| UniProt ID | VPS13_YEAST | |
|---|---|---|
| UniProt AC | Q07878 | |
| Protein Name | Vacuolar protein sorting-associated protein 13 | |
| Gene Name | VPS13 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 3144 | |
| Subcellular Localization | Golgi apparatus, trans-Golgi network . | |
| Protein Description | Required for sorting signal-dependent recycling of membrane proteins between an endocytic compartment and the TGN.. | |
| Protein Sequence | MLESLAANLLNRLLGSYVENFDPNQLNVGIWSGDVKLKNLKLRKDCLDSLNLPIDVKSGILGDLVLTVPWSSLKNKPVKIIIEDCYLLCSPRSEDHENDEEMIKRAFRLKMRKVSEWELTNQARILSTQSENKTSSSSSEKNNAGFMQSLTTKIIDNLQVTIKNIHLRYEDMDGIFTTGPSSVGLTLNELSAVSTDSNWAPSFIDITQNITHKLLTLNSLCLYWNTDSPPLISDDDQDRSLENFVRGFKDMIASKNSTAPKHQYILKPVSGLGKLSINKLGSTEEQPHIDLQMFYDEFGLELDDTEYNDILHVLSSIQLRQITKKFKKARPSFAVSENPTEWFKYIAACVINEIHEKNKMWTWESMKEKCEQRRLYTKLWVEKLKLKNLEAPLRDPIQEAQLSELHKDLTYDEIILFRSVAKRQYAQYKLGMTEDSPTPTASSNIEPQTSNKSATKNNGSWLSSWWNGKPTEEVDEDLIMTEEQRQELYDAIEFDENEDKGPVLQVPRERVELRVTSLLKKGSFTIRKKKQNLNLGSIIFENCKVDFAQRPDSFLSSFQLNKFSLEDGSPNALYKHIISVRNSSKDQSSIDNHATGEEEEEDEPLLRASFELNPLDGLADSNLNIKLLGMTVFYHVHFITEVHKFFKASNQHMETIGNIVNAAEATVEGWTTQTRMGIESLLEDHKTVNVSLDLQAPLIILPLDPHDWDTPCAIIDAGHMSILSDLVPKEKIKEIKELSPEEYDKIDGNEINRLMFDRFQILSQDTQIFVGPDIQSTIGKINTASSTNDFRILDKMKLELTVDLSILPKAYKLPTIRVFGHLPRLSLSINDIQYKTIMNLIANSIPSMIDDEENNGDYVNYSSGSEKEMKKQIQLQLKNTLKALENMQPLQIEQKFLELHFDIDQAKIAFFQCIKNDSRNSEKLVDILCQRLNFNFDKRAKEMNLDLRVHSLDVEDYIELTDNKEFKNLISSGVEKVTRSQKDLFTLKYKRVQRIVPHNDTLIELFDQDIVMHMSELQLVLTPRSVLTLMNYAMLTFTDPNAPEMPADVLRHNKEDRDDAPQKINMKIKMEAVNVIFNDDSIKLATLVLSAGEFTMVLLPERYNINLKLGGLELTDETNESFSRDSVFRKIIQMKGQELVELSYESFDPATNTKDYDSFLKYSTGSMHVNFIESAVNRMVNFFAKFQKSKVSFDRARLAAYNQAPSIDAVNNMKMDIVIKAPIIQFPKLVGTQENNYDTMRFYLGEFFIENKFSVIDESHKINHIKLGVREGQLSSNLNFDGSSQQLYLVENIGLLFNIDRDPLPQDDTPELKVTSNFESFALDLTENQLTYLLEISNKVSSAFNITDENSGESGGKGEIKSPSPDPASLSSESERTATPQSLQGSNKSNIKNPEQKYLDFSFKAPKIALTLYNKTKGVTSLNDCGLTRIMFQDIGCSLGLKNDGTVDGQAHVAAFRIEDVRNIKDNKHTELIPKSKNKEYQFVANISRKNLEVGRLLNISMTMDSPKMILAMDYLVSLKEFFDAIMSKSHENNLYYPENTNQKPENKAIVESVQEGGDVTKIQYSVNIIETALILLADPCDMNSEAISFKIGQFLVTDQNIMTVAANNVGIFLFKMNSSEEKLRLLDDFSSSLTIDKRNSTPQTLMTNIQLSVQPLLMRISLRDIRLAMLIFKRVTTLLNKMTEKEDNGEEEESTDKIQFSHEFERKLAVLDPSILGERSRASQSSDSESIEVPTAILKNETFNADLGGLRFILIGDVHEMPILDMNVNEITASAKDWSTDFEALASLETYVNIFNYSRSSWEPLLEMIPITFHLSKGHSEMDPAFSFDILTQRIAEITLSARSIAMLSHIPASLTEELPLASRVSQKPYQLVNDTELDFDVWIQDKTTEDNKNEVVLLKANTSLPWEFEDWRSIREKLDIDKSKNILGVCVSGQNYKTIMNIDATTEGENLHVLSPPRNNVHNRIVCEARCDENNVKIITFRSTLVIENTTSTEIELLVDSKDPNKPSLKYAIKPHQSKSVPVEYAYDSDIRIRPASEDIYDWSQQTLSWKSLLSNQMSIFCSSKEDSNQRFHFEIGAKYDEREPLAKIFPHMKIVVSASMTIENLLPADINFSIFDKREEKRTDFLKTGESMEVHHISLDSFLLMSVQPLQDEASASKPSIVNTPHKSPLNPEDSLSLTLSGGQNLLLKLDYKNIDGTRSKVIRIYSPYIIMNSTDRELYIQSSLLNIAQSKILLENEKRYTIPKMFSFDKEDDKSNRARIRFKESEWSSKLSFDAIGQSFDASVRIKNKEQESNLGINISEGKGKYLLSKVIEIAPRYIISNTLDIPIEVCETGSMDVQQIESNITKPLYRMRNIVDKQLVLKFLGGDSNWSQPFFIKNVGVTYLKVLKNSRHKLLKIEILLDKATIFIRIKDGGDRWPFSIRNFSDHDFIFYQRDPRKVSDPYKDDQSNESSSRSFKPIFYRIPSKSIMPYAWDFPTAKEKYLVLESGTRTREVRLAEIGELPPLRLDKRSKDKPAPIVGLHVVADDDMQALVIVNYKANVGLYKLKTASATTTSSVSVNSSVTDGFVQKDEDEKVNTQIVVSFKGVGISLINGRLQELLYINMRGIELRYNESKAYQTFSWKMKWMQIDNQLFSGNYSNILYPTEIPYTEKEIENHPVISGSISKVNDSLQAVPYFKHVTLLIQEFSIQLDEDMLYAMMDFIKFPGSPWIMDSRDYKYDEEIQLPDVSELKTAGDIYFEIFHIQPTVLHLSFIRSDEISPGLAEETEESFSSSLYYVHMFAMTLGNINEAPVKVNSLFMDNVRVPLPILMDHIERHYTTQFVYQIHKILGSADCFGNPVGLFNTISSGVWDLFYEPYQGYMMNDRPQEIGIHLAKGGLSFAKKTVFGLSDSMSKFTGSMAKGLSVTQDLEFQRVRRLQQRINKNNRNALANSAQSFASTLGSGLSGIALDPYKAMQKEGAAGFLKGLGKGIVGLPTKTAIGFLDLTSNLSQGVKSTTTVLDMQKGCRVRLPRYVDHDQIIKPYDLREAQGQYWLKTVNGGVFMNDEYLSHVILPGKELAVIVSMQHIAEVQMATQELMWSTGYPSIQGITLERSGLQIKLKSQSEYFIPISDPEERRSLYRNIAIAVREYNKYCEAIL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Ubiquitination | LKNLKLRKDCLDSLN ECCCEECHHHHHHCC | 64.33 | 17644757 | |
| 57 | Ubiquitination | LNLPIDVKSGILGDL CCCCCCCCCCCCCCE | 38.94 | 17644757 | |
| 115 | Phosphorylation | RLKMRKVSEWELTNQ HHHCCCCCHHHHHHH | 39.77 | 28889911 | |
| 133 | Ubiquitination | LSTQSENKTSSSSSE EEECCCCCCCCCCCC | 45.81 | 23749301 | |
| 213 | Ubiquitination | ITQNITHKLLTLNSL HHCCHHHHHHHHHHH | 36.22 | 17644757 | |
| 328 | Ubiquitination | QITKKFKKARPSFAV HHHHHHHHHCCCCCC | 53.40 | 17644757 | |
| 332 | Phosphorylation | KFKKARPSFAVSENP HHHHHCCCCCCCCCH | 21.93 | 21440633 | |
| 344 | Ubiquitination | ENPTEWFKYIAACVI CCHHHHHHHHHHHHH | 36.50 | 17644757 | |
| 425 | Phosphorylation | RSVAKRQYAQYKLGM HHHHHHHHHHHCCCC | 10.33 | 19779198 | |
| 433 | Phosphorylation | AQYKLGMTEDSPTPT HHHCCCCCCCCCCCC | 34.54 | 28889911 | |
| 436 | Phosphorylation | KLGMTEDSPTPTASS CCCCCCCCCCCCCCC | 25.17 | 25752575 | |
| 438 | Phosphorylation | GMTEDSPTPTASSNI CCCCCCCCCCCCCCC | 36.90 | 24909858 | |
