| UniProt ID | NPT1_YEAST | |
|---|---|---|
| UniProt AC | P39683 | |
| Protein Name | Nicotinate phosphoribosyltransferase | |
| Gene Name | NPT1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 429 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Essential for growth under anaerobic conditions.; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.. | |
| Protein Sequence | MSEPVIKSLLDTDMYKITMHAAVFTNFPDVTVTYKYTNRSSQLTFNKEAINWLKEQFSYLGNLRFTEEEIEYLKQEIPYLPSAYIKYISSSNYKLHPEEQISFTSEEIEGKPTHYKLKILVSGSWKDTILYEIPLLSLISEAYFKFVDIDWDYENQLEQAEKKAETLFDNGIRFSEFGTRRRRSLKAQDLIMQGIMKAVNGNPDRNKSLLLGTSNILFAKKYGVKPIGTVAHEWVMGVASISEDYLHANKNAMDCWINTFGAKNAGLALTDTFGTDDFLKSFRPPYSDAYVGVRQDSGDPVEYTKKISHHYHDVLKLPKFSKIICYSDSLNVEKAITYSHAAKENGMLATFGIGTNFTNDFRKKSEPQVKSEPLNIVIKLLEVNGNHAIKISDNLGKNMGDPATVKRVKEELGYTERSWSGDNEAHRWT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Acetylation | -MSEPVIKSLLDTDM -CCHHHHHHHHCCCC | 34.97 | 25381059 | |
| 8 | Phosphorylation | MSEPVIKSLLDTDMY CCHHHHHHHHCCCCH | 24.04 | 22369663 | |
| 12 | Phosphorylation | VIKSLLDTDMYKITM HHHHHHCCCCHHHHE | 23.72 | 22369663 | |
| 15 | Phosphorylation | SLLDTDMYKITMHAA HHHCCCCHHHHEEHH | 11.31 | 22369663 | |
| 18 | Phosphorylation | DTDMYKITMHAAVFT CCCCHHHHEEHHHHC | 9.96 | 27017623 | |
| 25 | Phosphorylation | TMHAAVFTNFPDVTV HEEHHHHCCCCCEEE | 29.38 | 27017623 | |
| 31 | Phosphorylation | FTNFPDVTVTYKYTN HCCCCCEEEEEEECC | 17.95 | 27017623 | |
| 33 | Phosphorylation | NFPDVTVTYKYTNRS CCCCEEEEEEECCCC | 12.63 | 27017623 | |
| 34 | Phosphorylation | FPDVTVTYKYTNRSS CCCEEEEEEECCCCC | 9.54 | 27017623 | |
| 41 | Phosphorylation | YKYTNRSSQLTFNKE EEECCCCCEEECCHH | 26.44 | 21440633 | |
| 47 | Acetylation | SSQLTFNKEAINWLK CCEEECCHHHHHHHH | 44.31 | 24489116 | |
| 79 | Phosphorylation | YLKQEIPYLPSAYIK HHHHHCCCCCHHHHE | 36.59 | 28889911 | |
| 94 | Acetylation | YISSSNYKLHPEEQI EECCCCCCCCHHHHC | 44.57 | 24489116 | |
| 111 | Acetylation | TSEEIEGKPTHYKLK CCCHHCCCCCEEEEE | 33.67 | 24489116 | |
| 116 | Acetylation | EGKPTHYKLKILVSG CCCCCEEEEEEEECC | 35.38 | 24489116 | |
| 163 | Ubiquitination | QLEQAEKKAETLFDN HHHHHHHHHHHHHHC | 42.85 | 23749301 | |
| 186 | Acetylation | TRRRRSLKAQDLIMQ HHHHHHHHHHHHHHH | 45.29 | 24489116 | |
| 197 | Acetylation | LIMQGIMKAVNGNPD HHHHHHHHHHCCCCC | 47.46 | 24489116 | |
| 232 | Phosphorylation | KPIGTVAHEWVMGVA CCCCCCHHHHHHHHH | 25.72 | - | |
| 297 | Phosphorylation | YVGVRQDSGDPVEYT EEEEECCCCCCCCHH | 36.44 | 22369663 | |
| 303 | Phosphorylation | DSGDPVEYTKKISHH CCCCCCCHHHEECCC | 24.88 | 22369663 | |
| 304 | Phosphorylation | SGDPVEYTKKISHHY CCCCCCHHHEECCCH | 16.62 | 22369663 | |
| 316 | Acetylation | HHYHDVLKLPKFSKI CCHHHHHCCCCCCEE | 63.69 | 22865919 | |
| 319 | Ubiquitination | HDVLKLPKFSKIICY HHHHCCCCCCEEEEE | 73.11 | 22817900 | |
| 322 | Ubiquitination | LKLPKFSKIICYSDS HCCCCCCEEEEECCC | 38.94 | 23749301 | |
| 379 | Acetylation | EPLNIVIKLLEVNGN CCCEEEEEEEEECCC | 35.80 | 24489116 | |
| 390 | Acetylation | VNGNHAIKISDNLGK ECCCEEEEEECCCCC | 36.62 | 24489116 | |
| 397 | Acetylation | KISDNLGKNMGDPAT EEECCCCCCCCCHHH | 47.10 | 24489116 | |
| 406 | Ubiquitination | MGDPATVKRVKEELG CCCHHHHHHHHHHHC | 47.31 | 23749301 | |
| 409 | Ubiquitination | PATVKRVKEELGYTE HHHHHHHHHHHCCCC | 49.88 | 23749301 | |
| 414 | Phosphorylation | RVKEELGYTERSWSG HHHHHHCCCCCCCCC | 20.32 | 19823750 | |
| 415 | Phosphorylation | VKEELGYTERSWSGD HHHHHCCCCCCCCCC | 24.11 | 19823750 | |
| 418 | Phosphorylation | ELGYTERSWSGDNEA HHCCCCCCCCCCCCC | 21.25 | 22369663 | |
| 420 | Phosphorylation | GYTERSWSGDNEAHR CCCCCCCCCCCCCCC | 37.20 | 22369663 | |
| 429 | Phosphorylation | DNEAHRWT------- CCCCCCCC------- | 28.79 | 19823750 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NPT1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NPT1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NPT1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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