| UniProt ID | PTK2_YEAST | |
|---|---|---|
| UniProt AC | P47116 | |
| Protein Name | Serine/threonine-protein kinase PTK2/STK2 | |
| Gene Name | PTK2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 818 | |
| Subcellular Localization | Nucleus . Cytoplasm . | |
| Protein Description | Essential determinant for high-affinity spermidine transport. Required for the activation of the plasma membrane proton pump PMA1 via phosphorylation of 'Ser-899'.. | |
| Protein Sequence | MAGNGKDKEVDKSPSVSTLKLLGKRLFNSSSHTDNSSLLLSAEQLGNGRSLRKRPTSPSISGSGSGGNSPSSSAGARQRSASLHRRKNNASVGFSNGSVSSHKSSVALQDLIKHNNNPYLNSPSDILGTGTGIASTRDRDRAVLDREKEKERARNKERNTHHAGLPQRSNSMASHHFPNENIVYNPYGISPNHARPDTAFADTLNTNKENDLSFYMHDGNSKIRMLPLPIANPNDFLPEDMKQYSVHLTDNFVFDTDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVKDLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREFEVSYDNFINHQNPHFRDKGCHKPGPGSEYSLARNFKNTDATRIAWRLADPNPATRYTMDDLFNDPFFQQIETCVEPNDDDLVRVPELRKSTSTNDFSENSLDAPHDQEVIHTSNPFLKKETLTSKPRSMLEIAESPSLKQKSKVKDSAKTKTHDVGDEGGNESTKPKQQDKKENLKKDEVKNGDKDKVIEEATTTNVDSILEKPTPTSTKVEDNLSEDDSTMKELKSMLNSTPTTPTHNGPTPLPAKAGTQLDKRMSDLSLKSETPASTKNFSAPNVSSSSNSLRSLGSPSVSSSKKKKVIHHHLDITNSVTNMSSVSAFISR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | KDKEVDKSPSVSTLK CCCCCCCCCCHHHHH | 20.24 | 22369663 | |
| 15 | Phosphorylation | KEVDKSPSVSTLKLL CCCCCCCCHHHHHHH | 35.47 | 22369663 | |
| 17 | Phosphorylation | VDKSPSVSTLKLLGK CCCCCCHHHHHHHHH | 32.15 | 20377248 | |
| 18 | Phosphorylation | DKSPSVSTLKLLGKR CCCCCHHHHHHHHHH | 26.25 | 20377248 | |
| 29 | Phosphorylation | LGKRLFNSSSHTDNS HHHHHHCCCCCCCCC | 26.36 | 22369663 | |
| 30 | Phosphorylation | GKRLFNSSSHTDNSS HHHHHCCCCCCCCCE | 27.52 | 22369663 | |
| 31 | Phosphorylation | KRLFNSSSHTDNSSL HHHHCCCCCCCCCEE | 30.17 | 21440633 | |
| 33 | Phosphorylation | LFNSSSHTDNSSLLL HHCCCCCCCCCEEEE | 38.53 | 22369663 | |
| 36 | Phosphorylation | SSSHTDNSSLLLSAE CCCCCCCCEEEEEHH | 25.77 | 22369663 | |
| 37 | Phosphorylation | SSHTDNSSLLLSAEQ CCCCCCCEEEEEHHH | 29.32 | 22369663 | |
| 41 | Phosphorylation | DNSSLLLSAEQLGNG CCCEEEEEHHHHCCC | 29.72 | 22369663 | |
| 50 | Phosphorylation | EQLGNGRSLRKRPTS HHHCCCCCCCCCCCC | 33.64 | 24961812 | |
| 56 | Phosphorylation | RSLRKRPTSPSISGS CCCCCCCCCCCCCCC | 58.25 | 22369663 | |
| 57 | Phosphorylation | SLRKRPTSPSISGSG CCCCCCCCCCCCCCC | 21.23 | 22369663 | |
| 59 | Phosphorylation | RKRPTSPSISGSGSG CCCCCCCCCCCCCCC | 29.20 | 22369663 | |
| 61 | Phosphorylation | RPTSPSISGSGSGGN CCCCCCCCCCCCCCC | 31.11 | 22369663 | |
| 63 | Phosphorylation | TSPSISGSGSGGNSP CCCCCCCCCCCCCCC | 24.01 | 22890988 | |
