| UniProt ID | BUB1_YEAST | |
|---|---|---|
| UniProt AC | P41695 | |
| Protein Name | Checkpoint serine/threonine-protein kinase BUB1 | |
| Gene Name | BUB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1021 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Involved in cell cycle checkpoint enforcement. The formation of a MAD1-BUB1-BUB3 complex seems to be required for the spindle checkpoint mechanism. Catalyzes the phosphorylation of BUB3 and its autophosphorylation. Associates with centromere (CEN) DNA via interaction with SKP1. The association with SKP1 is required for the mitotic delay induced by kinetochore tension defects, but not for the arrest induced by spindle depolymerization or kinetochore assembly defects.. | |
| Protein Sequence | MNLDLGSTVRGYESDKDTFPQSKGVSSSQKEQHSQLNQTKIAYEQRLLNDLEDMDDPLDLFLDYMIWISTSYIEVDSESGQEVLRSTMERCLIYIQDMETYRNDPRFLKIWIWYINLFLSNNFHESENTFKYMFNKGIGTKLSLFYEEFSKLLENAQFFLEAKVLLELGAENNCRPYNRLLRSLSNYEDRLREMNIVENQNSVPDSRERLKGRLIYRTAPFFIRKFLTSSLMTDDKENRANLNSNVGVGKSAPNVYQDSIVVADFKSETERLNLNSSKQPSNQRLKNGNKKTSIYADQKQSNNPVYKLINTPGRKPERIVFNFNLIYPENDEEFNTEEILAMIKGLYKVQRRGKKHTEDYTSDKNRKKRKLDVLVERRQDLPSSQPPVVPKSTRIEVFKDDDNPSQSTHHKNTQVQVQTTTSILPLKPVVDGNLAHETPVKPSLTSNASRSPTVTAFSKDAINEVFSMFNQHYSTPGALLDGDDTTTSKFNVFENFTQEFTAKNIEDLTEVKDPKQETVSQQTTSTNETNDRYERLSNSSTRPEKADYMTPIKETTETDVVPIIQTPKEQIRTEDKKSGDNTETQTQLTSTTIQSSPFLTQPEPQAEKLLQTAEHSEKSKEHYPTIIPPFTKIKNQPPVIIENPLSNNLRAKFLSEISPPLFQYNTFYNYNQELKMSSLLKKIHRVSRNENKNPIVDFKKTGDLYCIRGELGEGGYATVYLAESSQGHLRALKVEKPASVWEYYIMSQVEFRLRKSTILKSIINASALHLFLDESYLVLNYASQGTVLDLINLQREKAIDGNGIMDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPGEPLGAHYMRNGEDGWENKGIYLIDFGRSFDMTLLPPGTKFKSNWKADQQDCWEMRAGKPWSYEADYYGLAGVIHSMLFGKFIETIQLQNGRCKLKNPFKRYWKKEIWGVIFDLLLNSGQASNQALPMTEKIVEIRNLIESHLEQHAENHLRNVILSIEEELSHFQYKGKPSRRF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MNLDLGSTVRGYES -CCCCCCCCCCCCCC | 30.90 | 24961812 | |
| 8 | Phosphorylation | MNLDLGSTVRGYESD CCCCCCCCCCCCCCC | 16.66 | 24961812 | |
| 14 | Phosphorylation | STVRGYESDKDTFPQ CCCCCCCCCCCCCCC | 41.29 | 21440633 | |
| 18 | Phosphorylation | GYESDKDTFPQSKGV CCCCCCCCCCCCCCC | 42.85 | 24961812 | |
| 22 | Phosphorylation | DKDTFPQSKGVSSSQ CCCCCCCCCCCCHHH | 31.45 | 24961812 | |
| 228 | Phosphorylation | FFIRKFLTSSLMTDD HHHHHHHHHHCCCCC | 21.28 | 28889911 | |
| 229 | Phosphorylation | FIRKFLTSSLMTDDK HHHHHHHHHCCCCCC | 24.50 | 28889911 | |
| 230 | Phosphorylation | IRKFLTSSLMTDDKE HHHHHHHHCCCCCCC | 19.54 | 28889911 | |
| 438 | Phosphorylation | DGNLAHETPVKPSLT CCCCCCCCCCCCCCC | 24.42 | 21551504 | |
| 449 | Phosphorylation | PSLTSNASRSPTVTA CCCCCCCCCCCCEEE | 37.23 | 21551504 | |
| 451 | Phosphorylation | LTSNASRSPTVTAFS CCCCCCCCCCEEEEC | 23.56 | 21551504 | |
| 537 | Phosphorylation | NDRYERLSNSSTRPE HHHHHHHHCCCCCCH | 40.67 | 21551504 | |
| 539 | Phosphorylation | RYERLSNSSTRPEKA HHHHHHCCCCCCHHC | 29.70 | 27017623 | |
| 540 | Phosphorylation | YERLSNSSTRPEKAD HHHHHCCCCCCHHCC | 32.46 | 27017623 | |
| 541 | Phosphorylation | ERLSNSSTRPEKADY HHHHCCCCCCHHCCC | 50.49 | 21551504 | |
| 548 | Phosphorylation | TRPEKADYMTPIKET CCCHHCCCCCCCCCC | 14.03 | 19779198 | |
| 550 | Phosphorylation | PEKADYMTPIKETTE CHHCCCCCCCCCCCC | 18.68 | 21440633 | |
| 555 | Phosphorylation | YMTPIKETTETDVVP CCCCCCCCCCCCEEE | 25.57 | 21440633 | |
| 556 | Phosphorylation | MTPIKETTETDVVPI CCCCCCCCCCCEEEC | 37.67 | 27717283 | |
| 558 | Phosphorylation | PIKETTETDVVPIIQ CCCCCCCCCEEECEE | 31.81 | 27717283 | |
| 566 | Phosphorylation | DVVPIIQTPKEQIRT CEEECEECCHHHHCC | 26.39 | 21440633 | |
| 595 | Phosphorylation | LTSTTIQSSPFLTQP EEECEECCCCCCCCC | 35.81 | 28889911 | |
| 596 | Phosphorylation | TSTTIQSSPFLTQPE EECEECCCCCCCCCC | 11.86 | 23749301 | |
| 600 | Phosphorylation | IQSSPFLTQPEPQAE ECCCCCCCCCCHHHH | 42.32 | 21551504 | |
| 875 | Phosphorylation | YLIDFGRSFDMTLLP EEEECCCCEEEEECC | 26.44 | 28889911 | |
| 879 | Phosphorylation | FGRSFDMTLLPPGTK CCCCEEEEECCCCCC | 27.30 | 27017623 | |
| 885 | Phosphorylation | MTLLPPGTKFKSNWK EEECCCCCCCCCCCC | 38.80 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BUB1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BUB1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BUB1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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