BUB2_YEAST - dbPTM
BUB2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BUB2_YEAST
UniProt AC P26448
Protein Name Mitotic check point protein BUB2
Gene Name BUB2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 306
Subcellular Localization Cytoplasm, cytoskeleton, spindle pole.
Protein Description Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the GTP-binding protein TEM1 by the BFA1/BUB2 complex..
Protein Sequence MTSIEDLISNPPLLLHSSLSQLRYLILSEGLPISEDKQQQRTRCYVWTVLSQTSMEASTQRYLALLKLGPPSTTIYQKIKNDTSRTFQTDPNFRNRVSEDALIRCLSCFAWQTQQRRQKTRFGRIPVSTYVQGMNVLLAPLLYSCPSEPMAYQLFTKLCYEMIPTYLTKNLNGAQNGAKLLDISLRIIDPKLSKFLSDNLLTAEIYGMPSILTLSSCNKPLDQVIKLWDFMFAYGFHMNILFVVAFLVKMRSKVFKSDSPVNLLRQFPDFDADEIIRLGVGFIAKIPAQIYDLLVDHLTDPDIYIP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
37UbiquitinationGLPISEDKQQQRTRC
CCCCCCCHHHHHHHH
46.0523749301
256UbiquitinationKMRSKVFKSDSPVNL
HHHHHHHCCCCCHHH
57.2324961812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BUB2_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BUB2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BUB2_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SYIM_YEASTISM1physical
11805837
DDI1_YEASTDDI1physical
10688190
GIC1_YEASTGIC1physical
10688190
YG3O_YEASTYGR153Wphysical
10688190
NUD1_YEASTNUD1physical
11101520
TEM1_YEASTTEM1physical
12048186
GIC1_YEASTGIC1physical
14734533
BFA1_YEASTBFA1physical
10949022
TEM1_YEASTTEM1physical
10949022
BUB1_YEASTBUB1genetic
10329618
MAD1_YEASTMAD1genetic
10329618
MAD2_YEASTMAD2genetic
10329618
MAD3_YEASTMAD3genetic
10329618
TEM1_YEASTTEM1genetic
11014800
NOP56_YEASTNOP56genetic
15365764
CIN8_YEASTCIN8genetic
16449187
CDC5_YEASTCDC5genetic
16449187
TEM1_YEASTTEM1genetic
16449187
CLA4_YEASTCLA4genetic
16449187
NUD1_YEASTNUD1genetic
16449187
LTE1_YEASTLTE1genetic
16449187
CDC14_YEASTCDC14genetic
16449187
BFA1_YEASTBFA1physical
16682821
TEM1_YEASTTEM1physical
16682821
BIM1_YEASTBIM1genetic
17314980
CIN8_YEASTCIN8genetic
17314980
PFD2_YEASTGIM4genetic
17314980
PFD1_YEASTPFD1genetic
17314980
PFD6_YEASTYKE2genetic
17314980
BIK1_YEASTBIK1genetic
17314980
RAD18_YEASTRAD18genetic
17314980
RAD52_YEASTRAD52genetic
17314980
PFD3_YEASTPAC10genetic
17314980
PAC11_YEASTPAC11genetic
17314980
VPS64_YEASTVPS64genetic
17314980
CSF1_YEASTCSF1genetic
17314980
NUP84_YEASTNUP84genetic
17314980
XRS2_YEASTXRS2genetic
17314980
RT109_YEASTRTT109genetic
17314980
SIC1_YEASTSIC1genetic
17314980
PFD5_YEASTGIM5genetic
17314980
HCM1_YEASTHCM1genetic
17314980
YPT6_YEASTYPT6genetic
17314980
RIC1_YEASTRIC1genetic
17314980
RAD51_YEASTRAD51genetic
17314980
MMS22_YEASTMMS22genetic
17314980
ASF1_YEASTASF1genetic
17314980
TAF13_YEASTTAF13genetic
17314980
VPS8_YEASTVPS8genetic
17314980
HUR1_YEASTHUR1genetic
17314980
ATC6_YEASTSPF1genetic
17314980
BMH1_YEASTBMH1genetic
18728387
MAD2_YEASTMAD2genetic
18728387
KIN4_YEASTKIN4genetic
19605686
AMN1_YEASTAMN1genetic
20093466
BIK1_YEASTBIK1genetic
20093466
NUM1_YEASTNUM1genetic
20093466
SSD1_YEASTSSD1genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
DYL1_YEASTDYN2genetic
20093466
ARP1_YEASTARP1genetic
20093466
NACA_YEASTEGD2genetic
20093466
ASF1_YEASTASF1genetic
20093466
DYHC_YEASTDYN1genetic
20093466
LDB18_YEASTLDB18genetic
20093466
PFD6_YEASTYKE2genetic
20093466
MSC3_YEASTMSC3genetic
20093466
RSA3_YEASTRSA3genetic
20093466
NDE1_YEASTNDL1genetic
20093466
STP3_YEASTSTP3genetic
20093466
CYB2_YEASTCYB2genetic
20093466
YMF3_YEASTYML053Cgenetic
20093466
CIK1_YEASTCIK1genetic
20093466
DMA2_YEASTDMA2genetic
15146058
ORC1_YEASTORC1genetic
16716188
CDC15_YEASTCDC15genetic
20505077
TEM1_YEASTTEM1genetic