| 65 | Phosphorylation | PSISGSGSGGNSPSS CCCCCCCCCCCCCCC | 45.27 | 22369663 | |
| 69 | Phosphorylation | GSGSGGNSPSSSAGA CCCCCCCCCCCHHHH | 29.45 | 22369663 | |
| 71 | Phosphorylation | GSGGNSPSSSAGARQ CCCCCCCCCHHHHHH | 36.42 | 22890988 | |
| 72 | Phosphorylation | SGGNSPSSSAGARQR CCCCCCCCHHHHHHH | 27.82 | 22890988 | |
| 73 | Phosphorylation | GGNSPSSSAGARQRS CCCCCCCHHHHHHHH | 34.75 | 22890988 | |
| 80 | Phosphorylation | SAGARQRSASLHRRK HHHHHHHHHHCHHHC | 17.55 | 17287358 | |
| 82 | Phosphorylation | GARQRSASLHRRKNN HHHHHHHHCHHHCCC | 26.42 | 28889911 | |
| 91 | Phosphorylation | HRRKNNASVGFSNGS HHHCCCCCCCCCCCC | 25.54 | 22369663 | |
| 95 | Phosphorylation | NNASVGFSNGSVSSH CCCCCCCCCCCCCCC | 34.06 | 22369663 | |
| 98 | Phosphorylation | SVGFSNGSVSSHKSS CCCCCCCCCCCCCHH | 24.07 | 22369663 | |
| 100 | Phosphorylation | GFSNGSVSSHKSSVA CCCCCCCCCCCHHHH | 28.55 | 22369663 | |
| 101 | Phosphorylation | FSNGSVSSHKSSVAL CCCCCCCCCCHHHHH | 32.55 | 22369663 | |
| 104 | Phosphorylation | GSVSSHKSSVALQDL CCCCCCCHHHHHHHH | 25.31 | 22369663 | |
| 105 | Phosphorylation | SVSSHKSSVALQDLI CCCCCCHHHHHHHHH | 19.06 | 25521595 | |
| 119 | Phosphorylation | IKHNNNPYLNSPSDI HHHCCCCCCCCHHHH | 22.19 | 22369663 | |
| 122 | Phosphorylation | NNNPYLNSPSDILGT CCCCCCCCHHHHCCC | 24.16 | 28132839 | |
| 124 | Phosphorylation | NPYLNSPSDILGTGT CCCCCCHHHHCCCCC | 36.78 | 22369663 | |
| 129 | Phosphorylation | SPSDILGTGTGIAST CHHHHCCCCCCCCCC | 28.29 | 22369663 | |
| 131 | Phosphorylation | SDILGTGTGIASTRD HHHCCCCCCCCCCCH | 25.83 | 22369663 | |
| 135 | Phosphorylation | GTGTGIASTRDRDRA CCCCCCCCCCHHHHH | 23.27 | 22369663 | |
| 136 | Phosphorylation | TGTGIASTRDRDRAV CCCCCCCCCHHHHHH | 27.80 | 22369663 | |
| 160 | Phosphorylation | ARNKERNTHHAGLPQ HHHHHHHHCCCCCCC | 22.66 | 28889911 | |
| 169 | Phosphorylation | HAGLPQRSNSMASHH CCCCCCCCCCCCCCC | 28.19 | 19779198 | |
| 171 | Phosphorylation | GLPQRSNSMASHHFP CCCCCCCCCCCCCCC | 19.57 | 19779198 | |
| 174 | Phosphorylation | QRSNSMASHHFPNEN CCCCCCCCCCCCCCC | 14.62 | 19779198 | |
| 190 | Phosphorylation | VYNPYGISPNHARPD CCCCCCCCCCCCCCC | 18.45 | 28889911 | |
| 221 | Phosphorylation | FYMHDGNSKIRMLPL EEEECCCCCEEEEEC | 34.68 | 28889911 | |
| 245 | Phosphorylation | PEDMKQYSVHLTDNF CHHHHHHEEEECCCE | 10.68 | 28889911 | |
| 263 | Phosphorylation | TDNKPIGSGGSSEVR CCCCCCCCCCCHHHH | 40.47 | 27017623 | |
| 266 | Phosphorylation | KPIGSGGSSEVRKVK CCCCCCCCHHHHHHH | 27.18 | 30377154 | |
| 267 | Phosphorylation | PIGSGGSSEVRKVKS CCCCCCCHHHHHHHH | 43.30 | 30377154 | |
