dbPTM

AKR2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AKR2_YEAST
UniProt AC	Q12013
Protein Name	Probable palmitoyltransferase AKR2
Gene Name	AKR2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	749
Subcellular Localization	Membrane Multi-pass membrane protein.
Protein Description	May be involved in constitutive endocytosis of a-factor receptor STE3..
Protein Sequence	MTSMSIIDDENVKKTSNGAAVVTDVAQHAVSDSDNNKAQLLGDGSNTEYVVDIFIEAAKDGDLKVVKDVVESGAVDINNDRIDELSGLHWACINNRFSVAKFLLLRGANPNQAAGPGGATALHWAARYGNIYIVDLLLKHGADPTLKDEQGLNIMHFSVYSSNILLVVYVLYFVVNNNDNVDIDSKDNNNRTPLLWAAYQGDFLTVELLLKFGSTVAWTDNRGFNALHCALVGGDQRVICDLILSGANFYERNNQKQDCFDLAEGMGTKSLFEQALQHHGYDRLGNQKDKLFKKSSHAQFTIFLSPFLLMVYIYLISLVLSPVLAIMLSLLVTVVMVNTLKKFVLPCLPRKNTYKVSLTRTPFFSGLFLSTFCFLIYIWTKKLYPYSVSDYTMKNVQFLVTSFLTVVLFLRLVRSDPGCLKTDDSLTSIQETIKQLIDLGKFDRENFCVETLERKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHKLFVFFAVTVQYHMFLFMWLCLAYFKKTNYIYEQVEEYARCALLKNETLCKGSNYDPSTFFLFIWISVNFIWLGAMLIVQFFQILKGITTPELFILIKEEHKAKFINLIPFENSIYTSESKGVEDSDMIPEGPSATTITHTISIDGLEPRNRRRAILSACFSMMGINQWLVTIKEIVGITHILHGQVPQQHHSSLLRSFLVTNHWKTNLTDFWLNSDVTAPLWQRFFYSSDTSKAMLGGTEVDYYELYEYPAREGEVLRPN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	SNGAAVVTDVAQHAV CCCCEEECCHHHHHC	20.39	24961812
31	Phosphorylation	DVAQHAVSDSDNNKA CHHHHHCCCCCCCEE	31.98	24961812
33	Phosphorylation	AQHAVSDSDNNKAQL HHHHCCCCCCCEEEE	34.43	24961812
256	Ubiquitination	FYERNNQKQDCFDLA HHHHCCCCCCHHHHH	50.67	23749301
386	Phosphorylation	WTKKLYPYSVSDYTM HHCCCCCCCCCCCCH	14.24	19684113
387	Phosphorylation	TKKLYPYSVSDYTMK HCCCCCCCCCCCCHH	15.61	19684113
391	Phosphorylation	YPYSVSDYTMKNVQF CCCCCCCCCHHHHHH	10.96	19684113
392	Phosphorylation	PYSVSDYTMKNVQFL CCCCCCCCHHHHHHH	27.02	19684113
534	N-linked_Glycosylation	ARCALLKNETLCKGS HHHHHHCCCCCCCCC	47.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AKR2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AKR2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AKR2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LCB4_YEAST	LCB4	physical	16227572
SIN3_YEAST	SIN3	genetic	19547744
RRP6_YEAST	RRP6	genetic	20959818
AFT1_YEAST	AFT1	genetic	20959818
SIN3_YEAST	SIN3	genetic	20959818
YPT6_YEAST	YPT6	genetic	20959818
YOL19_YEAST	YOL019W	genetic	20526336
PLB3_YEAST	PLB3	genetic	20526336
TAT2_YEAST	TAT2	genetic	20526336
TOR2_YEAST	TOR2	genetic	20526336
ACEA_YEAST	ICL1	genetic	27708008
YRB30_YEAST	YRB30	genetic	27708008
MRX5_YEAST	YJL147C	genetic	27708008
SNF1_YEAST	SNF1	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
PEX8_YEAST	PEX8	genetic	27708008
PSA3_YEAST	PRE9	genetic	27708008
BIOB_YEAST	BIO2	genetic	27708008
COX23_YEAST	COX23	genetic	27708008
OM45_YEAST	OM45	genetic	27708008
SNX4_YEAST	SNX4	genetic	27708008
KAPA_YEAST	TPK1	genetic	27708008
PTK2_YEAST	PTK2	genetic	27708008
HOC1_YEAST	HOC1	genetic	27708008
DHOM_YEAST	HOM6	genetic	27708008
EF1G2_YEAST	TEF4	genetic	27708008
CYT2_YEAST	CYT2	genetic	27708008
FEN1_YEAST	RAD27	genetic	27708008
CANB_YEAST	CNB1	genetic	27708008
MEH1_YEAST	MEH1	genetic	27708008
DNM1_YEAST	DNM1	genetic	27708008
PSR1_YEAST	PSR1	genetic	27708008
POM33_YEAST	POM33	genetic	27708008
CHA4_YEAST	CHA4	genetic	27708008
AVL9_YEAST	AVL9	genetic	27708008
PALI_YEAST	RIM9	genetic	27708008
CTF18_YEAST	CTF18	genetic	27708008
TMA23_YEAST	TMA23	genetic	27708008
EAF7_YEAST	EAF7	genetic	27708008
NRM1_YEAST	NRM1	genetic	27708008
ATP23_YEAST	ATP23	genetic	27708008
TYW4_YEAST	PPM2	genetic	27708008
PMA2_YEAST	PMA2	genetic	27708008
YP108_YEAST	YPL108W	genetic	27708008
ATPN_YEAST	ATP20	genetic	27708008
YME1_YEAST	YME1	genetic	27708008
CGS5_YEAST	CLB5	genetic	27708008
MSS18_YEAST	MSS18	genetic	27708008
VPS4_YEAST	VPS4	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AKR2_YEAST

Related Literatures of Post-Translational Modification