| 440 | Phosphorylation | TEDSPTPTASSNIEP CCCCCCCCCCCCCCC | 41.47 | 23749301 | |
| 442 | Phosphorylation | DSPTPTASSNIEPQT CCCCCCCCCCCCCCC | 26.79 | 29734811 | |
| 443 | Phosphorylation | SPTPTASSNIEPQTS CCCCCCCCCCCCCCC | 39.09 | 23749301 | |
| 449 | Phosphorylation | SSNIEPQTSNKSATK CCCCCCCCCCCCCCC | 45.01 | 28889911 | |
| 450 | Phosphorylation | SNIEPQTSNKSATKN CCCCCCCCCCCCCCC | 36.69 | 28152593 | |
| 452 | Ubiquitination | IEPQTSNKSATKNNG CCCCCCCCCCCCCCC | 41.03 | 23749301 | |
| 588 | Phosphorylation | RNSSKDQSSIDNHAT CCCCCCCHHCCCCCC | 39.12 | 30377154 | |
| 801 | Phosphorylation | DKMKLELTVDLSILP HCCEEEEEEEEHHCC | 11.55 | 19823750 | |
| 805 | Phosphorylation | LELTVDLSILPKAYK EEEEEEEHHCCCCCC | 20.02 | 19823750 | |
| 882 | Ubiquitination | LQLKNTLKALENMQP HHHHHHHHHHHHCCC | 49.22 | 23749301 | |
| 961 | Phosphorylation | VEDYIELTDNKEFKN HHHHEECCCCHHHHH | 25.41 | 19779198 | |
| 976 | Acetylation | LISSGVEKVTRSQKD HHHHCHHHHHCCHHH | 46.64 | 24489116 | |
| 982 | Acetylation | EKVTRSQKDLFTLKY HHHHCCHHHCEEEEE | 58.61 | 24489116 | |
| 988 | Acetylation | QKDLFTLKYKRVQRI HHHCEEEEECEEEEE | 45.74 | 24489116 | |
| 1063 | Ubiquitination | DRDDAPQKINMKIKM CCCCCCHHHHHEEEE | 34.68 | 17644757 | |
| 1067 | Ubiquitination | APQKINMKIKMEAVN CCHHHHHEEEEEEEE | 34.39 | 17644757 | |
| 1069 | Ubiquitination | QKINMKIKMEAVNVI HHHHHEEEEEEEEEE | 25.77 | 17644757 | |
| 1146 | Phosphorylation | LVELSYESFDPATNT EEEECCCCCCCCCCC | 27.07 | 19779198 | |
| 1156 | Phosphorylation | PATNTKDYDSFLKYS CCCCCCCHHHHHHHC | 18.29 | 19779198 | |
| 1158 | Phosphorylation | TNTKDYDSFLKYSTG CCCCCHHHHHHHCCC | 26.67 | 19779198 | |
| 1163 | Phosphorylation | YDSFLKYSTGSMHVN HHHHHHHCCCCCCHH | 25.38 | 27017623 | |
| 1166 | Phosphorylation | FLKYSTGSMHVNFIE HHHHCCCCCCHHHHH | 13.05 | 27017623 | |
| 1341 | Phosphorylation | LEISNKVSSAFNITD HHHHCCCHHCCCCCC | 19.98 | 19779198 | |
| 1347 | Phosphorylation | VSSAFNITDENSGES CHHCCCCCCCCCCCC | 38.06 | 19779198 | |
| 1357 | Ubiquitination | NSGESGGKGEIKSPS CCCCCCCCCCCCCCC | 57.82 | 23749301 | |
| 1362 | Phosphorylation | GGKGEIKSPSPDPAS CCCCCCCCCCCCHHH | 35.95 | 22369663 | |
| 1364 | Phosphorylation | KGEIKSPSPDPASLS CCCCCCCCCCHHHCC | 49.37 | 22369663 | |
| 1369 | Phosphorylation | SPSPDPASLSSESER CCCCCHHHCCCCCCC | 33.88 | 25521595 | |
| 1371 | Phosphorylation | SPDPASLSSESERTA CCCHHHCCCCCCCCC | 29.57 | 20377248 | |
