PPQ1_YEAST - dbPTM
PPQ1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPQ1_YEAST
UniProt AC P32945
Protein Name Serine/threonine-protein phosphatase PPQ
Gene Name PPQ1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 549
Subcellular Localization
Protein Description Phosphatase involved in the regulation of protein synthesis. Affects translational accuracy..
Protein Sequence MRRSPSRSNNNFAVPNCSTNSNSSQQQLTTPSDDLNSNEPNDPDDSRSLPTIKKFNNKHSINNYNTLASAGKNNNNKRASNDNLLIPGENAHKQKIYTKDENLKSLYLDIDVSVAKALSSSATAPKLINTARTSSTTTATTSNNILTSPSYRESNYSSPSSYSFSSYYSSATSASSSTSSFLKSSGLSSRVKSPSSSVKAGSFGAPSSPTSGIPNPKSSKKPIFLRRYSHDTSSNEGLDIDVAIEKLLQVGESREITKTSKKKNFPFHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRALKNKKKLYKTKV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
80PhosphorylationNNNNKRASNDNLLIP
CCCCCCCCCCCCCCC		49.0722369663
98PhosphorylationAHKQKIYTKDENLKS
HHCCCCEECCCCHHH		35.1828889911
116UbiquitinationDIDVSVAKALSSSAT
ECHHHHHHHHCCCCC		47.9415699485
193PhosphorylationGLSSRVKSPSSSVKA
CCCCCCCCCCCCCCC		27.4530377154
196PhosphorylationSRVKSPSSSVKAGSF
CCCCCCCCCCCCCCC		42.4021440633
202PhosphorylationSSSVKAGSFGAPSSP
CCCCCCCCCCCCCCC		25.9320377248
207PhosphorylationAGSFGAPSSPTSGIP
CCCCCCCCCCCCCCC		48.7120377248
208PhosphorylationGSFGAPSSPTSGIPN
CCCCCCCCCCCCCCC		31.0119823750
210PhosphorylationFGAPSSPTSGIPNPK
CCCCCCCCCCCCCCC		41.3420377248
211PhosphorylationGAPSSPTSGIPNPKS
CCCCCCCCCCCCCCC		37.8020377248
218PhosphorylationSGIPNPKSSKKPIFL
CCCCCCCCCCCCEEE		48.9627017623
219PhosphorylationGIPNPKSSKKPIFLR
CCCCCCCCCCCEEEE		51.3121551504
229PhosphorylationPIFLRRYSHDTSSNE
CEEEEEECCCCCCCC		17.0528889911
502PhosphorylationFARKKFVTIFSAPNY
HEECCEEEEEECCCC		21.3119823750
505PhosphorylationKKFVTIFSAPNYCGE
CCEEEEEECCCCCCC		38.6819823750
509PhosphorylationTIFSAPNYCGEFHNW
EEEECCCCCCCCCCH		10.7719823750
521PhosphorylationHNWGAVMSVTTGMMC
CCHHHEEEECCCCHH		15.0919823750
523PhosphorylationWGAVMSVTTGMMCSF
HHHEEEECCCCHHCH		15.4319823750
524PhosphorylationGAVMSVTTGMMCSFE
HHEEEECCCCHHCHH		22.4119823750
529PhosphorylationVTTGMMCSFELLKPR
ECCCCHHCHHHHCHH		12.1219823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPQ1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPQ1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPQ1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SDS22_YEASTSDS22physical
11805837
KNS1_YEASTKNS1genetic
19269370
SDS22_YEASTSDS22physical
20489023
YPI1_YEASTYPI1physical
20489023
CBF1_YEASTCBF1genetic
21127252
SWI5_YEASTSWI5genetic
21127252
SLX5_YEASTSLX5genetic
21127252
ELP3_YEASTELP3genetic
21127252
BUB1_YEASTBUB1genetic
21127252
CTK2_YEASTCTK2genetic
21127252
OCA2_YEASTOCA2genetic
21127252
PDR1_YEASTPDR1genetic
21127252
VPS71_YEASTVPS71genetic
21127252
YAP3_YEASTYAP3genetic
21127252
CG11_YEASTCLN1genetic
21127252
RAD17_YEASTRAD17genetic
21127252
DAL82_YEASTDAL82genetic
21127252
GPR1_YEASTGPR1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
UAP1_YEASTQRI1genetic
27708008
LCB2_YEASTLCB2genetic
27708008
CDC37_YEASTCDC37genetic
27708008
CCA1_YEASTCCA1genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
RRP4_YEASTRRP4genetic
27708008
CTF8_YEASTCTF8genetic
27708008
MTR4_YEASTMTR4genetic
27708008
ESS1_YEASTESS1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
DBP9_YEASTDBP9genetic
27708008
IMB1_YEASTKAP95genetic
27708008
LCB1_YEASTLCB1genetic
27708008
DBP6_YEASTDBP6genetic
27708008
HRP1_YEASTHRP1genetic
27708008
PROF_YEASTPFY1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
YTM1_YEASTYTM1genetic
27708008
MED10_YEASTNUT2genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
THRC_YEASTTHR4genetic
27708008
BUD31_YEASTBUD31genetic
27708008
YCZ2_YEASTYCR102Cgenetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
RV167_YEASTRVS167genetic
27708008
PUF6_YEASTPUF6genetic
27708008
PFD3_YEASTPAC10genetic
27708008
VMA21_YEASTVMA21genetic
27708008
PHB2_YEASTPHB2genetic
27708008
STB5_YEASTSTB5genetic
27708008
PGM1_YEASTPGM1genetic
27708008
ATG3_YEASTATG3genetic
27708008
PHO80_YEASTPHO80genetic
27708008
KAR3_YEASTKAR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPQ1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80 AND SER-208, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208, AND MASSSPECTROMETRY.

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