19490645
CDC15_YEASTCDC15genetic
20123997
MOB1_YEASTMOB1genetic
20123997
BFA1_YEASTBFA1genetic
22321970
CDH1_YEASTCDH1genetic
22321970
CDC14_YEASTCDC14genetic
14551257
TEM1_YEASTTEM1genetic
14551257
CDC15_YEASTCDC15genetic
14551257
DYHC_YEASTDYN1genetic
12072457
BFA1_YEASTBFA1physical
25658911
TEM1_YEASTTEM1physical
25658911
CG22_YEASTCLB2genetic
24300211
UIP3_YEASTUIP3genetic
27708008
BIK1_YEASTBIK1genetic
27708008
NUM1_YEASTNUM1genetic
27708008
DYL1_YEASTDYN2genetic
27708008
AAKG_YEASTSNF4genetic
27708008
XRN1_YEASTXRN1genetic
27708008
PFD3_YEASTPAC10genetic
27708008
ARP1_YEASTARP1genetic
27708008
THIK_YEASTPOT1genetic
27708008
ASF1_YEASTASF1genetic
27708008
DYHC_YEASTDYN1genetic
27708008
LDB18_YEASTLDB18genetic
27708008
PFD6_YEASTYKE2genetic
27708008
NDE1_YEASTNDL1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
JNM1_YEASTJNM1genetic
27708008
COQ10_YEASTCOQ10genetic
27708008
YO036_YEASTYOL036Wgenetic
27708008
DIA2_YEASTDIA2genetic
27708008
LIS1_YEASTPAC1genetic
27708008
NIP80_YEASTNIP100genetic
27708008
KAR9_YEASTKAR9genetic
27708008
PPAL_YEASTLTP1genetic
27708008
PLR1_YEASTYPR127Wgenetic
27708008
KAR3_YEASTKAR3genetic
27708008
BFA1_YEASTBFA1physical
27159239
USBP1_HUMANUSHBP1physical
27107014
SPERT_HUMANSPERTphysical
27107014
JKIP2_HUMANJAKMIP2physical
27107014
ZBT7B_HUMANZBTB7Bphysical
27107014
EFHC2_HUMANEFHC2physical
27107014
KPC1_YEASTPKC1genetic
29674565
APC11_YEASTAPC11genetic
29674565
DAD1_YEASTDAD1genetic
29674565
MCM21_YEASTMCM21genetic
29674565
DYL1_YEASTDYN2genetic
29674565
GPI19_YEASTGPI19genetic
29674565
PAC11_YEASTPAC11genetic
29674565
PT122_YEASTPET122genetic
29674565
SLX9_YEASTSLX9genetic
29674565
OKP1_YEASTOKP1genetic
29674565
YOR1_YEASTYOR1genetic
29674565
ARP1_YEASTARP1genetic
29674565
CDC23_YEASTCDC23genetic
29674565
SYS1_YEASTSYS1genetic
29674565
ASF1_YEASTASF1genetic
29674565
RS21B_YEASTRPS21Bgenetic
29674565
RL14A_YEASTRPL14Agenetic
29674565
VPS24_YEASTVPS24genetic
29674565
ELM1_YEASTELM1genetic
29674565
FABG_YEASTOAR1genetic
29674565
FEN1_YEASTRAD27genetic
29674565
PRS7_YEASTRPT1genetic
29674565
SAC1_YEASTSAC1genetic
29674565
VPS51_YEASTVPS51genetic
29674565
BET3_YEASTBET3genetic
29674565
MLP1_YEASTMLP1genetic
29674565
LDB18_YEASTLDB18genetic
29674565
RIC1_YEASTRIC1genetic
29674565
SIC1_YEASTSIC1genetic
29674565
CFT2_YEASTCFT2genetic
29674565
PFD6_YEASTYKE2genetic
29674565
NDE1_YEASTNDL1genetic
29674565
MMS22_YEASTMMS22genetic
29674565
RNA1_YEASTRNA1genetic
29674565
DYN3_YEASTDYN3genetic
29674565
PFD4_YEASTGIM3genetic
29674565
NOP12_YEASTNOP12genetic
29674565
ASE1_YEASTASE1genetic
29674565
LIPA_YEASTLIP5genetic
29674565
APC5_YEASTAPC5genetic
29674565
LIS1_YEASTPAC1genetic
29674565
MYO2_YEASTMYO2genetic
29674565
CIN1_YEASTCIN1genetic
29674565
TBCC_YEASTCIN2genetic
29674565
KAR9_YEASTKAR9genetic
29674565
CGS5_YEASTCLB5genetic
29674565
KAR3_YEASTKAR3genetic
29674565
ABP1_YEASTABP1genetic
29674565
RAD57_YEASTRAD57genetic
29674565
BOI2_YEASTBOI2genetic
29674565
SLD3_YEASTSLD3genetic
29674565
PSMD9_YEASTNAS2genetic
29674565
EXO70_YEASTEXO70genetic
29674565
SRP40_YEASTSRP40genetic
29674565
RAD5_YEASTRAD5genetic
29674565
RTC6_YEASTRTC6genetic
29674565
HCM1_YEASTHCM1genetic
29674565
DBF4_YEASTDBF4genetic
29674565
PUF6_YEASTPUF6genetic
29674565
ARP4_YEASTARP4genetic
29674565
ATP18_YEASTATP18genetic
29674565
CAP_YEASTSRV2genetic
29674565
NCBP2_YEASTCBC2genetic
29674565

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BUB2_YEAST

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Related Literatures of Post-Translational Modification

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