| 1372 | Phosphorylation | PDPASLSSESERTAT CCHHHCCCCCCCCCC | 50.89 | 20377248 | |
| 1374 | Phosphorylation | PASLSSESERTATPQ HHHCCCCCCCCCCCC | 34.03 | 20377248 | |
| 1377 | Phosphorylation | LSSESERTATPQSLQ CCCCCCCCCCCCCCC | 30.72 | 22369663 | |
| 1379 | Phosphorylation | SESERTATPQSLQGS CCCCCCCCCCCCCCC | 22.65 | 22369663 | |
| 1382 | Phosphorylation | ERTATPQSLQGSNKS CCCCCCCCCCCCCCC | 24.70 | 22369663 | |
| 1386 | Phosphorylation | TPQSLQGSNKSNIKN CCCCCCCCCCCCCCC | 28.29 | 22369663 | |
| 1404 | Acetylation | KYLDFSFKAPKIALT HHHCCCCCCCEEEEE | 63.68 | 24489116 | |
| 1620 | Phosphorylation | FLFKMNSSEEKLRLL EEEECCCCHHHHHHH | 44.78 | 28889911 | |
| 1648 | Phosphorylation | STPQTLMTNIQLSVQ CCCCCHHHHEECCHH | 32.08 | 27017623 | |
| 1662 | Phosphorylation | QPLLMRISLRDIRLA HHHHHHHCHHHHHHH | 13.64 | 27017623 | |
| 1684 | Phosphorylation | TTLLNKMTEKEDNGE HHHHHHHHCCCCCCC | 45.58 | 19779198 | |
| 1695 | Phosphorylation | DNGEEEESTDKIQFS CCCCCCCCCCCCCCC | 45.23 | 24961812 | |
| 1696 | Phosphorylation | NGEEEESTDKIQFSH CCCCCCCCCCCCCCH | 44.59 | 24961812 | |
| 1715 | Phosphorylation | KLAVLDPSILGERSR HHHHCCHHHHCCCCC | 30.06 | 22369663 | |
| 1721 | Phosphorylation | PSILGERSRASQSSD HHHHCCCCCCCCCCC | 28.09 | 20377248 | |
| 1724 | Phosphorylation | LGERSRASQSSDSES HCCCCCCCCCCCCCC | 29.50 | 20377248 | |
| 1726 | Phosphorylation | ERSRASQSSDSESIE CCCCCCCCCCCCCCC | 33.35 | 22369663 | |
| 1727 | Phosphorylation | RSRASQSSDSESIEV CCCCCCCCCCCCCCC | 37.20 | 22369663 | |
| 1729 | Phosphorylation | RASQSSDSESIEVPT CCCCCCCCCCCCCCH | 34.88 | 22369663 | |
| 1731 | Phosphorylation | SQSSDSESIEVPTAI CCCCCCCCCCCCHHH | 28.18 | 22369663 | |
| 1736 | Phosphorylation | SESIEVPTAILKNET CCCCCCCHHHHCCCC | 31.35 | 22369663 | |
| 1743 | Phosphorylation | TAILKNETFNADLGG HHHHCCCCCCCCCCC | 31.42 | 21440633 | |
| 1801 | Phosphorylation | NIFNYSRSSWEPLLE HHHCCCCCCCHHHHH | 33.59 | 27017623 | |
| 1817 | Phosphorylation | IPITFHLSKGHSEMD CCEEEECCCCCCCCC | 28.20 | 27017623 | |
| 1894 | Ubiquitination | DKTTEDNKNEVVLLK CCCCCCCCCEEEEEE | 67.80 | 23749301 | |
| 2053 | Ubiquitination | SQQTLSWKSLLSNQM HHHHCCHHHHHCCCE | 28.05 | 17644757 | |
| 2141 | Phosphorylation | SMEVHHISLDSFLLM CEEEEEEECCHHEEE | 23.05 | 30377154 | |
| 2144 | Phosphorylation | VHHISLDSFLLMSVQ EEEEECCHHEEEECC | 24.08 | 30377154 | |
