SPC19_YEAST - dbPTM
SPC19_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPC19_YEAST
UniProt AC Q03954
Protein Name DASH complex subunit SPC19
Gene Name SPC19
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 165
Subcellular Localization Nucleus . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Associates with the mitotic spindle and the kinetochore.
Protein Description Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. The DASH ring complex may both stabilize microtubules during chromosome attachment in anaphase A, and allow the chromosome to remain attached to the depolymerizing microtubule in anaphase B. Microtubule depolymerization proceeds by protofilament splaying and induces the kinetochore-attached ring to slide longitudinally, thereby helping to transduce depolymerization energy into pulling forces to disjoin chromatids..
Protein Sequence MTDALEQSVLALEGTVSVLKDSVESLKCANEPSTNLASTMLQTKRVFRLVPEYDVERSKLDLIEEVEPLVRTLGDKLRKSMGRMQRELDTLQQTYELNDLRLKKNISMDDDDALNSPDMGQEYEGRDADDVVMMASSTNEELEELKKLKEKKKQLENKLEILKQK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationLKCANEPSTNLASTM
HHCCCCCCCCHHHHH		24.6127017623
34PhosphorylationKCANEPSTNLASTML
HCCCCCCCCHHHHHH		44.9927017623
44UbiquitinationASTMLQTKRVFRLVP
HHHHHHHHHHHHHCC		33.3423749301
107PhosphorylationLRLKKNISMDDDDAL
HHHHCCCCCCCCCHH		26.0823749301
116PhosphorylationDDDDALNSPDMGQEY
CCCCHHCCCCCCCCC		24.1122369663
123PhosphorylationSPDMGQEYEGRDADD
CCCCCCCCCCCCHHH		18.7830377154
158AcetylationKKKQLENKLEILKQK
HHHHHHHHHHHHHCC		37.8124489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPC19_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPC19_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPC19_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DAD2_YEASTDAD2physical
11283351
NDC80_YEASTNDC80physical
10688190
SPC34_YEASTSPC34physical
12925767
SMC1_YEASTSMC1physical
11087867
NUF2_YEASTNUF2physical
11087867
END3_YEASTEND3physical
11087867
SPC19_YEASTSPC19physical
11087867
DAM1_YEASTDAM1physical
14633972
SPC34_YEASTSPC34physical
14633972
DUO1_YEASTDUO1physical
16554755
DAM1_YEASTDAM1physical
16554755
ASK1_YEASTASK1physical
16554755
SPC34_YEASTSPC34physical
16554755
DAD2_YEASTDAD2physical
16554755
ADY3_YEASTADY3physical
17634282
DAD1_YEASTDAD1physical
17634282
SPC19_YEASTSPC19physical
17634282
DUO1_YEASTDUO1physical
17634282
DAM1_YEASTDAM1physical
17634282
MET28_YEASTMET28physical
17634282
SPC34_YEASTSPC34physical
17634282
DAD2_YEASTDAD2physical
17634282
MDM36_YEASTMDM36physical
17634282
SSB1_YEASTSSB1physical
19536198
SPC34_YEASTSPC34physical
20730753
HSK3_YEASTHSK3physical
20730753
HSK3_YEASTHSK3physical
22875988
NUF2_YEASTNUF2physical
22875988
YET3_YEASTYET3physical
22875988
YEF3_YEASTYEL043Wphysical
22875988
FMP32_YEASTFMP32physical
22875988
YKF0_YEASTYKL050Cphysical
22875988
SEG2_YEASTSEG2physical
22875988
CASP_YEASTCOY1physical
22875988
RCF1_YEASTRCF1physical
22875988
END3_YEASTEND3physical
22875988
AF9_YEASTYAF9physical
22875988
TBP6_YEASTYTA6physical
22875988
GYP5_YEASTGYP5physical
22875988
SPC19_YEASTSPC19physical
22875988
CKS1_YEASTCKS1genetic
27708008
SLI15_YEASTSLI15genetic
27708008
APC11_YEASTAPC11genetic
27708008
MPS1_YEASTMPS1genetic
27708008
CDC53_YEASTCDC53genetic
27708008
GLE1_YEASTGLE1genetic
27708008
DUO1_YEASTDUO1genetic
27708008
SP105_YEASTSPC105genetic
27708008
DAM1_YEASTDAM1genetic
27708008
NU159_YEASTNUP159genetic
27708008
NDC80_YEASTNDC80genetic
27708008
DSN1_YEASTDSN1genetic
27708008
ARP4_YEASTARP4genetic
27708008
ESS1_YEASTESS1genetic
27708008
ASK1_YEASTASK1genetic
27708008
DAD2_YEASTDAD2genetic
27708008
SMC4_YEASTSMC4genetic
27708008
RU1C_YEASTYHC1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
PDS5_YEASTPDS5genetic
27708008
SPC24_YEASTSPC24genetic
27708008
NOP2_YEASTNOP2genetic
27708008
HRP1_YEASTHRP1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
RPB2_YEASTRPB2genetic
27708008
NAB3_YEASTNAB3genetic
27708008
SWC3_YEASTSWC3genetic
27708008
SWD1_YEASTSWD1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
IML3_YEASTIML3genetic
27708008
ODPB_YEASTPDB1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
SNT1_YEASTSNT1genetic
27708008
HCM1_YEASTHCM1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
OST4_YEASTOST4genetic
27708008
LCMT1_YEASTPPM1genetic
27708008
VPS72_YEASTVPS72genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
YBP2_YEASTYBP2genetic
27708008
MAD1_YEASTMAD1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
PFD3_YEASTPAC10genetic
27708008
SLX9_YEASTSLX9genetic
27708008
BUB1_YEASTBUB1genetic
27708008
YOR1_YEASTYOR1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
MAD3_YEASTMAD3genetic
27708008
MAD2_YEASTMAD2genetic
27708008
MCM22_YEASTMCM22genetic
27708008
SAC1_YEASTSAC1genetic
27708008
ENV10_YEASTENV10genetic
27708008
ARP6_YEASTARP6genetic
27708008
PEX13_YEASTPEX13genetic
27708008
CTF3_YEASTCTF3genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
RM39_YEASTMRPL39genetic
27708008
BUB2_YEASTBUB2genetic
27708008
MUB1_YEASTMUB1genetic
27708008
EAF7_YEASTEAF7genetic
27708008
SWM2_YEASTSWM2genetic
27708008
BUB3_YEASTBUB3genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
CY1_YEASTCYT1genetic
27708008
SLK19_YEASTSLK19genetic
27708008
CTF19_YEASTCTF19genetic
27708008
RAD1_YEASTRAD1genetic
27708008
VIK1_YEASTVIK1genetic
27708008
MCM16_YEASTMCM16genetic
27708008
UBA3_YEASTUBA3genetic
27708008
KAR3_YEASTKAR3genetic
27708008
QCR2_YEASTQCR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPC19_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116, AND MASSSPECTROMETRY.
"Phospho-regulation of kinetochore-microtubule attachments by theAurora kinase Ipl1p.";
Cheeseman I.M., Anderson S., Jwa M., Green E.M., Kang J.-S.,Yates J.R. III, Chan C.S.M., Drubin D.G., Barnes G.;
Cell 111:163-172(2002).
Cited for: PHOSPHORYLATION AT SER-107 AND SER-116.

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