| 297 | Acetylation | IYHESPEKFYKRCSK CCCCCHHHHHHHHCC | 58.33 | 24489116 | |
| 346 | Acetylation | FIMELGVKDLFQLME HHHHHCHHHHHHHHH | 47.09 | 25381059 | |
| 585 | Phosphorylation | RVPELRKSTSTNDFS CCHHHHCCCCCCCCC | 22.58 | 22369663 | |
| 586 | Phosphorylation | VPELRKSTSTNDFSE CHHHHCCCCCCCCCC | 42.48 | 22369663 | |
| 587 | Phosphorylation | PELRKSTSTNDFSEN HHHHCCCCCCCCCCC | 32.10 | 22369663 | |
| 588 | Phosphorylation | ELRKSTSTNDFSENS HHHCCCCCCCCCCCC | 38.61 | 22369663 | |
| 592 | Phosphorylation | STSTNDFSENSLDAP CCCCCCCCCCCCCCC | 38.44 | 22369663 | |
| 595 | Phosphorylation | TNDFSENSLDAPHDQ CCCCCCCCCCCCCCH | 24.47 | 22369663 | |
| 607 | Phosphorylation | HDQEVIHTSNPFLKK CCHHCEECCCCCCCH | 21.05 | 22369663 | |
| 608 | Phosphorylation | DQEVIHTSNPFLKKE CHHCEECCCCCCCHH | 28.48 | 22369663 | |
| 616 | Phosphorylation | NPFLKKETLTSKPRS CCCCCHHHCCCCCCH | 44.19 | 21440633 | |
| 618 | Phosphorylation | FLKKETLTSKPRSML CCCHHHCCCCCCHHH | 41.97 | 20377248 | |
| 619 | Phosphorylation | LKKETLTSKPRSMLE CCHHHCCCCCCHHHH | 43.72 | 20377248 | |
| 623 | Phosphorylation | TLTSKPRSMLEIAES HCCCCCCHHHHHHHC | 35.93 | 22369663 | |
| 630 | Phosphorylation | SMLEIAESPSLKQKS HHHHHHHCCCHHHHH | 15.69 | 22369663 | |
| 632 | Phosphorylation | LEIAESPSLKQKSKV HHHHHCCCHHHHHHC | 58.43 | 22369663 | |
| 645 | Phosphorylation | KVKDSAKTKTHDVGD HCCCCCCCCCCCCCC | 40.67 | 30377154 | |
| 647 | Phosphorylation | KDSAKTKTHDVGDEG CCCCCCCCCCCCCCC | 28.65 | 30377154 | |
| 689 | Phosphorylation | KVIEEATTTNVDSIL HHHHHHHCCCHHHHH | 24.34 | 19779198 | |
| 694 | Phosphorylation | ATTTNVDSILEKPTP HHCCCHHHHHCCCCC | 25.45 | 22369663 | |
| 700 | Phosphorylation | DSILEKPTPTSTKVE HHHHCCCCCCCCCCC | 50.71 | 20377248 | |
| 702 | Phosphorylation | ILEKPTPTSTKVEDN HHCCCCCCCCCCCCC | 52.05 | 21440633 | |
| 703 | Phosphorylation | LEKPTPTSTKVEDNL HCCCCCCCCCCCCCC | 27.68 | 20377248 | |
| 704 | Phosphorylation | EKPTPTSTKVEDNLS CCCCCCCCCCCCCCC | 41.40 | 20377248 | |
| 711 | Phosphorylation | TKVEDNLSEDDSTMK CCCCCCCCCCHHHHH | 45.28 | 22369663 | |
| 715 | Phosphorylation | DNLSEDDSTMKELKS CCCCCCHHHHHHHHH | 42.60 | 22890988 | |
| 716 | Phosphorylation | NLSEDDSTMKELKSM CCCCCHHHHHHHHHH | 38.98 | 22890988 | |
| 722 | Phosphorylation | STMKELKSMLNSTPT HHHHHHHHHHHCCCC | 40.92 | 22369663 | |
| 726 | Phosphorylation | ELKSMLNSTPTTPTH HHHHHHHCCCCCCCC | 31.63 | 22369663 | |
| 727 | Phosphorylation | LKSMLNSTPTTPTHN HHHHHHCCCCCCCCC | 24.47 | 22369663 | |
| 729 | Phosphorylation | SMLNSTPTTPTHNGP HHHHCCCCCCCCCCC | 45.56 | 22369663 | |
