| UniProt ID | SIF2_YEAST | |
|---|---|---|
| UniProt AC | P38262 | |
| Protein Name | SIR4-interacting protein SIF2 | |
| Gene Name | SIF2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 535 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Antagonizes telomeric silencing in yeast. May recruit SIR4 to non-telomeric sites or repression.. | |
| Protein Sequence | MSITSEELNYLIWRYCQEMGHEVSALALQDETRVLEFDEKYKEHIPLGTLVNLVQRGILYTESELMVDSKGDISALNEHHLSEDFNLVQALQIDKEKFPEISSEGRFTLETNSESNKAGEDGASTVERETQEDDTNSIDSSDDLDGFVKILKEIVKLDNIVSSTWNPLDESILAYGEKNSVARLARIVETDQEGKKYWKLTIIAELRHPFALSASSGKTTNQVTCLAWSHDGNSIVTGVENGELRLWNKTGALLNVLNFHRAPIVSVKWNKDGTHIISMDVENVTILWNVISGTVMQHFELKETGGSSINAENHSGDGSLGVDVEWVDDDKFVIPGPKGAIFVYQITEKTPTGKLIGHHGPISVLEFNDTNKLLLSASDDGTLRIWHGGNGNSQNCFYGHSQSIVSASWVGDDKVISCSMDGSVRLWSLKQNTLLALSIVDGVPIFAGRISQDGQKYAVAFMDGQVNVYDLKKLNSKSRSLYGNRDGILNPLPIPLYASYQSSQDNDYIFDLSWNCAGNKISVAYSLQEGSVVAI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Phosphorylation | QEMGHEVSALALQDE HHHCCCHHHHHHCCC | 17.99 | 28889911 | |
| 32 | Phosphorylation | ALALQDETRVLEFDE HHHHCCCCEEEECCH | 34.07 | 28889911 | |
| 111 | Phosphorylation | EGRFTLETNSESNKA CCCEEEECCCCCCCC | 47.35 | 22369663 | |
| 113 | Phosphorylation | RFTLETNSESNKAGE CEEEECCCCCCCCCC | 50.23 | 22369663 | |
| 115 | Phosphorylation | TLETNSESNKAGEDG EEECCCCCCCCCCCC | 43.37 | 22369663 | |
| 124 | Phosphorylation | KAGEDGASTVERETQ CCCCCCCCHHCHHCC | 38.22 | 22369663 | |
| 125 | Phosphorylation | AGEDGASTVERETQE CCCCCCCHHCHHCCC | 26.33 | 20377248 | |
| 130 | Phosphorylation | ASTVERETQEDDTNS CCHHCHHCCCCCCCC | 43.40 | 20377248 | |
| 135 | Phosphorylation | RETQEDDTNSIDSSD HHCCCCCCCCCCCCC | 43.09 | 22369663 | |
| 137 | Phosphorylation | TQEDDTNSIDSSDDL CCCCCCCCCCCCCCH | 29.84 | 22369663 | |
| 140 | Phosphorylation | DDTNSIDSSDDLDGF CCCCCCCCCCCHHHH | 33.71 | 22369663 | |
| 141 | Phosphorylation | DTNSIDSSDDLDGFV CCCCCCCCCCHHHHH | 31.25 | 22369663 | |
| 213 | Phosphorylation | LRHPFALSASSGKTT ECCCEEEECCCCCCC | 23.75 | 21551504 | |
| 216 | Phosphorylation | PFALSASSGKTTNQV CEEEECCCCCCCCEE | 43.98 | 21551504 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SIF2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SIF2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SIF2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; SER-124 ANDSER-140, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, AND MASSSPECTROMETRY. | |
