| UniProt ID | CFT2_YEAST | |
|---|---|---|
| UniProt AC | Q12102 | |
| Protein Name | Cleavage factor two protein 2 | |
| Gene Name | CFT2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 859 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May be involved in poly(A)-site recognition. May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes.. | |
| Protein Sequence | MTYKYNCCDDGSGTTVGSVVRFDNVTLLIDPGWNPSKVSYEQCIKYWEKVIPEIDVIILSQPTIECLGAHSLLYYNFTSHFISRIQVYATLPVINLGRVSTIDSYASAGVIGPYDTNKLDLEDIEISFDHIVPLKYSQLVDLRSRYDGLTLLAYNAGVCPGGSIWCISTYSEKLVYAKRWNHTRDNILNAASILDATGKPLSTLMRPSAIITTLDRFGSSQPFKKRSKIFKDTLKKGLSSDGSVIIPVDMSGKFLDLFTQVHELLFESTKINAHTQVPVLILSYARGRTLTYAKSMLEWLSPSLLKTWENRNNTSPFEIGSRIKIIAPNELSKYPGSKICFVSEVGALINEVIIKVGNSEKTTLILTKPSFECASSLDKILEIVEQDERNWKTFPEDGKSFLCDNYISIDTIKEEPLSKEETEAFKVQLKEKKRDRNKKILLVKRESKKLANGNAIIDDTNGERAMRNQDILVENVNGVPPIDHIMGGDEDDDEEEENDNLLNLLKDNSEKSAAKKNTEVPVDIIIQPSAASKHKMFPFNPAKIKKDDYGTVVDFTMFLPDDSDNVNQNSRKRPLKDGAKTTSPVNEEDNKNEEEDGYNMSDPISKRSKHRASRYSGFSGTGEAENFDNLDYLKIDKTLSKRTISTVNVQLKCSVVILNLQSLVDQRSASIIWPSLKSRKIVLSAPKQIQNEEITAKLIKKNIEVVNMPLNKIVEFSTTIKTLDISIDSNLDNLLKWQRISDSYTVATVVGRLVKESLPQVNNHQKTASRSKLVLKPLHGSSRSHKTGALSIGDVRLAQLKKLLTEKNYIAEFKGEGTLVINEKVAVRKINDAETIIDGTPSELFDTVKKLVTDMLAKI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 136 | Phosphorylation | DHIVPLKYSQLVDLR CEEEECCHHHHHCCH | 14.88 | 25533186 | |
| 251 | Phosphorylation | VIIPVDMSGKFLDLF EEEEECCCCHHHHHH | 34.07 | 27017623 | |
| 314 | Phosphorylation | TWENRNNTSPFEIGS HHHCCCCCCCCCCCC | 41.13 | 27017623 | |
| 315 | Phosphorylation | WENRNNTSPFEIGSR HHCCCCCCCCCCCCE | 29.70 | 27017623 | |
| 549 | Phosphorylation | AKIKKDDYGTVVDFT HHCCCCCCCCEEEEE | 25.48 | 29136822 | |
| 551 | Phosphorylation | IKKDDYGTVVDFTMF CCCCCCCCEEEEEEE | 15.89 | 29136822 | |
| 556 | Phosphorylation | YGTVVDFTMFLPDDS CCCEEEEEEECCCCC | 11.53 | 29136822 | |
| 563 | Phosphorylation | TMFLPDDSDNVNQNS EEECCCCCCCCCCCC | 38.16 | 29136822 | |
| 570 | Phosphorylation | SDNVNQNSRKRPLKD CCCCCCCCCCCCCCC | 29.43 | 29136822 | |
| 581 | Phosphorylation | PLKDGAKTTSPVNEE CCCCCCCCCCCCCCC | 31.78 | 21440633 | |
| 582 | Phosphorylation | LKDGAKTTSPVNEED CCCCCCCCCCCCCCC | 30.26 | 24961812 | |
| 583 | Phosphorylation | KDGAKTTSPVNEEDN CCCCCCCCCCCCCCC | 31.89 | 28152593 | |
| 598 | Phosphorylation | KNEEEDGYNMSDPIS CCCCCCCCCCCCHHH | 21.73 | 25005228 | |
| 601 | Phosphorylation | EEDGYNMSDPISKRS CCCCCCCCCHHHHHH | 36.28 | 24961812 | |
| 605 | Phosphorylation | YNMSDPISKRSKHRA CCCCCHHHHHHHHHH | 27.66 | 24961812 | |
| 616 | Phosphorylation | KHRASRYSGFSGTGE HHHHHHCCCCCCCCC | 32.05 | 27214570 | |
| 697 | Acetylation | QNEEITAKLIKKNIE CCHHHHHHHHHCCCE | 41.94 | 24489116 | |
| 743 | Phosphorylation | KWQRISDSYTVATVV HHEECCCCHHHHHHH | 18.86 | 19779198 | |
| 745 | Phosphorylation | QRISDSYTVATVVGR EECCCCHHHHHHHHH | 13.96 | 19779198 | |
| 748 | Phosphorylation | SDSYTVATVVGRLVK CCCHHHHHHHHHHHH | 16.04 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CFT2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CFT2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CFT2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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