| UniProt ID | HDA2_YEAST | |
|---|---|---|
| UniProt AC | Q06629 | |
| Protein Name | HDA1 complex subunit 2 | |
| Gene Name | HDA2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 674 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Required for activity of HDA1 histone deacetylase complex. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.. | |
| Protein Sequence | MSRKNSKKLKVYYLPVTLTQFQKDLSEILISLHAKSFKASIIGEPQADAVNKPSGLPAGPETHPYPTLSQRQLTYIFDSNIRAIANHPSLLVDHYMPRQLLRMEPTESSIAGSHKFQVLNQLINSICFRDREGSPNEVIKCAIIAHSIKELDLLEGLILGKKFRTKRLSGTSLYNEKHKFPNLPTVDSTINKDGTPNSVSSTSSNSNSTSYTGYSKDDYDYSVKRNLKKRKINTDDWLFLATTKHLKHDQYLLANYDIDMIISFDPMLEVELPALQVLRNNANKDIPIIKLLVQNSPDHYLLDSEIKNSSVKSSHLSNNGHVDDSQEYEEIKSSLLYFLQARNAPVNNCEIDYIKLVKCCLEGKDCNNILPVLDLITLDEASKDSSDSGFWQPQLTKLQYSSTELPLWDGPLDIKTYQTELMHRAVIRLRDIQDEYAKGTVPLYEKRLNETQRQNQLDEIKNSVGLTFKKKQEVEKSINDSEKRLKHAMTESTKLQNKINHLLKNRQELENFNKLPSNTISSENHLEEGSALADKLKEYIDKNATLFNKLKELQQANAEKSKLNDELRSKYQIESSKAAESAQTLKILQESMKSLENEVNGPLTKFSTESLKKELERLQNDFQSLKARNKFLKNYITLMNRQYDLKNKNNVQVEKAAANGTRFRSTRSNTPNYT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 195 | Phosphorylation | STINKDGTPNSVSST CCCCCCCCCCCCCCC | 29.45 | 24961812 | |
| 198 | Phosphorylation | NKDGTPNSVSSTSSN CCCCCCCCCCCCCCC | 25.28 | 24961812 | |
| 244 | Acetylation | WLFLATTKHLKHDQY CHHHHHCCCCCCCCH | 42.45 | 24489116 | |
| 521 | Phosphorylation | KLPSNTISSENHLEE CCCCCCCCCCCCHHH | 29.57 | 30377154 | |
| 633 | Acetylation | KARNKFLKNYITLMN HHHHHHHHHHHHHHH | 51.33 | 24489116 | |
| 655 | Acetylation | KNNVQVEKAAANGTR CCCHHHHHHHHCCCC | 44.46 | 24489116 | |
| 666 | Phosphorylation | NGTRFRSTRSNTPNY CCCCCCCCCCCCCCC | 33.58 | 21440633 | |
| 668 | Phosphorylation | TRFRSTRSNTPNYT- CCCCCCCCCCCCCC- | 45.18 | 21440633 | |
| 670 | Phosphorylation | FRSTRSNTPNYT--- CCCCCCCCCCCC--- | 17.73 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HDA2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HDA2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HDA2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