| 2149 | Phosphorylation | LDSFLLMSVQPLQDE CCHHEEEECCCCCCC | 19.98 | 30377154 | |
| 2158 | Phosphorylation | QPLQDEASASKPSIV CCCCCCHHCCCCCCC | 30.90 | 30377154 | |
| 2209 | Phosphorylation | RSKVIRIYSPYIIMN CCEEEEEECCEEEEC | 8.17 | 21440633 | |
| 2210 | Phosphorylation | SKVIRIYSPYIIMNS CEEEEEECCEEEECC | 14.62 | 21440633 | |
| 2223 | Phosphorylation | NSTDRELYIQSSLLN CCCCCHHHHHHHHHH | 7.67 | 21440633 | |
| 2462 | Acetylation | ESSSRSFKPIFYRIP CCCCCCCCCEEEECC | 38.15 | 24489116 | |
| 2487 | Phosphorylation | FPTAKEKYLVLESGT CCCCCCEEEEEECCC | 11.79 | 28889911 | |
| 2492 | Phosphorylation | EKYLVLESGTRTREV CEEEEEECCCCEEEE | 41.10 | 28889911 | |
| 2557 | Phosphorylation | KLKTASATTTSSVSV EEEECCCCCCCCEEE | 28.28 | 19779198 | |
| 2561 | Phosphorylation | ASATTTSSVSVNSSV CCCCCCCCEEECCCC | 19.13 | 19779198 | |
| 2563 | Phosphorylation | ATTTSSVSVNSSVTD CCCCCCEEECCCCCC | 19.96 | 19779198 | |
| 2566 | Phosphorylation | TSSVSVNSSVTDGFV CCCEEECCCCCCCCC | 24.83 | 19779198 | |
| 2567 | Phosphorylation | SSVSVNSSVTDGFVQ CCEEECCCCCCCCCC | 24.67 | 19779198 | |
| 2569 | Phosphorylation | VSVNSSVTDGFVQKD EEECCCCCCCCCCCC | 32.14 | 19779198 | |
| 2885 | Phosphorylation | HLAKGGLSFAKKTVF EEHHCCCHHHHHHHH | 26.83 | 23749301 | |
| 2895 | Phosphorylation | KKTVFGLSDSMSKFT HHHHHCCCHHHHHHC | 28.19 | 19779198 | |
| 2897 | Phosphorylation | TVFGLSDSMSKFTGS HHHCCCHHHHHHCCC | 22.91 | 21440633 | |
| 2899 | Phosphorylation | FGLSDSMSKFTGSMA HCCCHHHHHHCCCCC | 28.68 | 19779198 | |
| 2948 | Phosphorylation | SFASTLGSGLSGIAL HHHHHHCCCCCCCCC | 39.41 | 24961812 | |
| 2951 | Phosphorylation | STLGSGLSGIALDPY HHHCCCCCCCCCCHH | 31.51 | 21440633 | |
| 3027 | Acetylation | VDHDQIIKPYDLREA CCCCCCCCCCCHHHH | 38.87 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS13_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS13_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS13_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1362; SER-1364;THR-1379; SER-1715; SER-1727; SER-1729 AND SER-1731, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1715, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1715, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1715 AND SER-1726, ANDMASS SPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1379 AND SER-1382, ANDMASS SPECTROMETRY. | |