| 730 | Phosphorylation | MLNSTPTTPTHNGPT HHHCCCCCCCCCCCC | 27.65 | 22369663 | |
| 732 | Phosphorylation | NSTPTTPTHNGPTPL HCCCCCCCCCCCCCC | 26.36 | 22369663 | |
| 737 | Phosphorylation | TPTHNGPTPLPAKAG CCCCCCCCCCCCCCC | 38.56 | 22369663 | |
| 745 | Phosphorylation | PLPAKAGTQLDKRMS CCCCCCCCHHHHHHH | 30.71 | 21440633 | |
| 752 | Phosphorylation | TQLDKRMSDLSLKSE CHHHHHHHHCCCCCC | 39.16 | 22369663 | |
| 755 | Phosphorylation | DKRMSDLSLKSETPA HHHHHHCCCCCCCCC | 38.45 | 22369663 | |
| 758 | Phosphorylation | MSDLSLKSETPASTK HHHCCCCCCCCCCCC | 52.58 | 22369663 | |
| 760 | Phosphorylation | DLSLKSETPASTKNF HCCCCCCCCCCCCCC | 31.11 | 22369663 | |
| 763 | Phosphorylation | LKSETPASTKNFSAP CCCCCCCCCCCCCCC | 40.91 | 22369663 | |
| 764 | Phosphorylation | KSETPASTKNFSAPN CCCCCCCCCCCCCCC | 31.92 | 22369663 | |
| 768 | Phosphorylation | PASTKNFSAPNVSSS CCCCCCCCCCCCCCC | 52.81 | 22369663 | |
| 773 | Phosphorylation | NFSAPNVSSSSNSLR CCCCCCCCCCCCHHH | 31.01 | 22369663 | |
| 774 | Phosphorylation | FSAPNVSSSSNSLRS CCCCCCCCCCCHHHH | 33.24 | 22369663 | |
| 775 | Phosphorylation | SAPNVSSSSNSLRSL CCCCCCCCCCHHHHC | 26.49 | 22369663 | |
| 776 | Phosphorylation | APNVSSSSNSLRSLG CCCCCCCCCHHHHCC | 32.17 | 22369663 | |
| 778 | Phosphorylation | NVSSSSNSLRSLGSP CCCCCCCHHHHCCCC | 27.40 | 22369663 | |
| 781 | Phosphorylation | SSSNSLRSLGSPSVS CCCCHHHHCCCCCCC | 42.23 | 22369663 | |
| 784 | Phosphorylation | NSLRSLGSPSVSSSK CHHHHCCCCCCCCCC | 21.21 | 22369663 | |
| 786 | Phosphorylation | LRSLGSPSVSSSKKK HHHCCCCCCCCCCCC | 36.01 | 22369663 | |
| 788 | Phosphorylation | SLGSPSVSSSKKKKV HCCCCCCCCCCCCCE | 32.98 | 22369663 | |
| 789 | Phosphorylation | LGSPSVSSSKKKKVI CCCCCCCCCCCCCEE | 43.98 | 22369663 | |
| 790 | Phosphorylation | GSPSVSSSKKKKVIH CCCCCCCCCCCCEEE | 40.77 | 20377248 | |
| 817 | Phosphorylation | SSVSAFISR------ HHHHHHHCC------ | 26.03 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PTK2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PTK2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PTK2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-57; SER-105;SER-190; SER-585; SER-587; SER-623; SER-630; SER-632; SER-711;SER-715; SER-726; THR-730; SER-752; SER-768; SER-773; SER-774;SER-775; SER-776; SER-778; SER-781; SER-784 AND SER-817, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37; THR-56; SER-57;SER-65; SER-585 AND SER-781, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-56; SER-80 AND THR-588,AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-56; SER-711; SER-752 ANDSER-755, AND MASS SPECTROMETRY. | |
