHLRSYTYGGSTMGSSHPITLKNTSDLRSTQELNNLRMTYERLRELSLNLGNRMVPPVGNFMPDSILKKMAAILPMNDSAFATLGTVEDKYRRRFKYFKATIADLSKKRSSEDHEKYDTILNDEFVNRAAASSNGIAQSTGTKSKFFGANLNEAKENEQIINQIRQSQLPKNTTSSKSGTRSISKSSKKSANGRRGFRNYRGHYRGRK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | Acetylation | IQKHIANKRPKTNSP HHHHHHCCCCCCCCC | 62.14 | 25381059 | |
| 44 | Phosphorylation | IANKRPKTNSPPTTP HHCCCCCCCCCCCCC | 43.54 | 20377248 | |
| 46 | Phosphorylation | NKRPKTNSPPTTPSK CCCCCCCCCCCCCCC | 37.17 | 21440633 | |
| 49 | Phosphorylation | PKTNSPPTTPSKDEC CCCCCCCCCCCCCCC | 55.51 | 28889911 | |
| 50 | Phosphorylation | KTNSPPTTPSKDECG CCCCCCCCCCCCCCC | 31.19 | 23749301 | |
| 52 | Phosphorylation | NSPPTTPSKDECGPG CCCCCCCCCCCCCCC | 51.12 | 21440633 | |
| 60 | Phosphorylation | KDECGPGTTNFITSI CCCCCCCCCCEEEEC | 23.00 | 21440633 | |
| 66 | Phosphorylation | GTTNFITSIPASGPT CCCCEEEECCCCCCC | 23.04 | 19779198 | |
| 159 | Phosphorylation | GSRNNNKSVIDNSSI CCCCCCCCCCCCCHH | 26.82 | 23749301 | |
| 164 | Phosphorylation | NKSVIDNSSIGKQLE CCCCCCCCHHHHHHC | 21.42 | 30377154 | |
| 256 | Phosphorylation | KDQSKGRSQVSSQDD CCCCCCCCCCCCCCC | 43.53 | 27017623 | |
| 259 | Phosphorylation | SKGRSQVSSQDDNII CCCCCCCCCCCCCHH | 18.04 | 21440633 | |
| 260 | Phosphorylation | KGRSQVSSQDDNIIS CCCCCCCCCCCCHHH | 38.48 | 21440633 | |
| 267 | Phosphorylation | SQDDNIISSILPSPL CCCCCHHHHCCCCCC | 13.92 | 19779198 | |
| 314 | Phosphorylation | TNNTGKNSNNDSNND CCCCCCCCCCCCCCC | 40.26 | 21551504 | |
| 482 | Phosphorylation | TRSTITLSQNKNVQV CCCEEEEECCCCEEE | 24.05 | 23749301 | |
| 492 | Phosphorylation | KNVQVILSSPTAQSV CCEEEEEECCCCCCC | 24.13 | 21440633 | |
| 493 | Phosphorylation | NVQVILSSPTAQSVP CEEEEEECCCCCCCC | 23.87 | 21440633 | |
| 498 | Phosphorylation | LSSPTAQSVPSNGQN EECCCCCCCCCCCCC | 33.27 | 21551504 | |
| 615 | Phosphorylation | DNEHPPPSWSPKIKR CCCCCCCCCCCCCCC | 46.06 | 21440633 | |
| 617 | Phosphorylation | EHPPPSWSPKIKREK CCCCCCCCCCCCCCC | 22.20 | 21440633 | |
| 621 | Sumoylation | PSWSPKIKREKSSVS CCCCCCCCCCCCCCC | 61.71 | - | |
| 626 | Phosphorylation | KIKREKSSVSQKDEE CCCCCCCCCCCCCCC | 36.53 | 21440633 | |
| 628 | Phosphorylation | KREKSSVSQKDEEDD CCCCCCCCCCCCCCC | 33.20 | 21551504 | |
| 641 | Phosphorylation | DDFDDDFSLSDIVSK CCCCCCCCHHHHHHH | 33.68 | 21440633 | |
| 643 | Phosphorylation | FDDDFSLSDIVSKSN CCCCCCHHHHHHHHC | 24.88 | 24961812 | |
| 750 | Phosphorylation | LNKNIKASMFSSRGT HCCCCCHHHHHCCCC | 18.50 | 28889911 | |
| 831 | Sumoylation | YKELKFFKREYPDIP HHHHHHHHCCCCCCC | 47.67 | - | |
| 843 | Phosphorylation | DIPMIALTATASEQV CCCEEEEECCCCHHH | 16.97 | 28889911 | |
| 1185 | Acetylation | AKKLLTGKMEIKMQF HHHHHCCCEEEEEEE | 28.29 | 24489116 | |
| 1244 | Phosphorylation | SAKEHLRSYTYGGST CHHHHHHHCCCCCCC | 28.34 | 27017623 | |
| 1247 | Phosphorylation | EHLRSYTYGGSTMGS HHHHHCCCCCCCCCC | 15.97 | 27017623 | |
| 1254 | Phosphorylation | YGGSTMGSSHPITLK CCCCCCCCCCCCCCC | 18.04 | 27017623 | |
| 1269 | Phosphorylation | NTSDLRSTQELNNLR CHHHCCCHHHHHHHH | 21.45 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SGS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SGS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SGS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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